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The map label for this gene is ispA [H]

Identifier: 162147645

GI number: 162147645

Start: 1899933

End: 1900868

Strand: Reverse

Name: ispA [H]

Synonym: GDI_1861

Alternate gene names: 162147645

Gene position: 1900868-1899933 (Counterclockwise)

Preceding gene: 162147646

Following gene: 162147644

Centisome position: 48.19

GC content: 70.51

Gene sequence:

>936_bases
ATGAGCCAGACAACTGCGACAGCCCACATGGAGAACTCCGCGGATCGCGCCAGCCTGCTGCGGTCCTCCCTGTCGAACAG
GGCGACGGCCATCGAGGCCGCGATCGACAGCCTTCTTCCGCCGGTGCCGGGCGCCGAAGGCCGGGTGGTGGACGCGATGC
GCTATGCGACGCTGGGCGGCGGCAAGCGGCTGCGCGGCTACCTGACGGCGGAGGTCGCAAGCCTGTTCGGCGTGGAGCCC
GCCCGGGCCTATCGGGTCGCCGCATCGGTCGAGATGCTGCATGCCTATTCACTGGTGCATGACGACCTGCCGGCGATGGA
TAATGACGACCTGCGCCGCGGCCAGCCTTCGACGCACAGGAAATTCGACGAGGCCACCGCCATCCTGGCCGGTGATGCCC
TGCAGACCATGGCCTTCGAGATCCTGACGGACACCGCGACCCACCCCAGCGCCACCATCCGCATCGGCCTGGTCGCGGCG
CTGGCCGCCGCGTCGGGCGCCGCCGGCATGGTCGGCGGCCAGATGATCGACATGGATGGCGAGGGCCGCGCCCTTTCGCT
GCCCGAGGTCGAGCGCCTGCACGCGCTGAAGACCGGCTGCCTGATCCGCTACGCGGCGGAAGCCGGGGCGATCCTGGGCG
ACGCGGACCTGCCGGCGCGCGCGCGCATCGCGGCCTATGGGCGCGACCTGGGCGCCGCCTTCCAGATCGCCGACGACGTG
CTGGACGCCACGGCCAGCGCCGAGGAACTGGGCAAGACCGCCGGCAAGGACCAGGCCGCGGGCAAATCCACCTATGTCGC
CCTGCTGGGCGTCGACGGCGCCGCGCGCGAGGCGCGGCGTGTGGCCGAACAGGCCGAATCGCATCTTGATGTTTTCGGTG
CCGAAGCCGACAGGCTCCGGAATCTCGTCCAGTACGTGGTCGATCGCAGGAGCTGA

Upstream 100 bases:

>100_bases
TATTGCGACACCAAGCTGAACGAGGCCGACGCCCGCGTTCAGGCGATTATCCAGCGCGCCGATGGCGCGCTGGAGACGAA
ATCTATGGATTGATGCGCCG

Downstream 100 bases:

>100_bases
GTATCATGTCCGAACAGAACACAGGCGCACAGCCGGGGGGCTCGGTTCCGACGCGTGGCCGCTTTCCGCTGCTGGACCGG
GTGGCGTATCCCGAGGACCT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSQTTATAHMENSADRASLLRSSLSNRATAIEAAIDSLLPPVPGAEGRVVDAMRYATLGGGKRLRGYLTAEVASLFGVEP
ARAYRVAASVEMLHAYSLVHDDLPAMDNDDLRRGQPSTHRKFDEATAILAGDALQTMAFEILTDTATHPSATIRIGLVAA
LAAASGAAGMVGGQMIDMDGEGRALSLPEVERLHALKTGCLIRYAAEAGAILGDADLPARARIAAYGRDLGAAFQIADDV
LDATASAEELGKTAGKDQAAGKSTYVALLGVDGAAREARRVAEQAESHLDVFGAEADRLRNLVQYVVDRRS

Sequences:

>Translated_311_residues
MSQTTATAHMENSADRASLLRSSLSNRATAIEAAIDSLLPPVPGAEGRVVDAMRYATLGGGKRLRGYLTAEVASLFGVEP
ARAYRVAASVEMLHAYSLVHDDLPAMDNDDLRRGQPSTHRKFDEATAILAGDALQTMAFEILTDTATHPSATIRIGLVAA
LAAASGAAGMVGGQMIDMDGEGRALSLPEVERLHALKTGCLIRYAAEAGAILGDADLPARARIAAYGRDLGAAFQIADDV
LDATASAEELGKTAGKDQAAGKSTYVALLGVDGAAREARRVAEQAESHLDVFGAEADRLRNLVQYVVDRRS
>Mature_310_residues
SQTTATAHMENSADRASLLRSSLSNRATAIEAAIDSLLPPVPGAEGRVVDAMRYATLGGGKRLRGYLTAEVASLFGVEPA
RAYRVAASVEMLHAYSLVHDDLPAMDNDDLRRGQPSTHRKFDEATAILAGDALQTMAFEILTDTATHPSATIRIGLVAAL
AAASGAAGMVGGQMIDMDGEGRALSLPEVERLHALKTGCLIRYAAEAGAILGDADLPARARIAAYGRDLGAAFQIADDVL
DATASAEELGKTAGKDQAAGKSTYVALLGVDGAAREARRVAEQAESHLDVFGAEADRLRNLVQYVVDRRS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=225, Percent_Identity=30.6666666666667, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786623, Length=284, Percent_Identity=45.7746478873239, Blast_Score=201, Evalue=4e-53,
Organism=Escherichia coli, GI1789578, Length=220, Percent_Identity=32.2727272727273, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17505681, Length=187, Percent_Identity=31.5508021390374, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24651612, Length=192, Percent_Identity=31.25, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32600; Mature: 32469

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTTATAHMENSADRASLLRSSLSNRATAIEAAIDSLLPPVPGAEGRVVDAMRYATLGG
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
GKRLRGYLTAEVASLFGVEPARAYRVAASVEMLHAYSLVHDDLPAMDNDDLRRGQPSTHR
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHH
KFDEATAILAGDALQTMAFEILTDTATHPSATIRIGLVAALAAASGAAGMVGGQMIDMDG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECC
EGRALSLPEVERLHALKTGCLIRYAAEAGAILGDADLPARARIAAYGRDLGAAFQIADDV
CCCEECCCHHHHHHHHHHHHHHEEHHHCCCEECCCCCCCHHHHHHHCCCHHHHHHHHHHH
LDATASAEELGKTAGKDQAAGKSTYVALLGVDGAAREARRVAEQAESHLDVFGAEADRLR
HHHHCCHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
NLVQYVVDRRS
HHHHHHHHCCC
>Mature Secondary Structure 
SQTTATAHMENSADRASLLRSSLSNRATAIEAAIDSLLPPVPGAEGRVVDAMRYATLGG
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
GKRLRGYLTAEVASLFGVEPARAYRVAASVEMLHAYSLVHDDLPAMDNDDLRRGQPSTHR
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHH
KFDEATAILAGDALQTMAFEILTDTATHPSATIRIGLVAALAAASGAAGMVGGQMIDMDG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECC
EGRALSLPEVERLHALKTGCLIRYAAEAGAILGDADLPARARIAAYGRDLGAAFQIADDV
CCCEECCCHHHHHHHHHHHHHHEEHHHCCCEECCCCCCCHHHHHHHCCCHHHHHHHHHHH
LDATASAEELGKTAGKDQAAGKSTYVALLGVDGAAREARRVAEQAESHLDVFGAEADRLR
HHHHCCHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
NLVQYVVDRRS
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]