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The map label for this gene is dht [H]

Identifier: 162147788

GI number: 162147788

Start: 2041422

End: 2042849

Strand: Reverse

Name: dht [H]

Synonym: GDI_2004

Alternate gene names: 162147788

Gene position: 2042849-2041422 (Counterclockwise)

Preceding gene: 162147792

Following gene: 162147787

Centisome position: 51.79

GC content: 68.35

Gene sequence:

>1428_bases
ATGCTTCTGGTGCGTGGTGGCACGGTCGTGACGGCGGAATGGTCGCGGCGGGCGGACGTGCTGTGCGACGACGCGGGGCG
GATCGCCGCCGTCGGGCCGGCGCTGGACGTGCCCGTGGGCTGCGACGTCCTCGATGCCGGCGGGCTTCTGGTCATGCCGG
GCGGGATCGACCCGCACACCCATATGGAAATGCCGTTCATGGGATCGGTCTCCAGCGACGATTTCCAGACCGGAACCGCC
GCCGGGGTGGCGGGCGGCACGACGACCATCATCGATTTCGTGATTCCCGATCCGGGGACATCGCTGCTGGGCGCCTGGAA
GGACTGGCGGGCCAAGGCCGAAAAGGCGGTCTCGGACTATTCGTTCCATGTCGCGGTCACGCATTGGGACCAGCGGGTGC
ATGACGAGATGGGCATCCTGACCCGGGATTGCGGGGTCAATTCCTTCAAGCATTTCATGGCGTACAAGGGGGCGCTGATG
GTCGATGACGGTGTGCTGCTCCGTTCGATCGGCCGCGCGCTGGAACTGGGCGCGCTGTGCAACGTGCATGCCGAAAACGG
TGACGCCGTCGCCTACCTGCAGCAGGATCTGCTGGCGCGCGGCGTGACCGGCCCCGCCGCCCATCCCCGGTCCCGCCCGC
CCGCGGTCGAGGGCGAGGCCGCGCAGCGCGTCATCGCCATTGCCGGCCTGCTGGGCGCGCCGGTCTATATCGTGCATGTC
TCGACCGAGGAAGCCGCCGCCGCCATCGCCGCCGCCCGCGCCCGTGGCCAGCGCGTGTATGGCGAAGTGCTGGCCCAGCA
TCTGGTGATCGATGACGGTGTCTATGCCGACCCGGACTGGCTGGGCGCCGCCCGGCATGTCATGAGCCCGCCTTTCCGCC
CGAAACATCACCAGAACGCCCTGTGGGCGGGCCTGGCCTCGGGCCAGTTGCAGACGACGGCGACCGATCATTGCTGCTTC
TGCGCCGGCCAGAAGCAGCAGGGACGCGATGATTTCACCCAAATCCCCAACGGCACCCCCGGTATCGAGGACCGGATGAG
CGTGCTGTGGCACCACGGCGTGCGTACCGGGCGTCTGACGCCGGAGGAATTCGTGGCCGTCACCTCGGCCAATGCCGCGA
AGATCTTCAACATCCATCCCCGCAAGGGCACCGTCACGCCGGGCGCCGATGCCGACCTGGTCCTGTGGGACGCCGATTCC
AGCCGTACCGTATCGGCCGCCACCCATCACCAGAACGTCGATTACAATGTCTATGAAGGCATGACCCTGACCGGCCTGGC
GCGTCATACGATCAGCGGAGGCCGGGTGGTGTGGTCGGATGGCGACCTGCGCACGGTGCGCGGTGCCGGCCGTTACGTCG
AACGGCCCTGCTTCGCCCCCGACATGGCGGCCCAGGCCAGGCGGAACGCCGTTGCGGCCGGGCGGTGA

Upstream 100 bases:

>100_bases
GCAGGACACCAGCGTTACGTTTTCGGCAATCCGCCCGGCGCGCAAGCCGCAAAACCGTGAATGCCCGCCCGCGTCTTGTG
ACACAGAATGGAGGATCGCG

Downstream 100 bases:

>100_bases
AGAGACATTCCTTGCCCTTCGGATTTTGACGCCTAGACTGGGCAGTCGGGCCGGTCTCGGGGGAGGCGGGCCTGATCTGA
GTTCCGGTCGCCTGCCCTGA

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MLLVRGGTVVTAEWSRRADVLCDDAGRIAAVGPALDVPVGCDVLDAGGLLVMPGGIDPHTHMEMPFMGSVSSDDFQTGTA
AGVAGGTTTIIDFVIPDPGTSLLGAWKDWRAKAEKAVSDYSFHVAVTHWDQRVHDEMGILTRDCGVNSFKHFMAYKGALM
VDDGVLLRSIGRALELGALCNVHAENGDAVAYLQQDLLARGVTGPAAHPRSRPPAVEGEAAQRVIAIAGLLGAPVYIVHV
STEEAAAAIAAARARGQRVYGEVLAQHLVIDDGVYADPDWLGAARHVMSPPFRPKHHQNALWAGLASGQLQTTATDHCCF
CAGQKQQGRDDFTQIPNGTPGIEDRMSVLWHHGVRTGRLTPEEFVAVTSANAAKIFNIHPRKGTVTPGADADLVLWDADS
SRTVSAATHHQNVDYNVYEGMTLTGLARHTISGGRVVWSDGDLRTVRGAGRYVERPCFAPDMAAQARRNAVAAGR

Sequences:

>Translated_475_residues
MLLVRGGTVVTAEWSRRADVLCDDAGRIAAVGPALDVPVGCDVLDAGGLLVMPGGIDPHTHMEMPFMGSVSSDDFQTGTA
AGVAGGTTTIIDFVIPDPGTSLLGAWKDWRAKAEKAVSDYSFHVAVTHWDQRVHDEMGILTRDCGVNSFKHFMAYKGALM
VDDGVLLRSIGRALELGALCNVHAENGDAVAYLQQDLLARGVTGPAAHPRSRPPAVEGEAAQRVIAIAGLLGAPVYIVHV
STEEAAAAIAAARARGQRVYGEVLAQHLVIDDGVYADPDWLGAARHVMSPPFRPKHHQNALWAGLASGQLQTTATDHCCF
CAGQKQQGRDDFTQIPNGTPGIEDRMSVLWHHGVRTGRLTPEEFVAVTSANAAKIFNIHPRKGTVTPGADADLVLWDADS
SRTVSAATHHQNVDYNVYEGMTLTGLARHTISGGRVVWSDGDLRTVRGAGRYVERPCFAPDMAAQARRNAVAAGR
>Mature_475_residues
MLLVRGGTVVTAEWSRRADVLCDDAGRIAAVGPALDVPVGCDVLDAGGLLVMPGGIDPHTHMEMPFMGSVSSDDFQTGTA
AGVAGGTTTIIDFVIPDPGTSLLGAWKDWRAKAEKAVSDYSFHVAVTHWDQRVHDEMGILTRDCGVNSFKHFMAYKGALM
VDDGVLLRSIGRALELGALCNVHAENGDAVAYLQQDLLARGVTGPAAHPRSRPPAVEGEAAQRVIAIAGLLGAPVYIVHV
STEEAAAAIAAARARGQRVYGEVLAQHLVIDDGVYADPDWLGAARHVMSPPFRPKHHQNALWAGLASGQLQTTATDHCCF
CAGQKQQGRDDFTQIPNGTPGIEDRMSVLWHHGVRTGRLTPEEFVAVTSANAAKIFNIHPRKGTVTPGADADLVLWDADS
SRTVSAATHHQNVDYNVYEGMTLTGLARHTISGGRVVWSDGDLRTVRGAGRYVERPCFAPDMAAQARRNAVAAGR

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=464, Percent_Identity=51.2931034482759, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI4503377, Length=463, Percent_Identity=45.3563714902808, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI4503379, Length=461, Percent_Identity=44.9023861171367, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI190194363, Length=463, Percent_Identity=45.7883369330454, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI4503051, Length=473, Percent_Identity=43.3403805496829, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI62422571, Length=473, Percent_Identity=43.3403805496829, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI19923821, Length=462, Percent_Identity=43.0735930735931, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI18105007, Length=430, Percent_Identity=23.4883720930233, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI87082175, Length=463, Percent_Identity=38.2289416846652, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1786722, Length=447, Percent_Identity=27.2930648769575, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17539558, Length=463, Percent_Identity=48.5961123110151, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71989490, Length=457, Percent_Identity=47.4835886214442, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI86575075, Length=454, Percent_Identity=34.3612334801762, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI193204318, Length=426, Percent_Identity=22.7699530516432, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=403, Percent_Identity=26.302729528536, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI221377917, Length=465, Percent_Identity=45.1612903225806, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI17137462, Length=463, Percent_Identity=43.4125269978402, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24644287, Length=298, Percent_Identity=44.9664429530201, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24644289, Length=230, Percent_Identity=47.3913043478261, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24642586, Length=438, Percent_Identity=24.8858447488584, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 50562; Mature: 50562

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLVRGGTVVTAEWSRRADVLCDDAGRIAAVGPALDVPVGCDVLDAGGLLVMPGGIDPHT
CEEEECCEEEEECCCCCCCEEECCCCCEEEECCCCCCCCCCCEECCCCEEEECCCCCCCC
HMEMPFMGSVSSDDFQTGTAAGVAGGTTTIIDFVIPDPGTSLLGAWKDWRAKAEKAVSDY
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
SFHVAVTHWDQRVHDEMGILTRDCGVNSFKHFMAYKGALMVDDGVLLRSIGRALELGALC
EEEEEEEECHHHHHHHHCCEEECCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCEE
NVHAENGDAVAYLQQDLLARGVTGPAAHPRSRPPAVEGEAAQRVIAIAGLLGAPVYIVHV
EEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEE
STEEAAAAIAAARARGQRVYGEVLAQHLVIDDGVYADPDWLGAARHVMSPPFRPKHHQNA
CCHHHHHHHHHHHHHCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCH
LWAGLASGQLQTTATDHCCFCAGQKQQGRDDFTQIPNGTPGIEDRMSVLWHHGVRTGRLT
HEEECCCCEEEECCCCCEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
PEEFVAVTSANAAKIFNIHPRKGTVTPGADADLVLWDADSSRTVSAATHHQNVDYNVYEG
HHHHEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEHHCCCCCEEHCCC
MTLTGLARHTISGGRVVWSDGDLRTVRGAGRYVERPCFAPDMAAQARRNAVAAGR
EEEEHHHHHCCCCCEEEECCCCEEEECCCCCHHCCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MLLVRGGTVVTAEWSRRADVLCDDAGRIAAVGPALDVPVGCDVLDAGGLLVMPGGIDPHT
CEEEECCEEEEECCCCCCCEEECCCCCEEEECCCCCCCCCCCEECCCCEEEECCCCCCCC
HMEMPFMGSVSSDDFQTGTAAGVAGGTTTIIDFVIPDPGTSLLGAWKDWRAKAEKAVSDY
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
SFHVAVTHWDQRVHDEMGILTRDCGVNSFKHFMAYKGALMVDDGVLLRSIGRALELGALC
EEEEEEEECHHHHHHHHCCEEECCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCEE
NVHAENGDAVAYLQQDLLARGVTGPAAHPRSRPPAVEGEAAQRVIAIAGLLGAPVYIVHV
EEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEE
STEEAAAAIAAARARGQRVYGEVLAQHLVIDDGVYADPDWLGAARHVMSPPFRPKHHQNA
CCHHHHHHHHHHHHHCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCH
LWAGLASGQLQTTATDHCCFCAGQKQQGRDDFTQIPNGTPGIEDRMSVLWHHGVRTGRLT
HEEECCCCEEEECCCCCEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
PEEFVAVTSANAAKIFNIHPRKGTVTPGADADLVLWDADSSRTVSAATHHQNVDYNVYEG
HHHHEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEHHCCCCCEEHCCC
MTLTGLARHTISGGRVVWSDGDLRTVRGAGRYVERPCFAPDMAAQARRNAVAAGR
EEEEHHHHHCCCCCEEEECCCCEEEECCCCCHHCCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]