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The map label for this gene is xdhA [H]

Identifier: 162147787

GI number: 162147787

Start: 2039791

End: 2041284

Strand: Reverse

Name: xdhA [H]

Synonym: GDI_2003

Alternate gene names: 162147787

Gene position: 2041284-2039791 (Counterclockwise)

Preceding gene: 162147788

Following gene: 162147786

Centisome position: 51.75

GC content: 71.75

Gene sequence:

>1494_bases
ATGCGCGACCATATCCGCTTTTACCTGGGCGACACGCTGTACGACCTGTCGGGCTTTTCCCCGACCCTGACGGTCCTGGA
CTGGCTGCGCGAGCAGCGCGGCCGGACCGGCACCAAGGAAGGCTGCAACGAGGGCGATTGCGGGGCCTGCACGGTGCTGG
TGGCGCGGCTGGACGGCGGCCCCCCCGATGGCCCGCGCCTGGCTTGGCGGGCGGTGAATGCCTGCATCCAGTTCGTGTCC
ATGCTGGACGGCGCGCAGCTTTTCACGGTGGAGGATCTGCGCGCGCCGGACGGCACGCTGCATCCGGTGCAGCAGGCGAT
GGTGGACCTGCACGGATCGCAATGCGGGTTCTGCACGCCGGGATTCGTCATGTCGATGGTCGCCTACCGCAAGCAACCGG
GCGCGGTGGCCGAGGACGGGCCGATCGACGACGCGCTGGCCGGCAATCTGTGCCGCTGTACCGGCTACGCCCCGATCGTC
CGCGCCATGAAACAGGCGATGGCGGCGGGGTCCGACCGGTTCGACGCGCAGGCCGCCGCGATTGCCGACCGTCTGTCGGC
CCTGCGGGACGGCCAGACGGTAAACATCTCGGGTCCGGCGGCCCGGCTGACCATTCCCGCGGACGCCGACGCGCTGGCCG
CCACCCTGCTGGCCGATCCCGAGGCCACGATCGTGGCCGGGGCCACGGATGTCGGGCTGTGGGTCACCAAGGGGCTGCGC
ACCCTGCCGCATGTCGTCGCCATCGGCCAGGTCCCCGACCTGAAGCGGCTGGACCGCACGGCGGACGGGCTGCGGATCGG
CGCGGCCGTCACCTACGAGGACGCGCGCGACGCCCTGGCCGGCCTGCTGCCGGACGCGGGTGAAATCGTGCGGCGGATCG
GCTCGACCCAGGTGCGCAACGCCGGGACGGTCTGCGGCAACATCGCCAACGGCTCGCCGATCGGGGACGGGCCGCCGGTC
TTCATCGCGGCGGGGGCGACGCTGCACCTGCGCCGGGGCGATGTGCGGCGAAACATGCCGCTGGAGGATTATTTCCTCGC
CTATGGCCAGCAGGACCGCCAACCCGGCGAATTCGTCGAGGGCGTGACCATTCCCGCCCTGCGCCAGGGACAGGTTTTCC
GGGCCTACAAGGTCTCCAAGCGGTTCGACCAGGATATCTCGGCCCTGCTGGGCGCTTTCGCGCTGACGCTGGACGATGCG
GGCACCATCACCGACGCCCGCATCGCCTTCGGCGGCATGGCGGCGACCCCCAGGCGGGCCCGCGCGACCGAGGAAGCCCT
GCGCGGCCATCCGTGGTCCGAGGCGACGCTGCAGGCCGCGCGGGCCGCCATCGCTACCGATTTCGCGCCGATTTCCGACA
TGCGGGCCAGCGACTGGTACCGCCGCACGGTCGCGGCCAACCTGCTGACCCGGCTGTTCGCCGAGACCGCCCCCGGCGCG
CGTCGGCCCGAAACCCGGCTGGCCGGACGGAGCGAGGCCGCGATCCATGCGTGA

Upstream 100 bases:

>100_bases
CTGGGCAGTCGGGCCGGTCTCGGGGGAGGCGGGCCTGATCTGAGTTCCGGTCGCCTGCCCTGAGGGGGACAGGGCGGCCG
CAGCGTTACGGAACCGAACG

Downstream 100 bases:

>100_bases
TACGATATCGGCCCCCATTTCTGGTGCCCTTCCTGACGCCGTTCCCGGCACCGTCGTGACGGGCGGCGCGTCGCACAGCC
TGCGGCACGAAAGTGCGGCG

Product: xanthine dehydrogenase, xdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MRDHIRFYLGDTLYDLSGFSPTLTVLDWLREQRGRTGTKEGCNEGDCGACTVLVARLDGGPPDGPRLAWRAVNACIQFVS
MLDGAQLFTVEDLRAPDGTLHPVQQAMVDLHGSQCGFCTPGFVMSMVAYRKQPGAVAEDGPIDDALAGNLCRCTGYAPIV
RAMKQAMAAGSDRFDAQAAAIADRLSALRDGQTVNISGPAARLTIPADADALAATLLADPEATIVAGATDVGLWVTKGLR
TLPHVVAIGQVPDLKRLDRTADGLRIGAAVTYEDARDALAGLLPDAGEIVRRIGSTQVRNAGTVCGNIANGSPIGDGPPV
FIAAGATLHLRRGDVRRNMPLEDYFLAYGQQDRQPGEFVEGVTIPALRQGQVFRAYKVSKRFDQDISALLGAFALTLDDA
GTITDARIAFGGMAATPRRARATEEALRGHPWSEATLQAARAAIATDFAPISDMRASDWYRRTVAANLLTRLFAETAPGA
RRPETRLAGRSEAAIHA

Sequences:

>Translated_497_residues
MRDHIRFYLGDTLYDLSGFSPTLTVLDWLREQRGRTGTKEGCNEGDCGACTVLVARLDGGPPDGPRLAWRAVNACIQFVS
MLDGAQLFTVEDLRAPDGTLHPVQQAMVDLHGSQCGFCTPGFVMSMVAYRKQPGAVAEDGPIDDALAGNLCRCTGYAPIV
RAMKQAMAAGSDRFDAQAAAIADRLSALRDGQTVNISGPAARLTIPADADALAATLLADPEATIVAGATDVGLWVTKGLR
TLPHVVAIGQVPDLKRLDRTADGLRIGAAVTYEDARDALAGLLPDAGEIVRRIGSTQVRNAGTVCGNIANGSPIGDGPPV
FIAAGATLHLRRGDVRRNMPLEDYFLAYGQQDRQPGEFVEGVTIPALRQGQVFRAYKVSKRFDQDISALLGAFALTLDDA
GTITDARIAFGGMAATPRRARATEEALRGHPWSEATLQAARAAIATDFAPISDMRASDWYRRTVAANLLTRLFAETAPGA
RRPETRLAGRSEAAIHA
>Mature_497_residues
MRDHIRFYLGDTLYDLSGFSPTLTVLDWLREQRGRTGTKEGCNEGDCGACTVLVARLDGGPPDGPRLAWRAVNACIQFVS
MLDGAQLFTVEDLRAPDGTLHPVQQAMVDLHGSQCGFCTPGFVMSMVAYRKQPGAVAEDGPIDDALAGNLCRCTGYAPIV
RAMKQAMAAGSDRFDAQAAAIADRLSALRDGQTVNISGPAARLTIPADADALAATLLADPEATIVAGATDVGLWVTKGLR
TLPHVVAIGQVPDLKRLDRTADGLRIGAAVTYEDARDALAGLLPDAGEIVRRIGSTQVRNAGTVCGNIANGSPIGDGPPV
FIAAGATLHLRRGDVRRNMPLEDYFLAYGQQDRQPGEFVEGVTIPALRQGQVFRAYKVSKRFDQDISALLGAFALTLDDA
GTITDARIAFGGMAATPRRARATEEALRGHPWSEATLQAARAAIATDFAPISDMRASDWYRRTVAANLLTRLFAETAPGA
RRPETRLAGRSEAAIHA

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=501, Percent_Identity=29.3413173652695, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI71773480, Length=550, Percent_Identity=25.4545454545455, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1786480, Length=157, Percent_Identity=40.7643312101911, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789231, Length=275, Percent_Identity=29.4545454545455, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789232, Length=148, Percent_Identity=39.8648648648649, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17540638, Length=539, Percent_Identity=28.7569573283859, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI32566215, Length=336, Percent_Identity=26.7857142857143, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17539860, Length=454, Percent_Identity=24.8898678414097, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17737937, Length=510, Percent_Identity=30.5882352941176, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24647201, Length=498, Percent_Identity=25.3012048192771, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24647197, Length=514, Percent_Identity=29.1828793774319, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24647199, Length=510, Percent_Identity=26.078431372549, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24647193, Length=502, Percent_Identity=26.8924302788845, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24647195, Length=329, Percent_Identity=30.6990881458967, Blast_Score=142, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR017606
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 52848; Mature: 52848

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDHIRFYLGDTLYDLSGFSPTLTVLDWLREQRGRTGTKEGCNEGDCGACTVLVARLDGG
CCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEECCCC
PPDGPRLAWRAVNACIQFVSMLDGAQLFTVEDLRAPDGTLHPVQQAMVDLHGSQCGFCTP
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCHHHHHHHHHHHCCCCCCCCCH
GFVMSMVAYRKQPGAVAEDGPIDDALAGNLCRCTGYAPIVRAMKQAMAAGSDRFDAQAAA
HHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCEECCCHHHHHHHHHHHHCCCCCHHHHHHH
IADRLSALRDGQTVNISGPAARLTIPADADALAATLLADPEATIVAGATDVGLWVTKGLR
HHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHH
TLPHVVAIGQVPDLKRLDRTADGLRIGAAVTYEDARDALAGLLPDAGEIVRRIGSTQVRN
HHHHHEEECCCCCHHHHHHCCCCEEECEEEEHHHHHHHHHHHCCCHHHHHHHHCCCHHCC
AGTVCGNIANGSPIGDGPPVFIAAGATLHLRRGDVRRNMPLEDYFLAYGQQDRQPGEFVE
CCCEECCCCCCCCCCCCCCEEEECCCEEEEECCCHHCCCCHHHHHHHCCCCCCCCCHHHC
GVTIPALRQGQVFRAYKVSKRFDQDISALLGAFALTLDDAGTITDARIAFGGMAATPRRA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCCCCCHHH
RATEEALRGHPWSEATLQAARAAIATDFAPISDMRASDWYRRTVAANLLTRLFAETAPGA
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
RRPETRLAGRSEAAIHA
CCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MRDHIRFYLGDTLYDLSGFSPTLTVLDWLREQRGRTGTKEGCNEGDCGACTVLVARLDGG
CCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEECCCC
PPDGPRLAWRAVNACIQFVSMLDGAQLFTVEDLRAPDGTLHPVQQAMVDLHGSQCGFCTP
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCHHHHHHHHHHHCCCCCCCCCH
GFVMSMVAYRKQPGAVAEDGPIDDALAGNLCRCTGYAPIVRAMKQAMAAGSDRFDAQAAA
HHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCEECCCHHHHHHHHHHHHCCCCCHHHHHHH
IADRLSALRDGQTVNISGPAARLTIPADADALAATLLADPEATIVAGATDVGLWVTKGLR
HHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHH
TLPHVVAIGQVPDLKRLDRTADGLRIGAAVTYEDARDALAGLLPDAGEIVRRIGSTQVRN
HHHHHEEECCCCCHHHHHHCCCCEEECEEEEHHHHHHHHHHHCCCHHHHHHHHCCCHHCC
AGTVCGNIANGSPIGDGPPVFIAAGATLHLRRGDVRRNMPLEDYFLAYGQQDRQPGEFVE
CCCEECCCCCCCCCCCCCCEEEECCCEEEEECCCHHCCCCHHHHHHHCCCCCCCCCHHHC
GVTIPALRQGQVFRAYKVSKRFDQDISALLGAFALTLDDAGTITDARIAFGGMAATPRRA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCCCCCHHH
RATEEALRGHPWSEATLQAARAAIATDFAPISDMRASDWYRRTVAANLLTRLFAETAPGA
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
RRPETRLAGRSEAAIHA
CCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]