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The map label for this gene is nagA

Identifier: 16272107

GI number: 16272107

Start: 155307

End: 156452

Strand: Reverse

Name: nagA

Synonym: HI0140

Alternate gene names: 16272107

Gene position: 156452-155307 (Counterclockwise)

Preceding gene: 16272108

Following gene: 16272104

Centisome position: 8.55

GC content: 38.48

Gene sequence:

>1146_bases
ATGAAATACGCATTAATTAATTGTGTAATTTACACAAAATATGATGTTTTACGTGATTTTGCTGTAATTATTAACGGTGA
AATTATTGAAGCAGTGATCCCCCAAGCTGAATTAGAAACAGGTATCAAAACCATTGATTTACAAGGTAATAATTTAACGG
CTGGTTTTATTGATCTGCAATTAAATGGCTGTGGTGGCGTGATGTTTAACGACCAAACTAGCGTTGAAACCTTGGAAATT
ATGCAGGAAACTAACTTAAAATCAGGTTGTACAAGTTTCCTTCCCACTTTTATTACCGCGCCTGATGAAAATATAAAAAG
TGCGGTAAAAATTATGCGTGAATATTTAAACAAGCATAAAAACCAAGCACTTGGTTTACATATTGAAGGACCTTATCTCA
GCATTGAGAAAAAAGGCGTACACCGTCCCGAATATATTCGTGAAATTACGCCTGAAATGAAAGATTTTCTCTGCGAAAAT
GGTGATGTGATTACAAAAATGACCATTGCCGCAGAAAACCCAACCATTAACTATACGCCTGATTTTGTGAAAGCGGGCAT
TATTGTCTCTGTAGGCCATTCTAATGCCACTTATGAAGTGGCTAAAGCCGCATTCCACAAAGGCGCAACTTTTGCGACTC
ACTTGCATAATGCGATGTCGCCAATTAGTTCTGGACGTGAAATGGGCGTAGTGGGTGCAGTATTAGATTCTGATGTTTAC
ACTGGCATTATCGTCGATGGTGTGCATATCAATTACGGCAATGTTCGCATTGATAAAAAAATCAAAGGCGACAAACTTTG
TATTGTGACTGACTCTATTGCAGCTGCAGGCGCACCGCCAGAACTAGAAAGTTTTACCTTTGTGGGAAAAACAATTTATA
TCAAAGAAGGGCGTTGCTATGATGCGAATGACACAATTGCAGGGGCATCAATCACAATGATGGAATCCATTAAAAATGCG
GTAGAATATGTCGAAATTCCTCTTGCGGAAGCCATTAGAATGAGTAACCTTTATCCTGCACGAGCAATTGGTATAGATGA
TCGTTTAGGTTCGGTAGAAAAAGGTAAGATAGCAAACTTAGCCGTGTTTACGCCAAATTACCAAGTAATCGGCACAGTAG
TAAACGGAAAGTGGAAAGAGAATTAA

Upstream 100 bases:

>100_bases
ATTCGCCCTATAATCACAAACAATCATAGGGCAAATTGTCCTTACGTTTAAGAGCAATATAGTTGCTATGTTAAACTGAT
GTTGATATTAGGAACAGAAT

Downstream 100 bases:

>100_bases
TAGTAAACACTTAAATAGTTAATTGATTTAAAAATCTGTGATATATATCACAGATTTTTTATTAATTATAAAATAGCCTA
AATATTTATACACTTTTAAC

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKYALINCVIYTKYDVLRDFAVIINGEIIEAVIPQAELETGIKTIDLQGNNLTAGFIDLQLNGCGGVMFNDQTSVETLEI
MQETNLKSGCTSFLPTFITAPDENIKSAVKIMREYLNKHKNQALGLHIEGPYLSIEKKGVHRPEYIREITPEMKDFLCEN
GDVITKMTIAAENPTINYTPDFVKAGIIVSVGHSNATYEVAKAAFHKGATFATHLHNAMSPISSGREMGVVGAVLDSDVY
TGIIVDGVHINYGNVRIDKKIKGDKLCIVTDSIAAAGAPPELESFTFVGKTIYIKEGRCYDANDTIAGASITMMESIKNA
VEYVEIPLAEAIRMSNLYPARAIGIDDRLGSVEKGKIANLAVFTPNYQVIGTVVNGKWKEN

Sequences:

>Translated_381_residues
MKYALINCVIYTKYDVLRDFAVIINGEIIEAVIPQAELETGIKTIDLQGNNLTAGFIDLQLNGCGGVMFNDQTSVETLEI
MQETNLKSGCTSFLPTFITAPDENIKSAVKIMREYLNKHKNQALGLHIEGPYLSIEKKGVHRPEYIREITPEMKDFLCEN
GDVITKMTIAAENPTINYTPDFVKAGIIVSVGHSNATYEVAKAAFHKGATFATHLHNAMSPISSGREMGVVGAVLDSDVY
TGIIVDGVHINYGNVRIDKKIKGDKLCIVTDSIAAAGAPPELESFTFVGKTIYIKEGRCYDANDTIAGASITMMESIKNA
VEYVEIPLAEAIRMSNLYPARAIGIDDRLGSVEKGKIANLAVFTPNYQVIGTVVNGKWKEN
>Mature_381_residues
MKYALINCVIYTKYDVLRDFAVIINGEIIEAVIPQAELETGIKTIDLQGNNLTAGFIDLQLNGCGGVMFNDQTSVETLEI
MQETNLKSGCTSFLPTFITAPDENIKSAVKIMREYLNKHKNQALGLHIEGPYLSIEKKGVHRPEYIREITPEMKDFLCEN
GDVITKMTIAAENPTINYTPDFVKAGIIVSVGHSNATYEVAKAAFHKGATFATHLHNAMSPISSGREMGVVGAVLDSDVY
TGIIVDGVHINYGNVRIDKKIKGDKLCIVTDSIAAAGAPPELESFTFVGKTIYIKEGRCYDANDTIAGASITMMESIKNA
VEYVEIPLAEAIRMSNLYPARAIGIDDRLGSVEKGKIANLAVFTPNYQVIGTVVNGKWKEN

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family

Homologues:

Organism=Homo sapiens, GI21361513, Length=430, Percent_Identity=28.6046511627907, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI224922791, Length=421, Percent_Identity=28.5035629453682, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1786892, Length=378, Percent_Identity=54.2328042328042, Blast_Score=415, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17553768, Length=398, Percent_Identity=30.6532663316583, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19920392, Length=387, Percent_Identity=29.7157622739018, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281361140, Length=400, Percent_Identity=29.25, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGA_HAEIN (P44537)

Other databases:

- EMBL:   L42023
- PIR:   E64050
- RefSeq:   NP_438309.1
- ProteinModelPortal:   P44537
- SMR:   P44537
- GeneID:   951049
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0140
- NMPDR:   fig|71421.1.peg.131
- TIGR:   HI_0140
- HOGENOM:   HBG464950
- OMA:   TSSDEDM
- ProtClustDB:   PRK11170
- BioCyc:   HINF71421:HI_0140-MONOMER
- BRENDA:   3.5.1.25
- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00221

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.1.25

Molecular weight: Translated: 41593; Mature: 41593

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYALINCVIYTKYDVLRDFAVIINGEIIEAVIPQAELETGIKTIDLQGNNLTAGFIDLQ
CCEEEEEEEEEEHHHHHHHEEEEECCHHHHHHCCHHHHHCCCEEEEECCCEEEEEEEEEE
LNGCGGVMFNDQTSVETLEIMQETNLKSGCTSFLPTFITAPDENIKSAVKIMREYLNKHK
ECCCCCEEECCCCCHHHHHHHHHCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHHCC
NQALGLHIEGPYLSIEKKGVHRPEYIREITPEMKDFLCENGDVITKMTIAAENPTINYTP
CCEEEEEECCCEEEEECCCCCCHHHHHHHCHHHHHHHHCCCCEEEEEEEEECCCEECCCC
DFVKAGIIVSVGHSNATYEVAKAAFHKGATFATHLHNAMSPISSGREMGVVGAVLDSDVY
HHHHCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCE
TGIIVDGVHINYGNVRIDKKIKGDKLCIVTDSIAAAGAPPELESFTFVGKTIYIKEGRCY
EEEEEEEEEEECCCEEEECCCCCCEEEEEECCHHCCCCCCCCCCEEEECEEEEEECCEEE
DANDTIAGASITMMESIKNAVEYVEIPLAEAIRMSNLYPARAIGIDDRLGSVEKGKIANL
CCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCCHHCCCCCCCCEEEE
AVFTPNYQVIGTVVNGKWKEN
EEECCCCEEEEEEECCEECCC
>Mature Secondary Structure
MKYALINCVIYTKYDVLRDFAVIINGEIIEAVIPQAELETGIKTIDLQGNNLTAGFIDLQ
CCEEEEEEEEEEHHHHHHHEEEEECCHHHHHHCCHHHHHCCCEEEEECCCEEEEEEEEEE
LNGCGGVMFNDQTSVETLEIMQETNLKSGCTSFLPTFITAPDENIKSAVKIMREYLNKHK
ECCCCCEEECCCCCHHHHHHHHHCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHHCC
NQALGLHIEGPYLSIEKKGVHRPEYIREITPEMKDFLCENGDVITKMTIAAENPTINYTP
CCEEEEEECCCEEEEECCCCCCHHHHHHHCHHHHHHHHCCCCEEEEEEEEECCCEECCCC
DFVKAGIIVSVGHSNATYEVAKAAFHKGATFATHLHNAMSPISSGREMGVVGAVLDSDVY
HHHHCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCE
TGIIVDGVHINYGNVRIDKKIKGDKLCIVTDSIAAAGAPPELESFTFVGKTIYIKEGRCY
EEEEEEEEEEECCCEEEECCCCCCEEEEEECCHHCCCCCCCCCCEEEECEEEEEECCEEE
DANDTIAGASITMMESIKNAVEYVEIPLAEAIRMSNLYPARAIGIDDRLGSVEKGKIANL
CCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCCHHCCCCCCCCEEEE
AVFTPNYQVIGTVVNGKWKEN
EEECCCCEEEEEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800