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The map label for this gene is hisD [H]

Identifier: 162147235

GI number: 162147235

Start: 1442967

End: 1444280

Strand: Reverse

Name: hisD [H]

Synonym: GDI_1440

Alternate gene names: 162147235

Gene position: 1444280-1442967 (Counterclockwise)

Preceding gene: 162147236

Following gene: 162147234

Centisome position: 36.62

GC content: 74.12

Gene sequence:

>1314_bases
ATGAAACGGCTGGATACCGCGCAACCCGATTTCCGTGCCGCCTTCGCCCGCCTGCTGGACGACCGCGAGGGCGACACCGC
CCGCGTCGATGCCCCGGTCGCCGAGATCCTGGCCGCCGTGCGTGCGCGGGGCGACGAGGCGCTGTGCGCCTATACCGCCC
GGTTCGACCGCATGCCGGTCACGCCGGACCGCCTGCGCATCACCGAGGCCGAGATCGAGGCCGCCTGCGCCCGGGTCCCG
CCCGACCTGCTGGCGGCCCTGGATGTCGCGGCCACCCGGATCGAGGCCTTCCACCGCGCCCAGATGCCGGCCGACCTGCG
CTATACCGACGCGGACGGGGTGGATCTGGGCATGCGCTGGACGGCGCTGGACGCGGTCGGGCTGTACGTGCCCGGCGGCA
CGGCGGCCTATCCGTCCTCGGTCCTGATGAACGCCATGCCCGCGCGGGTGGCGGGGGCGGCGCGGCTGGCGATGTGCGTG
CCGACCCCGGACGGCGTGCTGAATCCGCTGGTGCTGGCCGCCGCCCGACGCGCCGGCGTGACCGAGATCTATCGCGTCGG
CGGGGCGCAGGCCGTGGCGGCCATGGCCTACGGCACCGCGACCATCCGCCCGGTGGACCGCGTGGTCGGACCCGGCAACG
CCTATGTGGCCGAGGCCAAGCGTCAGGTGTTCGGCCGGGTGGGCATCGACAGCATCGCCGGCCCGTCCGAGGTCGTGGTG
GTGGCCGACAGCGGCACCGATCCGCGCATCGTCGCGCTGGACCTGCTGGCGCAGGCCGAGCATGACGCCCTGGCGCAGTC
GATCCTGATCACCCAGGACGCCACCCTGGCCGACCGGGTGGCGGAGGCGGTCGAGGCCGAACTGCGCACCCTGCCCCGCG
CCGCCATCGCGGGGGCGAGCTGGGGCGCCCACGGCGCCATCATCACCGTGCGCGACCTGGACGAGGCCGCGTCGCTGATC
GACGCGATCGCGCCCGAACATCTGGAACTGCTGCTGGCCGATCCGGAACCGCTGTTCGCCCGGGTCCGCCATGCCGGGGC
GATCTTCCTGGGCCGGCAATGCGCCGAGGCGATCGGCGATTATGTCGGCGGTCCGAACCATGTCCTGCCCACCAGCCGGA
CCGCGCGCTTCGCCTCGGGCCTGTCGGTGTTCGACTTCCTGAAGCGCACGACCTTCATCGGCGCGGGGCCGGACGCGCTG
CGCCGGATCGGGCCGGCGGCGGTGGCCCTGGCGCGGGCCGAGGGGCTGGACGCACACGCGCTGAGCGTGTCGGCGCGGCT
GGACGCCGTGGCGCGCGAGTCCGACAAAGCTTGA

Upstream 100 bases:

>100_bases
ACCGCACGGCGCTGAAGACCCAGCCGGAGCGGATCGGCGCGCTGATCGCGCGCTTCCGCCACGCCCTGGCCGCGTCCACG
GTGGCGGAGACCGTCAGCGC

Downstream 100 bases:

>100_bases
CCGCAGTGCCTACAATCCGCACATATCCGCCTGCATTCCACTTCATGGGCCGCTGGATCGCGCCACCTGGCCGATCCAGC
GGTTCCGCCTGCACCGTTCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKRLDTAQPDFRAAFARLLDDREGDTARVDAPVAEILAAVRARGDEALCAYTARFDRMPVTPDRLRITEAEIEAACARVP
PDLLAALDVAATRIEAFHRAQMPADLRYTDADGVDLGMRWTALDAVGLYVPGGTAAYPSSVLMNAMPARVAGAARLAMCV
PTPDGVLNPLVLAAARRAGVTEIYRVGGAQAVAAMAYGTATIRPVDRVVGPGNAYVAEAKRQVFGRVGIDSIAGPSEVVV
VADSGTDPRIVALDLLAQAEHDALAQSILITQDATLADRVAEAVEAELRTLPRAAIAGASWGAHGAIITVRDLDEAASLI
DAIAPEHLELLLADPEPLFARVRHAGAIFLGRQCAEAIGDYVGGPNHVLPTSRTARFASGLSVFDFLKRTTFIGAGPDAL
RRIGPAAVALARAEGLDAHALSVSARLDAVARESDKA

