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The map label for this gene is sdhA [H]

Identifier: 161869863

GI number: 161869863

Start: 893577

End: 895340

Strand: Direct

Name: sdhA [H]

Synonym: NMCC_0894

Alternate gene names: 161869863

Gene position: 893577-895340 (Clockwise)

Preceding gene: 161869862

Following gene: 161869864

Centisome position: 41.5

GC content: 52.55

Gene sequence:

>1764_bases
ATGGGTTTTCCTGTTCGCAAGTTTGATGCCGTGATTGTCGGCGGTGGTGGTGCAGGTTTACGCGCAGCCCTCCAATTATC
CAAATCCGGTCTGAATTGTGCCGTTTTGTCTAAAGTGTTCCCGACCCGTTCGCATACCGTAGCGGCGCAGGGCGGTATTT
CCGCCTCTCTGGGTAATGTGCAGGAAGACCGTTGGGACTGGCACATGTACGATACCGTGAAAGGTTCCGACTGGTTGGGC
GACCAAGATGCGATTGAGTTTATGTGTCGCGCTGCGCCTGAAGCCGTAATTGAGTTGGAACACATGGGTATGCCTTTTGA
CCGCGTTGAAAGCGGCAAAATTTATCAGCGTCCTTTCGGCGGTCATACTGCCGAACACGGTAAACGCGCGGTAGAACGTG
CTTGCGCGGTTGCCGACCGTACCGGTCATGCGATGTTGCATACGTTGTATCAACAAAACGTCCGTGTCAATACGCAATTC
TTTGTGGAATGGACGGCACAAGATTTGATTCGTGATGAAAACGGCGATGTCGTCGGCGTAACCGCCATGGAAATGGAAAC
CGGCGAAGTTTATATTTTCCACGCTAAAGCTGTGATGTTTGCTACCGGCGGCGGCGGCCGTATTTATGCGTCTTCTACCA
ATGCCTATATGAATACCGGCGATGGTTTGGGTATTTGCGCGCGTGCAGGTATCCCGTTGGAAGACATGGAATTCTGGCAA
TTCCACCCGACCGGCGTGGCAGGTGCGGGCGTGTTGATTACCGAAGGCGTACGCGGCGAGGGCGGTATTCTGTTGAATGC
CGACAGCGAACGCTTTATGGAACGCTATGCGCCGACCGTAAAAGACTTGGCTTCTCGCGACGTTGTTTCCCGCGCGATGG
CGATGGAAATCTACGAAGGTCGCGGCTGCGGTAAAAACAAAGACCATGTCTTACTGAAAATCGACCATATCGGCGCAGAA
AAAATTATGGAAAAACTGCCGGGCATCCGCGAGATTTCCATTCAGTTCGCCGGTATCGATCCGATTAAAGACCCGATTCC
TGTTGTGCCGACTACCCACTATATGATGGGCGGCATTCCGACCAATTACCAAGGCGAAGTCGTTGTGCCGCAAGGAGACG
AATACGAAGTGCCTGTAAAAGGCCTGTATGCCGCAGGTGAGTGCGCCTGTGCTTCCGTACACGGTGCGAACCGTTTGGGT
ACGAACTCTCTGCTGGACTTGGTGGTGTTCGGTAAAGCTGCCGGCGACAGCATGATTAAATTCATCAAAGAGCAAAGCGA
CTGGAAACCTTTGCCTGCGGATGCGGGCGAGCTGACCCGCCAACGTATCGAGCGTTTGGACAATCAAACTGATGGCGAAA
ACGTTGATGCATTGCGCCGCGAACTGCAACGCTCTGTACAACTGCACGCCGGCGTGTTCCGTACTGATGAGATTCTGAGC
AAAGGCGTTCGAGAAGTCATGGCGATTGCCGAGCGTGTGAAACGTACCGAAATCAAAGACAAGAGCAAAGTGTGGAATAC
CGCGCGTATCGAGGCTTTGGAATTGGATAACCTGATTGAAGTGGCGAAAGCGACTTTGGTGTCTGCCGAAGCACGTAAAG
AATCACGCGGTGCGCACGCTTCAGACGACCATCCTGAGCGCGATGATGAAAACTGGATGAAACATACGCTGTACCATTCA
GATATCAATACCTTGTCCTACAAACCGGTGCACACCAAGCCTTTGAGCGTGGAATACATCAAACCGGCCAAGCGCGTTTA
TTGA

Upstream 100 bases:

>100_bases
ATATCAAACCCTTCGGCGTGCGTTTGTTTTTGCAGGTTGCCACCATCGTTTGGCTGGTCGGCTGTCTCGTGTATTCAGTT
AAAGTGATTTGGGGGTAAGT

Downstream 100 bases:

>100_bases
TGCGTTTTCAGACGGTCTTCGCCTCAAAGGTCGTCTGAAATCTAACCATACCCACATTGAACTGCTTGAATTTATAATAC
AAAATCATTGGGCAGTTGAT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MGFPVRKFDAVIVGGGGAGLRAALQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNVQEDRWDWHMYDTVKGSDWLG
DQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFGGHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRVNTQF
FVEWTAQDLIRDENGDVVGVTAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ
FHPTGVAGAGVLITEGVRGEGGILLNADSERFMERYAPTVKDLASRDVVSRAMAMEIYEGRGCGKNKDHVLLKIDHIGAE
KIMEKLPGIREISIQFAGIDPIKDPIPVVPTTHYMMGGIPTNYQGEVVVPQGDEYEVPVKGLYAAGECACASVHGANRLG
TNSLLDLVVFGKAAGDSMIKFIKEQSDWKPLPADAGELTRQRIERLDNQTDGENVDALRRELQRSVQLHAGVFRTDEILS
KGVREVMAIAERVKRTEIKDKSKVWNTARIEALELDNLIEVAKATLVSAEARKESRGAHASDDHPERDDENWMKHTLYHS
DINTLSYKPVHTKPLSVEYIKPAKRVY

Sequences:

>Translated_587_residues
MGFPVRKFDAVIVGGGGAGLRAALQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNVQEDRWDWHMYDTVKGSDWLG
DQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFGGHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRVNTQF
FVEWTAQDLIRDENGDVVGVTAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ
FHPTGVAGAGVLITEGVRGEGGILLNADSERFMERYAPTVKDLASRDVVSRAMAMEIYEGRGCGKNKDHVLLKIDHIGAE
KIMEKLPGIREISIQFAGIDPIKDPIPVVPTTHYMMGGIPTNYQGEVVVPQGDEYEVPVKGLYAAGECACASVHGANRLG
TNSLLDLVVFGKAAGDSMIKFIKEQSDWKPLPADAGELTRQRIERLDNQTDGENVDALRRELQRSVQLHAGVFRTDEILS
KGVREVMAIAERVKRTEIKDKSKVWNTARIEALELDNLIEVAKATLVSAEARKESRGAHASDDHPERDDENWMKHTLYHS
DINTLSYKPVHTKPLSVEYIKPAKRVY
>Mature_586_residues
GFPVRKFDAVIVGGGGAGLRAALQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNVQEDRWDWHMYDTVKGSDWLGD
QDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFGGHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRVNTQFF
VEWTAQDLIRDENGDVVGVTAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQF
HPTGVAGAGVLITEGVRGEGGILLNADSERFMERYAPTVKDLASRDVVSRAMAMEIYEGRGCGKNKDHVLLKIDHIGAEK
IMEKLPGIREISIQFAGIDPIKDPIPVVPTTHYMMGGIPTNYQGEVVVPQGDEYEVPVKGLYAAGECACASVHGANRLGT
NSLLDLVVFGKAAGDSMIKFIKEQSDWKPLPADAGELTRQRIERLDNQTDGENVDALRRELQRSVQLHAGVFRTDEILSK
GVREVMAIAERVKRTEIKDKSKVWNTARIEALELDNLIEVAKATLVSAEARKESRGAHASDDHPERDDENWMKHTLYHSD
INTLSYKPVHTKPLSVEYIKPAKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=587, Percent_Identity=51.7887563884157, Blast_Score=597, Evalue=1e-171,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=56.2925170068027, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=573, Percent_Identity=40.1396160558464, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1788928, Length=557, Percent_Identity=32.1364452423698, Blast_Score=221, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17550100, Length=590, Percent_Identity=51.864406779661, Blast_Score=590, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17505833, Length=590, Percent_Identity=50.6779661016949, Blast_Score=580, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI71986328, Length=458, Percent_Identity=25.764192139738, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322701, Length=592, Percent_Identity=53.0405405405405, Blast_Score=614, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6322416, Length=577, Percent_Identity=53.7261698440208, Blast_Score=605, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=28.0163599182004, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322511, Length=492, Percent_Identity=25.2032520325203, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137288, Length=612, Percent_Identity=51.9607843137255, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24655642, Length=612, Percent_Identity=51.9607843137255, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24655647, Length=612, Percent_Identity=51.9607843137255, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24663005, Length=608, Percent_Identity=49.0131578947368, Blast_Score=543, Evalue=1e-154,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64553; Mature: 64422

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFPVRKFDAVIVGGGGAGLRAALQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNV
CCCCCCEECEEEECCCCHHHHHHHHHHCCCCCEEEHHHHCCCCCCEEEECCCCCCCCCCC
QEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHHEEHHHCCCCHHHCCCCCEEECCCC
GHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRVNTQFFVEWTAQDLIRDENGDVVGV
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEECEEEEEEEEHHHHHCCCCCCEEEE
TAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCCCHHEE
FHPTGVAGAGVLITEGVRGEGGILLNADSERFMERYAPTVKDLASRDVVSRAMAMEIYEG
ECCCCCCCCCEEEECCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
RGCGKNKDHVLLKIDHIGAEKIMEKLPGIREISIQFAGIDPIKDPIPVVPTTHYMMGGIP
CCCCCCCCEEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCHHHCCCCC
TNYQGEVVVPQGDEYEVPVKGLYAAGECACASVHGANRLGTNSLLDLVVFGKAAGDSMIK
CCCCCCEEECCCCCCCCCHHHEEECCCEEEEECCCCCCCCCHHHEEHHEECCCCCHHHHH
FIKEQSDWKPLPADAGELTRQRIERLDNQTDGENVDALRRELQRSVQLHAGVFRTDEILS
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
KGVREVMAIAERVKRTEIKDKSKVWNTARIEALELDNLIEVAKATLVSAEARKESRGAHA
HHHHHHHHHHHHHHHHHCCHHHHHCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDDHPERDDENWMKHTLYHSDINTLSYKPVHTKPLSVEYIKPAKRVY
CCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCEEHEECCHHHCC
>Mature Secondary Structure 
GFPVRKFDAVIVGGGGAGLRAALQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNV
CCCCCEECEEEECCCCHHHHHHHHHHCCCCCEEEHHHHCCCCCCEEEECCCCCCCCCCC
QEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHHEEHHHCCCCHHHCCCCCEEECCCC
GHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRVNTQFFVEWTAQDLIRDENGDVVGV
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEECEEEEEEEEHHHHHCCCCCCEEEE
TAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCCCHHEE
FHPTGVAGAGVLITEGVRGEGGILLNADSERFMERYAPTVKDLASRDVVSRAMAMEIYEG
ECCCCCCCCCEEEECCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
RGCGKNKDHVLLKIDHIGAEKIMEKLPGIREISIQFAGIDPIKDPIPVVPTTHYMMGGIP
CCCCCCCCEEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCHHHCCCCC
TNYQGEVVVPQGDEYEVPVKGLYAAGECACASVHGANRLGTNSLLDLVVFGKAAGDSMIK
CCCCCCEEECCCCCCCCCHHHEEECCCEEEEECCCCCCCCCHHHEEHHEECCCCCHHHHH
FIKEQSDWKPLPADAGELTRQRIERLDNQTDGENVDALRRELQRSVQLHAGVFRTDEILS
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
KGVREVMAIAERVKRTEIKDKSKVWNTARIEALELDNLIEVAKATLVSAEARKESRGAHA
HHHHHHHHHHHHHHHHHCCHHHHHCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDDHPERDDENWMKHTLYHSDINTLSYKPVHTKPLSVEYIKPAKRVY
CCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCEEHEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA