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The map label for this gene is hemA [H]

Identifier: 161869509

GI number: 161869509

Start: 542701

End: 543948

Strand: Direct

Name: hemA [H]

Synonym: NMCC_0522

Alternate gene names: 161869509

Gene position: 542701-543948 (Clockwise)

Preceding gene: 161869508

Following gene: 161869510

Centisome position: 25.2

GC content: 53.61

Gene sequence:

>1248_bases
ATGCAACTTACCGCTGTCGGACTCAATCATCAAACCGCACCTTTAAGCATACGGGAAAAGCTGGCGTTTGCCGCGGCCTG
CCTGCCCGAAGCCGTCCGCAATCTTGCCCGAAGCAATGCGGCAACGGAGGCGGTAATCCTTTCTACCTGCAACCGCACCG
AGCTTTACTGTGTAGGCGATTCGGAAGAAATCATCCGTTGGCTCGCAGACTATCACAGCCTTCCCATAGAAGAAATCAGC
CCCTACCTTTATACTTTGGGGATGCAGGAGACTGTGCGCCATGCTTTCCGCGTCGCCTGCGGCTTGGATTCGATGGTGTT
GGGCGAGCCGCAGATTTTAGGACAGATTAAGGATGCGGTCAGGGTTGCTCAAGAGCAGGAAAGTATGGGTAAGAAACTCA
ATGCCCTGTTCCAAAAAACCTTTTCCGTTGCTAAAGAGATCCGTACCGATACCGCTGTCGGCGAGAACTCGGTTTCCATG
GCTTCCGCTTCCGTCAAGTTGGCAGAGCAGATTTTCCCCGACATCGGCGATTTGAATGTCTTGTTTATCGGTGCGGGTGA
GATGATTGAGCTGGTTGCCACTTATTTTGCCGCCAAAAGTCCCCGGCTGATGACGGTTGCCAACCGGACGCTGGCGCGTG
CACAGGAGTTGTGCGACAAGCTCGGTGTCAACGCCGAACCGTGCCTGCTGTCCGATCTGCCTGCCATTTTGCATGAGTAC
GACGTGGTGGTTTCTTCAACGGCAAGCCAGTTGCCCATTGTCGGCAAAGGTATGGTGGAGCGCGCATTGAAACAAAGGCA
GAGTATGCCGTTGTTTATGCTTGACTTGGCCGTGCCGCGAGACATTGAGGCGGAAGTCGGAGATTTGAACGATGCCTATC
TTTATACGGTGGACGATATGGTCAATATCGTCCAAAGCGGCAAGGAGGCAAGGCAGAAGGCCGCCGCCGCCGCCGAAACG
CTGGTGTCCGAGAAGGTTGCCGAATTTGTCAGGCAGCAGCAGGGCAGGCAGAGTGTCCCGTTAATCAGGGCATTGAGGGA
TGAGGGAGAGAAAGCGCGCAAACAGGTCTTGGAAAATGCGATGAAACAGCTTGCCAAAGGCGCAACGGCAGAAGAGGTTT
TGGAAAGGCTGTCGATCCAACTGACCAACAAGCTGCTGCATTCGCCGACCCAAACTTTGAATAAGGCGGGGGAAGAAGAT
AAAGATTTGGTTCATGCCGTCGCGCAGATTTATCATTTGGACAAATAA

Upstream 100 bases:

>100_bases
AGACGGCATTTTTGCGGTCGGAGGTGCAGTTTTTTGTCCGTGTTTTAAGGAAGCAGTTAGGCTATAATAACGGTCTATAT
TCATCTTTACCGATTTTTTC

Downstream 100 bases:

>100_bases
CGGTGCGCCGGGAAAAATGCCGTCTGAAGAGGTTTCAGACGGCATTTTTTTGTGCCGTCTGACAACATCGTGAAATCCCA
CATTATATCGATGTAATCAC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MQLTAVGLNHQTAPLSIREKLAFAAACLPEAVRNLARSNAATEAVILSTCNRTELYCVGDSEEIIRWLADYHSLPIEEIS
PYLYTLGMQETVRHAFRVACGLDSMVLGEPQILGQIKDAVRVAQEQESMGKKLNALFQKTFSVAKEIRTDTAVGENSVSM
ASASVKLAEQIFPDIGDLNVLFIGAGEMIELVATYFAAKSPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHEY
DVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDMVNIVQSGKEARQKAAAAAET
LVSEKVAEFVRQQQGRQSVPLIRALRDEGEKARKQVLENAMKQLAKGATAEEVLERLSIQLTNKLLHSPTQTLNKAGEED
KDLVHAVAQIYHLDK

Sequences:

>Translated_415_residues
MQLTAVGLNHQTAPLSIREKLAFAAACLPEAVRNLARSNAATEAVILSTCNRTELYCVGDSEEIIRWLADYHSLPIEEIS
PYLYTLGMQETVRHAFRVACGLDSMVLGEPQILGQIKDAVRVAQEQESMGKKLNALFQKTFSVAKEIRTDTAVGENSVSM
ASASVKLAEQIFPDIGDLNVLFIGAGEMIELVATYFAAKSPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHEY
DVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDMVNIVQSGKEARQKAAAAAET
LVSEKVAEFVRQQQGRQSVPLIRALRDEGEKARKQVLENAMKQLAKGATAEEVLERLSIQLTNKLLHSPTQTLNKAGEED
KDLVHAVAQIYHLDK
>Mature_415_residues
MQLTAVGLNHQTAPLSIREKLAFAAACLPEAVRNLARSNAATEAVILSTCNRTELYCVGDSEEIIRWLADYHSLPIEEIS
PYLYTLGMQETVRHAFRVACGLDSMVLGEPQILGQIKDAVRVAQEQESMGKKLNALFQKTFSVAKEIRTDTAVGENSVSM
ASASVKLAEQIFPDIGDLNVLFIGAGEMIELVATYFAAKSPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHEY
DVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDMVNIVQSGKEARQKAAAAAET
LVSEKVAEFVRQQQGRQSVPLIRALRDEGEKARKQVLENAMKQLAKGATAEEVLERLSIQLTNKLLHSPTQTLNKAGEED
KDLVHAVAQIYHLDK

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=404, Percent_Identity=44.5544554455446, Blast_Score=340, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 45487; Mature: 45487

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTAVGLNHQTAPLSIREKLAFAAACLPEAVRNLARSNAATEAVILSTCNRTELYCVGD
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECC
SEEIIRWLADYHSLPIEEISPYLYTLGMQETVRHAFRVACGLDSMVLGEPQILGQIKDAV
HHHHHHHHHHHHCCCHHHHCHHHHHCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
RVAQEQESMGKKLNALFQKTFSVAKEIRTDTAVGENSVSMASASVKLAEQIFPDIGDLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
LFIGAGEMIELVATYFAAKSPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHEY
EEECCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDM
HHHHHCCHHCCCCCCHHHHHHHHHHHHCCCEEEEHHCCCCCCCHHHCCCCCCEEEEHHHH
VNIVQSGKEARQKAAAAAETLVSEKVAEFVRQQQGRQSVPLIRALRDEGEKARKQVLENA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHH
MKQLAKGATAEEVLERLSIQLTNKLLHSPTQTLNKAGEEDKDLVHAVAQIYHLDK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLTAVGLNHQTAPLSIREKLAFAAACLPEAVRNLARSNAATEAVILSTCNRTELYCVGD
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECC
SEEIIRWLADYHSLPIEEISPYLYTLGMQETVRHAFRVACGLDSMVLGEPQILGQIKDAV
HHHHHHHHHHHHCCCHHHHCHHHHHCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
RVAQEQESMGKKLNALFQKTFSVAKEIRTDTAVGENSVSMASASVKLAEQIFPDIGDLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
LFIGAGEMIELVATYFAAKSPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHEY
EEECCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDM
HHHHHCCHHCCCCCCHHHHHHHHHHHHCCCEEEEHHCCCCCCCHHHCCCCCCEEEEHHHH
VNIVQSGKEARQKAAAAAETLVSEKVAEFVRQQQGRQSVPLIRALRDEGEKARKQVLENA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHH
MKQLAKGATAEEVLERLSIQLTNKLLHSPTQTLNKAGEEDKDLVHAVAQIYHLDK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9811666 [H]