BacMap

Definition	Acholeplasma laidlawii PG-8A chromosome, complete genome.
Accession	NC_010163
Length	1,496,992

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The map label for this gene is yvgN [H]

Identifier: 162447244

GI number: 162447244

Start: 395694

End: 396533

Strand: Direct

Name: yvgN [H]

Synonym: ACL_0378

Alternate gene names: 162447244

Gene position: 395694-396533 (Clockwise)

Preceding gene: 162447243

Following gene: 162447245

Centisome position: 26.43

GC content: 32.38

Gene sequence:

>840_bases
ATGGAAACTTATACATTAAACAATGGTAAGAAAATTCCTAAATTCGGTTTAGGAACCTTTAGGGTTGAGGCTGGTGAATC
AGCATATGATACTGTGAAACTCGCATTAAAGATAGGATACAGACATATTGATACAGCCATAATGTATGGCAACGAATCAG
ATATAGGTAGAGCTATAAGGGACTCAGGTATTCCAAGAGAAGAGATATTTGTTACATCTAAGCTTGCTAAACACTATGAT
GGAGATATTGTTCTTATCAAAGAGGCTTTAGATAAATCTTTAAAAACATTAAATATCGGATATATTGATTTAATGTTAAT
TCATTGGCCTGATCATGATCACCACATCAATGATTTAATTTGGAAAATTTTTGAAAGTTATTACCAGGAAGGATTATTTA
AATCGATTGGTGTATCTAATTTCCAAATTCACCATTTAGAAAATTTACTTAAAAAAGCTATAGTAAGACCAGTAATGAAT
CAAGTAGAATGTCATCCACTATTAAGTCAAGTACCTTTACAAAAATACTTAACTGATAATGATATTTTAATGACTTCCTA
CGGGCCACTTGCAAGAGGTGAAGTCTTTACTGGTAAAACACATGAGGTATTAGAAGAAATTGCGAAACAATATGGTGCAA
CAGTTGCACAAGTTATTGTTCAGTGGGGGCTAGCAAGAGGCATTGTAATGATTCCAAAAAGTGTCCATGAGGAAAGGTTA
ATTGAAAACTTTAAGGGGCAAGAATTAGTACTTGCACCTGAAGATATTGAAAAAATTAATCAACTTAATAGAGGCAGAAG
ACTCTATTCTGATCCAGATAACAACATCAATTTTTTATAA

Upstream 100 bases:

>100_bases
CAGATTTATTTGATTTAGCAGAGGCTAGAAAGATGCTATTTACACTCATTAGTGATTTAACTAGTGATAAAATTAAGTCA
TTCTACTAAGGAGGTATAAT

Downstream 100 bases:

>100_bases
ATTAATACAGCAAGAAAATACTTTTAAAGATAATCATTCTTGTTATAATGATTATCTTTTAATGTATAATAGAGATATAA
TTTCAATGATTGGAGTACAA

Product: aldo/keto reductase family protein

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
METYTLNNGKKIPKFGLGTFRVEAGESAYDTVKLALKIGYRHIDTAIMYGNESDIGRAIRDSGIPREEIFVTSKLAKHYD
GDIVLIKEALDKSLKTLNIGYIDLMLIHWPDHDHHINDLIWKIFESYYQEGLFKSIGVSNFQIHHLENLLKKAIVRPVMN
QVECHPLLSQVPLQKYLTDNDILMTSYGPLARGEVFTGKTHEVLEEIAKQYGATVAQVIVQWGLARGIVMIPKSVHEERL
IENFKGQELVLAPEDIEKINQLNRGRRLYSDPDNNINFL

Sequences:

>Translated_279_residues
METYTLNNGKKIPKFGLGTFRVEAGESAYDTVKLALKIGYRHIDTAIMYGNESDIGRAIRDSGIPREEIFVTSKLAKHYD
GDIVLIKEALDKSLKTLNIGYIDLMLIHWPDHDHHINDLIWKIFESYYQEGLFKSIGVSNFQIHHLENLLKKAIVRPVMN
QVECHPLLSQVPLQKYLTDNDILMTSYGPLARGEVFTGKTHEVLEEIAKQYGATVAQVIVQWGLARGIVMIPKSVHEERL
IENFKGQELVLAPEDIEKINQLNRGRRLYSDPDNNINFL
>Mature_279_residues
METYTLNNGKKIPKFGLGTFRVEAGESAYDTVKLALKIGYRHIDTAIMYGNESDIGRAIRDSGIPREEIFVTSKLAKHYD
GDIVLIKEALDKSLKTLNIGYIDLMLIHWPDHDHHINDLIWKIFESYYQEGLFKSIGVSNFQIHHLENLLKKAIVRPVMN
QVECHPLLSQVPLQKYLTDNDILMTSYGPLARGEVFTGKTHEVLEEIAKQYGATVAQVIVQWGLARGIVMIPKSVHEERL
IENFKGQELVLAPEDIEKINQLNRGRRLYSDPDNNINFL

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=296, Percent_Identity=35.8108108108108, Blast_Score=187, Evalue=8e-48,
Organism=Homo sapiens, GI5174391, Length=296, Percent_Identity=35.8108108108108, Blast_Score=187, Evalue=8e-48,
Organism=Homo sapiens, GI223468663, Length=299, Percent_Identity=34.4481605351171, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4502049, Length=297, Percent_Identity=37.037037037037, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI310109922, Length=294, Percent_Identity=36.734693877551, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI24497585, Length=296, Percent_Identity=35.1351351351351, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=34.1137123745819, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI5453543, Length=312, Percent_Identity=35.8974358974359, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI310109920, Length=312, Percent_Identity=35.8974358974359, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI45446745, Length=312, Percent_Identity=35.8974358974359, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI4503285, Length=312, Percent_Identity=35.8974358974359, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI300116273, Length=276, Percent_Identity=34.7826086956522, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI24497583, Length=298, Percent_Identity=34.2281879194631, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI291291012, Length=271, Percent_Identity=32.1033210332103, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI93277124, Length=305, Percent_Identity=32.1311475409836, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI300116271, Length=279, Percent_Identity=30.4659498207885, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI310109924, Length=159, Percent_Identity=35.8490566037736, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310109926, Length=128, Percent_Identity=41.40625, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI207028673, Length=115, Percent_Identity=42.6086956521739, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI87082198, Length=273, Percent_Identity=41.3919413919414, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1786400, Length=262, Percent_Identity=37.0229007633588, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1788081, Length=268, Percent_Identity=26.4925373134328, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17537075, Length=302, Percent_Identity=36.0927152317881, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17561298, Length=276, Percent_Identity=35.1449275362319, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17537077, Length=298, Percent_Identity=34.8993288590604, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17538386, Length=276, Percent_Identity=34.7826086956522, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17552492, Length=282, Percent_Identity=33.6879432624113, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17562292, Length=284, Percent_Identity=30.2816901408451, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71998625, Length=279, Percent_Identity=34.0501792114695, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17564128, Length=307, Percent_Identity=34.2019543973941, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17550248, Length=293, Percent_Identity=34.8122866894198, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17561300, Length=273, Percent_Identity=33.6996336996337, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=27.6094276094276, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17566692, Length=270, Percent_Identity=34.4444444444444, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324694, Length=292, Percent_Identity=38.013698630137, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320576, Length=290, Percent_Identity=36.8965517241379, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321896, Length=313, Percent_Identity=31.9488817891374, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319625, Length=272, Percent_Identity=33.4558823529412, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322556, Length=263, Percent_Identity=33.4600760456274, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6320079, Length=284, Percent_Identity=32.3943661971831, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24662789, Length=300, Percent_Identity=36.3333333333333, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI20129731, Length=291, Percent_Identity=35.3951890034364, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21356425, Length=290, Percent_Identity=34.1379310344828, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24663317, Length=296, Percent_Identity=33.7837837837838, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45553081, Length=294, Percent_Identity=34.0136054421769, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24657054, Length=294, Percent_Identity=34.3537414965986, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24644950, Length=302, Percent_Identity=33.112582781457, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24662781, Length=277, Percent_Identity=35.7400722021661, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221378297, Length=323, Percent_Identity=32.1981424148607, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24662785, Length=275, Percent_Identity=35.6363636363636, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI281366140, Length=259, Percent_Identity=33.5907335907336, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31856; Mature: 31856

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METYTLNNGKKIPKFGLGTFRVEAGESAYDTVKLALKIGYRHIDTAIMYGNESDIGRAIR
CCEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHH
DSGIPREEIFVTSKLAKHYDGDIVLIKEALDKSLKTLNIGYIDLMLIHWPDHDHHINDLI
HCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHEECCCEEEEEEEECCCCCCHHHHHH
WKIFESYYQEGLFKSIGVSNFQIHHLENLLKKAIVRPVMNQVECHPLLSQVPLQKYLTDN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
DILMTSYGPLARGEVFTGKTHEVLEEIAKQYGATVAQVIVQWGLARGIVMIPKSVHEERL
CEEEECCCCCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEECCHHHHHHHH
IENFKGQELVLAPEDIEKINQLNRGRRLYSDPDNNINFL
HHHCCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
METYTLNNGKKIPKFGLGTFRVEAGESAYDTVKLALKIGYRHIDTAIMYGNESDIGRAIR
CCEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHH
DSGIPREEIFVTSKLAKHYDGDIVLIKEALDKSLKTLNIGYIDLMLIHWPDHDHHINDLI
HCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHEECCCEEEEEEEECCCCCCHHHHHH
WKIFESYYQEGLFKSIGVSNFQIHHLENLLKKAIVRPVMNQVECHPLLSQVPLQKYLTDN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
DILMTSYGPLARGEVFTGKTHEVLEEIAKQYGATVAQVIVQWGLARGIVMIPKSVHEERL
CEEEECCCCCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEECCHHHHHHHH
IENFKGQELVLAPEDIEKINQLNRGRRLYSDPDNNINFL
HHHCCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]