| Definition | Acholeplasma laidlawii PG-8A chromosome, complete genome. |
|---|---|
| Accession | NC_010163 |
| Length | 1,496,992 |
Click here to switch to the map view.
The map label for this gene is parC [H]
Identifier: 162447246
GI number: 162447246
Start: 398588
End: 401161
Strand: Direct
Name: parC [H]
Synonym: ACL_0380
Alternate gene names: 162447246
Gene position: 398588-401161 (Clockwise)
Preceding gene: 162447245
Following gene: 162447247
Centisome position: 26.63
GC content: 32.52
Gene sequence:
>2574_bases ATGAGTAAAATTGACAAAAAACTAGACAAATTCATAGAAGAAAAAATTGAAAAAGTTCTCTTAGAAGATATTATGTCTTC TAGATTTGGACGATACTCTAAATATATCATTCAAGATCGTGCACTACCAGATGCTAGAGATGGTTTAAAACCAGTTCAAC GTCGTATTTTATACGCAATGGGACAAATGGGTTTAGCCTTTAACAAATCATATAAAAAATCTGCAAGAATTGCAGGAGAA GTTATGGGGAAATATCACCCTCATGGGGATTCATCTATTTATGAAGCAATGGTTCGTATGAGCCAGGACTTTAAAATGAG AGTACCTCTAGTTGATATGCATGGTAACAATGGTTCCATAGATGGTGACTCTGCTGCGGCAATGCGTTATACCGAGGCTA GACTATCTAAAGAAGCAGAATTTTTACTTAAAGATATCGATAAAAGAACAGTAAACTTTGTACCTAACTTTGATGATGAG GAACAAGAACCTACCGTATTACCCGCACGTTTTCCAAACTTACTTGTCAATGGTGCAATGGGTATTTCAGCAGGTTATGC AACAAAAATACCACCACATAACTTAAATGAAGTCATTGATGCAACGATTGCTTTAATTGATAATCCAAATATTACAAATG ATGAAATATTAAAGTATATAAAAGGACCGGACTTCCCAACAGGTGGTATTGTTCAAGGTAAAGCAGGTATTAAAGAAGCA CTCACCACAGGTAGTGGGAAAATTATTATCAGGGCTAAGATGAATGTCGAAGAGATGAGTAAATCTCAAGACCGTATTGT GATTACTGAAATACCTTATGAAGTTAATAAAGCAGATTTAGTGCGTCAAATTGATAATTTACGTATCAATAACAATATCG AGGATATCTTAGAAATCCGTGATGAAACGGACCAAGAAGGTCTAAGAATTGCCATTGATCTTAAAAAAGGTGCAGATGCA CAATTTATTCAAAACTACTTATTAAAATCAAGTGATCTTCAAGTAAACTACAACTATAATATGGTTGCTATTTTAAAACA CCGTCCAGTTTTATCTGGTGCTTTTGAATTATTAAAAGTGTATTTAGAACACCAAAAAGAAGTAGTAACCAATAGATCTA ATTATGAATTAGAACGTGCAACAAAAAGAAATCATATTGTTGATGGTTTAATTCAAATGACTTCTGTTGTATCAGAAGTT ATTGAAGAAATTAGAAAATCTAAAAATAAAGCAGACTCAAAAGAAAATATCCAAAAGCGTTTTGGTTTTTCAGAACTACA AGCTGAAGCGATTGTCATGCTTCAACTATATAGATTATCTACAACCGATATCCAAGCACTACTAGATGAAAAAGATACTT TATATAAAGAAATTACTAGACTAGAACAAATATTATCGAATGAACGTATTTTACTTAAGACCATCAAATCTGAACTTCAA GAAGTTCAAACACTACTTCCCTCACCTAGACGTACCGAACTAGAAGCGGAAATTGAAACGATAAAGATTGATGAAAAAGA TCTCATCTCAGATGAACAAACCTATGTAGCTATCACTAAAGATGGTTACGTAAAACGTGCCTCACTAAGATCTGTTGTAG CATCTAAAGAAGTAGGTTTAAAAGAAAATGATGCAATGCTTTATGAAGAAGAATTAAACACACTAGATACCTTACTCTTA TTTACAAATTTAGGTCAATATATTTATTTACCGGTATATAAAATAGAAGAACAAAAATGGCGTGATCTCGGTGTTTATAT TAATAACATTGTACCTACCTCAAAAGGTGAAACTATTATACGTGTTTTAAAGGTCAGTGATTTTTCAATTGATCAAAAAA TATTGCTTACAACAAAACAAGGACAAATGAAACAAGTAAATCTAGCAGATTTTGAAGTTTCAAGGTATAATAGACCGTTA CGCGCAATGAAGTTGTCAAAAGACGATGAATTAGTATCTGTTGACTATAACCAACTAGACAATATAGTAGCTATTTCTAA ACATGGTTATGTCTTAAGATTCGATACAGAAGAACTGCCAGTATATGGTTTAACCGCTGGTGGGGTTAAATCTATGGCAT TAGCAGAAGGTGATGAAGTTGCAGTAGCATTTTACGCTAAAGAATCAGATGATTTTTACTTCTTAACATCACGCGGGCAT ATCATTAAAGATACAGTATTAGAATTACCTAAATACGCTAGAAATAGACGTGGTATTATTTTAGTAGATCGTATTAAAAC ATCTCCTCATTTCATAATCTCAGCATCTAGAGTATCCAAAACACAAATCAAAGAAGATGTAAAGGTACGTATTTTATCCA CTAAAGAAGCGCTGATTACTACAGTATCTGACTTAAAATATGTTGCGAATAAATATGGAAAGAAAATGGTAGAGGACGGT TACTATTTAGAAATATACCCAGCAGAAACTGAAGAAAAAGATACGCCAGTACAACCAAAAAAAGAAGTAAAAAAAGATGA TACATTACAAGCTAAAGTCATTGAAGAAACAATACAAACAAAACAAAATCAAAAGTTAAGACTATCAAGGCTTGATTTAT TTGATGAAGAATAG
Upstream 100 bases:
>100_bases GTGTATTAATGGGTGACCAGGTTGCACCAAGACGTGAATGGATTGAAGCAAACGTTGATTTTGAAGTAACTGATGAATTT GACATAGAAGGTAAGGTAAG
Downstream 100 bases:
>100_bases AGGAAAAAGTATGAAACTAAAGATTAACAATGAAGTACTTGAGTTAAAAGAACCATTAACACTGGAAAAACTTGCTCAAA AATTAAATATTTCTAATGCA
Product: DNA topoisomerase IV subunit A
Products: NA
Alternate protein names: Topoisomerase IV subunit A [H]
Number of amino acids: Translated: 857; Mature: 856
Protein sequence:
>857_residues MSKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMGQMGLAFNKSYKKSARIAGE VMGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSIDGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDE EQEPTVLPARFPNLLVNGAMGISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEA LTTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIRDETDQEGLRIAIDLKKGADA QFIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKVYLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEV IEEIRKSKNKADSKENIQKRFGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQ EVQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGLKENDAMLYEEELNTLDTLLL FTNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETIIRVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPL RAMKLSKDDELVSVDYNQLDNIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGH IIKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALITTVSDLKYVANKYGKKMVEDG YYLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQTKQNQKLRLSRLDLFDEE
Sequences:
>Translated_857_residues MSKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMGQMGLAFNKSYKKSARIAGE VMGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSIDGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDE EQEPTVLPARFPNLLVNGAMGISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEA LTTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIRDETDQEGLRIAIDLKKGADA QFIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKVYLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEV IEEIRKSKNKADSKENIQKRFGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQ EVQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGLKENDAMLYEEELNTLDTLLL FTNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETIIRVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPL RAMKLSKDDELVSVDYNQLDNIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGH IIKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALITTVSDLKYVANKYGKKMVEDG YYLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQTKQNQKLRLSRLDLFDEE >Mature_856_residues SKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMGQMGLAFNKSYKKSARIAGEV MGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSIDGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDEE QEPTVLPARFPNLLVNGAMGISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEAL TTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIRDETDQEGLRIAIDLKKGADAQ FIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKVYLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEVI EEIRKSKNKADSKENIQKRFGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQE VQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGLKENDAMLYEEELNTLDTLLLF TNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETIIRVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPLR AMKLSKDDELVSVDYNQLDNIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGHI IKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALITTVSDLKYVANKYGKKMVEDGY YLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQTKQNQKLRLSRLDLFDEE
Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
GO:0003677: DNA topoisomerase IV, subunit A
GO:0003916: DNA topoisomerase IV, subunit A
GO:0003918: DNA topoisomerase IV, subunit A
GO:0005524: DNA topoisomerase IV, subunit A
GO:0005694: DNA topoisomerase IV, subunit A
GO:0006259: DNA topoisomerase IV, subunit A
GO:0006265: DNA topoisomerase IV, subunit A
GO:0006355: DNA topoisomerase IV, subunit A
GO:0016853: DNA topoisomerase IV, subunit A
Cell location: Cytoplasm. Note=Bipolarly localized [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913406, Length=176, Percent_Identity=31.8181818181818, Blast_Score=81, Evalue=5e-15, Organism=Homo sapiens, GI19913408, Length=176, Percent_Identity=30.6818181818182, Blast_Score=79, Evalue=2e-14, Organism=Escherichia coli, GI1788562, Length=769, Percent_Identity=37.7113133940182, Blast_Score=501, Evalue=1e-143, Organism=Escherichia coli, GI1789396, Length=751, Percent_Identity=35.1531291611185, Blast_Score=382, Evalue=1e-107, Organism=Caenorhabditis elegans, GI212645845, Length=184, Percent_Identity=31.5217391304348, Blast_Score=73, Evalue=6e-13, Organism=Caenorhabditis elegans, GI212645657, Length=165, Percent_Identity=31.5151515151515, Blast_Score=73, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=31.1377245508982, Blast_Score=72, Evalue=1e-12, Organism=Caenorhabditis elegans, GI115534553, Length=173, Percent_Identity=30.635838150289, Blast_Score=70, Evalue=5e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=170, Percent_Identity=33.5294117647059, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI17136538, Length=170, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013760 - InterPro: IPR005741 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: 5.99.1.-
Molecular weight: Translated: 97767; Mature: 97636
Theoretical pI: Translated: 5.87; Mature: 5.87
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAM CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHCCHHHHHHHHHHHH GQMGLAFNKSYKKSARIAGEVMGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSI HHCCCHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCEEEECCCCCCC DGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDEEQEPTVLPARFPNLLVNGAM CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCHHHHCCCC GISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEA CCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHH LTTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIR HHCCCCEEEEEEECCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCEECCCHHHHHHHH DETDQEGLRIAIDLKKGADAQFIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKV CCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHH YLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEVIEEIRKSKNKADSKENIQKR HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH FGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQ CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH EVQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGL HHHHHCCCCCCCCEEEEEEEEEECHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCC KENDAMLYEEELNTLDTLLLFTNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETII CCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHHHHHCEEEECCCCCCCCCEEE RVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPLRAMKLSKDDELVSVDYNQLD EEEEECCCCCCCEEEEEECCCCCEECCCCCEEHHHCCCCHHHHCCCCCCCEEEECHHHCC NIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGH CEEEEECCCEEEEECCCCCCEEEECCCCCHHHHCCCCCCEEEEEEEECCCCEEEEECCCC IIKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALIT CHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECHHHHHHHHCCCEEEEEECHHHHHH TVSDLKYVANKYGKKMVEDGYYLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQT HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHH KQNQKLRLSRLDLFDEE CCCCCEEHHHCCCCCCC >Mature Secondary Structure SKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAM CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHCCHHHHHHHHHHHH GQMGLAFNKSYKKSARIAGEVMGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSI HHCCCHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCEEEECCCCCCC DGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDEEQEPTVLPARFPNLLVNGAM CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCHHHHCCCC GISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEA CCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHH LTTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIR HHCCCCEEEEEEECCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCEECCCHHHHHHHH DETDQEGLRIAIDLKKGADAQFIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKV CCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHH YLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEVIEEIRKSKNKADSKENIQKR HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH FGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQ CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH EVQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGL HHHHHCCCCCCCCEEEEEEEEEECHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCC KENDAMLYEEELNTLDTLLLFTNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETII CCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHHHHHCEEEECCCCCCCCCEEE RVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPLRAMKLSKDDELVSVDYNQLD EEEEECCCCCCCEEEEEECCCCCEECCCCCEEHHHCCCCHHHHCCCCCCCEEEECHHHCC NIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGH CEEEEECCCEEEEECCCCCCEEEECCCCCHHHHCCCCCCEEEEEEEECCCCEEEEECCCC IIKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALIT CHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECHHHHHHHHCCCEEEEEECHHHHHH TVSDLKYVANKYGKKMVEDGYYLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQT HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHH KQNQKLRLSRLDLFDEE CCCCCEEHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8969507; 9539793; 9384377 [H]