Click here to switch to the map view.

The map label for this gene is argF [H]

Identifier: 161870428

GI number: 161870428

Start: 1504712

End: 1505707

Strand: Direct

Name: argF [H]

Synonym: NMCC_1476

Alternate gene names: 161870428

Gene position: 1504712-1505707 (Clockwise)

Preceding gene: 161870427

Following gene: 161870433

Centisome position: 69.88

GC content: 54.02

Gene sequence:

>996_bases
GTGAACCTGAAAAACCGCCATTTTCTGAAACTTTTAGACTTCACGCCGGAAGAAATCACCGCCTACCTCGACCTTGCCGC
CGAATTGAAAGCCGCCAAAAAAGCAGGGCGCGAGATTCAGCGGATGAAAGGGAAAAACATCGCCCTGATTTTTGAAAAAA
TCTCTACTCGGACGCGCTGCGCGTTTGAAGTCGCCGCGCGCGATCAAGGCGCGGGAGTGACTTATTTAGAGCCGTCCGCC
AGCCAAATCGGGCATAAGGAAAGCATCAAAGACACCGCCCGCGTGTTGGGCAGGATGTACGATGCCATCGAATATCGCGG
TTTCGGTCAGGAAGTTGTTGAAGAATTGGCGAAATACGCGGGCGTACCCGTGTTCAACGGGCTGACCAACGAGTTCCATC
CCACACAAATGCTTGCCGACGCACTGACTATGCGCGAACACAGCGGCAAACCTTTGAACCAAACCGCGTTTGCCTACGTC
GGCGACGCGCGTTACAACATGGGCAATTCCCTGCTGATTTTAGGGGCAAAATTGGGGATGGACGTGCGTATCGGCGCACC
GCAAAGCCTGTGGCCGTCTGAAGGCATTATTGCCGCCGCACACGCCGCCGCCAAAGAAACCGGCGCAAAAATTACCCTGA
CCGAAAACGCGCATGAAGCCGTGAAGAATGTTGATTTTATTCATACCGATGTGTGGGTCAGCATGGGCGAGCCGAAAGAA
GTCTGGCAGGAACGCATCGATTTGCTGAAAGATTACCGCGTTACGCCCGAACTGATGGCGGCATCGGGCAATCCGCAAGT
CAAATTCATGCACTGCCTGCCCGCCTTCCACAACCGCGAAACCAAAGTCGGCGAATGGATTTACGAAACCTTCGGGCTGA
ACGGTGTGGAAGTTACAGAAGAAATATTCGAAAGCCCCGCCAGCATCGTGTTCGATCAGGCGGAAAACCGTATGCACACG
ATTAAAGCGGTAATGGTCGCGGCTCTGGGCGACTGA

Upstream 100 bases:

>100_bases
GTCTGAACAACCTTCAGACGGCATTGCAACATTCCGCTAACCCTTCTTTCCGCAAACGCTGCAAATACGGCGTTCACGCC
CCCACATAAAGGAAACGACA

Downstream 100 bases:

>100_bases
CAGAACTGTGCCTGTTTAAATTCATCCGCAACACAGATACCGTCTGAACACGATGTTCAGACGGTATCCATATATAGTGG
ATTAAATTTAAACCAGTACG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MNLKNRHFLKLLDFTPEEITAYLDLAAELKAAKKAGREIQRMKGKNIALIFEKISTRTRCAFEVAARDQGAGVTYLEPSA
SQIGHKESIKDTARVLGRMYDAIEYRGFGQEVVEELAKYAGVPVFNGLTNEFHPTQMLADALTMREHSGKPLNQTAFAYV
GDARYNMGNSLLILGAKLGMDVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKNVDFIHTDVWVSMGEPKE
VWQERIDLLKDYRVTPELMAASGNPQVKFMHCLPAFHNRETKVGEWIYETFGLNGVEVTEEIFESPASIVFDQAENRMHT
IKAVMVAALGD

Sequences:

>Translated_331_residues
MNLKNRHFLKLLDFTPEEITAYLDLAAELKAAKKAGREIQRMKGKNIALIFEKISTRTRCAFEVAARDQGAGVTYLEPSA
SQIGHKESIKDTARVLGRMYDAIEYRGFGQEVVEELAKYAGVPVFNGLTNEFHPTQMLADALTMREHSGKPLNQTAFAYV
GDARYNMGNSLLILGAKLGMDVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKNVDFIHTDVWVSMGEPKE
VWQERIDLLKDYRVTPELMAASGNPQVKFMHCLPAFHNRETKVGEWIYETFGLNGVEVTEEIFESPASIVFDQAENRMHT
IKAVMVAALGD
>Mature_331_residues
MNLKNRHFLKLLDFTPEEITAYLDLAAELKAAKKAGREIQRMKGKNIALIFEKISTRTRCAFEVAARDQGAGVTYLEPSA
SQIGHKESIKDTARVLGRMYDAIEYRGFGQEVVEELAKYAGVPVFNGLTNEFHPTQMLADALTMREHSGKPLNQTAFAYV
GDARYNMGNSLLILGAKLGMDVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKNVDFIHTDVWVSMGEPKE
VWQERIDLLKDYRVTPELMAASGNPQVKFMHCLPAFHNRETKVGEWIYETFGLNGVEVTEEIFESPASIVFDQAENRMHT
IKAVMVAALGD

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=332, Percent_Identity=36.7469879518072, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI18105007, Length=338, Percent_Identity=25.4437869822485, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1786469, Length=332, Percent_Identity=65.3614457831325, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1790703, Length=327, Percent_Identity=65.1376146788991, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI48994908, Length=373, Percent_Identity=25.7372654155496, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI2367364, Length=310, Percent_Identity=29.3548387096774, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322373, Length=328, Percent_Identity=31.7073170731707, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322331, Length=274, Percent_Identity=27.3722627737226, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24642586, Length=339, Percent_Identity=24.188790560472, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 36728; Mature: 36728

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKNRHFLKLLDFTPEEITAYLDLAAELKAAKKAGREIQRMKGKNIALIFEKISTRTRC
CCCCCCHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCHHH
AFEVAARDQGAGVTYLEPSASQIGHKESIKDTARVLGRMYDAIEYRGFGQEVVEELAKYA
EEEEECCCCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
GVPVFNGLTNEFHPTQMLADALTMREHSGKPLNQTAFAYVGDARYNMGNSLLILGAKLGM
CCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCC
DVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKNVDFIHTDVWVSMGEPKE
EEEECCCCCCCCCCCEEHHHHHHHHHCCCEEEEECCHHHHHHCCCEEEEEEEEECCCHHH
VWQERIDLLKDYRVTPELMAASGNPQVKFMHCLPAFHNRETKVGEWIYETFGLNGVEVTE
HHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCHHCCCCCHHHHHHHHHHCCCCHHHHH
EIFESPASIVFDQAENRMHTIKAVMVAALGD
HHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLKNRHFLKLLDFTPEEITAYLDLAAELKAAKKAGREIQRMKGKNIALIFEKISTRTRC
CCCCCCHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCHHH
AFEVAARDQGAGVTYLEPSASQIGHKESIKDTARVLGRMYDAIEYRGFGQEVVEELAKYA
EEEEECCCCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
GVPVFNGLTNEFHPTQMLADALTMREHSGKPLNQTAFAYVGDARYNMGNSLLILGAKLGM
CCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCC
DVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKNVDFIHTDVWVSMGEPKE
EEEECCCCCCCCCCCEEHHHHHHHHHCCCEEEEECCHHHHHHCCCEEEEEEEEECCCHHH
VWQERIDLLKDYRVTPELMAASGNPQVKFMHCLPAFHNRETKVGEWIYETFGLNGVEVTE
HHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCHHCCCCCHHHHHHHHHHCCCCHHHHH
EIFESPASIVFDQAENRMHTIKAVMVAALGD
HHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA