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The map label for this gene is adhC

Identifier: 16272150

GI number: 16272150

Start: 199474

End: 200610

Strand: Reverse

Name: adhC

Synonym: HI0185

Alternate gene names: 16272150

Gene position: 200610-199474 (Counterclockwise)

Preceding gene: 16272154

Following gene: 16272149

Centisome position: 10.96

GC content: 45.82

Gene sequence:

>1137_bases
ATGGAAATTAAACAAATCAATTCAACCATCAAATCTCGTGCGGCGGTAGCATTCGCCCCAAATCAACCCTTACAAATTGT
AGAAATCGACGTAGAAATGCCACGCAAAGGTGAAGTGTTAATCCGCAACACTCACACGGGCGTTTGCCATACTGATGCGT
TTACGTTATCAGGAAGCGATCCTGAAGGGGTATTCCCTGTGGTGCTAGGACACGAAGGTGCGGGTGTGGTTGTTGCGGTT
GGCGAAGGTGTGTTAAGCGTAAAACCGGGCGATCACGTCATTCCTCTTTATACAGCTGAATGTGGCGAATGTGAGTTTTG
CCGCTCGGGTAAAACCAACTTATGCGTCTCAGTGCGTGACACGCAAGGTAAAGGCTTAATGCCTGATTGCACGACACGTT
TTTCTTATCAAGGTCAGCCGATCTATCACTATATGGGCTGTTCAACCTTCAGTGAATACTCAGTTGTTGCGGAAGTTTCA
CTGGCGAAAATCAACCCTGAAGCGAACCACGAACAAGTGTGTTTGCTCGGCTGCGGTGTCACTACAGGTATTGGTGCGGT
GCATAATACAGCAAAAGTACAAGAAGGCGACTCTGTTGCCGTGTTTGGCTTGGGTGCGATTGGTTTAGCGGTAGTGCAAG
GTGCGCGTCAAGCCAAAGCAGGTCGCATTATCGCTATTGATACCAATCCTGCAAAATTTGAGTTGGCAAAACAGTTTGGT
GCAACGGATTGTTTAAACCCTAATGATTACGATAAGCCGATCAAAGATGTGTTGTTAGATATTAATAAATGGGGCATTGA
CCATACCTTTGAATGTATCGGTAATGTAAACGTAATGCGTCAAGCATTAGAAAGTGCTCACCGTGGCTGGGGACAATCCA
TTATCATCGGCGTAGCGGGTGCAGGACAAGAAATTTCAACGCGTCCGTTCCAATTGGTAACAGGCCGTGTTTGGAAAGGT
TCGGCATTTGGTGGCGTGAAAGGTCGCTCTGAACTTCCGCAAATGGTGGAAGATTCAATGAAAGGCGACATCCAGTTAGA
ACCGTTTGTGACTCACACAATGCCACTTGATAAAATTAATGAAGCCTTTGAATTAATGCACGAAGGTAAATCAATCCGTA
CTGTTATTCACTACTAA

Upstream 100 bases:

>100_bases
ATGATAAAAAAACACTTGCTTTAGAGTGAACTCTAAAGTGTAAACTGTTGCTATCTTGCTTACGTAAGGCAACTTTGTCA
ATGAATTAAGAGGAAAAACA

Downstream 100 bases:

>100_bases
GGTACGCTATGAAACTAATTGAACAACATCAAATTTTTGGCGGTTCGCAGCAAGTTTGGGCGCATAATGCTCAAACACTT
CAATGTGAAATGAAATTTGC

Product: alcohol dehydrogenase class III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MEIKQINSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSDPEGVFPVVLGHEGAGVVVAV
GEGVLSVKPGDHVIPLYTAECGECEFCRSGKTNLCVSVRDTQGKGLMPDCTTRFSYQGQPIYHYMGCSTFSEYSVVAEVS
LAKINPEANHEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAGAGQEISTRPFQLVTGRVWKG
SAFGGVKGRSELPQMVEDSMKGDIQLEPFVTHTMPLDKINEAFELMHEGKSIRTVIHY

Sequences:

>Translated_378_residues
MEIKQINSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSDPEGVFPVVLGHEGAGVVVAV
GEGVLSVKPGDHVIPLYTAECGECEFCRSGKTNLCVSVRDTQGKGLMPDCTTRFSYQGQPIYHYMGCSTFSEYSVVAEVS
LAKINPEANHEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAGAGQEISTRPFQLVTGRVWKG
SAFGGVKGRSELPQMVEDSMKGDIQLEPFVTHTMPLDKINEAFELMHEGKSIRTVIHY
>Mature_378_residues
MEIKQINSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSDPEGVFPVVLGHEGAGVVVAV
GEGVLSVKPGDHVIPLYTAECGECEFCRSGKTNLCVSVRDTQGKGLMPDCTTRFSYQGQPIYHYMGCSTFSEYSVVAEVS
LAKINPEANHEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAGAGQEISTRPFQLVTGRVWKG
SAFGGVKGRSELPQMVEDSMKGDIQLEPFVTHTMPLDKINEAFELMHEGKSIRTVIHY

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily

Homologues:

Organism=Homo sapiens, GI71565154, Length=370, Percent_Identity=59.4594594594595, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=46.0916442048518, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=47.3262032085562, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=45.2830188679245, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=44.743935309973, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=45.2574525745258, Blast_Score=347, Evalue=9e-96,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=45.2574525745258, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=45.5040871934605, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=45.7063711911357, Blast_Score=340, Evalue=9e-94,
Organism=Homo sapiens, GI156627571, Length=362, Percent_Identity=25.1381215469613, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=89.9728997289973, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI1787863, Length=356, Percent_Identity=28.6516853932584, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI87082125, Length=385, Percent_Identity=25.4545454545455, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1788073, Length=364, Percent_Identity=26.0989010989011, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790045, Length=358, Percent_Identity=26.2569832402235, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=28.023598820059, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786825, Length=362, Percent_Identity=24.8618784530387, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788407, Length=235, Percent_Identity=26.8085106382979, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI226510992, Length=370, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788075, Length=359, Percent_Identity=25.0696378830084, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=56.0321715817694, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=55.7333333333333, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17565904, Length=338, Percent_Identity=56.508875739645, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71988145, Length=219, Percent_Identity=31.5068493150685, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=360, Percent_Identity=23.6111111111111, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=172, Percent_Identity=31.3953488372093, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=380, Percent_Identity=59.4736842105263, Blast_Score=471, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319621, Length=368, Percent_Identity=27.1739130434783, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=27.4725274725275, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=378, Percent_Identity=27.5132275132275, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=366, Percent_Identity=27.0491803278689, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=381, Percent_Identity=27.2965879265092, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=349, Percent_Identity=25.5014326647564, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=349, Percent_Identity=25.5014326647564, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=61.7250673854447, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=25.6484149855908, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737897, Length=348, Percent_Identity=25, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FRMA_HAEIN (P44557)

Other databases:

- EMBL:   L42023
- PIR:   H64052
- RefSeq:   NP_438353.1
- ProteinModelPortal:   P44557
- SMR:   P44557
- GeneID:   951091
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0185
- NMPDR:   fig|71421.1.peg.174
- TIGR:   HI_0185
- HOGENOM:   HBG753318
- OMA:   VDHTFEC
- ProtClustDB:   CLSK2393140
- BioCyc:   HINF71421:HI_0185-MONOMER
- BRENDA:   1.1.1.1
- BRENDA:   1.1.1.284
- GO:   GO:0005737
- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR02818

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.284; =1.1.1.1

Molecular weight: Translated: 40652; Mature: 40652

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKQINSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSD
CCHHHHHHHHHHCEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCEEECCEEEECCCC
PEGVFPVVLGHEGAGVVVAVGEGVLSVKPGDHVIPLYTAECGECEFCRSGKTNLCVSVRD
CCCEEEEEECCCCCEEEEEECCCEEEECCCCEEEEEEECCCCCCHHHHCCCCEEEEEEEE
TQGKGLMPDCTTRFSYQGQPIYHYMGCSTFSEYSVVAEVSLAKINPEANHEQVCLLGCGV
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCEEEEEECCH
TTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
HHCCCHHCCCCEECCCCCEEEEEHHHHHHHHHHCHHHHCCCEEEEEECCCCHHHHHHHCC
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAG
CCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEEC
AGQEISTRPFQLVTGRVWKGSAFGGVKGRSELPQMVEDSMKGDIQLEPFVTHTMPLDKIN
CCCCCCCCCEEEEECEEECCCCCCCCCCHHHHHHHHHHHCCCCEEECCEEEECCCHHHHH
EAFELMHEGKSIRTVIHY
HHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MEIKQINSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSD
CCHHHHHHHHHHCEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCEEECCEEEECCCC
PEGVFPVVLGHEGAGVVVAVGEGVLSVKPGDHVIPLYTAECGECEFCRSGKTNLCVSVRD
CCCEEEEEECCCCCEEEEEECCCEEEECCCCEEEEEEECCCCCCHHHHCCCCEEEEEEEE
TQGKGLMPDCTTRFSYQGQPIYHYMGCSTFSEYSVVAEVSLAKINPEANHEQVCLLGCGV
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCEEEEEECCH
TTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
HHCCCHHCCCCEECCCCCEEEEEHHHHHHHHHHCHHHHCCCEEEEEECCCCHHHHHHHCC
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAG
CCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEEC
AGQEISTRPFQLVTGRVWKGSAFGGVKGRSELPQMVEDSMKGDIQLEPFVTHTMPLDKIN
CCCCCCCCCEEEEECEEECCCCCCCCCCHHHHHHHHHHHCCCCEEECCEEEECCCHHHHH
EAFELMHEGKSIRTVIHY
HHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800