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The map label for this gene is tmk [H]

Identifier: 162147582

GI number: 162147582

Start: 1829689

End: 1830336

Strand: Direct

Name: tmk [H]

Synonym: GDI_1798

Alternate gene names: 162147582

Gene position: 1829689-1830336 (Clockwise)

Preceding gene: 162147581

Following gene: 162147583

Centisome position: 46.39

GC content: 74.85

Gene sequence:

>648_bases
GTGGCGGGCCTGTTCATCACCTTCGAAGGGGGCGAGGGCGCGGGGAAATCTACCCAGGCGCAGCGCCTGGAGGCGCATCT
GCGCGCCGCCGGCCGCGAGGTGGTGCGCACGCGCGAACCGGGCGGCACCCCGGGGGCCGAGGCCCTGCGCCAGTTGCTGC
TGTTCGGCGGGCACGACCTGTCGCTGCGGGCGGAGATCCTGGCCCATTTCGCCGCGCGCTGCGACCATGTGGACCAGTTG
ATCCGCCCGGCGCTGGCGCGCGGCGCGGTCGTCATCTGCGACCGCTTCATCGATTCCACCCTGGCCTATCAGGGCTACGG
GCTGGGTCGCGCCGATCCGGGGATCCTGCACCTGATCGCGGTGCTGGGCGCCCAGGTGGGGCTGGCGCCCGACCTGACGC
TGGTCCTGATGCTGGAGCGGGCCGGCGCGCTGGCCCGCCTGCGCGCGCGCGGCGGCCCGGCGGACAGGTACGAGGCCGCC
GACGAAGCCTTCCACGCCCGCGTCGCGGACGGATTCGACACCATCGCGCGGGCCGAGGCCGGGCGCTGCGTCACGATCGC
GGCCGACCGGCCGGTGGATGTGGTCGCGGGCGACATCGCCCGCCTGGTGGACGCAAGGCTGGAAACGGATGCCCCCGGCG
CCGCGTGA

Upstream 100 bases:

>100_bases
TCCGCATGCCCCTGGTGGCGGGGCAGGGCGTGCCGCGCCTGGGCCTGTTCGCCCGGGCGTCGGCGGTGCTGGGCCAGAAA
CTGGGCCGGCACTGAGTTCC

Downstream 100 bases:

>100_bases
CGCTCCGGACCTGGTGGGGCAGCAGGAAGCGCGACGCGCGTTCGAGGACGCGCTTCGCACCGGGCGGCTGCATCACGCCT
GGCTGCTGACCGGCACCGAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MAGLFITFEGGEGAGKSTQAQRLEAHLRAAGREVVRTREPGGTPGAEALRQLLLFGGHDLSLRAEILAHFAARCDHVDQL
IRPALARGAVVICDRFIDSTLAYQGYGLGRADPGILHLIAVLGAQVGLAPDLTLVLMLERAGALARLRARGGPADRYEAA
DEAFHARVADGFDTIARAEAGRCVTIAADRPVDVVAGDIARLVDARLETDAPGAA

Sequences:

>Translated_215_residues
MAGLFITFEGGEGAGKSTQAQRLEAHLRAAGREVVRTREPGGTPGAEALRQLLLFGGHDLSLRAEILAHFAARCDHVDQL
IRPALARGAVVICDRFIDSTLAYQGYGLGRADPGILHLIAVLGAQVGLAPDLTLVLMLERAGALARLRARGGPADRYEAA
DEAFHARVADGFDTIARAEAGRCVTIAADRPVDVVAGDIARLVDARLETDAPGAA
>Mature_214_residues
AGLFITFEGGEGAGKSTQAQRLEAHLRAAGREVVRTREPGGTPGAEALRQLLLFGGHDLSLRAEILAHFAARCDHVDQLI
RPALARGAVVICDRFIDSTLAYQGYGLGRADPGILHLIAVLGAQVGLAPDLTLVLMLERAGALARLRARGGPADRYEAAD
EAFHARVADGFDTIARAEAGRCVTIAADRPVDVVAGDIARLVDARLETDAPGAA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=202, Percent_Identity=41.0891089108911, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22563; Mature: 22432

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS01331 THYMIDYLATE_KINASE ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLFITFEGGEGAGKSTQAQRLEAHLRAAGREVVRTREPGGTPGAEALRQLLLFGGHDL
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCH
SLRAEILAHFAARCDHVDQLIRPALARGAVVICDRFIDSTLAYQGYGLGRADPGILHLIA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
VLGAQVGLAPDLTLVLMLERAGALARLRARGGPADRYEAADEAFHARVADGFDTIARAEA
HHHHHCCCCCCHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GRCVTIAADRPVDVVAGDIARLVDARLETDAPGAA
CCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AGLFITFEGGEGAGKSTQAQRLEAHLRAAGREVVRTREPGGTPGAEALRQLLLFGGHDL
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCH
SLRAEILAHFAARCDHVDQLIRPALARGAVVICDRFIDSTLAYQGYGLGRADPGILHLIA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
VLGAQVGLAPDLTLVLMLERAGALARLRARGGPADRYEAADEAFHARVADGFDTIARAEA
HHHHHCCCCCCHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GRCVTIAADRPVDVVAGDIARLVDARLETDAPGAA
CCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA