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The map label for this gene is cpxA [H]

Identifier: 161869526

GI number: 161869526

Start: 564875

End: 566281

Strand: Reverse

Name: cpxA [H]

Synonym: NMCC_0540

Alternate gene names: 161869526

Gene position: 566281-564875 (Counterclockwise)

Preceding gene: 161869527

Following gene: 161869525

Centisome position: 26.3

GC content: 53.52

Gene sequence:

>1407_bases
ATGAAACTGTTCCAACGCATCTTCGCCACATTTTGCGCGGTTATCGTCTGTGCAATCTTTGTGGCGAGTTTTTCTTTTTG
GCTGGTGCAGAACACCCTTGCCGAAAACCAGTTCAACCAACGCCGCACCATCGAAACCACTTTGATGGGCAGCATCATTT
CCGCATTCCGGGCACGCGGGGACGCGGGCGCGCGCGAAATCCTGACGGAATGGAAAGACAGCCCCGTCTCATCGGGCGTG
TACGTTATACAGGGCGACGAGAAAAAAGATATCCTGAACCGGTATATCGACAGCTACACCATCGAACGCGCCCGGCTTTT
CGCCGCCGGACACCCGCATTCCAACCTCGTCCATATCGAATACGACCGCTTCGGCGAAGAATACCTGTTCTTCACCAAAG
ACTGGGACAAACTCCAAGCCCGCCGCCTGCCCAGCCCCCTGTTGATCCCCGGTCTGCCGCTCGCCCCGATTTGGCACGAA
CTCATCATATTGTCCTTCATCATCATCGTCGGACTGCTGATGGCGTACATCCTCGCCGGCAACATTGCCAAACCCATCAG
AATCTTAGGCAACGGCATGGACAGGGTGGCAAACGGAGAACTTGAAACCCGTATCTCCCAACAGGTCGACGACCGCGACG
ACGAATTGTCCCATCTTGCCATCCAATTCGACAAAATGGTGGAAAAACTCGAAAAACTCGTTGCCAAAGAACGCCACCTG
CTCCATCACGTCTCCCATGAAATGCGTTCTCCCCTTGCGCGCATGCAGGCAATTGTCGGACTGATTCAGGCGCAGCCCCA
AAAACAGGAGCAATATCTCAAACGGCTGGAAGGCGAACTGACCCGCATGGATACGCTGGCCGGGGAACTGTTAACCCTGT
CCCGTCTCGAAACTTCCAATATGGCTTTGGAAAAAGAAAGCCTGAAACTCCTGCCCTTCCTGGGCAACCTGGTAGAAGAC
AATCAAAGCATTGCCCAGAAAAACGGACAAACGGTTACCCTGTCTGCCGACGGAAAAATCCCCGAAAACACAACCATCCT
TGCCAACGAAAGCTACCTGTACCGCGCCTTCGACAACGTCATCCGCAACGCCGTCAACTACAGTCCCGAAGGCAGCACCA
TCCTGATCAACATCGGACAAGACCACAAACACTGGATAATCGACGTTACCGACAACGGCCCCGGCGTGGACGAAATGCAG
CTCCCGCACATCTTCACCGCTTTCTACCGTGCAGACTCCAGTGCGAACAAACCCGGAACAGGACTGGGGCTTGCATTGAC
CCAACATATTATTGAACAGCACTGCGGAAAAATCATCGCCGAAAACATCAAACCAAACGGTCTGCGGATGCGCTTCATCC
TGCCCAAGAAAAAAACCGGTTCCAAAACAGAAAAAAGTGCGAACTGA

Upstream 100 bases:

>100_bases
CACATCTCCAGCATCCGCCACAAGTTGGGCGATGCCTCTCTGATTCAAACCGTACGCGGCTTGGGCTACCTGTTTGTCAA
AAACTGAAATAAACAGATAA

Downstream 100 bases:

>100_bases
CCATAATGCCGTCTGAACCGGCTTCAGACGGCATTGCACAAACAGTTACCCCAAAACAAACACACAGCGGGTGCATCTCC
AAAAATCACGCACATACCGT

Product: two-component system sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKLFQRIFATFCAVIVCAIFVASFSFWLVQNTLAENQFNQRRTIETTLMGSIISAFRARGDAGAREILTEWKDSPVSSGV
YVIQGDEKKDILNRYIDSYTIERARLFAAGHPHSNLVHIEYDRFGEEYLFFTKDWDKLQARRLPSPLLIPGLPLAPIWHE
LIILSFIIIVGLLMAYILAGNIAKPIRILGNGMDRVANGELETRISQQVDDRDDELSHLAIQFDKMVEKLEKLVAKERHL
LHHVSHEMRSPLARMQAIVGLIQAQPQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSNMALEKESLKLLPFLGNLVED
NQSIAQKNGQTVTLSADGKIPENTTILANESYLYRAFDNVIRNAVNYSPEGSTILINIGQDHKHWIIDVTDNGPGVDEMQ
LPHIFTAFYRADSSANKPGTGLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKTEKSAN

Sequences:

>Translated_468_residues
MKLFQRIFATFCAVIVCAIFVASFSFWLVQNTLAENQFNQRRTIETTLMGSIISAFRARGDAGAREILTEWKDSPVSSGV
YVIQGDEKKDILNRYIDSYTIERARLFAAGHPHSNLVHIEYDRFGEEYLFFTKDWDKLQARRLPSPLLIPGLPLAPIWHE
LIILSFIIIVGLLMAYILAGNIAKPIRILGNGMDRVANGELETRISQQVDDRDDELSHLAIQFDKMVEKLEKLVAKERHL
LHHVSHEMRSPLARMQAIVGLIQAQPQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSNMALEKESLKLLPFLGNLVED
NQSIAQKNGQTVTLSADGKIPENTTILANESYLYRAFDNVIRNAVNYSPEGSTILINIGQDHKHWIIDVTDNGPGVDEMQ
LPHIFTAFYRADSSANKPGTGLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKTEKSAN
>Mature_468_residues
MKLFQRIFATFCAVIVCAIFVASFSFWLVQNTLAENQFNQRRTIETTLMGSIISAFRARGDAGAREILTEWKDSPVSSGV
YVIQGDEKKDILNRYIDSYTIERARLFAAGHPHSNLVHIEYDRFGEEYLFFTKDWDKLQARRLPSPLLIPGLPLAPIWHE
LIILSFIIIVGLLMAYILAGNIAKPIRILGNGMDRVANGELETRISQQVDDRDDELSHLAIQFDKMVEKLEKLVAKERHL
LHHVSHEMRSPLARMQAIVGLIQAQPQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSNMALEKESLKLLPFLGNLVED
NQSIAQKNGQTVTLSADGKIPENTTILANESYLYRAFDNVIRNAVNYSPEGSTILINIGQDHKHWIIDVTDNGPGVDEMQ
LPHIFTAFYRADSSANKPGTGLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKTEKSAN

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=32.4817518248175, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=28.8808664259928, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=30.8016877637131, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786783, Length=296, Percent_Identity=26.6891891891892, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787894, Length=263, Percent_Identity=25.0950570342205, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=23, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=29.1479820627803, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787374, Length=250, Percent_Identity=24.8, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=306, Percent_Identity=26.1437908496732, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788279, Length=247, Percent_Identity=27.1255060728745, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789149, Length=329, Percent_Identity=22.1884498480243, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=316, Percent_Identity=26.2658227848101, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=24.0174672489083, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789808, Length=247, Percent_Identity=24.6963562753036, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081816, Length=269, Percent_Identity=23.0483271375465, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87082128, Length=309, Percent_Identity=23.3009708737864, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=20.703125, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=29.6943231441048, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52783; Mature: 52783

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFQRIFATFCAVIVCAIFVASFSFWLVQNTLAENQFNQRRTIETTLMGSIISAFRARG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAGAREILTEWKDSPVSSGVYVIQGDEKKDILNRYIDSYTIERARLFAAGHPHSNLVHIE
CCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEE
YDRFGEEYLFFTKDWDKLQARRLPSPLLIPGLPLAPIWHELIILSFIIIVGLLMAYILAG
CCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
NIAKPIRILGNGMDRVANGELETRISQQVDDRDDELSHLAIQFDKMVEKLEKLVAKERHL
CCHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHHVSHEMRSPLARMQAIVGLIQAQPQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSN
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MALEKESLKLLPFLGNLVEDNQSIAQKNGQTVTLSADGKIPENTTILANESYLYRAFDNV
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHH
IRNAVNYSPEGSTILINIGQDHKHWIIDVTDNGPGVDEMQLPHIFTAFYRADSSANKPGT
HHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
GLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKTEKSAN
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKLFQRIFATFCAVIVCAIFVASFSFWLVQNTLAENQFNQRRTIETTLMGSIISAFRARG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAGAREILTEWKDSPVSSGVYVIQGDEKKDILNRYIDSYTIERARLFAAGHPHSNLVHIE
CCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEE
YDRFGEEYLFFTKDWDKLQARRLPSPLLIPGLPLAPIWHELIILSFIIIVGLLMAYILAG
CCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
NIAKPIRILGNGMDRVANGELETRISQQVDDRDDELSHLAIQFDKMVEKLEKLVAKERHL
CCHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHHVSHEMRSPLARMQAIVGLIQAQPQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSN
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MALEKESLKLLPFLGNLVEDNQSIAQKNGQTVTLSADGKIPENTTILANESYLYRAFDNV
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHH
IRNAVNYSPEGSTILINIGQDHKHWIIDVTDNGPGVDEMQLPHIFTAFYRADSSANKPGT
HHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
GLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKTEKSAN
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]