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The map label for this gene is bioA

Identifier: 16273454

GI number: 16273454

Start: 1624413

End: 1625705

Strand: Reverse

Name: bioA

Synonym: HI1554

Alternate gene names: 16273454

Gene position: 1625705-1624413 (Counterclockwise)

Preceding gene: 16273455

Following gene: 16273453

Centisome position: 88.83

GC content: 40.53

Gene sequence:

>1293_bases
ATGGTGGATGAACAATCACTTTTAGCTTTTGATACACAACATATTTGGCATCCTTATTCTTCAGTTTCTTCTGATATGCC
GCTTTATGCGGTGGAACGTGCTGATGGCGTGATGATAACTTTAAAAGATGGTCGTCGTTTGATTGATGGTATGTCCTCTT
GGTGGGCGGCGTTGCACGGTTATAATCATCCTCGTTTAAATGCGGCGGCACAGAATCAATTAGCAAAAATGAGCCATATT
ATGTTTGGCGGATTTACCCATGACCCAGCGGTGGAATTAGCTCAATTATTGGTACAAATTTTGCCCAATGGATTAGATAA
GATCTTTTTTGCTGATAGTGGTTCTGTTGCAGTGGAAGTAGCGATGAAAATGGCTATTCAATATCAGCACGCTAAAGGAG
AAGTGCAACGACAAAAATTTGCCACTATTCGTTCTGGTTATCACGGCGATACTTGGAATGCAATGTCAGTGTGTGATCCA
ACCACAGGGATGCATCATTTATTTCATCATAGCTTACCCGTGCAGTATTTTCTTCCTCAACCCAACATTCCATTTAATGA
ATCTTGGAATGATTGTGCCATTGAACCTTTAGCTGATTTACTTAAGAAAAAAGGTAATGAAATCGCCGCACTGATTTTAG
AACCGGTTGTGCAAGGTGCGGGCGGTATGTATTTTTATTCGCCAACTTATTTAGTGAAAGCGCAAGCGCTTTGTAAACAA
TATGGTATATTGCTAATTTTTGATGAAATTGCCACGGGATTTGGTCGAACAGGAAAATTATTTGCAGCTGAACACGCAGG
CATTTCGCCAGATATTATGTGTATCGGTAAAGCCTTAACAGGTGGGTATTTGACTTTATCTGCAAGCATTACGACCACTG
AAATTGCGCAAACTATTTGTAGCGGTGAGGCTAAATGCTTTATGCACGGGCCCACTTTTATGGCAAATCCGTTGGCTTGT
GCGATTGCAGCAGAATCTATCCGTTTATTGTTGGAAAGCCCTTGGCAGCAAAATATTCAGCGAATTGAGTCTTCCTTAAA
ACAACAGCTTTCGCCTTTATCTGAAAAAGATTACGTCAAAGAAGTTCGTGCATTAGGGGCGATTGGGGTGGTTGAAATGA
AAAGTGCGGTAAATATGAAAACTTTAGTCCCACGTTTTGTGGAACAAGGTGTTTGGATTCGGCCTTTCGGAAAATTGGTT
TATGTTATGCCACCATTTGTGATTAAAGATGATGAACTTCAGAAATTAACGGAAGGCATGATTCTGGCTTTAACTCAGGA
ATATGAACATTAG

Upstream 100 bases:

>100_bases
GTTACTTTCCTTGCTTTCAACCCTTTATCCTGCTTATCGAGCTGCGAAAGTAGAACCTGCAGCAGCTTTGAGATACGAAT
AAGTTTTTAATGGTAAATAA

Downstream 100 bases:

>100_bases
GATAAAAAATGGATGCTTTCAAACAGCAACTGGAACAGCTTAGCGCAAAAAATCAATATCGTTCAATTCCAGATTTAGTT
CATCAAGGACGATATATTAC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MVDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHGYNHPRLNAAAQNQLAKMSHI
MFGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEVAMKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDP
TTGMHHLFHHSLPVQYFLPQPNIPFNESWNDCAIEPLADLLKKKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQ
YGILLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQTICSGEAKCFMHGPTFMANPLAC
AIAAESIRLLLESPWQQNIQRIESSLKQQLSPLSEKDYVKEVRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLV
YVMPPFVIKDDELQKLTEGMILALTQEYEH

Sequences:

>Translated_430_residues
MVDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHGYNHPRLNAAAQNQLAKMSHI
MFGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEVAMKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDP
TTGMHHLFHHSLPVQYFLPQPNIPFNESWNDCAIEPLADLLKKKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQ
YGILLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQTICSGEAKCFMHGPTFMANPLAC
AIAAESIRLLLESPWQQNIQRIESSLKQQLSPLSEKDYVKEVRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLV
YVMPPFVIKDDELQKLTEGMILALTQEYEH
>Mature_430_residues
MVDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHGYNHPRLNAAAQNQLAKMSHI
MFGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEVAMKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDP
TTGMHHLFHHSLPVQYFLPQPNIPFNESWNDCAIEPLADLLKKKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQ
YGILLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQTICSGEAKCFMHGPTFMANPLAC
AIAAESIRLLLESPWQQNIQRIESSLKQQLSPLSEKDYVKEVRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLV
YVMPPFVIKDDELQKLTEGMILALTQEYEH

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=411, Percent_Identity=28.4671532846715, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI13994255, Length=426, Percent_Identity=28.8732394366197, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI284507298, Length=313, Percent_Identity=30.0319488817891, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI37574042, Length=454, Percent_Identity=23.7885462555066, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI226442709, Length=395, Percent_Identity=24.8101265822785, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI226442705, Length=370, Percent_Identity=24.8648648648649, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI24119277, Length=423, Percent_Identity=26.0047281323877, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786991, Length=420, Percent_Identity=58.0952380952381, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI145693181, Length=358, Percent_Identity=34.6368715083799, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1789016, Length=411, Percent_Identity=28.4671532846715, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=28.463476070529, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1789759, Length=407, Percent_Identity=28.2555282555283, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1787560, Length=413, Percent_Identity=28.8135593220339, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786349, Length=266, Percent_Identity=30.8270676691729, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=402, Percent_Identity=26.1194029850746, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25144274, Length=245, Percent_Identity=30.2040816326531, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=434, Percent_Identity=23.0414746543779, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17541228, Length=445, Percent_Identity=24.4943820224719, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=469, Percent_Identity=42.4307036247335, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6323470, Length=428, Percent_Identity=27.803738317757, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324432, Length=386, Percent_Identity=25.1295336787565, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21357415, Length=406, Percent_Identity=28.0788177339901, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=25.8139534883721, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI161085790, Length=373, Percent_Identity=27.0777479892761, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21356575, Length=380, Percent_Identity=26.8421052631579, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281366494, Length=294, Percent_Identity=28.9115646258503, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667139, Length=294, Percent_Identity=28.9115646258503, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667143, Length=294, Percent_Identity=28.9115646258503, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOA_HAEIN (P44426)

Other databases:

- EMBL:   L42023
- PIR:   E64129
- RefSeq:   NP_439703.1
- ProteinModelPortal:   P44426
- SMR:   P44426
- GeneID:   950608
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1554
- NMPDR:   fig|71421.1.peg.1481
- TIGR:   HI_1554
- HOGENOM:   HBG725944
- OMA:   SAVEIAM
- ProtClustDB:   PRK06173
- BioCyc:   HINF71421:HI_1554-MONOMER
- BRENDA:   2.6.1.62
- GO:   GO:0005737
- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF8
- TIGRFAMs:   TIGR00508

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.62

Molecular weight: Translated: 47607; Mature: 47607

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 19-19 BINDING 248-248 BINDING 277-277 BINDING 310-310 BINDING 312-312 BINDING 394-394

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHG
CCCCCHHHHCCHHHHHCCHHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHC
YNHPRLNAAAQNQLAKMSHIMFGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
AMKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDPTTGMHHLFHHSLPVQYFLPQ
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCC
PNIPFNESWNDCAIEPLADLLKKKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQ
CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
YGILLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQTIC
CCEEEEEHHHHHCCCCCCCEEEECCCCCCCCCEEEEHHCCCCEEEEEECCHHHHHHHHHH
SGEAKCFMHGPTFMANPLACAIAAESIRLLLESPWQQNIQRIESSLKQQLSPLSEKDYVK
CCCCEEEEECCCHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHH
EVRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLVYVMPPFVIKDDELQKLTEGM
HHHHHCCCCHHHHHHHCCHHHHHHHHHHCCCEEEECCCEEEECCCEEECCHHHHHHHCCC
ILALTQEYEH
EEEEEHHCCC
>Mature Secondary Structure
MVDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHG
CCCCCHHHHCCHHHHHCCHHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHC
YNHPRLNAAAQNQLAKMSHIMFGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
AMKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDPTTGMHHLFHHSLPVQYFLPQ
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCC
PNIPFNESWNDCAIEPLADLLKKKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQ
CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
YGILLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQTIC
CCEEEEEHHHHHCCCCCCCEEEECCCCCCCCCEEEEHHCCCCEEEEEECCHHHHHHHHHH
SGEAKCFMHGPTFMANPLACAIAAESIRLLLESPWQQNIQRIESSLKQQLSPLSEKDYVK
CCCCEEEEECCCHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHH
EVRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLVYVMPPFVIKDDELQKLTEGM
HHHHHCCCCHHHHHHHCCHHHHHHHHHHCCCEEEECCCEEEECCCEEECCHHHHHHHCCC
ILALTQEYEH
EEEEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800