BacMap

Definition	Acholeplasma laidlawii PG-8A chromosome, complete genome.
Accession	NC_010163
Length	1,496,992

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The map label for this gene is yvgN [H]

Identifier: 162447396

GI number: 162447396

Start: 568111

End: 568905

Strand: Direct

Name: yvgN [H]

Synonym: ACL_0534

Alternate gene names: 162447396

Gene position: 568111-568905 (Clockwise)

Preceding gene: 162447395

Following gene: 162447397

Centisome position: 37.95

GC content: 32.7

Gene sequence:

>795_bases
ATGGAATATTTAACACTTCATAATGGTTTTAAAGTACCAGTTGTAGGTATGGGTGCAAACACATTTGGTAAAGTGAATCA
TGATTTTTATGGTGCACTTGATAATGACACTAAAGAACTAATTTGGGCATATGAAAATGGCTACCGCCTCATAGATACAG
CAATCGTTTATAGAAATGAAACAGTGATTGCCAAATCAATTAAAGATGCCCATCTAAATAGAAAAGATGTCATGGTTACA
TCTAAAATACCTACCAAAGAATTACCACTAGAAGATGATGAAAAAATTGAGGCGATGATACAATCGTCCATCAATATATT
TGGAGGTTATGTAGATATCTATTTAATTCATCATCCATCCACGGATGAAATTAATTTAAAGGTCTGGAAAGCACTTGAAA
GTCATTATCTAAAAGGACACTTTAAAGCAATTGGTGTATCCAATTTTAGTAAGGAGCAACTTGATTACATCATGAAGTAT
GCAAATATTAAACCCATGATGAATCAAATAGAATCTAATCCAGCAAACTGGCAACAGGAACTCATCTCTTATTGTAAGGC
GTATGACATTGTTCCAGTAGCATGGGGTCCACTAGATCCTGTGCCTAATAAGGATATATTAACAACCATTGGTAACCATT
ATGGTAAGACTTGGGCACAAATACTACTTAGACATCAAATACAAAAAGGTGTCGTTGTCATACCAAAGAGTCACAATAAA
TTAAGACAATTTGAAAATATAAATATCTTTGATTTCACATTATCTTTAGAAGATATGCGTAAAATAGAAGAATAA

Upstream 100 bases:

>100_bases
TGAAAACGGTTATAAGATTGTTCAAGACAGATCGATTGAAAAAATTGGTGAAGGCTTGAAACAAGCCTACCAAGAAGTTA
TCAAAATTAAGAGGTAACCT

Downstream 100 bases:

>100_bases
TTATCATTACTTATGTATTTTCACGAAAAAAAGATTTATAATGTTATAATATTAAAGTTGATATAATTTAGGAGGAAACT
ATGAAATTTGAACATATAAA

Product: aldo/keto reductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MEYLTLHNGFKVPVVGMGANTFGKVNHDFYGALDNDTKELIWAYENGYRLIDTAIVYRNETVIAKSIKDAHLNRKDVMVT
SKIPTKELPLEDDEKIEAMIQSSINIFGGYVDIYLIHHPSTDEINLKVWKALESHYLKGHFKAIGVSNFSKEQLDYIMKY
ANIKPMMNQIESNPANWQQELISYCKAYDIVPVAWGPLDPVPNKDILTTIGNHYGKTWAQILLRHQIQKGVVVIPKSHNK
LRQFENINIFDFTLSLEDMRKIEE

Sequences:

>Translated_264_residues
MEYLTLHNGFKVPVVGMGANTFGKVNHDFYGALDNDTKELIWAYENGYRLIDTAIVYRNETVIAKSIKDAHLNRKDVMVT
SKIPTKELPLEDDEKIEAMIQSSINIFGGYVDIYLIHHPSTDEINLKVWKALESHYLKGHFKAIGVSNFSKEQLDYIMKY
ANIKPMMNQIESNPANWQQELISYCKAYDIVPVAWGPLDPVPNKDILTTIGNHYGKTWAQILLRHQIQKGVVVIPKSHNK
LRQFENINIFDFTLSLEDMRKIEE
>Mature_264_residues
MEYLTLHNGFKVPVVGMGANTFGKVNHDFYGALDNDTKELIWAYENGYRLIDTAIVYRNETVIAKSIKDAHLNRKDVMVT
SKIPTKELPLEDDEKIEAMIQSSINIFGGYVDIYLIHHPSTDEINLKVWKALESHYLKGHFKAIGVSNFSKEQLDYIMKY
ANIKPMMNQIESNPANWQQELISYCKAYDIVPVAWGPLDPVPNKDILTTIGNHYGKTWAQILLRHQIQKGVVVIPKSHNK
LRQFENINIFDFTLSLEDMRKIEE

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI5174695, Length=300, Percent_Identity=33, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI24497577, Length=296, Percent_Identity=32.7702702702703, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI5174391, Length=296, Percent_Identity=32.7702702702703, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI5453543, Length=301, Percent_Identity=32.2259136212625, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI24497583, Length=303, Percent_Identity=33.6633663366337, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI310109922, Length=282, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI310109920, Length=301, Percent_Identity=31.8936877076412, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI223468663, Length=301, Percent_Identity=33.5548172757475, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI45446745, Length=301, Percent_Identity=31.2292358803987, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI4503285, Length=301, Percent_Identity=31.2292358803987, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI24497585, Length=302, Percent_Identity=31.4569536423841, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI300116273, Length=286, Percent_Identity=31.4685314685315, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI93277124, Length=305, Percent_Identity=30.4918032786885, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI291291012, Length=296, Percent_Identity=31.0810810810811, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4502049, Length=296, Percent_Identity=30.0675675675676, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI300116271, Length=279, Percent_Identity=29.0322580645161, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI310109924, Length=140, Percent_Identity=37.1428571428571, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI87082198, Length=266, Percent_Identity=31.203007518797, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1786400, Length=261, Percent_Identity=26.8199233716475, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17564128, Length=307, Percent_Identity=33.5504885993485, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71998625, Length=267, Percent_Identity=32.9588014981273, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17537077, Length=302, Percent_Identity=29.8013245033113, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17537075, Length=302, Percent_Identity=29.8013245033113, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550248, Length=298, Percent_Identity=29.1946308724832, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17566692, Length=299, Percent_Identity=30.4347826086957, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17537079, Length=303, Percent_Identity=27.0627062706271, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17561300, Length=279, Percent_Identity=27.2401433691756, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17561298, Length=278, Percent_Identity=26.978417266187, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562292, Length=281, Percent_Identity=28.1138790035587, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17552492, Length=240, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17538386, Length=281, Percent_Identity=27.0462633451957, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322556, Length=274, Percent_Identity=28.8321167883212, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324694, Length=293, Percent_Identity=31.3993174061433, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320576, Length=293, Percent_Identity=30.7167235494881, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319625, Length=293, Percent_Identity=30.3754266211604, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320079, Length=283, Percent_Identity=29.3286219081272, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321896, Length=311, Percent_Identity=28.9389067524116, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24663317, Length=291, Percent_Identity=32.9896907216495, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24644950, Length=306, Percent_Identity=33.9869281045752, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21356425, Length=292, Percent_Identity=33.5616438356164, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI221378297, Length=326, Percent_Identity=31.9018404907975, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI20129731, Length=291, Percent_Identity=31.6151202749141, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24657054, Length=294, Percent_Identity=32.6530612244898, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=30.1369863013699, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281366140, Length=251, Percent_Identity=31.4741035856574, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24662781, Length=289, Percent_Identity=30.7958477508651, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24662789, Length=299, Percent_Identity=27.4247491638796, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24662785, Length=284, Percent_Identity=30.9859154929577, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 30399; Mature: 30399

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYLTLHNGFKVPVVGMGANTFGKVNHDFYGALDNDTKELIWAYENGYRLIDTAIVYRNE
CCEEEECCCCEEEEEECCCCCCCCCCCCEECCCCCCCHHEEEEECCCCEEEEEEEEEECC
TVIAKSIKDAHLNRKDVMVTSKIPTKELPLEDDEKIEAMIQSSINIFGGYVDIYLIHHPS
EEEEHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCC
TDEINLKVWKALESHYLKGHFKAIGVSNFSKEQLDYIMKYANIKPMMNQIESNPANWQQE
CCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCCCCHHHHH
LISYCKAYDIVPVAWGPLDPVPNKDILTTIGNHYGKTWAQILLRHQIQKGVVVIPKSHNK
HHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
LRQFENINIFDFTLSLEDMRKIEE
HHHHCCCEEEEEEECHHHHHHHCC
>Mature Secondary Structure
MEYLTLHNGFKVPVVGMGANTFGKVNHDFYGALDNDTKELIWAYENGYRLIDTAIVYRNE
CCEEEECCCCEEEEEECCCCCCCCCCCCEECCCCCCCHHEEEEECCCCEEEEEEEEEECC
TVIAKSIKDAHLNRKDVMVTSKIPTKELPLEDDEKIEAMIQSSINIFGGYVDIYLIHHPS
EEEEHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCC
TDEINLKVWKALESHYLKGHFKAIGVSNFSKEQLDYIMKYANIKPMMNQIESNPANWQQE
CCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCCCCHHHHH
LISYCKAYDIVPVAWGPLDPVPNKDILTTIGNHYGKTWAQILLRHQIQKGVVVIPKSHNK
HHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
LRQFENINIFDFTLSLEDMRKIEE
HHHHCCCEEEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]