Sequences:

>Translated_437_residues
MKRLDTAQPDFRAAFARLLDDREGDTARVDAPVAEILAAVRARGDEALCAYTARFDRMPVTPDRLRITEAEIEAACARVP
PDLLAALDVAATRIEAFHRAQMPADLRYTDADGVDLGMRWTALDAVGLYVPGGTAAYPSSVLMNAMPARVAGAARLAMCV
PTPDGVLNPLVLAAARRAGVTEIYRVGGAQAVAAMAYGTATIRPVDRVVGPGNAYVAEAKRQVFGRVGIDSIAGPSEVVV
VADSGTDPRIVALDLLAQAEHDALAQSILITQDATLADRVAEAVEAELRTLPRAAIAGASWGAHGAIITVRDLDEAASLI
DAIAPEHLELLLADPEPLFARVRHAGAIFLGRQCAEAIGDYVGGPNHVLPTSRTARFASGLSVFDFLKRTTFIGAGPDAL
RRIGPAAVALARAEGLDAHALSVSARLDAVARESDKA
>Mature_437_residues
MKRLDTAQPDFRAAFARLLDDREGDTARVDAPVAEILAAVRARGDEALCAYTARFDRMPVTPDRLRITEAEIEAACARVP
PDLLAALDVAATRIEAFHRAQMPADLRYTDADGVDLGMRWTALDAVGLYVPGGTAAYPSSVLMNAMPARVAGAARLAMCV
PTPDGVLNPLVLAAARRAGVTEIYRVGGAQAVAAMAYGTATIRPVDRVVGPGNAYVAEAKRQVFGRVGIDSIAGPSEVVV
VADSGTDPRIVALDLLAQAEHDALAQSILITQDATLADRVAEAVEAELRTLPRAAIAGASWGAHGAIITVRDLDEAASLI
DAIAPEHLELLLADPEPLFARVRHAGAIFLGRQCAEAIGDYVGGPNHVLPTSRTARFASGLSVFDFLKRTTFIGAGPDAL
RRIGPAAVALARAEGLDAHALSVSARLDAVARESDKA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=404, Percent_Identity=42.3267326732673, Blast_Score=280, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6319819, Length=418, Percent_Identity=36.8421052631579, Blast_Score=234, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45823; Mature: 45823

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLDTAQPDFRAAFARLLDDREGDTARVDAPVAEILAAVRARGDEALCAYTARFDRMPV
CCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCCCCEEHHHHHCCCCCC
TPDRLRITEAEIEAACARVPPDLLAALDVAATRIEAFHRAQMPADLRYTDADGVDLGMRW
CHHHEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCEE
TALDAVGLYVPGGTAAYPSSVLMNAMPARVAGAARLAMCVPTPDGVLNPLVLAAARRAGV
EEEHEEEEEECCCCCCCCHHHHHHHHHHHHHCHHEEEEEECCCCHHHHHHHHHHHHHCCH
TEIYRVGGAQAVAAMAYGTATIRPVDRVVGPGNAYVAEAKRQVFGRVGIDSIAGPSEVVV
HHHHHCCCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
VADSGTDPRIVALDLLAQAEHDALAQSILITQDATLADRVAEAVEAELRTLPRAAIAGAS
EECCCCCCEEEHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCHHHHCCCC
WGAHGAIITVRDLDEAASLIDAIAPEHLELLLADPEPLFARVRHAGAIFLGRQCAEAIGD
CCCCCCEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
YVGGPNHVLPTSRTARFASGLSVFDFLKRTTFIGAGPDALRRIGPAAVALARAEGLDAHA
HCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHCCCCHHH
LSVSARLDAVARESDKA
EEHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKRLDTAQPDFRAAFARLLDDREGDTARVDAPVAEILAAVRARGDEALCAYTARFDRMPV
CCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCCCCEEHHHHHCCCCCC
TPDRLRITEAEIEAACARVPPDLLAALDVAATRIEAFHRAQMPADLRYTDADGVDLGMRW
CHHHEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCEE
TALDAVGLYVPGGTAAYPSSVLMNAMPARVAGAARLAMCVPTPDGVLNPLVLAAARRAGV
EEEHEEEEEECCCCCCCCHHHHHHHHHHHHHCHHEEEEEECCCCHHHHHHHHHHHHHCCH
TEIYRVGGAQAVAAMAYGTATIRPVDRVVGPGNAYVAEAKRQVFGRVGIDSIAGPSEVVV
HHHHHCCCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
VADSGTDPRIVALDLLAQAEHDALAQSILITQDATLADRVAEAVEAELRTLPRAAIAGAS
EECCCCCCEEEHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCHHHHCCCC
WGAHGAIITVRDLDEAASLIDAIAPEHLELLLADPEPLFARVRHAGAIFLGRQCAEAIGD
CCCCCCEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
YVGGPNHVLPTSRTARFASGLSVFDFLKRTTFIGAGPDALRRIGPAAVALARAEGLDAHA
HCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHCCCCHHH
LSVSARLDAVARESDKA
EEHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA