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The map label for this gene is xdhB [H]

Identifier: 162147786

GI number: 162147786

Start: 2037417

End: 2039735

Strand: Reverse

Name: xdhB [H]

Synonym: GDI_2002

Alternate gene names: 162147786

Gene position: 2039735-2037417 (Counterclockwise)

Preceding gene: 162147787

Following gene: 162147785

Centisome position: 51.72

GC content: 69.04

Gene sequence:

>2319_bases
GTGACGGGCGGCGCGTCGCACAGCCTGCGGCACGAAAGTGCGGCGATGCATGTCGCCGGCGCCGCCGCCTATATCGACGA
CATGCCCGAACCGAAGGGACTGCTGCATGTCGTGCCGGGACTGAGCACGCGGGCGCATGCCCGGATCGTCTCGATGGACC
TCGATGCCGTCCGTGCCGCCCCCGGGGTCGTGCGGGTGCTGACGGCGGCGGATATTCCCGGCCACAACCAGGTCAGCCCG
GTGGGCCGCAATGACGAACCGCTGCTCGCGACGGACCTGGTATCCTATTACGGCCAGCCGATCTTCGCCGTGGTGGCCGA
AACCCGCCTGCAGGCCCGGCACGCGGCCAGGCTGGCGCGGATCGAGTACGAGGACCTGCCCGCCATCCTGGACATCGCGC
AGGCCCGCGCGGCGGGTGGCGCCATGGTCTGGCGGCCCCTGACCATGCAGCGCGGCGATGCCCCGTCCGGCCTGGCCGCG
TCGCCCCGCCGCGTGGCGGGGCGCATCACCATGGGTGGGCAGGAGCATTTCTACCTGGAAGGCCAGGCGGCCATGGCCCA
ACCCGGCGAGGAGGGCGAGATGCGGGTCTGGTCCTCCACCCAGCATCCGACCGAAACCCAGCATATGGTGGCCCATGTGC
TGGACCGGCCCAGCAATCTGGTGACGACGGAAATCCGCCGCATGGGCGGCGGTTTCGGCGGCAAGGAAACCCAGGCCAAC
ACCCCGGCCTGCCTGGCGGCGCTGGCGGCGGAACTGACGGGGCGGGCGGCCAAGATCCGGCTGGACCGCGACGACGACAT
GATGATGACCGGCAAGCGGCATGATTTCGTGGTCGATTATGATGTCGGATTCGACGATGACGGCCGCATCCGCGCTGTGG
ACATGGTGCTGGCGGCCCGCTGCGGCTGGTCGGCCGACCTGTCCGGCCCGGTGACCGACCGCGCGCTGTTTCATGCCGAC
AACGCCTATTACTACCCCGATGTCCGGCTGCGGTCGGAACCGCTGAAGACCAACACCCAGTCCAATACCGCCTATCGCGG
TTTCGGCGGTCCGCAGGGCATCGTCGCGGCGGAACGCGTGATCGAGGAAATCGCGTTCGCGACCGGTCTGGACCCGCTGG
ATGTCCGCCTGCGCAACGTCTACGGCACCGGCACGCGCGACCTGACGCCCTATCACATGACGGTCGAGGATTCGATTTCG
GCCGACATCATGGCGAAGCTGGCCGATGACTGCGCCTATCGCGCGCGCCGCGCCGCCCTGCGCGCCGCCAATGAGGGCAG
CCCGCATATCAGGCGCGGCATCGCGCTGACGCCGGTCAAGTTCGGCATTTCCTTCACCGCCACGCATTACAACCAGGCCG
GCGCGCTGGTGCATGTCTATACCGATGGGTCGGTGCAGGTGAATCACGGCGGGACCGAAATGGGGCAGGGGCTGCACACC
AAGATGGTACAGATCGCCATGCGCGAATTCGGCCTGCCGGCCGACCGCGTCCGCATCACCGCGACGACGACCGGCAAGGT
GCCCAACACATCCGCCACCGCCGCCTCGTCCGGCGCCGACCTGAACGGCATGGCGGTGCTGGACGCGGTGCGCCGGATCA
AGGATCGGCTGGTGGAATTCGCGGCCGGCCATTGGGGCGTGGATGCCGCCCAGGTCCGGTTCCTGCCGGATGGCGTGCAT
GTCGGCGCGACCGTGGTGCCGTTCCCGGACCTGACCCGCGCCGCCTATTTCGCCCGGGTGTCGATGTCCTCCAGCGGGTT
CTACAAGACGCCGAAAATCTCGTGGAACGCCGAGACCGGGCGGGGGCGGCCGTTCTTCTATTTCGCCTATGGCGCCGCCT
GCGCCGAGGTCGCGATCGACCTGCTGACCGGCGAGACGCGGATCGAACAGGTGGACATCCTGCACGATGCCGGACAATCG
CTGAATCCGGCGATCGATATCGGCCAGATCGAGGGCGGATTCGTCCAGGGCGCGGGCTGGCTGACGACCGAGGAACTGGT
GTGGGACGCGTCCGGCCGCCTGCGCACCCACGCCCCCAGCACCTACAAGATCCCGGCCTGTTCCGACCGGCCGCGCCGGT
TCACGGTGAAGCTGCTGGACCACGCCCCCAATCGCGAGGACACGATCTTCCGGTCCAAGGCGGTGGGGGAGCCGCCCTTC
GTGCATGGGGTGGCGGTCCTGCACGCCATATCCGACGCCCTGGCCAGCATCGATGGCTACCGCACCTGTCCCCGGCTGGA
CGCGCCCGCGACGCCCGAGACGATCCTGCGCACGGCGGAGCGGATGCGCGGCCTTGCGGCAACCCGTCCCGTCGGCTGA

Upstream 100 bases:

>100_bases
GAAACCCGGCTGGCCGGACGGAGCGAGGCCGCGATCCATGCGTGATACGATATCGGCCCCCATTTCTGGTGCCCTTCCTG
ACGCCGTTCCCGGCACCGTC

Downstream 100 bases:

>100_bases
GCGGGTCTCGCGATGGACGAGATCCTGGCCGCGCTTGATCTCTGGCGGCCCGCCGGGCAGCCCATCGCCCGGATCGCGAT
CCGCGCCGCCCGCGGGTCCA

Product: xanthine dehydrogenase/oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 772; Mature: 771

Protein sequence:

>772_residues
MTGGASHSLRHESAAMHVAGAAAYIDDMPEPKGLLHVVPGLSTRAHARIVSMDLDAVRAAPGVVRVLTAADIPGHNQVSP
VGRNDEPLLATDLVSYYGQPIFAVVAETRLQARHAARLARIEYEDLPAILDIAQARAAGGAMVWRPLTMQRGDAPSGLAA
SPRRVAGRITMGGQEHFYLEGQAAMAQPGEEGEMRVWSSTQHPTETQHMVAHVLDRPSNLVTTEIRRMGGGFGGKETQAN
TPACLAALAAELTGRAAKIRLDRDDDMMMTGKRHDFVVDYDVGFDDDGRIRAVDMVLAARCGWSADLSGPVTDRALFHAD
NAYYYPDVRLRSEPLKTNTQSNTAYRGFGGPQGIVAAERVIEEIAFATGLDPLDVRLRNVYGTGTRDLTPYHMTVEDSIS
ADIMAKLADDCAYRARRAALRAANEGSPHIRRGIALTPVKFGISFTATHYNQAGALVHVYTDGSVQVNHGGTEMGQGLHT
KMVQIAMREFGLPADRVRITATTTGKVPNTSATAASSGADLNGMAVLDAVRRIKDRLVEFAAGHWGVDAAQVRFLPDGVH
VGATVVPFPDLTRAAYFARVSMSSSGFYKTPKISWNAETGRGRPFFYFAYGAACAEVAIDLLTGETRIEQVDILHDAGQS
LNPAIDIGQIEGGFVQGAGWLTTEELVWDASGRLRTHAPSTYKIPACSDRPRRFTVKLLDHAPNREDTIFRSKAVGEPPF
VHGVAVLHAISDALASIDGYRTCPRLDAPATPETILRTAERMRGLAATRPVG

Sequences:

>Translated_772_residues
MTGGASHSLRHESAAMHVAGAAAYIDDMPEPKGLLHVVPGLSTRAHARIVSMDLDAVRAAPGVVRVLTAADIPGHNQVSP
VGRNDEPLLATDLVSYYGQPIFAVVAETRLQARHAARLARIEYEDLPAILDIAQARAAGGAMVWRPLTMQRGDAPSGLAA
SPRRVAGRITMGGQEHFYLEGQAAMAQPGEEGEMRVWSSTQHPTETQHMVAHVLDRPSNLVTTEIRRMGGGFGGKETQAN
TPACLAALAAELTGRAAKIRLDRDDDMMMTGKRHDFVVDYDVGFDDDGRIRAVDMVLAARCGWSADLSGPVTDRALFHAD
NAYYYPDVRLRSEPLKTNTQSNTAYRGFGGPQGIVAAERVIEEIAFATGLDPLDVRLRNVYGTGTRDLTPYHMTVEDSIS
ADIMAKLADDCAYRARRAALRAANEGSPHIRRGIALTPVKFGISFTATHYNQAGALVHVYTDGSVQVNHGGTEMGQGLHT
KMVQIAMREFGLPADRVRITATTTGKVPNTSATAASSGADLNGMAVLDAVRRIKDRLVEFAAGHWGVDAAQVRFLPDGVH
VGATVVPFPDLTRAAYFARVSMSSSGFYKTPKISWNAETGRGRPFFYFAYGAACAEVAIDLLTGETRIEQVDILHDAGQS
LNPAIDIGQIEGGFVQGAGWLTTEELVWDASGRLRTHAPSTYKIPACSDRPRRFTVKLLDHAPNREDTIFRSKAVGEPPF
VHGVAVLHAISDALASIDGYRTCPRLDAPATPETILRTAERMRGLAATRPVG
>Mature_771_residues
TGGASHSLRHESAAMHVAGAAAYIDDMPEPKGLLHVVPGLSTRAHARIVSMDLDAVRAAPGVVRVLTAADIPGHNQVSPV
GRNDEPLLATDLVSYYGQPIFAVVAETRLQARHAARLARIEYEDLPAILDIAQARAAGGAMVWRPLTMQRGDAPSGLAAS
PRRVAGRITMGGQEHFYLEGQAAMAQPGEEGEMRVWSSTQHPTETQHMVAHVLDRPSNLVTTEIRRMGGGFGGKETQANT
PACLAALAAELTGRAAKIRLDRDDDMMMTGKRHDFVVDYDVGFDDDGRIRAVDMVLAARCGWSADLSGPVTDRALFHADN
AYYYPDVRLRSEPLKTNTQSNTAYRGFGGPQGIVAAERVIEEIAFATGLDPLDVRLRNVYGTGTRDLTPYHMTVEDSISA
DIMAKLADDCAYRARRAALRAANEGSPHIRRGIALTPVKFGISFTATHYNQAGALVHVYTDGSVQVNHGGTEMGQGLHTK
MVQIAMREFGLPADRVRITATTTGKVPNTSATAASSGADLNGMAVLDAVRRIKDRLVEFAAGHWGVDAAQVRFLPDGVHV
GATVVPFPDLTRAAYFARVSMSSSGFYKTPKISWNAETGRGRPFFYFAYGAACAEVAIDLLTGETRIEQVDILHDAGQSL
NPAIDIGQIEGGFVQGAGWLTTEELVWDASGRLRTHAPSTYKIPACSDRPRRFTVKLLDHAPNREDTIFRSKAVGEPPFV
HGVAVLHAISDALASIDGYRTCPRLDAPATPETILRTAERMRGLAATRPVG

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=754, Percent_Identity=43.7665782493369, Blast_Score=598, Evalue=1e-171,
Organism=Homo sapiens, GI71773480, Length=764, Percent_Identity=38.8743455497382, Blast_Score=504, Evalue=1e-143,
Organism=Escherichia coli, GI1789230, Length=731, Percent_Identity=26.6757865937073, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI1789246, Length=729, Percent_Identity=26.7489711934156, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1786478, Length=716, Percent_Identity=24.8603351955307, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17540638, Length=764, Percent_Identity=39.2670157068063, Blast_Score=503, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI32566215, Length=739, Percent_Identity=31.2584573748309, Blast_Score=338, Evalue=8e-93,
Organism=Caenorhabditis elegans, GI17539860, Length=738, Percent_Identity=31.029810298103, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI17737937, Length=729, Percent_Identity=41.9753086419753, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24647193, Length=772, Percent_Identity=32.2538860103627, Blast_Score=335, Evalue=9e-92,
Organism=Drosophila melanogaster, GI24647199, Length=762, Percent_Identity=30.9711286089239, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24647201, Length=762, Percent_Identity=31.1023622047244, Blast_Score=293, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24647195, Length=757, Percent_Identity=30.1188903566711, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24647197, Length=757, Percent_Identity=30.1188903566711, Blast_Score=273, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 83149; Mature: 83018

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGASHSLRHESAAMHVAGAAAYIDDMPEPKGLLHVVPGLSTRAHARIVSMDLDAVRAA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHCC
PGVVRVLTAADIPGHNQVSPVGRNDEPLLATDLVSYYGQPIFAVVAETRLQARHAARLAR
CCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IEYEDLPAILDIAQARAAGGAMVWRPLTMQRGDAPSGLAASPRRVAGRITMGGQEHFYLE
CCHHHCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHEEEEEECCCEEEEEC
GQAAMAQPGEEGEMRVWSSTQHPTETQHMVAHVLDRPSNLVTTEIRRMGGGFGGKETQAN
CCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCC
TPACLAALAAELTGRAAKIRLDRDDDMMMTGKRHDFVVDYDVGFDDDGRIRAVDMVLAAR
CHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEEECCCCCCCCEEEEHHHHHHH
CGWSADLSGPVTDRALFHADNAYYYPDVRLRSEPLKTNTQSNTAYRGFGGPQGIVAAERV
CCCCCCCCCCCCCCEEEECCCEEECCCCEECCCCCCCCCCCCCEEECCCCCCCHHHHHHH
IEEIAFATGLDPLDVRLRNVYGTGTRDLTPYHMTVEDSISADIMAKLADDCAYRARRAAL
HHHHHHHCCCCHHHHEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RAANEGSPHIRRGIALTPVKFGISFTATHYNQAGALVHVYTDGSVQVNHGGTEMGQGLHT
HHCCCCCCHHHCCEEECEEEECEEEEEEEECCCCCEEEEEECCEEEECCCCHHHCCCHHH
KMVQIAMREFGLPADRVRITATTTGKVPNTSATAASSGADLNGMAVLDAVRRIKDRLVEF
HHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AAGHWGVDAAQVRFLPDGVHVGATVVPFPDLTRAAYFARVSMSSSGFYKTPKISWNAETG
HCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHEEEEEECCCCCEECCCEEECCCCC
RGRPFFYFAYGAACAEVAIDLLTGETRIEQVDILHDAGQSLNPAIDIGQIEGGFVQGAGW
CCCEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCC
LTTEELVWDASGRLRTHAPSTYKIPACSDRPRRFTVKLLDHAPNREDTIFRSKAVGEPPF
CCHHHHEECCCCCEEECCCCCEECCCCCCCCCEEEEEEECCCCCCCCCEEHHHCCCCCCH
VHGVAVLHAISDALASIDGYRTCPRLDAPATPETILRTAERMRGLAATRPVG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TGGASHSLRHESAAMHVAGAAAYIDDMPEPKGLLHVVPGLSTRAHARIVSMDLDAVRAA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHCC
PGVVRVLTAADIPGHNQVSPVGRNDEPLLATDLVSYYGQPIFAVVAETRLQARHAARLAR
CCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IEYEDLPAILDIAQARAAGGAMVWRPLTMQRGDAPSGLAASPRRVAGRITMGGQEHFYLE
CCHHHCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHEEEEEECCCEEEEEC
GQAAMAQPGEEGEMRVWSSTQHPTETQHMVAHVLDRPSNLVTTEIRRMGGGFGGKETQAN
CCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCC
TPACLAALAAELTGRAAKIRLDRDDDMMMTGKRHDFVVDYDVGFDDDGRIRAVDMVLAAR
CHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEEECCCCCCCCEEEEHHHHHHH
CGWSADLSGPVTDRALFHADNAYYYPDVRLRSEPLKTNTQSNTAYRGFGGPQGIVAAERV
CCCCCCCCCCCCCCEEEECCCEEECCCCEECCCCCCCCCCCCCEEECCCCCCCHHHHHHH
IEEIAFATGLDPLDVRLRNVYGTGTRDLTPYHMTVEDSISADIMAKLADDCAYRARRAAL
HHHHHHHCCCCHHHHEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RAANEGSPHIRRGIALTPVKFGISFTATHYNQAGALVHVYTDGSVQVNHGGTEMGQGLHT
HHCCCCCCHHHCCEEECEEEECEEEEEEEECCCCCEEEEEECCEEEECCCCHHHCCCHHH
KMVQIAMREFGLPADRVRITATTTGKVPNTSATAASSGADLNGMAVLDAVRRIKDRLVEF
HHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AAGHWGVDAAQVRFLPDGVHVGATVVPFPDLTRAAYFARVSMSSSGFYKTPKISWNAETG
HCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHEEEEEECCCCCEECCCEEECCCCC
RGRPFFYFAYGAACAEVAIDLLTGETRIEQVDILHDAGQSLNPAIDIGQIEGGFVQGAGW
CCCEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCC
LTTEELVWDASGRLRTHAPSTYKIPACSDRPRRFTVKLLDHAPNREDTIFRSKAVGEPPF
CCHHHHEECCCCCEEECCCCCEECCCCCCCCCEEEEEEECCCCCCCCCEEHHHCCCCCCH
VHGVAVLHAISDALASIDGYRTCPRLDAPATPETILRTAERMRGLAATRPVG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]