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The map label for this gene is adk

Identifier: 162446978

GI number: 162446978

Start: 94518

End: 95171

Strand: Direct

Name: adk

Synonym: ACL_0108

Alternate gene names: 162446978

Gene position: 94518-95171 (Clockwise)

Preceding gene: 162446977

Following gene: 162446979

Centisome position: 6.31

GC content: 34.4

Gene sequence:

>654_bases
ATGAAAACAAGGATGATATTTGTAGGCCCTCCTGGGGCTGGCAAGGGATCACAGGCAAAAATAATTTCACAGACATTAAA
TATCCCACATATATCAACCGGTGATATGTTCAGAACACATATAAAGGGTAGTACGCCACTTGGTTTGGAAGCTAAAAAGT
ATACAGACCAAGGGCTACTTGTACCTGATGATGTAACCAATCAAATGGTTAAAGATCGCCTAAGTCAGAAAGATGTTGAA
AAGGGATTCATCTTTGATGGATATCCAAGAACACCTGATCAAGCAATTTTCTTAGACAATCTATTAATGGTAACAAATCA
AAAACTTGATGTAGTATTAAATATTTCATCAAGTGATGAAGTTATTGTTAAACGAATCACAGGTAGAAGAACATGCCCAG
TATGTGGTGCTATATATCATGTTGATAACTATCCACCAAAAGTGGCAGGTATTTGTGATAATGATGGTGCAACCTTGGTT
CAAAGAAAAGATGATCAAAAAGAAACAATTATTCGTAGACTTAGTGTTTACAAAGAAGAAACATTCCCATTAATTAAGTA
TTATGCACATAAAAACTTACTTATGGATGTTGATGGTAATCAACCTTTAGAGGTGATTACAAAACATGTATTAGAAATTC
TGGAGCAAAAATGA

Upstream 100 bases:

>100_bases
TAGGTGGAACCGGGCTATTAATCGTAGTTGGGGTTGCTGCAGACACTACACAACAACTTGAAGCACAAGCTAATCAAGAG
ACGTATCAAGGATTGTTCTA

Downstream 100 bases:

>100_bases
TTACAATAAAAAGTTCTAGAGAAATTGAACTCATGAAAACAGCTGGTGACATCTTGGCACGTACTAGGGAATATCTAATT
CCTTTCATTAAGCCAGGTGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MKTRMIFVGPPGAGKGSQAKIISQTLNIPHISTGDMFRTHIKGSTPLGLEAKKYTDQGLLVPDDVTNQMVKDRLSQKDVE
KGFIFDGYPRTPDQAIFLDNLLMVTNQKLDVVLNISSSDEVIVKRITGRRTCPVCGAIYHVDNYPPKVAGICDNDGATLV
QRKDDQKETIIRRLSVYKEETFPLIKYYAHKNLLMDVDGNQPLEVITKHVLEILEQK

Sequences:

>Translated_217_residues
MKTRMIFVGPPGAGKGSQAKIISQTLNIPHISTGDMFRTHIKGSTPLGLEAKKYTDQGLLVPDDVTNQMVKDRLSQKDVE
KGFIFDGYPRTPDQAIFLDNLLMVTNQKLDVVLNISSSDEVIVKRITGRRTCPVCGAIYHVDNYPPKVAGICDNDGATLV
QRKDDQKETIIRRLSVYKEETFPLIKYYAHKNLLMDVDGNQPLEVITKHVLEILEQK
>Mature_217_residues
MKTRMIFVGPPGAGKGSQAKIISQTLNIPHISTGDMFRTHIKGSTPLGLEAKKYTDQGLLVPDDVTNQMVKDRLSQKDVE
KGFIFDGYPRTPDQAIFLDNLLMVTNQKLDVVLNISSSDEVIVKRITGRRTCPVCGAIYHVDNYPPKVAGICDNDGATLV
QRKDDQKETIIRRLSVYKEETFPLIKYYAHKNLLMDVDGNQPLEVITKHVLEILEQK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=35.2112676056338, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=35.2112676056338, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI19923437, Length=214, Percent_Identity=35.5140186915888, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=35.3535353535354, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=35.3535353535354, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=35.3535353535354, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=35.3535353535354, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI4502011, Length=211, Percent_Identity=29.3838862559242, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI22749187, Length=187, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7706497, Length=225, Percent_Identity=25.7777777777778, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=42.5925925925926, Blast_Score=165, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=36.6197183098592, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=27.1889400921659, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17533833, Length=216, Percent_Identity=25.462962962963, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=27.906976744186, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=212, Percent_Identity=41.5094339622642, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=36.4102564102564, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=210, Percent_Identity=25.7142857142857, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=37.7358490566038, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17737899, Length=202, Percent_Identity=33.1683168316832, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24645822, Length=202, Percent_Identity=33.1683168316832, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17647141, Length=195, Percent_Identity=26.1538461538462, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24663208, Length=195, Percent_Identity=26.1538461538462, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221459597, Length=217, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356893, Length=217, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ACHLI (A9NEF4)

Other databases:

- EMBL:   CP000896
- RefSeq:   YP_001620110.1
- ProteinModelPortal:   A9NEF4
- SMR:   A9NEF4
- GeneID:   5804128
- GenomeReviews:   CP000896_GR
- KEGG:   acl:ACL_0108
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- BioCyc:   ALAI441768:ACL_0108-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24355; Mature: 24355

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRMIFVGPPGAGKGSQAKIISQTLNIPHISTGDMFRTHIKGSTPLGLEAKKYTDQGLL
CCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCHHHEECCCCCCCCCCHHCCCCCCCC
VPDDVTNQMVKDRLSQKDVEKGFIFDGYPRTPDQAIFLDNLLMVTNQKLDVVLNISSSDE
CCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEHHHHEEEEECCCEEEEEEECCCCC
VIVKRITGRRTCPVCGAIYHVDNYPPKVAGICDNDGATLVQRKDDQKETIIRRLSVYKEE
EEEEECCCCCCCCHHHEEEECCCCCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHH
TFPLIKYYAHKNLLMDVDGNQPLEVITKHVLEILEQK
CCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTRMIFVGPPGAGKGSQAKIISQTLNIPHISTGDMFRTHIKGSTPLGLEAKKYTDQGLL
CCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCHHHEECCCCCCCCCCHHCCCCCCCC
VPDDVTNQMVKDRLSQKDVEKGFIFDGYPRTPDQAIFLDNLLMVTNQKLDVVLNISSSDE
CCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEHHHHEEEEECCCEEEEEEECCCCC
VIVKRITGRRTCPVCGAIYHVDNYPPKVAGICDNDGATLVQRKDDQKETIIRRLSVYKEE
EEEEECCCCCCCCHHHEEEECCCCCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHH
TFPLIKYYAHKNLLMDVDGNQPLEVITKHVLEILEQK
CCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA