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The map label for this gene is fur

Identifier: 16272154

GI number: 16272154

Start: 204748

End: 205188

Strand: Reverse

Name: fur

Synonym: HI0190

Alternate gene names: 16272154

Gene position: 205188-204748 (Counterclockwise)

Preceding gene: 16272155

Following gene: 16272150

Centisome position: 11.21

GC content: 31.52

Gene sequence:

>441_bases
ATGTCTGAAGGAAATATTAAATTACTCAAAAAAGTGGGATTAAAAATTACAGAGCCTCGCTTAACTATTCTCGCTTTAAT
GCAAAATCATAAAAATGAACATTTTTCTGCAGAAGATGTTTATAAAATTTTCCTGGAACAAGGTTGTGAAATTGGATTAG
CCACAGTTTATCGTGTGCTTAATCAATTTGATGAAGCGCATATTGTAATCCGTCATAATTTTGAGGGAAATAAATCCGTT
TTTGAGCTTGCTCCAACAGAACATCACGATCATATTATTTGTGAAGATTGCGGTAAAGTATTTGAATTTACGGATAATAT
TATTGAACAACGTCAGCGTGAAATCAGTGAAAAATACGGCATAAAATTAAAAACGCATAACGTGTATCTTTACGGCAAAT
GCAGTGATATTAATCATTGTGACGAAAACAATTCAAAATAA

Upstream 100 bases:

>100_bases
CTTACCGCAGAGCGTGTAGAAAAATGGTGTAAACAAATTTATGATGAAATGTGCTTAGCTGAATTGGCTTAGCATTTTGT
GCATAATAGGAAGGAAAATT

Downstream 100 bases:

>100_bases
ATAATATCTAAGGCGACAAAATGTCGCTTTCTTATATTCAAATTTCATCCTAAAAAAATAACCGCACTTTATTACAGTGC
GGTTATTTAGTTTAACTTTT

Product: ferric uptake regulation protein

Products: NA

Alternate protein names: Ferric uptake regulator

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MSEGNIKLLKKVGLKITEPRLTILALMQNHKNEHFSAEDVYKIFLEQGCEIGLATVYRVLNQFDEAHIVIRHNFEGNKSV
FELAPTEHHDHIICEDCGKVFEFTDNIIEQRQREISEKYGIKLKTHNVYLYGKCSDINHCDENNSK

Sequences:

>Translated_146_residues
MSEGNIKLLKKVGLKITEPRLTILALMQNHKNEHFSAEDVYKIFLEQGCEIGLATVYRVLNQFDEAHIVIRHNFEGNKSV
FELAPTEHHDHIICEDCGKVFEFTDNIIEQRQREISEKYGIKLKTHNVYLYGKCSDINHCDENNSK
>Mature_145_residues
SEGNIKLLKKVGLKITEPRLTILALMQNHKNEHFSAEDVYKIFLEQGCEIGLATVYRVLNQFDEAHIVIRHNFEGNKSVF
ELAPTEHHDHIICEDCGKVFEFTDNIIEQRQREISEKYGIKLKTHNVYLYGKCSDINHCDENNSK

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family

Homologues:

Organism=Escherichia coli, GI1786899, Length=136, Percent_Identity=62.5, Blast_Score=176, Evalue=5e-46,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): FUR_HAEIN (P44561)

Other databases:

- EMBL:   L42023
- EMBL:   AF020350
- PIR:   B64053
- RefSeq:   NP_438359.1
- ProteinModelPortal:   P44561
- SMR:   P44561
- GeneID:   951099
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0190
- NMPDR:   fig|71421.1.peg.180
- TIGR:   HI_0190
- HOGENOM:   HBG731501
- OMA:   GEVIEFF
- ProtClustDB:   CLSK870064
- BioCyc:   HINF71421:HI_0190-MONOMER
- GO:   GO:0005737
- InterPro:   IPR002481

Pfam domain/function: PF01475 FUR

EC number: NA

Molecular weight: Translated: 16962; Mature: 16830

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEGNIKLLKKVGLKITEPRLTILALMQNHKNEHFSAEDVYKIFLEQGCEIGLATVYRVL
CCCCHHHHHHHCCCEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
NQFDEAHIVIRHNFEGNKSVFELAPTEHHDHIICEDCGKVFEFTDNIIEQRQREISEKYG
HCCCCEEEEEEECCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
IKLKTHNVYLYGKCSDINHCDENNSK
CEEEECEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SEGNIKLLKKVGLKITEPRLTILALMQNHKNEHFSAEDVYKIFLEQGCEIGLATVYRVL
CCCHHHHHHHCCCEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
NQFDEAHIVIRHNFEGNKSVFELAPTEHHDHIICEDCGKVFEFTDNIIEQRQREISEKYG
HCCCCEEEEEEECCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
IKLKTHNVYLYGKCSDINHCDENNSK
CEEEECEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 9727086