Click here to switch to the map view.

The map label for this gene is trxM

Identifier: 16272058

GI number: 16272058

Start: 88739

End: 89062

Strand: Reverse

Name: trxM

Synonym: HI0084

Alternate gene names: 16272058

Gene position: 89062-88739 (Counterclockwise)

Preceding gene: 16272059

Following gene: 16272052

Centisome position: 4.87

GC content: 35.8

Gene sequence:

>324_bases
ATGAGCGAAGTATTACACATTAATGACGCAGATTTTGAAAGTGTTGTAGTTAATTCAGATATCCCCATTTTATTAGACTT
TTGGGCACCTTGGTGTGGTCCTTGCAAAATGATTGCACCAGTGTTAGATGAACTTGCACCTGAATTTGCAGGTAAAGTTA
AAATCGTGAAAATGAATGTGGATGATAACCAAGCAACGCCAGCACAATTTGGTGTTCGTAGTATCCCAACATTATTATTG
ATTAAAAATGGTCAAGTTGTTGCAACTCAAGTTGGTGCATTACCAAAAACTCAATTGGCTAACTTCATTAACCAACATAT
TTAA

Upstream 100 bases:

>100_bases
TTAGTTTACATTTTTTAAAACGGTGTTATTCTGCACCGCACTTGTAAGTTTAAAAAAAGCCCTTATATAGGGATTCCATT
CACAAAATAAGGAAAACAAA

Downstream 100 bases:

>100_bases
TCGTTGTTTAAAGCTATAAGTAACTTTAGAACATTGATAAGATTGCCCCTTAATGGGGCAATTTTTTGTCTGAAATTTTG
ATATTTGCTCTGGTGGAAGG

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSEVLHINDADFESVVVNSDIPILLDFWAPWCGPCKMIAPVLDELAPEFAGKVKIVKMNVDDNQATPAQFGVRSIPTLLL
IKNGQVVATQVGALPKTQLANFINQHI

Sequences:

>Translated_107_residues
MSEVLHINDADFESVVVNSDIPILLDFWAPWCGPCKMIAPVLDELAPEFAGKVKIVKMNVDDNQATPAQFGVRSIPTLLL
IKNGQVVATQVGALPKTQLANFINQHI
>Mature_106_residues
SEVLHINDADFESVVVNSDIPILLDFWAPWCGPCKMIAPVLDELAPEFAGKVKIVKMNVDDNQATPAQFGVRSIPTLLLI
KNGQVVATQVGALPKTQLANFINQHI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=105, Percent_Identity=39.0476190476191, Blast_Score=85, Evalue=1e-17,
Organism=Homo sapiens, GI21361657, Length=108, Percent_Identity=32.4074074074074, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI4758304, Length=87, Percent_Identity=35.632183908046, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=52.3809523809524, Blast_Score=132, Evalue=7e-33,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=43.4782608695652, Blast_Score=103, Evalue=3e-24,
Organism=Escherichia coli, GI87081747, Length=85, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=36.1702127659575, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=39.0804597701149, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=78, Percent_Identity=37.1794871794872, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=106, Percent_Identity=33.0188679245283, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=112, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=99, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=112, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=112, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=31.3953488372093, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=84, Percent_Identity=34.5238095238095, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=87, Percent_Identity=34.4827586206897, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17507915, Length=84, Percent_Identity=38.0952380952381, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=85, Percent_Identity=37.6470588235294, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=90, Percent_Identity=35.5555555555556, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=36.046511627907, Blast_Score=70, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=38.3720930232558, Blast_Score=70, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=88, Percent_Identity=35.2272727272727, Blast_Score=63, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=39.3617021276596, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=36.0824742268041, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=42.2535211267606, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=41.1764705882353, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=41.1764705882353, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921434, Length=87, Percent_Identity=35.632183908046, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358065, Length=91, Percent_Identity=34.0659340659341, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45551086, Length=70, Percent_Identity=41.4285714285714, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_HAEIN (P43785)

Other databases:

- EMBL:   L42023
- PIR:   E64047
- RefSeq:   NP_438257.1
- ProteinModelPortal:   P43785
- SMR:   P43785
- GeneID:   950983
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0084
- NMPDR:   fig|71421.1.peg.83
- TIGR:   HI_0084
- HOGENOM:   HBG493509
- OMA:   TLMLFKG
- ProtClustDB:   CLSK870324
- BioCyc:   HINF71421:HI_0084-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11681; Mature: 11550

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVLHINDADFESVVVNSDIPILLDFWAPWCGPCKMIAPVLDELAPEFAGKVKIVKMNV
CCCEEECCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEC
DDNQATPAQFGVRSIPTLLLIKNGQVVATQVGALPKTQLANFINQHI
CCCCCCHHHCCHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SEVLHINDADFESVVVNSDIPILLDFWAPWCGPCKMIAPVLDELAPEFAGKVKIVKMNV
CCEEECCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEC
DDNQATPAQFGVRSIPTLLLIKNGQVVATQVGALPKTQLANFINQHI
CCCCCCHHHCCHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800