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The map label for this gene is map [H]

Identifier: 162446979

GI number: 162446979

Start: 95168

End: 95923

Strand: Direct

Name: map [H]

Synonym: ACL_0109

Alternate gene names: 162446979

Gene position: 95168-95923 (Clockwise)

Preceding gene: 162446978

Following gene: 162446980

Centisome position: 6.36

GC content: 37.7

Gene sequence:

>756_bases
ATGATTACAATAAAAAGTTCTAGAGAAATTGAACTCATGAAAACAGCTGGTGACATCTTGGCACGTACTAGGGAATATCT
AATTCCTTTCATTAAGCCAGGTGTTACCACACATGAGCTTGATATGCTCGCACATAATTTCATACTCGAAAATGATGCAA
CACCGTCATTTAAAGGATACCAAGGATTTGATGGATCGATTTGTGCATCCGTCAATGAAGTTGTGATTCACGGTATACCT
TCCAAAAAGAAGGTTCTCAAAGATGGCGATATTCTATCACTCGATTTAGGTGTGAATTATAAGGGTTATCACGCTGACTC
TGCATGGACATTTCCTGTTGGGGTTATCTCAAATGAAGTTAAAAAGTTGTTAGAAGTAACAGAAGAAGCACTATGGAATG
GCTTAGCGGTTATTAAACCAGGTGCAAGCGTCAATGAGATTTCTAAAGCAGTTGAACAAACCATTAGACCACATGGTTAT
GGTATTGTTGAAGAATTTACCGGTCATGGCATCGGTCAAAGTCTCCATGAAGATCCAGCGATTCCTAACTTTGGTTATGA
ACCAAATCATGTGATTTTAAAAGCTGGAATGACCTTTTGTGTAGAACCAATGGTCAATATAGGAACTAAAAGAGTTCGTA
TATTAAAAGATGGTTGGACAACAGTTACACAAGACAAATCATATAGTGCACATTTCGAGCATACGGTACTTGTAACCGAA
ACAGGCTATGAAGTATTGACTAAAACAAAGGAGTAA

Upstream 100 bases:

>100_bases
TAATTAAGTATTATGCACATAAAAACTTACTTATGGATGTTGATGGTAATCAACCTTTAGAGGTGATTACAAAACATGTA
TTAGAAATTCTGGAGCAAAA

Downstream 100 bases:

>100_bases
TTATGGCAAGAGAAGATTTAATAGAAGTTGAAGCAAAGGTTAAAGAAATTTTACCGAACACAAAGTTTATAGTTGAGCTA
GACAACGGTCACACCGTTGT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MITIKSSREIELMKTAGDILARTREYLIPFIKPGVTTHELDMLAHNFILENDATPSFKGYQGFDGSICASVNEVVIHGIP
SKKKVLKDGDILSLDLGVNYKGYHADSAWTFPVGVISNEVKKLLEVTEEALWNGLAVIKPGASVNEISKAVEQTIRPHGY
GIVEEFTGHGIGQSLHEDPAIPNFGYEPNHVILKAGMTFCVEPMVNIGTKRVRILKDGWTTVTQDKSYSAHFEHTVLVTE
TGYEVLTKTKE

Sequences:

>Translated_251_residues
MITIKSSREIELMKTAGDILARTREYLIPFIKPGVTTHELDMLAHNFILENDATPSFKGYQGFDGSICASVNEVVIHGIP
SKKKVLKDGDILSLDLGVNYKGYHADSAWTFPVGVISNEVKKLLEVTEEALWNGLAVIKPGASVNEISKAVEQTIRPHGY
GIVEEFTGHGIGQSLHEDPAIPNFGYEPNHVILKAGMTFCVEPMVNIGTKRVRILKDGWTTVTQDKSYSAHFEHTVLVTE
TGYEVLTKTKE
>Mature_251_residues
MITIKSSREIELMKTAGDILARTREYLIPFIKPGVTTHELDMLAHNFILENDATPSFKGYQGFDGSICASVNEVVIHGIP
SKKKVLKDGDILSLDLGVNYKGYHADSAWTFPVGVISNEVKKLLEVTEEALWNGLAVIKPGASVNEISKAVEQTIRPHGY
GIVEEFTGHGIGQSLHEDPAIPNFGYEPNHVILKAGMTFCVEPMVNIGTKRVRILKDGWTTVTQDKSYSAHFEHTVLVTE
TGYEVLTKTKE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=248, Percent_Identity=36.2903225806452, Blast_Score=178, Evalue=3e-45,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=36.0323886639676, Blast_Score=167, Evalue=6e-42,
Organism=Escherichia coli, GI1786364, Length=251, Percent_Identity=43.0278884462151, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI1788728, Length=251, Percent_Identity=28.6852589641434, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1789275, Length=269, Percent_Identity=24.907063197026, Blast_Score=67, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=249, Percent_Identity=38.5542168674699, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6323273, Length=247, Percent_Identity=38.8663967611336, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21355531, Length=250, Percent_Identity=38, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=38.4615384615385, Blast_Score=184, Evalue=5e-47,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27711; Mature: 27711

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIKSSREIELMKTAGDILARTREYLIPFIKPGVTTHELDMLAHNFILENDATPSFKGY
CEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCCCC
QGFDGSICASVNEVVIHGIPSKKKVLKDGDILSLDLGVNYKGYHADSAWTFPVGVISNEV
CCCCCHHHHCCCEEEEECCCCHHHHHCCCCEEEEEECCCCCCEECCCCEEEEHHHHHHHH
KKLLEVTEEALWNGLAVIKPGASVNEISKAVEQTIRPHGYGIVEEFTGHGIGQSLHEDPA
HHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHCCCC
IPNFGYEPNHVILKAGMTFCVEPMVNIGTKRVRILKDGWTTVTQDKSYSAHFEHTVLVTE
CCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCEEEEEEEE
TGYEVLTKTKE
CCHHHHHCCCC
>Mature Secondary Structure
MITIKSSREIELMKTAGDILARTREYLIPFIKPGVTTHELDMLAHNFILENDATPSFKGY
CEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCCCC
QGFDGSICASVNEVVIHGIPSKKKVLKDGDILSLDLGVNYKGYHADSAWTFPVGVISNEV
CCCCCHHHHCCCEEEEECCCCHHHHHCCCCEEEEEECCCCCCEECCCCEEEEHHHHHHHH
KKLLEVTEEALWNGLAVIKPGASVNEISKAVEQTIRPHGYGIVEEFTGHGIGQSLHEDPA
HHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHCCCC
IPNFGYEPNHVILKAGMTFCVEPMVNIGTKRVRILKDGWTTVTQDKSYSAHFEHTVLVTE
CCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCEEEEEEEE
TGYEVLTKTKE
CCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]