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The map label for this gene is tyrB [H]

Identifier: 161870526

GI number: 161870526

Start: 1619958

End: 1621151

Strand: Reverse

Name: tyrB [H]

Synonym: NMCC_1591

Alternate gene names: 161870526

Gene position: 1621151-1619958 (Counterclockwise)

Preceding gene: 161870527

Following gene: 161870525

Centisome position: 75.28

GC content: 55.95

Gene sequence:

>1194_bases
ATGTACCGACACATCGAATACTATCCCGGCGATCCGATTTTGAGTTTGGTCGAAACCTTCAAAAACGACCCGCGCCCCGA
AAAAGTCAATTTGAGCATAGGCATTTATTTCGACGACGAAGGCAAAATGCCCGTGTTGGAATCCGTGAGCCGCGCCGAAA
CCGCCCGCGCCGCCACTCCTGTGCCGTCGCCCTACCTGCCGATGGAAGGCTTAGACACTTACCGCAGCGCGGTGCAGCAT
TTGTTGTTCGGCAAAGACAACCCCGCGCTCGCGCAAGGACGTATTGTTACCGTACAAACCTTGGGCGGCTCAGGCGCGCT
CAAAGTCGGGGCGGACTTTCTGCACCGCTGGTTTCCCGAAGCGCGCGCCTACGTCAGCGACCCGACTTGGGACAACCATC
GCGGCATTTTTGAAAGCGCAGGTTTCGAGGTCGGCACTTACCCATATTACGACCCTGCTGCCGTCGGCGTGAAATTCGAC
GAAATGACCGCGTTTTTCAACACCCTGCCCGAAAACAGCGTCCTGATCCTCCATCCCTGCTGCCACAACCCGACCGGCGT
GGATATGTCGGAACAACAATGGGACGAAGTGTTGCACATCATCAAAACGCGCAAACTGATTCCGTTTATGGACATCGCCT
ACCAAGGCTTCGGCGGCGATTTGGACAGCGATGCCTACGCCGTCCGCAAAGCGGTGGAAATGGAATTGCCCTTGTTCGTC
AGCAATTCCTTCTCAAAAAACCTGTCGCTCTACGGCGAGCGCGTCGGCGGCCTGAGCGTGGTTTGCCCGAATAAGGAAGA
AGCGGATTTGGTGTTCGGACAGCTCAAATTCACCGTCCGCCGCATCTACTCCAGCCCGCCCGCGCACGGCGCGTATATCG
CCGCCGACGTGATGAACAGCCCCGAACTTTACGCCTTGTGGCAAAACGAGGTTTATATGATGCGCGACCGCATCCGTGCG
ATGCGGCAGAAACTTTATGATGTCTTAACTGCGCAAATCCCCGATCGCGATTTCACTTATTTCATCAAACAGCGCGGCAT
GTTCGGCTACACAGGATTGAGCGTGGAACAAGTCCGCAGGCTGCGCGACGAATTTGCCGTTTACCTGCTGGATTCCGGCA
GGATGTGCGTCGCCGGACTGAATACGTCGAATACCGACTATGTTGCCCGCGCATTTGCGGAAGTCTTGAAATAA

Upstream 100 bases:

>100_bases
AACGTGCCGCCCTGTTCGATCAATTTCCGTTTACGCACCATATTGAAAGCGGTGTGCTGTTGAAAAAGAAAATCCTTGGA
AAAAGCAAGAGGTAAGGACT

Downstream 100 bases:

>100_bases
GAGTTTGAAGTAAGTCAAAAGACCGTCTGAAAAATATTTATCTTTCAGACGGTCTCTTTATAATTGGCGCACCCAACAGG
GATCGAACCTGTGACCTCCA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MYRHIEYYPGDPILSLVETFKNDPRPEKVNLSIGIYFDDEGKMPVLESVSRAETARAATPVPSPYLPMEGLDTYRSAVQH
LLFGKDNPALAQGRIVTVQTLGGSGALKVGADFLHRWFPEARAYVSDPTWDNHRGIFESAGFEVGTYPYYDPAAVGVKFD
EMTAFFNTLPENSVLILHPCCHNPTGVDMSEQQWDEVLHIIKTRKLIPFMDIAYQGFGGDLDSDAYAVRKAVEMELPLFV
SNSFSKNLSLYGERVGGLSVVCPNKEEADLVFGQLKFTVRRIYSSPPAHGAYIAADVMNSPELYALWQNEVYMMRDRIRA
MRQKLYDVLTAQIPDRDFTYFIKQRGMFGYTGLSVEQVRRLRDEFAVYLLDSGRMCVAGLNTSNTDYVARAFAEVLK

Sequences:

>Translated_397_residues
MYRHIEYYPGDPILSLVETFKNDPRPEKVNLSIGIYFDDEGKMPVLESVSRAETARAATPVPSPYLPMEGLDTYRSAVQH
LLFGKDNPALAQGRIVTVQTLGGSGALKVGADFLHRWFPEARAYVSDPTWDNHRGIFESAGFEVGTYPYYDPAAVGVKFD
EMTAFFNTLPENSVLILHPCCHNPTGVDMSEQQWDEVLHIIKTRKLIPFMDIAYQGFGGDLDSDAYAVRKAVEMELPLFV
SNSFSKNLSLYGERVGGLSVVCPNKEEADLVFGQLKFTVRRIYSSPPAHGAYIAADVMNSPELYALWQNEVYMMRDRIRA
MRQKLYDVLTAQIPDRDFTYFIKQRGMFGYTGLSVEQVRRLRDEFAVYLLDSGRMCVAGLNTSNTDYVARAFAEVLK
>Mature_397_residues
MYRHIEYYPGDPILSLVETFKNDPRPEKVNLSIGIYFDDEGKMPVLESVSRAETARAATPVPSPYLPMEGLDTYRSAVQH
LLFGKDNPALAQGRIVTVQTLGGSGALKVGADFLHRWFPEARAYVSDPTWDNHRGIFESAGFEVGTYPYYDPAAVGVKFD
EMTAFFNTLPENSVLILHPCCHNPTGVDMSEQQWDEVLHIIKTRKLIPFMDIAYQGFGGDLDSDAYAVRKAVEMELPLFV
SNSFSKNLSLYGERVGGLSVVCPNKEEADLVFGQLKFTVRRIYSSPPAHGAYIAADVMNSPELYALWQNEVYMMRDRIRA
MRQKLYDVLTAQIPDRDFTYFIKQRGMFGYTGLSVEQVRRLRDEFAVYLLDSGRMCVAGLNTSNTDYVARAFAEVLK

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=398, Percent_Identity=44.4723618090452, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI4504067, Length=395, Percent_Identity=42.0253164556962, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI117414139, Length=385, Percent_Identity=27.7922077922078, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=59.4458438287154, Blast_Score=499, Evalue=1e-143,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=41.9191919191919, Blast_Score=341, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=39.0428211586902, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI25147133, Length=399, Percent_Identity=42.1052631578947, Blast_Score=327, Evalue=7e-90,
Organism=Caenorhabditis elegans, GI17569539, Length=402, Percent_Identity=38.8059701492537, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17569537, Length=388, Percent_Identity=32.7319587628866, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17550384, Length=269, Percent_Identity=36.0594795539033, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25147136, Length=213, Percent_Identity=39.906103286385, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323055, Length=409, Percent_Identity=39.8533007334963, Blast_Score=303, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6322743, Length=425, Percent_Identity=35.7647058823529, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI19922362, Length=395, Percent_Identity=42.5316455696203, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24654046, Length=395, Percent_Identity=42.5316455696203, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=39.6984924623116, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=39.6984924623116, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI19920542, Length=391, Percent_Identity=40.4092071611253, Blast_Score=312, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 44780; Mature: 44780

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRHIEYYPGDPILSLVETFKNDPRPEKVNLSIGIYFDDEGKMPVLESVSRAETARAATP
CCCEEEECCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
VPSPYLPMEGLDTYRSAVQHLLFGKDNPALAQGRIVTVQTLGGSGALKVGADFLHRWFPE
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCHH
ARAYVSDPTWDNHRGIFESAGFEVGTYPYYDPAAVGVKFDEMTAFFNTLPENSVLILHPC
HHHEECCCCCCCCCCCHHHCCCCCCCCCCCCCHHCCEEHHHHHHHHHCCCCCCEEEEECC
CHNPTGVDMSEQQWDEVLHIIKTRKLIPFMDIAYQGFGGDLDSDAYAVRKAVEMELPLFV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEE
SNSFSKNLSLYGERVGGLSVVCPNKEEADLVFGQLKFTVRRIYSSPPAHGAYIAADVMNS
CCCCCCCHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
PELYALWQNEVYMMRDRIRAMRQKLYDVLTAQIPDRDFTYFIKQRGMFGYTGLSVEQVRR
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHH
LRDEFAVYLLDSGRMCVAGLNTSNTDYVARAFAEVLK
HHHHHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MYRHIEYYPGDPILSLVETFKNDPRPEKVNLSIGIYFDDEGKMPVLESVSRAETARAATP
CCCEEEECCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
VPSPYLPMEGLDTYRSAVQHLLFGKDNPALAQGRIVTVQTLGGSGALKVGADFLHRWFPE
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCHH
ARAYVSDPTWDNHRGIFESAGFEVGTYPYYDPAAVGVKFDEMTAFFNTLPENSVLILHPC
HHHEECCCCCCCCCCCHHHCCCCCCCCCCCCCHHCCEEHHHHHHHHHCCCCCCEEEEECC
CHNPTGVDMSEQQWDEVLHIIKTRKLIPFMDIAYQGFGGDLDSDAYAVRKAVEMELPLFV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEE
SNSFSKNLSLYGERVGGLSVVCPNKEEADLVFGQLKFTVRRIYSSPPAHGAYIAADVMNS
CCCCCCCHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
PELYALWQNEVYMMRDRIRAMRQKLYDVLTAQIPDRDFTYFIKQRGMFGYTGLSVEQVRR
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHH
LRDEFAVYLLDSGRMCVAGLNTSNTDYVARAFAEVLK
HHHHHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]