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The map label for this gene is cpxR [H]

Identifier: 161869527

GI number: 161869527

Start: 566295

End: 566972

Strand: Reverse

Name: cpxR [H]

Synonym: NMCC_0541

Alternate gene names: 161869527

Gene position: 566972-566295 (Counterclockwise)

Preceding gene: 161869528

Following gene: 161869526

Centisome position: 26.33

GC content: 56.64

Gene sequence:

>678_bases
ATGAGCCGCGTATTACTCGTAGATGACGATGCCCTGCTAACCGAACTGCTGACCGAATACCTGAGCGCCGAAGGTCTGAA
CGTCCGCAGCGTTCCCGACGGGGAAGCAGGCGTACAGGAAATCCTGAGCGGGCAGTACGATGTAGTCGTATTGGATTCCA
TGATGCCCAAAATGAACGGCTTGGATGTCTTGAAAAACGTACGCGCCCGAAGCACCGTCCCCATCATCATGCTGACCGCC
AAAGGCGACGACATCGACCGAATCATCGGCTTGGAAATGGGCGCGGACGACTATGTCCCCAAACCCTGCACACCACGCGA
ACTCTTGGCACGCATCAATGCCATCCTGCGCCGCGCACAACACAGCGGCGAACAGAACAACGCACCCAACAGCATCTCCG
TCAGCGATGTCGTCCTGTACCCCGCCAAACGCCAGGCATCCGTCAAAGACATGCCGCTCGAACTGACCAGCACCGAATTC
AACCTGCTCGAAGTCCTGATGCGCCATGCCGGACAGGTAGTCAGCAAAGAAACCCTGTCCGTCGAAGCACTCGACCGCAA
GCTGGCAAAATTCGACCGCAGTATCGACGTACACATCTCCAGCATCCGCCACAAGTTGGGCGATGCCTCTCTGATTCAAA
CCGTACGCGGCTTGGGCTACCTGTTTGTCAAAAACTGA

Upstream 100 bases:

>100_bases
TCAAAAAACATTGCAGCCGTGTTAAGATAAACCGTCAAACAATCTTTTCACGCCCCGCCCGAAACAGGGTCGGGGCATAC
CCTTACGAAAAGGAAACACC

Downstream 100 bases:

>100_bases
AATAAACAGATAAATGAAACTGTTCCAACGCATCTTCGCCACATTTTGCGCGGTTATCGTCTGTGCAATCTTTGTGGCGA
GTTTTTCTTTTTGGCTGGTG

Product: two-component system regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSRVLLVDDDALLTELLTEYLSAEGLNVRSVPDGEAGVQEILSGQYDVVVLDSMMPKMNGLDVLKNVRARSTVPIIMLTA
KGDDIDRIIGLEMGADDYVPKPCTPRELLARINAILRRAQHSGEQNNAPNSISVSDVVLYPAKRQASVKDMPLELTSTEF
NLLEVLMRHAGQVVSKETLSVEALDRKLAKFDRSIDVHISSIRHKLGDASLIQTVRGLGYLFVKN

Sequences:

>Translated_225_residues
MSRVLLVDDDALLTELLTEYLSAEGLNVRSVPDGEAGVQEILSGQYDVVVLDSMMPKMNGLDVLKNVRARSTVPIIMLTA
KGDDIDRIIGLEMGADDYVPKPCTPRELLARINAILRRAQHSGEQNNAPNSISVSDVVLYPAKRQASVKDMPLELTSTEF
NLLEVLMRHAGQVVSKETLSVEALDRKLAKFDRSIDVHISSIRHKLGDASLIQTVRGLGYLFVKN
>Mature_224_residues
SRVLLVDDDALLTELLTEYLSAEGLNVRSVPDGEAGVQEILSGQYDVVVLDSMMPKMNGLDVLKNVRARSTVPIIMLTAK
GDDIDRIIGLEMGADDYVPKPCTPRELLARINAILRRAQHSGEQNNAPNSISVSDVVLYPAKRQASVKDMPLELTSTEFN
LLEVLMRHAGQVVSKETLSVEALDRKLAKFDRSIDVHISSIRHKLGDASLIQTVRGLGYLFVKN

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=50, Blast_Score=204, Evalue=5e-54,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=41.8103448275862, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=36.7256637168142, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=34.9557522123894, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=36.6071428571429, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=35.2678571428571, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=37.0535714285714, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=34.5291479820628, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=33.7777777777778, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=34.9557522123894, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=32.618025751073, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=30.2631578947368, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=32.5892857142857, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=31.304347826087, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=32.5, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=28.6764705882353, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=31.6666666666667, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24780; Mature: 24649

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVLLVDDDALLTELLTEYLSAEGLNVRSVPDGEAGVQEILSGQYDVVVLDSMMPKMNG
CCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCC
LDVLKNVRARSTVPIIMLTAKGDDIDRIIGLEMGADDYVPKPCTPRELLARINAILRRAQ
HHHHHHHHHCCCCCEEEEEECCCCHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
HSGEQNNAPNSISVSDVVLYPAKRQASVKDMPLELTSTEFNLLEVLMRHAGQVVSKETLS
HCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
VEALDRKLAKFDRSIDVHISSIRHKLGDASLIQTVRGLGYLFVKN
HHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEC
>Mature Secondary Structure 
SRVLLVDDDALLTELLTEYLSAEGLNVRSVPDGEAGVQEILSGQYDVVVLDSMMPKMNG
CCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCC
LDVLKNVRARSTVPIIMLTAKGDDIDRIIGLEMGADDYVPKPCTPRELLARINAILRRAQ
HHHHHHHHHCCCCCEEEEEECCCCHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
HSGEQNNAPNSISVSDVVLYPAKRQASVKDMPLELTSTEFNLLEVLMRHAGQVVSKETLS
HCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
VEALDRKLAKFDRSIDVHISSIRHKLGDASLIQTVRGLGYLFVKN
HHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]