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The map label for this gene is qor [C]

Identifier: 162146018

GI number: 162146018

Start: 198887

End: 199906

Strand: Direct

Name: qor [C]

Synonym: GDI_0186

Alternate gene names: 162146018

Gene position: 198887-199906 (Clockwise)

Preceding gene: 162146013

Following gene: 162146019

Centisome position: 5.04

GC content: 65.39

Gene sequence:

>1020_bases
ATGCGTGCCGTTGGTTATCAATCCCCCCTTCCGATCGACGATCCCGATGCGTTGCAGGACATCGAACTCCCCGAACCCGT
GCCGACCGGACATGACCTCCTGGTCGAGGTCCGGGCTGTTTCGGTCAATCCCGTCGACACCAAGGTGCGACGGAGTGCCG
CACCCGAACCGGGCCAATGGCGCGTGCTGGGCTGGGACGCGGCAGGCGTCGTCACAGCGACGGGGCCGGACGTCCGTGAC
TTCACGGCAGGGGATGAAGTCTTCTATGCCGGATCTCTGCACCGATCGGGCACGAATGCCCAGTTCCATCTGGTCGACGA
GCGGATCGTGGGCCACAAGCCGAAATCGCTGGACTGGGCGCAGGCCGCGGCACTTCCGCTGACCGCGATCACGGCGTGGG
AGATGTTGTTCGACCGGCTCGATATCCGGCGGCCGGTCCCCGGCACCGTCCCGTCCCTGCTGATCGTGGGCGGCGCGGGT
GGCGTCGGCTCGATGGCGATCCAGCTTGCCCGCGCGCTGACGGACCTGACAATCATCGCCACGGCGTCGCGCCCCGAGAC
GCAGGAGTGGGTCCGCAGCCTGGGCGCGCATCATGTGATCGACCATCGGAACGCCCTCGCCGGACAGGTGGCTAACCTGC
CGACCGGCGCGCCCGGCTTCGTCTTCTCCACGACCCAGACGGACCAGCACTTCGCCGACATCGTGGAGTTGCTGGCGCCA
CAGGGCCACCTGGGACTGATCGACGATCCGGAAGAACTCAGCGCGTTGCCGCTCAAGCGCAAAAGCCTGTCGCTGCATTG
GGAACTGATGTTCACCCGTCCGATGTTCGAAACAGCCGACATGGCCGAACAAGGCAAATTGCTGAACGAGATCGCGTCAC
TCGTGGACAGCGGGCGCATCCGCACGACGCTGGGCGAGAATTTCGGTCCGATCAACGCGGACAATTTGCGCCGCGCGCAC
GCCCTGATCGAGAGCGGGCGGGCGAAGGGGAAAATCGTTCTCACCGGCTTCGGTCAATAA

Upstream 100 bases:

>100_bases
GACGGTATCATTTCCGATACTATGAGCATTATATGTGCGTTCTTGCGTATGCCGAACATAACGCTCCATCTTCCCTCCAT
TCAACGATGGAGCGAAACCC

Downstream 100 bases:

>100_bases
GCAGGGTTATCACACACGGTGCGACGAAATCCGGCCTGTGCCGCGCTGCTGTCTCCCTGAGTGGAATAAATATTGATAAT
GGGTTTTTACATATAAAATC

Product: Zinc-type alcohol dehydrogenase-like protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRAVGYQSPLPIDDPDALQDIELPEPVPTGHDLLVEVRAVSVNPVDTKVRRSAAPEPGQWRVLGWDAAGVVTATGPDVRD
FTAGDEVFYAGSLHRSGTNAQFHLVDERIVGHKPKSLDWAQAAALPLTAITAWEMLFDRLDIRRPVPGTVPSLLIVGGAG
GVGSMAIQLARALTDLTIIATASRPETQEWVRSLGAHHVIDHRNALAGQVANLPTGAPGFVFSTTQTDQHFADIVELLAP
QGHLGLIDDPEELSALPLKRKSLSLHWELMFTRPMFETADMAEQGKLLNEIASLVDSGRIRTTLGENFGPINADNLRRAH
ALIESGRAKGKIVLTGFGQ

Sequences:

