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The map label for this gene is hisG [H]

Identifier: 162147236

GI number: 162147236

Start: 1444277

End: 1444984

Strand: Reverse

Name: hisG [H]

Synonym: GDI_1441

Alternate gene names: 162147236

Gene position: 1444984-1444277 (Counterclockwise)

Preceding gene: 162147237

Following gene: 162147235

Centisome position: 36.64

GC content: 70.9

Gene sequence:

>708_bases
ATGACCGCCCTAACCCGGGAGACAACCCAGGACACGAAGCTGATCCTCGCCCTGCCCAAGGGACGCATCCTGAAGGCCGC
CGCCCCGCTGCTGGCCGGGGCCGGCCTGACGCCCGCCGCCGACTGCCTGGACGAGGGCAGCCGCCGCCTGCGCTTTCCCA
CCGACGATGCGATGCTGGACGTGGTGCGCGTGCGCTCGTTCGACGTCGCGACCTTCGTGGCCTTCGGCGGCGCGCAACTG
GGCATCTGCGGCGCCGACGTGCTGATGGAATTCGACTATCCCGAGATCTACGCCCCGCTGGACCTGCGGATCGGCGCCTG
CCGCGTGTCGGTCGCCCGGCCCAGGGGGCAGGAAGGAACCGACAATCCCGCGCGCTGGTCGCGGGTGCGGGTGGCCACCA
AATATCCGGCCATCACCCGCCGCCATTTCGCCGCGCGCGGCATCAATGCCGACATCGTGCACCTGCACGGCGCGATGGAG
CTGGCCCCGGTGCTGGACCTGTCGCACCTGATCGTGGACCTGGTCGATACCGGGTCCACCCTGCGCGCCAACGGGCTGGA
GGAGACCGAGACGATCGCGACCGTCACCAGCCGGCTGATCGTCAACCGCACGGCGCTGAAGACCCAGCCGGAGCGGATCG
GCGCGCTGATCGCGCGCTTCCGCCACGCCCTGGCCGCGTCCACGGTGGCGGAGACCGTCAGCGCATGA

Upstream 100 bases:

>100_bases
CGCGCGCCCTTCCTGCGGCGGGGCGGAATGTGATAAGGCGCAGCCCACATGGCGCCTGGCCGGTATCGCATGGGGCGCGC
GTTTTGTAGCTGGAGACCGC

Downstream 100 bases:

>100_bases
AACGGCTGGATACCGCGCAACCCGATTTCCGTGCCGCCTTCGCCCGCCTGCTGGACGACCGCGAGGGCGACACCGCCCGC
GTCGATGCCCCGGTCGCCGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTALTRETTQDTKLILALPKGRILKAAAPLLAGAGLTPAADCLDEGSRRLRFPTDDAMLDVVRVRSFDVATFVAFGGAQL
GICGADVLMEFDYPEIYAPLDLRIGACRVSVARPRGQEGTDNPARWSRVRVATKYPAITRRHFAARGINADIVHLHGAME
LAPVLDLSHLIVDLVDTGSTLRANGLEETETIATVTSRLIVNRTALKTQPERIGALIARFRHALAASTVAETVSA

Sequences:

>Translated_235_residues
MTALTRETTQDTKLILALPKGRILKAAAPLLAGAGLTPAADCLDEGSRRLRFPTDDAMLDVVRVRSFDVATFVAFGGAQL
GICGADVLMEFDYPEIYAPLDLRIGACRVSVARPRGQEGTDNPARWSRVRVATKYPAITRRHFAARGINADIVHLHGAME
LAPVLDLSHLIVDLVDTGSTLRANGLEETETIATVTSRLIVNRTALKTQPERIGALIARFRHALAASTVAETVSA
>Mature_234_residues
TALTRETTQDTKLILALPKGRILKAAAPLLAGAGLTPAADCLDEGSRRLRFPTDDAMLDVVRVRSFDVATFVAFGGAQLG
ICGADVLMEFDYPEIYAPLDLRIGACRVSVARPRGQEGTDNPARWSRVRVATKYPAITRRHFAARGINADIVHLHGAMEL
APVLDLSHLIVDLVDTGSTLRANGLEETETIATVTSRLIVNRTALKTQPERIGALIARFRHALAASTVAETVSA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=228, Percent_Identity=32.0175438596491, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320896, Length=227, Percent_Identity=25.9911894273128, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25279; Mature: 25148

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALTRETTQDTKLILALPKGRILKAAAPLLAGAGLTPAADCLDEGSRRLRFPTDDAMLD
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCCHHHHH
VVRVRSFDVATFVAFGGAQLGICGADVLMEFDYPEIYAPLDLRIGACRVSVARPRGQEGT
HHHHCCCCHHHHHHHCCCEEEEECHHHEEECCCCCEECCCCEEEEEEEEEEECCCCCCCC
DNPARWSRVRVATKYPAITRRHFAARGINADIVHLHGAMELAPVLDLSHLIVDLVDTGST
CCCCHHHEEEEEECCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCE
LRANGLEETETIATVTSRLIVNRTALKTQPERIGALIARFRHALAASTVAETVSA
EECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TALTRETTQDTKLILALPKGRILKAAAPLLAGAGLTPAADCLDEGSRRLRFPTDDAMLD
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCCHHHHH
VVRVRSFDVATFVAFGGAQLGICGADVLMEFDYPEIYAPLDLRIGACRVSVARPRGQEGT
HHHHCCCCHHHHHHHCCCEEEEECHHHEEECCCCCEECCCCEEEEEEEEEEECCCCCCCC
DNPARWSRVRVATKYPAITRRHFAARGINADIVHLHGAMELAPVLDLSHLIVDLVDTGST
CCCCHHHEEEEEECCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCE
LRANGLEETETIATVTSRLIVNRTALKTQPERIGALIARFRHALAASTVAETVSA
EECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA