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The map label for this gene is gcvH [H]

Identifier: 161869508

GI number: 161869508

Start: 542163

End: 542549

Strand: Direct

Name: gcvH [H]

Synonym: NMCC_0521

Alternate gene names: 161869508

Gene position: 542163-542549 (Clockwise)

Preceding gene: 161869507

Following gene: 161869509

Centisome position: 25.18

GC content: 56.33

Gene sequence:

>387_bases
ATGAGCAACAACATCCCGGCCGAACTGAAATACGTTGCCAGCCATGAATGGCTGCGCCTTGAAGAAGACGGTACGATTAC
CGTCGGCATTACCCACCACGCGCAAGAGCTGTTGGGCGACATCGTGTTCGTCGAGCTGCCCGAAGTCGGCGCGAACCTTG
CCGCTGAAGAGCAAGCCGGTGTGGTTGAGTCTGTAAAAGCCGCGTCCGACGTGTACGCACCGATTGCAGGCGAAGTCGTT
GCCGTCAACGATGACTTACCCAGTGCACCTGAAACTGCCAACAGCGACCCTTACGGCGCAGGCTGGTTCTTCAAAATCAA
ACCTGCCAATCCTGCCGATTACGACGGTCTGCTGACTGCCGAACAATACGCGGGCGAAGTAGATTAA

Upstream 100 bases:

>100_bases
CGATACGGACGTTTGTAGAAAGCATTGAACAAGGCATCTGTGGATATTGATTCATGCAGATGCCGTCTGAAAATAACCCC
TATCAATGGAGTATCAAACC

Downstream 100 bases:

>100_bases
ACCGCCCGGCTGCCCGACGGCAACCGCCGGACAAACGGAAACTGCACCTTCAGACGGCATTTTTGCGGTCGGAGGTGCAG
TTTTTTGTCCGTGTTTTAAG

Product: glycine cleavage system protein H

Products: H-protein-S-aminomethyldihydrolipoyllysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 128; Mature: 127

Protein sequence:

>128_residues
MSNNIPAELKYVASHEWLRLEEDGTITVGITHHAQELLGDIVFVELPEVGANLAAEEQAGVVESVKAASDVYAPIAGEVV
AVNDDLPSAPETANSDPYGAGWFFKIKPANPADYDGLLTAEQYAGEVD

Sequences:

>Translated_128_residues
MSNNIPAELKYVASHEWLRLEEDGTITVGITHHAQELLGDIVFVELPEVGANLAAEEQAGVVESVKAASDVYAPIAGEVV
AVNDDLPSAPETANSDPYGAGWFFKIKPANPADYDGLLTAEQYAGEVD
>Mature_127_residues
SNNIPAELKYVASHEWLRLEEDGTITVGITHHAQELLGDIVFVELPEVGANLAAEEQAGVVESVKAASDVYAPIAGEVVA
VNDDLPSAPETANSDPYGAGWFFKIKPANPADYDGLLTAEQYAGEVD

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein [H]

COG id: COG0509

COG function: function code E; Glycine cleavage system H protein (lipoate-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI49574537, Length=114, Percent_Identity=43.859649122807, Blast_Score=105, Evalue=8e-24,
Organism=Homo sapiens, GI89057342, Length=114, Percent_Identity=42.9824561403509, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1789271, Length=121, Percent_Identity=61.9834710743802, Blast_Score=160, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17507493, Length=114, Percent_Identity=46.4912280701754, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17551294, Length=113, Percent_Identity=42.4778761061947, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319272, Length=125, Percent_Identity=41.6, Blast_Score=104, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17865652, Length=123, Percent_Identity=39.8373983739837, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002930
- InterPro:   IPR017453
- InterPro:   IPR011053 [H]

Pfam domain/function: PF01597 GCV_H [H]

EC number: 1.4.4.2

Molecular weight: Translated: 13597; Mature: 13466

Theoretical pI: Translated: 3.78; Mature: 3.78

Prosite motif: PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNIPAELKYVASHEWLRLEEDGTITVGITHHAQELLGDIVFVELPEVGANLAAEEQAG
CCCCCCCEEEEECCCCEEEECCCCEEEEEECHHHHHHHHCEEEEECCCCCCCCCCCCCCC
VVESVKAASDVYAPIAGEVVAVNDDLPSAPETANSDPYGAGWFFKIKPANPADYDGLLTA
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEH
EQYAGEVD
HHCCCCCC
>Mature Secondary Structure 
SNNIPAELKYVASHEWLRLEEDGTITVGITHHAQELLGDIVFVELPEVGANLAAEEQAG
CCCCCCEEEEECCCCEEEECCCCEEEEEECHHHHHHHHCEEEEECCCCCCCCCCCCCCC
VVESVKAASDVYAPIAGEVVAVNDDLPSAPETANSDPYGAGWFFKIKPANPADYDGLLTA
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEH
EQYAGEVD
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycine; H-protein-lipoyllysine

Specific reaction: glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA