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The map label for this gene is parE [H]

Identifier: 161870530

GI number: 161870530

Start: 1624093

End: 1626078

Strand: Reverse

Name: parE [H]

Synonym: NMCC_1595

Alternate gene names: 161870530

Gene position: 1626078-1624093 (Counterclockwise)

Preceding gene: 161870531

Following gene: 161870527

Centisome position: 75.51

GC content: 57.91

Gene sequence:

>1986_bases
ATGGCTAAAAACAACCAATACAGCGAATCCAGCATCACCGTCCTCAAAGGTTTGGAACCGGTCAAAGAACGTCCCGGTAT
GTACACCCGCACCGACAGCCCGACCCATATCTGTCAGGAAGTGATTGATAACGCGGCGGACGAGGCGTTGGGCGGTTTCG
CTACGGCAATCGACGTGCAAATTCATGAAGACGGTTCGCTTTCCGTACGCGACAACGGCCGCGGTATTCCCGTCGGTCTG
CACCCTGAAGAAGGCGTACCCGTAGTCGAACTCGTGTTCACCCGTCTGCACGCAGGCGGCAAGTTCAACAAAAAAGACGG
CGGCAGCGCGTATGCCTTTTCAGGCGGCCTGCACGGCGTGGGCGTATCCGTGACCAACGCCCTTTCCACCCGCCTTGAGG
TAACGGTCAAACGCGAAGGCAAAATCCACCGTATCGTGTTTGCCGGCGGCGACGTGGTCGAACCGTTGGCACAAGTGGGC
AAATGCGCCGTCAAAGACAGCGGCACCGAAGTGCGCGTGTGGCCGGACGGCAAATATTTTGAAAGCCCGAATTACAGCAT
TCCCGAACTCGAACGCCTGCTGCGCGCCAAAGCCGTGCTGCTGCCGGGCGTGCGCGTTTCCCTGACCCGTCCGGTCAAAG
GCGAAGACGAAGCGCACACCCAAACCTGGCATTACCCCGACGGTCTGAAAAGCTATCTGACCGACCTGATTGCCGACGCG
CAGGAAGCCGTGCCTATCTTCTCTTGCGAAAACTACATTTCAGACGGCCACAACGGCGATTTCAGCATCGGCGAAGGCGC
CGCGTTTGCCCTGACCTGGCTGGAAGAAGGCTCGTGCGCCAACGAAAGCTACGTCAACCTCATCCCCACCCCGCTGGGCG
GCACGCACGAAGCGGGCTTGAAACAAGCCGTGTTCAACGCCGTCAGCAACTTCATCAATCTGCACAACCTTTTACCACGC
GGCGTGAAAGTGCAAAGCGACGACGTGTTCGGCAAAACCGCCTTTGTCCTCTCTGCCCGTGTCCTCGACCCGCAGTTCCA
AGGTCAGACCAAAGACAAACTGACCAACCGCGACGCGCTGAAACTCGTTGCTACCGTATCGGGCGACCCTTTGGAATTGT
GGCTGAACCAAAACGTGGACTTCGGCAAAAAAATCGCCGAACTCGCCATCCGTCAGGCACAGGCGCGGATGCGTTCGGTT
AAAAAGATTGAAAAGAAAAAAGGCAGCGGCGTCGCCGTCCTGCCCGGTAAGCTGACCGACTGCGAAAGCGAAGACATCCG
CGAAAACGAACTCTTCCTCGTCGAAGGCGATTCCGCCGGCGGCTCCGCCAAACTCGCCCGCGACAAAGCCACCCAAGCCA
TCCTGCCCCTGCGCGGCAAAGTGCTCAACAGCTTTGAAGTCCACCCCGACCAGCTCTTCGGCAACGCCGAAATCCACGAC
ATTTCAGTTGCCATCGGCGTCGATCCGCACGGCATCAACGACCATCCCGATTTAAGCGGCCTGCGTTACGGCAAAATCGC
CATCCTGTCCGATGCCGACGTGGACGGCTCGCATATTCAAGTTTTGCTGCTGACCCTGTTCTACCGCCACTTCCCGAAAC
TGGTCGCTGACGGACACATCTACGTCGCCCAGCCGCCGCTGTTCCGCGTAGATGTCAACGCACAAGGTAAAAGCAAACCC
GCCCGCAAATTCTACGCCCTCGACCAAAACGAACTTGACGGCATTTTAGAGCGGCTGCAAAAAGAAGGCGTTAAAGAAAC
TGCTTATTCCATCAGCCGTTTCAAAGGTTTGGGTGAGATGAACCCAGACCAGCTCAAAGATACTACCATGCACCCCGACA
CCCGCCGCCTGTTGCAGGTACAAATCCCCGAAGGCGCGGATGACGAGACGCGCGACATCTTCGTCAAACTGATGGGCAAA
GGCGAAGCCGCCGCCCGCCGTGCCTGGATGGAGCGCGAAGGCGATACGGCGGAACTCGATATTTGA

Upstream 100 bases:

>100_bases
CTTTGCCGCCCGCCAACCTTCCGGCAACCGGTAAAACAACGGAACGCAACGCTTTCAGGCCGTCTGAAAGCGTTGTTTTT
CTTACTTTCAGATTATTCCT

Downstream 100 bases:

>100_bases
ACCGTGATTGCCGCATACGGAAAAATGCCGTCTGAAACCAAATCGGTTTTCAGACGGCATTTCATTTGGGGATTTATTCT
GCTGCGGAAGATTCGGCTGC

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MAKNNQYSESSITVLKGLEPVKERPGMYTRTDSPTHICQEVIDNAADEALGGFATAIDVQIHEDGSLSVRDNGRGIPVGL
HPEEGVPVVELVFTRLHAGGKFNKKDGGSAYAFSGGLHGVGVSVTNALSTRLEVTVKREGKIHRIVFAGGDVVEPLAQVG
KCAVKDSGTEVRVWPDGKYFESPNYSIPELERLLRAKAVLLPGVRVSLTRPVKGEDEAHTQTWHYPDGLKSYLTDLIADA
QEAVPIFSCENYISDGHNGDFSIGEGAAFALTWLEEGSCANESYVNLIPTPLGGTHEAGLKQAVFNAVSNFINLHNLLPR
GVKVQSDDVFGKTAFVLSARVLDPQFQGQTKDKLTNRDALKLVATVSGDPLELWLNQNVDFGKKIAELAIRQAQARMRSV
KKIEKKKGSGVAVLPGKLTDCESEDIRENELFLVEGDSAGGSAKLARDKATQAILPLRGKVLNSFEVHPDQLFGNAEIHD
ISVAIGVDPHGINDHPDLSGLRYGKIAILSDADVDGSHIQVLLLTLFYRHFPKLVADGHIYVAQPPLFRVDVNAQGKSKP
ARKFYALDQNELDGILERLQKEGVKETAYSISRFKGLGEMNPDQLKDTTMHPDTRRLLQVQIPEGADDETRDIFVKLMGK
GEAAARRAWMEREGDTAELDI

Sequences:

>Translated_661_residues
MAKNNQYSESSITVLKGLEPVKERPGMYTRTDSPTHICQEVIDNAADEALGGFATAIDVQIHEDGSLSVRDNGRGIPVGL
HPEEGVPVVELVFTRLHAGGKFNKKDGGSAYAFSGGLHGVGVSVTNALSTRLEVTVKREGKIHRIVFAGGDVVEPLAQVG
KCAVKDSGTEVRVWPDGKYFESPNYSIPELERLLRAKAVLLPGVRVSLTRPVKGEDEAHTQTWHYPDGLKSYLTDLIADA
QEAVPIFSCENYISDGHNGDFSIGEGAAFALTWLEEGSCANESYVNLIPTPLGGTHEAGLKQAVFNAVSNFINLHNLLPR
GVKVQSDDVFGKTAFVLSARVLDPQFQGQTKDKLTNRDALKLVATVSGDPLELWLNQNVDFGKKIAELAIRQAQARMRSV
KKIEKKKGSGVAVLPGKLTDCESEDIRENELFLVEGDSAGGSAKLARDKATQAILPLRGKVLNSFEVHPDQLFGNAEIHD
ISVAIGVDPHGINDHPDLSGLRYGKIAILSDADVDGSHIQVLLLTLFYRHFPKLVADGHIYVAQPPLFRVDVNAQGKSKP
ARKFYALDQNELDGILERLQKEGVKETAYSISRFKGLGEMNPDQLKDTTMHPDTRRLLQVQIPEGADDETRDIFVKLMGK
GEAAARRAWMEREGDTAELDI
>Mature_660_residues
AKNNQYSESSITVLKGLEPVKERPGMYTRTDSPTHICQEVIDNAADEALGGFATAIDVQIHEDGSLSVRDNGRGIPVGLH
PEEGVPVVELVFTRLHAGGKFNKKDGGSAYAFSGGLHGVGVSVTNALSTRLEVTVKREGKIHRIVFAGGDVVEPLAQVGK
CAVKDSGTEVRVWPDGKYFESPNYSIPELERLLRAKAVLLPGVRVSLTRPVKGEDEAHTQTWHYPDGLKSYLTDLIADAQ
EAVPIFSCENYISDGHNGDFSIGEGAAFALTWLEEGSCANESYVNLIPTPLGGTHEAGLKQAVFNAVSNFINLHNLLPRG
VKVQSDDVFGKTAFVLSARVLDPQFQGQTKDKLTNRDALKLVATVSGDPLELWLNQNVDFGKKIAELAIRQAQARMRSVK
KIEKKKGSGVAVLPGKLTDCESEDIRENELFLVEGDSAGGSAKLARDKATQAILPLRGKVLNSFEVHPDQLFGNAEIHDI
SVAIGVDPHGINDHPDLSGLRYGKIAILSDADVDGSHIQVLLLTLFYRHFPKLVADGHIYVAQPPLFRVDVNAQGKSKPA
RKFYALDQNELDGILERLQKEGVKETAYSISRFKGLGEMNPDQLKDTTMHPDTRRLLQVQIPEGADDETRDIFVKLMGKG
EAAARRAWMEREGDTAELDI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=616, Percent_Identity=25.487012987013, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI19913406, Length=608, Percent_Identity=25.4934210526316, Blast_Score=123, Evalue=7e-28,
Organism=Escherichia coli, GI1789408, Length=657, Percent_Identity=49.4672754946728, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=561, Percent_Identity=40.4634581105169, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17535065, Length=660, Percent_Identity=23.4848484848485, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI212645845, Length=626, Percent_Identity=24.7603833865815, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI212645657, Length=216, Percent_Identity=28.7037037037037, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=652, Percent_Identity=23.7730061349693, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17136538, Length=389, Percent_Identity=27.2493573264781, Blast_Score=99, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72101; Mature: 71970

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNNQYSESSITVLKGLEPVKERPGMYTRTDSPTHICQEVIDNAADEALGGFATAIDVQ
CCCCCCCCCCHHHHHHCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEE
IHEDGSLSVRDNGRGIPVGLHPEEGVPVVELVFTRLHAGGKFNKKDGGSAYAFSGGLHGV
EECCCCEEECCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCC
GVSVTNALSTRLEVTVKREGKIHRIVFAGGDVVEPLAQVGKCAVKDSGTEVRVWPDGKYF
CHHHHHHHCCEEEEEEECCCCEEEEEEECCHHHHHHHHHCCEEECCCCCEEEECCCCCEE
ESPNYSIPELERLLRAKAVLLPGVRVSLTRPVKGEDEAHTQTWHYPDGLKSYLTDLIADA
CCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
QEAVPIFSCENYISDGHNGDFSIGEGAAFALTWLEEGSCANESYVNLIPTPLGGTHEAGL
HHCCEEEECHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCHHHHH
KQAVFNAVSNFINLHNLLPRGVKVQSDDVFGKTAFVLSARVLDPQFQGQTKDKLTNRDAL
HHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEEHHCCCCCCCCCHHHHCCCCCE
KLVATVSGDPLELWLNQNVDFGKKIAELAIRQAQARMRSVKKIEKKKGSGVAVLPGKLTD
EEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
CESEDIRENELFLVEGDSAGGSAKLARDKATQAILPLRGKVLNSFEVHPDQLFGNAEIHD
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCHHHHCCCCEEEE
ISVAIGVDPHGINDHPDLSGLRYGKIAILSDADVDGSHIQVLLLTLFYRHFPKLVADGHI
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
YVAQPPLFRVDVNAQGKSKPARKFYALDQNELDGILERLQKEGVKETAYSISRFKGLGEM
EEECCCEEEEEECCCCCCCCCHHEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
NPDQLKDTTMHPDTRRLLQVQIPEGADDETRDIFVKLMGKGEAAARRAWMEREGDTAELD
CHHHHHCCCCCCCCEEEEEEECCCCCCCHHHEEEEEEECCCHHHHHHHHHHCCCCEEECC
I
C
>Mature Secondary Structure 
AKNNQYSESSITVLKGLEPVKERPGMYTRTDSPTHICQEVIDNAADEALGGFATAIDVQ
CCCCCCCCCHHHHHHCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEE
IHEDGSLSVRDNGRGIPVGLHPEEGVPVVELVFTRLHAGGKFNKKDGGSAYAFSGGLHGV
EECCCCEEECCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCC
GVSVTNALSTRLEVTVKREGKIHRIVFAGGDVVEPLAQVGKCAVKDSGTEVRVWPDGKYF
CHHHHHHHCCEEEEEEECCCCEEEEEEECCHHHHHHHHHCCEEECCCCCEEEECCCCCEE
ESPNYSIPELERLLRAKAVLLPGVRVSLTRPVKGEDEAHTQTWHYPDGLKSYLTDLIADA
CCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
QEAVPIFSCENYISDGHNGDFSIGEGAAFALTWLEEGSCANESYVNLIPTPLGGTHEAGL
HHCCEEEECHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCHHHHH
KQAVFNAVSNFINLHNLLPRGVKVQSDDVFGKTAFVLSARVLDPQFQGQTKDKLTNRDAL
HHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEEHHCCCCCCCCCHHHHCCCCCE
KLVATVSGDPLELWLNQNVDFGKKIAELAIRQAQARMRSVKKIEKKKGSGVAVLPGKLTD
EEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
CESEDIRENELFLVEGDSAGGSAKLARDKATQAILPLRGKVLNSFEVHPDQLFGNAEIHD
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCHHHHCCCCEEEE
ISVAIGVDPHGINDHPDLSGLRYGKIAILSDADVDGSHIQVLLLTLFYRHFPKLVADGHI
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
YVAQPPLFRVDVNAQGKSKPARKFYALDQNELDGILERLQKEGVKETAYSISRFKGLGEM
EEECCCEEEEEECCCCCCCCCHHEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
NPDQLKDTTMHPDTRRLLQVQIPEGADDETRDIFVKLMGKGEAAARRAWMEREGDTAELD
CHHHHHCCCCCCCCEEEEEEECCCCCCCHHHEEEEEEECCCHHHHHHHHHHCCCCEEECC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]