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The map label for this gene is dxs [H]

Identifier: 162147644

GI number: 162147644

Start: 1897924

End: 1899927

Strand: Reverse

Name: dxs [H]

Synonym: GDI_1860

Alternate gene names: 162147644

Gene position: 1899927-1897924 (Counterclockwise)

Preceding gene: 162147645

Following gene: 162147643

Centisome position: 48.17

GC content: 70.76

Gene sequence:

>2004_bases
ATGTCCGAACAGAACACAGGCGCACAGCCGGGGGGCTCGGTTCCGACGCGTGGCCGCTTTCCGCTGCTGGACCGGGTGGC
GTATCCCGAGGACCTGCGGAACCTGTCGGTGGAGCAGCTGAAGCAGCTGGCCGAGGAATTGCGGGCCGAGACGGTGGACG
CGGTATCCACCACCGGCGGGCACCTGGGCGCGTCGCTGGGCGTGGTGGAGCTGACGGTGGCGCTGCACGCGGTGTTCGAC
ACCCCGGCCGACCGGGTGATCTGGGATGTCGGCCACCAGGCCTATCCGCACAAGATCCTGACCGGACGGCGCGAGCGCAT
CCGCACCCTGCGCCAGCCCGGCGGCCTGTCGGGCTTCACCCGCCGGTGCGAGAGCGAATACGACCCGTTCGGCGCCGCCC
ATTCCTCGACCTCGATCTCCGCCGGGCTGGGCATGGCGGTGGCGCACCACCTGCGCGCCGAGCACGACCCCGCCTATCGC
GAGCGCAACGTCGTCGCCGTCATCGGTGACGGCTCGATTTCCGCCGGCATGGCCTACGAGGCGATGAACAACGCCTCGGT
CGCCGGTCCCGGCGCCGGGCGGCTGATCGTGGTGCTGAACGACAACGAGATGTCGATCGCGCCCCCGGTCGGCGCCATGT
CCAACTACCTGTCGCGGCTGATGTCCTCGCGCCAGTTCCTCGGCCTGCGCGACCTGGCCGGCAAGGTGGCCCGCCGCCTG
CCCGAGCGGCTGGAGCGCACCGCCAAGAAGGCCGATGAATATGCCCGCGGCATGATCACCGGCGGCACCCTGTTCGAGGA
GCTGGGCTTCTACTACGTCGGCCCGGTCGACGGCCACGACCTGAACCAGCTGGTGCCGATCCTGCGCAACCTGCGCGACG
CCGACGACAAGGGCCCGATCCTGCTGCACATCCTCACCGAGAAGGGACGCGGCTACCGCCCGGCCGAATCGGCGGGTGAC
AAGTACCACGCGGTGGCCAAGTTCAACGTGGTGACCGGCGAGCAGAAGAAGGCCCCGCCGGGACCGCCCAGCTATACCTC
GGTGTTCAGCCGCGAGCTGGTGCGCCGGGCGAAGCAGGACGACACCATCGTCGCCGTCACCGCCGCCATGCCCTCGGGCA
CCGGGCTGGACGCCTTCGCCCGCGCCTGCCCCGACCGCTTCTTCGACGTCGGCATCGCCGAACAGCATGCGGTGACGTTC
GCCGCCGGCATGGCGACCGAGGGGCTGCGGCCGTTCTGCGCCATCTATTCCACCTTCCTGCAGCGCGCCTACGACCAGGT
GATGCATGACGTGGTGCTGCAGAACCTGCCGGTGCGCTTCGCCATCGACCGCGCCGGGCTGGTCGGCGCCGACGGCGCCA
CCCATGCCGGGGCGTTCGACATCAACTATCTGGGCTGCCTGCCGGGCATGACCATCATGGCCCCCAGCGACGAGCTGGAA
CTGCTGCACATGACGGCGACCGCCTGCGCCTTCGATGCCGGGCCGATCGCCCTGCGCTACCCGCGCGGCAACGGGCTGGG
CCTGGCGCTGCCCGAGGCCGGCGAGATCCTGGAGATCGGCCGCGGCCGCATCATCCGCGAGATGGGCCGCCAGTCGGGGC
GCGAGACCGGCGGTATCGCCATCCTGTCGCTGGGCACCCGCCTGGCCGAGGTGCTGAAGGCCGCCGACATGCTGGCCGCC
CAGGGGCTGGCCCCCACCGTCGCCGACGCCCGCTTCGCCAAGCCGCTGGATACCGCGCTGATCGAGAACCTGGCCCGCAA
CCACGCCGTGCTGCTGACCATCGAGGACGGCGCCGAGGGCGGTTTCGGCGCCTATGTCATGCACCACCTGGCCCGCACCG
GGCTGCTGGACACCATCCGCTTCCGGCCCATGACCCTGCCGGACCGCTTCATCGACCACAACACCCAGGACGCCCAATAC
CACCAGGCCGGCCTGGACGCCCCAGCCATCGCCGCATGCGCCATGCAGGCCCTGGGGGTTGCCGCGTCCCAACAGACGGC
CTGA

Upstream 100 bases:

>100_bases
TGGCCGAACAGGCCGAATCGCATCTTGATGTTTTCGGTGCCGAAGCCGACAGGCTCCGGAATCTCGTCCAGTACGTGGTC
GATCGCAGGAGCTGAGTATC

Downstream 100 bases:

>100_bases
CCGCCCCCGGAAAGGAACGAAGGGGCGCACAGGTGGCCAAGCAACGCGCGGACCAGATGCTGGTCGACCGGGGACTGGTG
GAAAGCCGTACCCGCGCCCA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSEQNTGAQPGGSVPTRGRFPLLDRVAYPEDLRNLSVEQLKQLAEELRAETVDAVSTTGGHLGASLGVVELTVALHAVFD
TPADRVIWDVGHQAYPHKILTGRRERIRTLRQPGGLSGFTRRCESEYDPFGAAHSSTSISAGLGMAVAHHLRAEHDPAYR
ERNVVAVIGDGSISAGMAYEAMNNASVAGPGAGRLIVVLNDNEMSIAPPVGAMSNYLSRLMSSRQFLGLRDLAGKVARRL
PERLERTAKKADEYARGMITGGTLFEELGFYYVGPVDGHDLNQLVPILRNLRDADDKGPILLHILTEKGRGYRPAESAGD
KYHAVAKFNVVTGEQKKAPPGPPSYTSVFSRELVRRAKQDDTIVAVTAAMPSGTGLDAFARACPDRFFDVGIAEQHAVTF
AAGMATEGLRPFCAIYSTFLQRAYDQVMHDVVLQNLPVRFAIDRAGLVGADGATHAGAFDINYLGCLPGMTIMAPSDELE
LLHMTATACAFDAGPIALRYPRGNGLGLALPEAGEILEIGRGRIIREMGRQSGRETGGIAILSLGTRLAEVLKAADMLAA
QGLAPTVADARFAKPLDTALIENLARNHAVLLTIEDGAEGGFGAYVMHHLARTGLLDTIRFRPMTLPDRFIDHNTQDAQY
HQAGLDAPAIAACAMQALGVAASQQTA

Sequences:

>Translated_667_residues
MSEQNTGAQPGGSVPTRGRFPLLDRVAYPEDLRNLSVEQLKQLAEELRAETVDAVSTTGGHLGASLGVVELTVALHAVFD
TPADRVIWDVGHQAYPHKILTGRRERIRTLRQPGGLSGFTRRCESEYDPFGAAHSSTSISAGLGMAVAHHLRAEHDPAYR
ERNVVAVIGDGSISAGMAYEAMNNASVAGPGAGRLIVVLNDNEMSIAPPVGAMSNYLSRLMSSRQFLGLRDLAGKVARRL
PERLERTAKKADEYARGMITGGTLFEELGFYYVGPVDGHDLNQLVPILRNLRDADDKGPILLHILTEKGRGYRPAESAGD
KYHAVAKFNVVTGEQKKAPPGPPSYTSVFSRELVRRAKQDDTIVAVTAAMPSGTGLDAFARACPDRFFDVGIAEQHAVTF
AAGMATEGLRPFCAIYSTFLQRAYDQVMHDVVLQNLPVRFAIDRAGLVGADGATHAGAFDINYLGCLPGMTIMAPSDELE
LLHMTATACAFDAGPIALRYPRGNGLGLALPEAGEILEIGRGRIIREMGRQSGRETGGIAILSLGTRLAEVLKAADMLAA
QGLAPTVADARFAKPLDTALIENLARNHAVLLTIEDGAEGGFGAYVMHHLARTGLLDTIRFRPMTLPDRFIDHNTQDAQY
HQAGLDAPAIAACAMQALGVAASQQTA
>Mature_666_residues
SEQNTGAQPGGSVPTRGRFPLLDRVAYPEDLRNLSVEQLKQLAEELRAETVDAVSTTGGHLGASLGVVELTVALHAVFDT
PADRVIWDVGHQAYPHKILTGRRERIRTLRQPGGLSGFTRRCESEYDPFGAAHSSTSISAGLGMAVAHHLRAEHDPAYRE
RNVVAVIGDGSISAGMAYEAMNNASVAGPGAGRLIVVLNDNEMSIAPPVGAMSNYLSRLMSSRQFLGLRDLAGKVARRLP
ERLERTAKKADEYARGMITGGTLFEELGFYYVGPVDGHDLNQLVPILRNLRDADDKGPILLHILTEKGRGYRPAESAGDK
YHAVAKFNVVTGEQKKAPPGPPSYTSVFSRELVRRAKQDDTIVAVTAAMPSGTGLDAFARACPDRFFDVGIAEQHAVTFA
AGMATEGLRPFCAIYSTFLQRAYDQVMHDVVLQNLPVRFAIDRAGLVGADGATHAGAFDINYLGCLPGMTIMAPSDELEL
LHMTATACAFDAGPIALRYPRGNGLGLALPEAGEILEIGRGRIIREMGRQSGRETGGIAILSLGTRLAEVLKAADMLAAQ
GLAPTVADARFAKPLDTALIENLARNHAVLLTIEDGAEGGFGAYVMHHLARTGLLDTIRFRPMTLPDRFIDHNTQDAQYH
QAGLDAPAIAACAMQALGVAASQQTA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=512, Percent_Identity=23.046875, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI4507521, Length=512, Percent_Identity=23.046875, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI225637459, Length=392, Percent_Identity=24.7448979591837, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI225637461, Length=392, Percent_Identity=24.7448979591837, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI225637463, Length=392, Percent_Identity=24.7448979591837, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI133778974, Length=377, Percent_Identity=24.1379310344828, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786622, Length=639, Percent_Identity=49.6087636932707, Blast_Score=578, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17539652, Length=419, Percent_Identity=25.2983293556086, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551847, Length=389, Percent_Identity=26.9922879177378, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550715, Length=389, Percent_Identity=26.9922879177378, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645119, Length=389, Percent_Identity=26.9922879177378, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666278, Length=387, Percent_Identity=26.0981912144703, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 71383; Mature: 71252

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQNTGAQPGGSVPTRGRFPLLDRVAYPEDLRNLSVEQLKQLAEELRAETVDAVSTTGG
CCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
HLGASLGVVELTVALHAVFDTPADRVIWDVGHQAYPHKILTGRRERIRTLRQPGGLSGFT
HHCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCHHHHHHHHCCCCCCHHH
RRCESEYDPFGAAHSSTSISAGLGMAVAHHLRAEHDPAYRERNVVAVIGDGSISAGMAYE
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCEEEEEECCCCCCCHHHH
AMNNASVAGPGAGRLIVVLNDNEMSIAPPVGAMSNYLSRLMSSRQFLGLRDLAGKVARRL
HCCCCCCCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
PERLERTAKKADEYARGMITGGTLFEELGFYYVGPVDGHDLNQLVPILRNLRDADDKGPI
HHHHHHHHHHHHHHHCCEECCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCE
LLHILTEKGRGYRPAESAGDKYHAVAKFNVVTGEQKKAPPGPPSYTSVFSRELVRRAKQD
EEEEEECCCCCCCCHHHCCCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
DTIVAVTAAMPSGTGLDAFARACPDRFFDVGIAEQHAVTFAAGMATEGLRPFCAIYSTFL
CCEEEEEECCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
QRAYDQVMHDVVLQNLPVRFAIDRAGLVGADGATHAGAFDINYLGCLPGMTIMAPSDELE
HHHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCCCEECCCHHHHCCCCEEECCCCCCE
LLHMTATACAFDAGPIALRYPRGNGLGLALPEAGEILEIGRGRIIREMGRQSGRETGGIA
EEEEHHHHHHCCCCCEEEEECCCCCCEEECCCCCCHHHHCCCHHHHHHHHHCCCCCCCEE
ILSLGTRLAEVLKAADMLAAQGLAPTVADARFAKPLDTALIENLARNHAVLLTIEDGAEG
EEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCC
GFGAYVMHHLARTGLLDTIRFRPMTLPDRFIDHNTQDAQYHQAGLDAPAIAACAMQALGV
CHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHC
AASQQTA
CCCCCCC
>Mature Secondary Structure 
SEQNTGAQPGGSVPTRGRFPLLDRVAYPEDLRNLSVEQLKQLAEELRAETVDAVSTTGG
CCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
HLGASLGVVELTVALHAVFDTPADRVIWDVGHQAYPHKILTGRRERIRTLRQPGGLSGFT
HHCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCHHHHHHHHCCCCCCHHH
RRCESEYDPFGAAHSSTSISAGLGMAVAHHLRAEHDPAYRERNVVAVIGDGSISAGMAYE
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCEEEEEECCCCCCCHHHH
AMNNASVAGPGAGRLIVVLNDNEMSIAPPVGAMSNYLSRLMSSRQFLGLRDLAGKVARRL
HCCCCCCCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
PERLERTAKKADEYARGMITGGTLFEELGFYYVGPVDGHDLNQLVPILRNLRDADDKGPI
HHHHHHHHHHHHHHHCCEECCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCE
LLHILTEKGRGYRPAESAGDKYHAVAKFNVVTGEQKKAPPGPPSYTSVFSRELVRRAKQD
EEEEEECCCCCCCCHHHCCCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
DTIVAVTAAMPSGTGLDAFARACPDRFFDVGIAEQHAVTFAAGMATEGLRPFCAIYSTFL
CCEEEEEECCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
QRAYDQVMHDVVLQNLPVRFAIDRAGLVGADGATHAGAFDINYLGCLPGMTIMAPSDELE
HHHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCCCEECCCHHHHCCCCEEECCCCCCE
LLHMTATACAFDAGPIALRYPRGNGLGLALPEAGEILEIGRGRIIREMGRQSGRETGGIA
EEEEHHHHHHCCCCCEEEEECCCCCCEEECCCCCCHHHHCCCHHHHHHHHHCCCCCCCEE
ILSLGTRLAEVLKAADMLAAQGLAPTVADARFAKPLDTALIENLARNHAVLLTIEDGAEG
EEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCC
GFGAYVMHHLARTGLLDTIRFRPMTLPDRFIDHNTQDAQYHQAGLDAPAIAACAMQALGV
CHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHC
AASQQTA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA