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The map label for this gene is rspB [C]

Identifier: 16272027

GI number: 16272027

Start: 53641

End: 54669

Strand: Reverse

Name: rspB [C]

Synonym: HI0053

Alternate gene names: 16272027

Gene position: 54669-53641 (Counterclockwise)

Preceding gene: 16272030

Following gene: 16272026

Centisome position: 2.99

GC content: 34.6

Gene sequence:

>1029_bases
ATGAAGGAGCGAATCAAAGCAATATGTTTAGAAAAACCAAACAATGTAGTTGTTAAAGAAGTGCCTTATCCCGAGAAAAG
TGATAATGATGTACTTATTCAGGTAGAATCAATGGGGATTTGTGGTTCTGATATTGGTGCATATAGAGGAACTAATCCAT
TAGTAACTTATCCAAGAATACTTGGGCATGAAATTGTAGGGAGAGTAATTGAAAGTGGAATTGGTATGTCAGATGGGGTA
AGGGTTGGAGACCGAGTAATTGTTGATCCTTATGTTTGTTGTGGTCAATGCTATCCTTGTTCAATTGGTAGAACCAATTG
TTGTGAATCATTAAAGGTAATTGGTGTTCATATTGATGGAGGTATGCAAGAGGTAATTAGACATCCCGCTCATCTTTTAA
CTAAAGTCCCAGATAACCTACCGATTCATCAATTACCTTTAGCTGAACCTTTAACAATAGCTTTACACGCTTTACATAGA
ACAACTTTAAAATCAGGGGAACACATAGTAATTATTGGAGCTGGTGCAATTGGATTAATGGCTGCATTAGCAGCGGTTCA
ATATGGAGCAATCCCAATTTTAGTTGATATATTAGAACAACGTCTTGAGTATGCAAAATCCTTGGGAATTGAACATATTG
TAAATCCGCATAAGGAGGATGACATTAAAAGAATTAAGGAAATTACAAGTGGTCGTATGGCTGAAGTTGTTATGGAGGCA
TCTGGTGCTAATATTTCTATCAAAAATACTCTGCATTATGCCTCCTTTGCAGGAAGAATTGCTTTAACAGGATGGCCAAA
AACAGAAACTCCATTACCAACAAATTTAATTACCTTTAAAGAATTGAATATTTATGGTTCTAGAACAAGCAAGGGGGAAT
TTGAGGAGGCATTGGATATGCTTGCTACTAATAAAATTAATGCATCTCATATCATTACTAAGTGTATCAAATTTGAAGAA
ATTCCTAGTTTTATTTCTGATTTATCTGATCATCCAGAAAATTATTTAAAAATTAATGCAGTTTTCTAA

Upstream 100 bases:

>100_bases
TATTTGGTATTCCAAAAAGAGTTTTTATGTTTCATAATCATATCATAGTTAAACATAACAAGTAATTTTATTCTGTCAAT
GGCATATAAGGAGTCTAAAA

Downstream 100 bases:

>100_bases
AAAACATAATCAATAAGGAGAAAGTTATGAAATCAATTAAAGGCTTAGGTAAATTATTACTTGCTTCAAGTATATTGTTT
AGTAGCAGTGCATTTGCAAA

Product: zinc-type alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKERIKAICLEKPNNVVVKEVPYPEKSDNDVLIQVESMGICGSDIGAYRGTNPLVTYPRILGHEIVGRVIESGIGMSDGV
RVGDRVIVDPYVCCGQCYPCSIGRTNCCESLKVIGVHIDGGMQEVIRHPAHLLTKVPDNLPIHQLPLAEPLTIALHALHR
TTLKSGEHIVIIGAGAIGLMAALAAVQYGAIPILVDILEQRLEYAKSLGIEHIVNPHKEDDIKRIKEITSGRMAEVVMEA
SGANISIKNTLHYASFAGRIALTGWPKTETPLPTNLITFKELNIYGSRTSKGEFEEALDMLATNKINASHIITKCIKFEE
IPSFISDLSDHPENYLKINAVF

Sequences:

>Translated_342_residues
MKERIKAICLEKPNNVVVKEVPYPEKSDNDVLIQVESMGICGSDIGAYRGTNPLVTYPRILGHEIVGRVIESGIGMSDGV
RVGDRVIVDPYVCCGQCYPCSIGRTNCCESLKVIGVHIDGGMQEVIRHPAHLLTKVPDNLPIHQLPLAEPLTIALHALHR
TTLKSGEHIVIIGAGAIGLMAALAAVQYGAIPILVDILEQRLEYAKSLGIEHIVNPHKEDDIKRIKEITSGRMAEVVMEA
SGANISIKNTLHYASFAGRIALTGWPKTETPLPTNLITFKELNIYGSRTSKGEFEEALDMLATNKINASHIITKCIKFEE
IPSFISDLSDHPENYLKINAVF
>Mature_342_residues
MKERIKAICLEKPNNVVVKEVPYPEKSDNDVLIQVESMGICGSDIGAYRGTNPLVTYPRILGHEIVGRVIESGIGMSDGV
RVGDRVIVDPYVCCGQCYPCSIGRTNCCESLKVIGVHIDGGMQEVIRHPAHLLTKVPDNLPIHQLPLAEPLTIALHALHR
TTLKSGEHIVIIGAGAIGLMAALAAVQYGAIPILVDILEQRLEYAKSLGIEHIVNPHKEDDIKRIKEITSGRMAEVVMEA
SGANISIKNTLHYASFAGRIALTGWPKTETPLPTNLITFKELNIYGSRTSKGEFEEALDMLATNKINASHIITKCIKFEE
IPSFISDLSDHPENYLKINAVF

Specific function: Not Known; Probable Catabolic Enzyme. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=321, Percent_Identity=29.595015576324, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI4501929, Length=345, Percent_Identity=27.536231884058, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787863, Length=340, Percent_Identity=34.1176470588235, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI226510992, Length=313, Percent_Identity=35.4632587859425, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1790045, Length=320, Percent_Identity=31.5625, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=27.6276276276276, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=28.2738095238095, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1790718, Length=327, Percent_Identity=27.217125382263, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788075, Length=311, Percent_Identity=27.3311897106109, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786825, Length=268, Percent_Identity=29.8507462686567, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082125, Length=347, Percent_Identity=27.3775216138329, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87081918, Length=309, Percent_Identity=28.1553398058252, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082401, Length=116, Percent_Identity=33.6206896551724, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786552, Length=253, Percent_Identity=28.8537549407115, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=315, Percent_Identity=29.5238095238095, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562878, Length=320, Percent_Identity=27.5, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71988145, Length=321, Percent_Identity=25.5451713395639, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=323, Percent_Identity=26.625386996904, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=332, Percent_Identity=25.6024096385542, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=343, Percent_Identity=32.6530612244898, Blast_Score=162, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6322619, Length=327, Percent_Identity=29.9694189602446, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6319955, Length=327, Percent_Identity=29.6636085626911, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319258, Length=374, Percent_Identity=28.0748663101604, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319257, Length=352, Percent_Identity=26.9886363636364, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319621, Length=347, Percent_Identity=27.0893371757925, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=331, Percent_Identity=26.8882175226586, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=26.4705882352941, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=345, Percent_Identity=26.0869565217391, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=294, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=293, Percent_Identity=26.962457337884, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17737897, Length=313, Percent_Identity=31.629392971246, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI17137530, Length=327, Percent_Identity=29.3577981651376, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45550770, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551930, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221457811, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y053_HAEIN (Q57517)

Other databases:

- EMBL:   L42023
- PIR:   F64141
- RefSeq:   NP_438226.1
- ProteinModelPortal:   Q57517
- SMR:   Q57517
- GeneID:   950952
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0053
- NMPDR:   fig|71421.1.peg.52
- TIGR:   HI_0053
- HOGENOM:   HBG753318
- ProtClustDB:   CLSK892353
- BioCyc:   HINF71421:HI_0053-MONOMER
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: 1.1.1.- [C]

Molecular weight: Translated: 37430; Mature: 37430

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERIKAICLEKPNNVVVKEVPYPEKSDNDVLIQVESMGICGSDIGAYRGTNPLVTYPRI
CCCHHHHHEECCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECHHH
LGHEIVGRVIESGIGMSDGVRVGDRVIVDPYVCCGQCYPCSIGRTNCCESLKVIGVHIDG
HHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCHHHHCCEEEEEEEECC
GMQEVIRHPAHLLTKVPDNLPIHQLPLAEPLTIALHALHRTTLKSGEHIVIIGAGAIGLM
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
AALAAVQYGAIPILVDILEQRLEYAKSLGIEHIVNPHKEDDIKRIKEITSGRMAEVVMEA
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHC
SGANISIKNTLHYASFAGRIALTGWPKTETPLPTNLITFKELNIYGSRTSKGEFEEALDM
CCCEEEEHHHHEEHHHCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHH
LATNKINASHIITKCIKFEEIPSFISDLSDHPENYLKINAVF
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure
MKERIKAICLEKPNNVVVKEVPYPEKSDNDVLIQVESMGICGSDIGAYRGTNPLVTYPRI
CCCHHHHHEECCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECHHH
LGHEIVGRVIESGIGMSDGVRVGDRVIVDPYVCCGQCYPCSIGRTNCCESLKVIGVHIDG
HHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCHHHHCCEEEEEEEECC
GMQEVIRHPAHLLTKVPDNLPIHQLPLAEPLTIALHALHRTTLKSGEHIVIIGAGAIGLM
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
AALAAVQYGAIPILVDILEQRLEYAKSLGIEHIVNPHKEDDIKRIKEITSGRMAEVVMEA
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHC
SGANISIKNTLHYASFAGRIALTGWPKTETPLPTNLITFKELNIYGSRTSKGEFEEALDM
CCCEEEEHHHHEEHHHCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHH
LATNKINASHIITKCIKFEEIPSFISDLSDHPENYLKINAVF
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800