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The map label for this gene is gyrB [H]

Identifier: 161723181

GI number: 161723181

Start: 3693412

End: 3695880

Strand: Direct

Name: gyrB [H]

Synonym: BTH_I3241

Alternate gene names: 161723181

Gene position: 3693412-3695880 (Clockwise)

Preceding gene: 83720585

Following gene: 83720538

Centisome position: 96.96

GC content: 64.32

Gene sequence:

>2469_bases
ATGACTGAACAGCACAATTCGCAGCCCGAAAATAGCTACGGCGCGTCGTCGATCCAGATCCTCGAAGGCCTGGAAGCGGT
GCGCAAGCGACCCGGGATGTACATCGGCGACACGTCGGACGGCACCGGTCTGCACCACCTCGTGTTCGAGGTGCTCGACA
ACTCGATCGACGAAGCGCTTGCCGGCTACTGCAACGACATCCACGTGACCATTCACGCGGACAATTCGATCTCCGTGACC
GACAACGGCCGCGGCATCCCGACCGACGTCAAGCTCAACGACAAGCACGAACCGAAGCGCTCGGCCGCCGAGATCGTGAT
GACCGAGCTGCACGCGGGCGGCAAGTTCGACCAGAACAGCTACAAGGTGTCGGGCGGCCTGCACGGCGTCGGCGTATCGT
GCGTGAACGCGCTCTCCAGCTGGCTGCGCCTCACCGTGCGCCGCGACGGCAAGAAGCACTTCATGGAATTCCATCGCGGC
ATCGCGCAGAACCGCGTGCTCGAGGAGCGCGACGGCGAGCAGGTGTCGCCGATGCAGGTGATCGGCGACACCGAGAACCG
CGGCACCGAAGTGCACTTCATGGCCGATTCGACGATCTTCGGCACCGTCGAATACCACTACGACATCCTCGCGAAACGCA
TCCGCGAGCTGTCGTTCCTGAACAACGGCGTGCGCATCCGCCTGACCGACCAGCGCTCCGGCAAGGAAGACGATTTCGCG
TTCGCGGGCGGCGTGAAGGGCTTCGTCGAGTACATCAACAAGACGAAGAGCGTGCTGCATCCGACGATCTTCCACATCAA
CGGCGAGAAGGACGGCGTCGGCGTGGAAGTGGCGATGCAGTGGAATGACAGCTACAACGAAAACGTGCTGTGCTTCACGA
ACAACATCCCGCAGCGCGACGGCGGCACGCACTTGACCGGCCTGCGCGCGGCGATGACGCGCGTGATCAACAAGTACATC
GCCGACAACGAAATCGCGAAGAAGGCAAAGGTCGAGACGAGCGGCGACGACATGCGCGAAGGGCTTTCGTGCGTGCTGTC
GGTGAAGGTGCCGGAGCCGAAGTTCAGCTCGCAGACGAAGGACAAGCTGGTTTCGTCCGAAGTGCGCGCGCCGGTGGAGG
AAGTGGTGGCGAAGGCGCTCGAGGAGTTCCTGCTCGAAACGCCGAACGACGCGAAGATCATCTGCGGCAAGATCGTCGAA
GCGGCGCGCGCGCGCGATGCCGCGCGCAAGGCGCGCGAGATGACGCGCCGCAAGGGCGTGCTCGACGGCGTGGGCCTGCC
GGGCAAGCTCGCGGATTGCCAGGAGAAGGACCCGGCGAAATCGGAGATCTACATCGTCGAGGGCGATTCGGCGGGCGGCT
CGGCGAAGCAAGGGCGCGACCGCAAGTTCCAGGCGATCCTGCCGCTGCGCGGCAAGGTGCTGAACGTGGAGAAGGCGCGC
TACGACAAGCTGCTGTCGTCCGAGCAGATCGTCACGCTCGTGACCGCGCTCGGCTGCGGGATCGGCAAGGACGACTACAA
CCTCGACAAGCTGCGCTACCACCGGATCATCATCATGACCGATGCGGACGTGGACGGCGCGCACATCCGCACGCTGCTGC
TGACGTTCTTCTACCGGCAGATGCCGGAGATGATCGAGCGCGGCTACGTGTACATCGCGCAGCCGCCGCTCTACAAGGTG
AAGGCTGGCCGCGACGAGCGCTACCTGAAGGACGACACCGAGCTGAACGCGCACATGCTGCGCCTCGCGCTGCAGGGCTC
GGAGCTCGTGCCGACCGAGAACGGCACACCGATCTCGGGCGACGCGCTCGGCGAGCTTGCGCGCTCGTATCTGCTCGCGC
GGGGCGTGGTGGAGCGGCTGAGCCGCCTGTACGACCCGGCCGCGCTCGAGGCGGTCATGGACGGCGTCGCGATCGATCTG
TCGAGCGAGGCGTCGACGGAGGCGTCGGCGAAGGCGCTGGCCGCCATGCTGTCCGACGATTCGAAGACCGAAGTGCGCGT
CGTGCCCGCTTACGATGCGGTGCGCGAGCAGCGCTCGCTGCGTGTCGAGCGCACGCATCACGGCAACGTGCGCGTATCGG
TGATCGACGAGGAGTTCCAGCACACGGCTGATTATCAGCAACTCGTAAACACCGCGAATACGTTCAAGGGTTTGATCGGC
GCGGGGGCGGCGATCAAGCGCGGCGAACGGAGCTCGAACGTGGCGGACTTCAAGGAAGCGATGAAGTGGCTGATGGCCGA
CGCCGAGCGGAACATGTCTAAGCAGCGGTATAAGGGGTTGGGCGAGATGAACCCCGAGCAGCTGTGGGAAACGACGATGG
ACCCGGCGGTGCGGCGGTTGCTGCGCGTGCAGATCGAGGATGCGATTGCGGCGGATGGGATCTTTACCACCCTCATGGGG
GACGAGGTCGAGCCGCGACGGGCGTTTATCGAGAATAATGCGTTGCGGGCGGGGAATATTGATGTTTGA

Upstream 100 bases:

>100_bases
GCCGGCCCCCGAAAGGGGCGAAAAACCCGAGGCGGCCCGGTTTTTTCGGCGGAAGCACCCCGCCGCCACTCGAGTAGCCC
AGCAGAACCGGAAGACACCC

Downstream 100 bases:

>100_bases
GGTTGTGTAGCGGGAACCATAATGTGAGATTTTGGGAAGCATCCATTGAGACATTTATTGGTGGATGCATTCCAATAGCT
CTAATGACGTCATCTAACTG

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 822; Mature: 821

Protein sequence:

>822_residues
MTEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISVT
DNGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKHFMEFHRG
IAQNRVLEERDGEQVSPMQVIGDTENRGTEVHFMADSTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDQRSGKEDDFA
FAGGVKGFVEYINKTKSVLHPTIFHINGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKYI
ADNEIAKKAKVETSGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVE
AARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
YDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPEMIERGYVYIAQPPLYKV
KAGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISGDALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDL
SSEASTEASAKALAAMLSDDSKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIG
AGAAIKRGERSSNVADFKEAMKWLMADAERNMSKQRYKGLGEMNPEQLWETTMDPAVRRLLRVQIEDAIAADGIFTTLMG
DEVEPRRAFIENNALRAGNIDV

Sequences:

>Translated_822_residues
MTEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISVT
DNGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKHFMEFHRG
IAQNRVLEERDGEQVSPMQVIGDTENRGTEVHFMADSTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDQRSGKEDDFA
FAGGVKGFVEYINKTKSVLHPTIFHINGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKYI
ADNEIAKKAKVETSGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVE
AARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
YDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPEMIERGYVYIAQPPLYKV
KAGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISGDALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDL
SSEASTEASAKALAAMLSDDSKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIG
AGAAIKRGERSSNVADFKEAMKWLMADAERNMSKQRYKGLGEMNPEQLWETTMDPAVRRLLRVQIEDAIAADGIFTTLMG
DEVEPRRAFIENNALRAGNIDV
>Mature_821_residues
TEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISVTD
NGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKHFMEFHRGI
AQNRVLEERDGEQVSPMQVIGDTENRGTEVHFMADSTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDQRSGKEDDFAF
AGGVKGFVEYINKTKSVLHPTIFHINGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKYIA
DNEIAKKAKVETSGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVEA
ARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKARY
DKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPEMIERGYVYIAQPPLYKVK
AGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISGDALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDLS
SEASTEASAKALAAMLSDDSKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIGA
GAAIKRGERSSNVADFKEAMKWLMADAERNMSKQRYKGLGEMNPEQLWETTMDPAVRRLLRVQIEDAIAADGIFTTLMGD
EVEPRRAFIENNALRAGNIDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=558, Percent_Identity=24.3727598566308, Blast_Score=116, Evalue=9e-26,
Organism=Homo sapiens, GI19913408, Length=573, Percent_Identity=23.7347294938918, Blast_Score=115, Evalue=2e-25,
Organism=Escherichia coli, GI48994957, Length=820, Percent_Identity=59.2682926829268, Blast_Score=953, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=561, Percent_Identity=37.6114081996435, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17535065, Length=604, Percent_Identity=24.0066225165563, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI212645845, Length=519, Percent_Identity=24.0847784200385, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=155, Percent_Identity=30.9677419354839, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=611, Percent_Identity=24.0589198036007, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17136538, Length=554, Percent_Identity=23.4657039711191, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91040; Mature: 90909

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
AGYCNDIHVTIHADNSISVTDNGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNS
HHCCCEEEEEEEECCEEEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCC
YKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKHFMEFHRGIAQNRVLEERDGEQVSPMQV
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCEE
IGDTENRGTEVHFMADSTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDQRSGKEDDFA
ECCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
FAGGVKGFVEYINKTKSVLHPTIFHINGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRD
HHCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCC
GGTHLTGLRAAMTRVINKYIADNEIAKKAKVETSGDDMREGLSCVLSVKVPEPKFSSQTK
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHCEEEEEEECCCCCCCCHHH
DKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVEAARARDAARKAREMTRRKGV
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEEECHHHH
YDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQ
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHH
MPEMIERGYVYIAQPPLYKVKAGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISG
HHHHHHCCEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCH
DALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDLSSEASTEASAKALAAMLSDD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCC
SKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIG
CCCEEEEEECHHHHHHHHHCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AGAAIKRGERSSNVADFKEAMKWLMADAERNMSKQRYKGLGEMNPEQLWETTMDPAVRRL
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LRVQIEDAIAADGIFTTLMGDEVEPRRAFIENNALRAGNIDV
HHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEAL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
AGYCNDIHVTIHADNSISVTDNGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNS
HHCCCEEEEEEEECCEEEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCC
YKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKHFMEFHRGIAQNRVLEERDGEQVSPMQV
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCEE
IGDTENRGTEVHFMADSTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDQRSGKEDDFA
ECCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
FAGGVKGFVEYINKTKSVLHPTIFHINGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRD
HHCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCC
GGTHLTGLRAAMTRVINKYIADNEIAKKAKVETSGDDMREGLSCVLSVKVPEPKFSSQTK
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHCEEEEEEECCCCCCCCHHH
DKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVEAARARDAARKAREMTRRKGV
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEEECHHHH
YDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQ
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHH
MPEMIERGYVYIAQPPLYKVKAGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISG
HHHHHHCCEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCH
DALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDLSSEASTEASAKALAAMLSDD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCC
SKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIG
CCCEEEEEECHHHHHHHHHCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AGAAIKRGERSSNVADFKEAMKWLMADAERNMSKQRYKGLGEMNPEQLWETTMDPAVRRL
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LRVQIEDAIAADGIFTTLMGDEVEPRRAFIENNALRAGNIDV
HHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1906260 [H]