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The map label for this gene is lolC

Identifier: 16273455

GI number: 16273455

Start: 1625724

End: 1626905

Strand: Reverse

Name: lolC

Synonym: HI1555

Alternate gene names: 16273455

Gene position: 1626905-1625724 (Counterclockwise)

Preceding gene: 16273456

Following gene: 16273454

Centisome position: 88.9

GC content: 39.51

Gene sequence:

>1182_bases
ATGAATTTTCCTATTTCTCTTTATATTGCACTACGTTATTGGCGTGCGAAAAGTGCGGATCGTTTTGGGCGATTAGTGAC
TAATCTTGCAAGCCTGGGGATTGTGCTAGGTGTGATGGCATTGATCATCGTGCTTTCGGTGATGAATGGATTAGAAGGTT
ACCAAAAACAACAGGTGCTATCTTCTATTCCTCATGCGATTGTGAGCGAAGAGCAGCCTATTTCTACAGAAAAAACGCTA
GAAAATTTACCGCACTTTGTCCAAAAAGCCGTGCCGATCAATACAACAAATGTGATTTATCAAACGGCAAAAGGCGTAAG
TGCAGGACAAATTATAGGTATTCAATCATTTTCTGATGATCCTTTGGTTGAATCTTTTGATCAGACTAAATTTAATGAAA
TTTTGCCTAGAGGGGAGTTTAAACTGGTCATTGGCGATCAACTGGCGCAAAAACTGGGCGTGAATATTGGGGATAAAATC
CGTTTGATGATTACGGAAAATAGCCAATATACACCATTCGGTCGGGTGCCAATGCAGCGTTTATTTACTGTTAGCGATAT
TTATTATGGTTATGGCGAAGCATCTGGTTACGAAGCCTTTGCTAATATTACAGATATTGGTCGCTTAATGCGTATTCAAC
CTCAGCAAGCACAGGGCTATCGTTTATTTCTGAATGATCCGTTCCAAATTACAGAACTCCCACAACATTTCCCGACACAA
AAAATCACAGATTGGCGTGTGCAAAAAGGCGAATTTTTCCAAGCAGTGAGAATGGAAAAAAATATGATGGGTTTGCTGAT
TAGTTTGATTATTGTCGTGGCGATTTCCAATATTGTCACCTCTTTAAGTTTGATGGTGGTGGATAAACAAGGGGAAATTG
CGATTTTGCAAACTCAAGGCTTAACAAAATCCCAAGTGCGTTCAGTGTTCATTTATCAAGGATTACTGGTGGGATTTGTT
GGCACATTACTCGGTGCTATTTTAGGTGTTTTAGCTACGTTGAATTTAACGGACATTGTAAGTGCGGTAAATCCACAAGG
TGTTTTTTTACCGACAGAATTATCCTTTGTTCAAATGATTTTTGTCATTGGATTTTCGCTGTTACTTTCCTTGCTTTCAA
CCCTTTATCCTGCTTATCGAGCTGCGAAAGTAGAACCTGCAGCAGCTTTGAGATACGAATAA

Upstream 100 bases:

>100_bases
CACCACATATTGCTTGGGCGAGTGATAGTGCAGTGACAACATTAGTTGGCAAAGTAATGCAAAACATCGAAGAATTTGTA
CAACAATTACATCAAAAATA

Downstream 100 bases:

>100_bases
GTTTTTAATGGTAAATAAATGGTGGATGAACAATCACTTTTAGCTTTTGATACACAACATATTTGGCATCCTTATTCTTC
AGTTTCTTCTGATATGCCGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNFPISLYIALRYWRAKSADRFGRLVTNLASLGIVLGVMALIIVLSVMNGLEGYQKQQVLSSIPHAIVSEEQPISTEKTL
ENLPHFVQKAVPINTTNVIYQTAKGVSAGQIIGIQSFSDDPLVESFDQTKFNEILPRGEFKLVIGDQLAQKLGVNIGDKI
RLMITENSQYTPFGRVPMQRLFTVSDIYYGYGEASGYEAFANITDIGRLMRIQPQQAQGYRLFLNDPFQITELPQHFPTQ
KITDWRVQKGEFFQAVRMEKNMMGLLISLIIVVAISNIVTSLSLMVVDKQGEIAILQTQGLTKSQVRSVFIYQGLLVGFV
GTLLGAILGVLATLNLTDIVSAVNPQGVFLPTELSFVQMIFVIGFSLLLSLLSTLYPAYRAAKVEPAAALRYE

Sequences:

>Translated_393_residues
MNFPISLYIALRYWRAKSADRFGRLVTNLASLGIVLGVMALIIVLSVMNGLEGYQKQQVLSSIPHAIVSEEQPISTEKTL
ENLPHFVQKAVPINTTNVIYQTAKGVSAGQIIGIQSFSDDPLVESFDQTKFNEILPRGEFKLVIGDQLAQKLGVNIGDKI
RLMITENSQYTPFGRVPMQRLFTVSDIYYGYGEASGYEAFANITDIGRLMRIQPQQAQGYRLFLNDPFQITELPQHFPTQ
KITDWRVQKGEFFQAVRMEKNMMGLLISLIIVVAISNIVTSLSLMVVDKQGEIAILQTQGLTKSQVRSVFIYQGLLVGFV
GTLLGAILGVLATLNLTDIVSAVNPQGVFLPTELSFVQMIFVIGFSLLLSLLSTLYPAYRAAKVEPAAALRYE
>Mature_393_residues
MNFPISLYIALRYWRAKSADRFGRLVTNLASLGIVLGVMALIIVLSVMNGLEGYQKQQVLSSIPHAIVSEEQPISTEKTL
ENLPHFVQKAVPINTTNVIYQTAKGVSAGQIIGIQSFSDDPLVESFDQTKFNEILPRGEFKLVIGDQLAQKLGVNIGDKI
RLMITENSQYTPFGRVPMQRLFTVSDIYYGYGEASGYEAFANITDIGRLMRIQPQQAQGYRLFLNDPFQITELPQHFPTQ
KITDWRVQKGEFFQAVRMEKNMMGLLISLIIVVAISNIVTSLSLMVVDKQGEIAILQTQGLTKSQVRSVFIYQGLLVGFV
GTLLGAILGVLATLNLTDIVSAVNPQGVFLPTELSFVQMIFVIGFSLLLSLLSTLYPAYRAAKVEPAAALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily

Homologues:

Organism=Escherichia coli, GI1787360, Length=398, Percent_Identity=46.2311557788945, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1787362, Length=414, Percent_Identity=29.4685990338164, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LOLC_HAEIN (P44252)

Other databases:

- EMBL:   L42023
- PIR:   A64036
- RefSeq:   NP_439704.1
- GeneID:   949639
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1555
- TIGR:   HI_1555
- HOGENOM:   HBG675801
- OMA:   LVIAVNT
- ProtClustDB:   CLSK870158
- BioCyc:   HINF71421:HI_1555-MONOMER
- GO:   GO:0006810
- InterPro:   IPR003838
- InterPro:   IPR011925
- TIGRFAMs:   TIGR02212

Pfam domain/function: PF02687 FtsX

EC number: NA

Molecular weight: Translated: 43580; Mature: 43580

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xeb764a4)-; HASH(0xbc2f7c4)-; HASH(0xeb0b008)-; HASH(0xc373198)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFPISLYIALRYWRAKSADRFGRLVTNLASLGIVLGVMALIIVLSVMNGLEGYQKQQVL
CCCCEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIPHAIVSEEQPISTEKTLENLPHFVQKAVPINTTNVIYQTAKGVSAGQIIGIQSFSDD
HHCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEECCCCCC
PLVESFDQTKFNEILPRGEFKLVIGDQLAQKLGVNIGDKIRLMITENSQYTPFGRVPMQR
HHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHH
LFTVSDIYYGYGEASGYEAFANITDIGRLMRIQPQQAQGYRLFLNDPFQITELPQHFPTQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHCHHHCCCC
KITDWRVQKGEFFQAVRMEKNMMGLLISLIIVVAISNIVTSLSLMVVDKQGEIAILQTQG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECC
LTKSQVRSVFIYQGLLVGFVGTLLGAILGVLATLNLTDIVSAVNPQGVFLPTELSFVQMI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCHHHHHHHH
FVIGFSLLLSLLSTLYPAYRAAKVEPAAALRYE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCH
>Mature Secondary Structure
MNFPISLYIALRYWRAKSADRFGRLVTNLASLGIVLGVMALIIVLSVMNGLEGYQKQQVL
CCCCEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIPHAIVSEEQPISTEKTLENLPHFVQKAVPINTTNVIYQTAKGVSAGQIIGIQSFSDD
HHCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEECCCCCC
PLVESFDQTKFNEILPRGEFKLVIGDQLAQKLGVNIGDKIRLMITENSQYTPFGRVPMQR
HHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHH
LFTVSDIYYGYGEASGYEAFANITDIGRLMRIQPQQAQGYRLFLNDPFQITELPQHFPTQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHCHHHCCCC
KITDWRVQKGEFFQAVRMEKNMMGLLISLIIVVAISNIVTSLSLMVVDKQGEIAILQTQG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECC
LTKSQVRSVFIYQGLLVGFVGTLLGAILGVLATLNLTDIVSAVNPQGVFLPTELSFVQMI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCHHHHHHHH
FVIGFSLLLSLLSTLYPAYRAAKVEPAAALRYE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800