>Translated_339_residues
MRAVGYQSPLPIDDPDALQDIELPEPVPTGHDLLVEVRAVSVNPVDTKVRRSAAPEPGQWRVLGWDAAGVVTATGPDVRD
FTAGDEVFYAGSLHRSGTNAQFHLVDERIVGHKPKSLDWAQAAALPLTAITAWEMLFDRLDIRRPVPGTVPSLLIVGGAG
GVGSMAIQLARALTDLTIIATASRPETQEWVRSLGAHHVIDHRNALAGQVANLPTGAPGFVFSTTQTDQHFADIVELLAP
QGHLGLIDDPEELSALPLKRKSLSLHWELMFTRPMFETADMAEQGKLLNEIASLVDSGRIRTTLGENFGPINADNLRRAH
ALIESGRAKGKIVLTGFGQ
>Mature_339_residues
MRAVGYQSPLPIDDPDALQDIELPEPVPTGHDLLVEVRAVSVNPVDTKVRRSAAPEPGQWRVLGWDAAGVVTATGPDVRD
FTAGDEVFYAGSLHRSGTNAQFHLVDERIVGHKPKSLDWAQAAALPLTAITAWEMLFDRLDIRRPVPGTVPSLLIVGGAG
GVGSMAIQLARALTDLTIIATASRPETQEWVRSLGAHHVIDHRNALAGQVANLPTGAPGFVFSTTQTDQHFADIVELLAP
QGHLGLIDDPEELSALPLKRKSLSLHWELMFTRPMFETADMAEQGKLLNEIASLVDSGRIRTTLGENFGPINADNLRRAH
ALIESGRAKGKIVLTGFGQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=335, Percent_Identity=31.044776119403, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI194239676, Length=207, Percent_Identity=34.7826086956522, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI194239674, Length=179, Percent_Identity=35.7541899441341, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13236495, Length=179, Percent_Identity=35.7541899441341, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI24308257, Length=159, Percent_Identity=27.6729559748428, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI18379349, Length=171, Percent_Identity=33.9181286549708, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790485, Length=323, Percent_Identity=25.6965944272446, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71987554, Length=180, Percent_Identity=35.5555555555556, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=240, Percent_Identity=28.3333333333333, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36540; Mature: 36540

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVGYQSPLPIDDPDALQDIELPEPVPTGHDLLVEVRAVSVNPVDTKVRRSAAPEPGQW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCE
RVLGWDAAGVVTATGPDVRDFTAGDEVFYAGSLHRSGTNAQFHLVDERIVGHKPKSLDWA
EEEEECCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECHHHHCCCCCCCCHH
QAAALPLTAITAWEMLFDRLDIRRPVPGTVPSLLIVGGAGGVGSMAIQLARALTDLTIIA
HHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCEEEEE
TASRPETQEWVRSLGAHHVIDHRNALAGQVANLPTGAPGFVFSTTQTDQHFADIVELLAP
ECCCCCHHHHHHHHCCHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCC
QGHLGLIDDPEELSALPLKRKSLSLHWELMFTRPMFETADMAEQGKLLNEIASLVDSGRI
CCCCCCCCCHHHHHCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCE
RTTLGENFGPINADNLRRAHALIESGRAKGKIVLTGFGQ
EEHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCC
>Mature Secondary Structure
MRAVGYQSPLPIDDPDALQDIELPEPVPTGHDLLVEVRAVSVNPVDTKVRRSAAPEPGQW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCE
RVLGWDAAGVVTATGPDVRDFTAGDEVFYAGSLHRSGTNAQFHLVDERIVGHKPKSLDWA
EEEEECCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECHHHHCCCCCCCCHH
QAAALPLTAITAWEMLFDRLDIRRPVPGTVPSLLIVGGAGGVGSMAIQLARALTDLTIIA
HHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCEEEEE
TASRPETQEWVRSLGAHHVIDHRNALAGQVANLPTGAPGFVFSTTQTDQHFADIVELLAP
ECCCCCHHHHHHHHCCHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCC
QGHLGLIDDPEELSALPLKRKSLSLHWELMFTRPMFETADMAEQGKLLNEIASLVDSGRI
CCCCCCCCCHHHHHCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCE
RTTLGENFGPINADNLRRAHALIESGRAKGKIVLTGFGQ
EEHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]