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The map label for this gene is serS [H]

Identifier: 161611303

GI number: 161611303

Start: 1770921

End: 1772201

Strand: Direct

Name: serS [H]

Synonym: pc1488

Alternate gene names: 161611303

Gene position: 1770921-1772201 (Clockwise)

Preceding gene: 46447117

Following gene: 46447123

Centisome position: 73.35

GC content: 35.91

Gene sequence:

>1281_bases
ATGATTGATATTCGCTTAATCCGTAAAGATCGTTTTGCAGTTGAGAAACAGTTAAAAACGAAAGATCCGCAAATTGATCT
TACTAATATTTGTCACCTCGATCATTCTATTCGCGAAGCTAAAACAAAAGTTGAAACTCTCAAGGCAAAACGTAATGAGA
TTTCTCAGAAAATCGGAGAAATGAAACGGGCTAACCAAGATACTTTTTCTTTAATGAATGAAGTAGCAGGATTTGGAACA
GAAATTCATTTTTTGGATAACCAAATTAAAGAATGGGAAGAACAATTTAATTATGAGTTATCTAGCTTACCTAATCTTCC
CATGGAAGATATTAAAATCTCTCAAGATCCTAAAGAAAATGTTGTTATCAAAGAGTTTGGACAAAAACCTATTTTTTCTT
TTCCATTCAAAAATCACGTAGAACTTAATGAAAAATTAAATTTATTTGATTTTAAGCGTGGAGCTAAAATTTCTGGAACA
GGCTGGCCCGTTTATCGAGCCATGGGAGCACGTCTAGAATGGGCCCTCATCCAATATATGATCGAAATTCACGTCAAAAA
TGGATTTACACAATGGATCCCTCCCCTTCTTGTTAGAAAAAATACTGTGTTTGGATCTGGACAATTACCTAAATTTGAAA
GTCAACAATTTAAAATTCAAGATGAGGATTATCATCTTTATTTAATTCCTACAGCCGAAGTTCCTCTTAATGGATTGCAT
ATGGATGAGATTATTCCTCAAGAAGAGCTCAGTCTAAAATATGTAGCCTACACCCCTTGTTTTAGGCGTGAAGCAGGAGC
AGCAGGATCGCAAGAACGTGGTCTAATTAGAATGCATCAATTTAATAAAGTCGAAATGTTTTGCTTTACAAAACCGGAGG
AAAGCGCACAAGTATTCAATCAAATGATGGATAGCGCAGAGGAAATTTTGCAAGGCTTAGAACTCCATTATCGTAATGCT
TTACTAGTAACTGGGGACATGTCTTTCGCTGCAGCGCGCACAATAGACATTGAAGTTTGGTTACCCGGACAAAACAGATA
TTATGAAGTCTCTTCTGTATCTAATTGTACAGATTATCAATCCCGTCGTTCTAATACACGTTTTAGACGCGAAGACGGAA
AGTTAGATTTTGTTCATACCCTTAATGGTTCTGGATTAGCGACTTCTCGATTAATGGTTGCTTTATTAGAAAATAATCAG
CGGGAAGATGGCTCTGTTTGTATTCCTAATGTCTTACAACGCTATTTAAACGGACAAAGCACATTGAATCCCACAATTTG
A

Upstream 100 bases:

>100_bases
AATCTGTTAGATTATTTTTTTGTCATCTATAGAAATCCTTCCTTTTAAGAAGGGAGTTTTTTATACTCTTTTTATTATCA
TTTTGAGTAAAGGACATGCC

Downstream 100 bases:

>100_bases
AATACAAGTAAGCGAATTTACATTGTTAACAATGTAAATTCGCTCTAAGGCTTCTCTTACTAATAAAAATAAGTCTTTTA
AAATCAATCAATTACAAAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MIDIRLIRKDRFAVEKQLKTKDPQIDLTNICHLDHSIREAKTKVETLKAKRNEISQKIGEMKRANQDTFSLMNEVAGFGT
EIHFLDNQIKEWEEQFNYELSSLPNLPMEDIKISQDPKENVVIKEFGQKPIFSFPFKNHVELNEKLNLFDFKRGAKISGT
GWPVYRAMGARLEWALIQYMIEIHVKNGFTQWIPPLLVRKNTVFGSGQLPKFESQQFKIQDEDYHLYLIPTAEVPLNGLH
MDEIIPQEELSLKYVAYTPCFRREAGAAGSQERGLIRMHQFNKVEMFCFTKPEESAQVFNQMMDSAEEILQGLELHYRNA
LLVTGDMSFAAARTIDIEVWLPGQNRYYEVSSVSNCTDYQSRRSNTRFRREDGKLDFVHTLNGSGLATSRLMVALLENNQ
REDGSVCIPNVLQRYLNGQSTLNPTI

Sequences:

>Translated_426_residues
MIDIRLIRKDRFAVEKQLKTKDPQIDLTNICHLDHSIREAKTKVETLKAKRNEISQKIGEMKRANQDTFSLMNEVAGFGT
EIHFLDNQIKEWEEQFNYELSSLPNLPMEDIKISQDPKENVVIKEFGQKPIFSFPFKNHVELNEKLNLFDFKRGAKISGT
GWPVYRAMGARLEWALIQYMIEIHVKNGFTQWIPPLLVRKNTVFGSGQLPKFESQQFKIQDEDYHLYLIPTAEVPLNGLH
MDEIIPQEELSLKYVAYTPCFRREAGAAGSQERGLIRMHQFNKVEMFCFTKPEESAQVFNQMMDSAEEILQGLELHYRNA
LLVTGDMSFAAARTIDIEVWLPGQNRYYEVSSVSNCTDYQSRRSNTRFRREDGKLDFVHTLNGSGLATSRLMVALLENNQ
REDGSVCIPNVLQRYLNGQSTLNPTI
>Mature_426_residues
MIDIRLIRKDRFAVEKQLKTKDPQIDLTNICHLDHSIREAKTKVETLKAKRNEISQKIGEMKRANQDTFSLMNEVAGFGT
EIHFLDNQIKEWEEQFNYELSSLPNLPMEDIKISQDPKENVVIKEFGQKPIFSFPFKNHVELNEKLNLFDFKRGAKISGT
GWPVYRAMGARLEWALIQYMIEIHVKNGFTQWIPPLLVRKNTVFGSGQLPKFESQQFKIQDEDYHLYLIPTAEVPLNGLH
MDEIIPQEELSLKYVAYTPCFRREAGAAGSQERGLIRMHQFNKVEMFCFTKPEESAQVFNQMMDSAEEILQGLELHYRNA
LLVTGDMSFAAARTIDIEVWLPGQNRYYEVSSVSNCTDYQSRRSNTRFRREDGKLDFVHTLNGSGLATSRLMVALLENNQ
REDGSVCIPNVLQRYLNGQSTLNPTI

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI225579074, Length=415, Percent_Identity=34.9397590361446, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI8923421, Length=413, Percent_Identity=34.8668280871671, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI16306548, Length=293, Percent_Identity=34.8122866894198, Blast_Score=192, Evalue=6e-49,
Organism=Escherichia coli, GI1787120, Length=425, Percent_Identity=39.7647058823529, Blast_Score=320, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17539260, Length=454, Percent_Identity=29.7356828193833, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=244, Percent_Identity=33.6065573770492, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6321799, Length=288, Percent_Identity=37.8472222222222, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6320226, Length=399, Percent_Identity=32.0802005012531, Blast_Score=213, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24581334, Length=341, Percent_Identity=32.258064516129, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17737985, Length=353, Percent_Identity=30.3116147308782, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 49225; Mature: 49225

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIRLIRKDRFAVEKQLKTKDPQIDLTNICHLDHSIREAKTKVETLKAKRNEISQKIGE
CEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKRANQDTFSLMNEVAGFGTEIHFLDNQIKEWEEQFNYELSSLPNLPMEDIKISQDPKEN
HHHCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCEEHHHCCCCCHHHCCCCCCCCCC
VVIKEFGQKPIFSFPFKNHVELNEKLNLFDFKRGAKISGTGWPVYRAMGARLEWALIQYM
CHHHHCCCCCCEECCCCCCCCCCCCCCEEECCCCCEECCCCCHHHHHHCCCHHHHHHHHH
IEIHVKNGFTQWIPPLLVRKNTVFGSGQLPKFESQQFKIQDEDYHLYLIPTAEVPLNGLH
HHHHCCCCCHHHCCHHHEECCEEECCCCCCCCCCCCEEEECCCEEEEEEEECCCCCCCCC
MDEIIPQEELSLKYVAYTPCFRREAGAAGSQERGLIRMHQFNKVEMFCFTKPEESAQVFN
HHHCCCHHHCCEEEEEECCHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECCCHHHHHHH
QMMDSAEEILQGLELHYRNALLVTGDMSFAAARTIDIEVWLPGQNRYYEVSSVSNCTDYQ
HHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEEEEEEEECCCCCEEEECCCCCCHHHH
SRRSNTRFRREDGKLDFVHTLNGSGLATSRLMVALLENNQREDGSVCIPNVLQRYLNGQS
HHHCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCC
TLNPTI
CCCCCC
>Mature Secondary Structure
MIDIRLIRKDRFAVEKQLKTKDPQIDLTNICHLDHSIREAKTKVETLKAKRNEISQKIGE
CEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKRANQDTFSLMNEVAGFGTEIHFLDNQIKEWEEQFNYELSSLPNLPMEDIKISQDPKEN
HHHCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCEEHHHCCCCCHHHCCCCCCCCCC
VVIKEFGQKPIFSFPFKNHVELNEKLNLFDFKRGAKISGTGWPVYRAMGARLEWALIQYM
CHHHHCCCCCCEECCCCCCCCCCCCCCEEECCCCCEECCCCCHHHHHHCCCHHHHHHHHH
IEIHVKNGFTQWIPPLLVRKNTVFGSGQLPKFESQQFKIQDEDYHLYLIPTAEVPLNGLH
HHHHCCCCCHHHCCHHHEECCEEECCCCCCCCCCCCEEEECCCEEEEEEEECCCCCCCCC
MDEIIPQEELSLKYVAYTPCFRREAGAAGSQERGLIRMHQFNKVEMFCFTKPEESAQVFN
HHHCCCHHHCCEEEEEECCHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECCCHHHHHHH
QMMDSAEEILQGLELHYRNALLVTGDMSFAAARTIDIEVWLPGQNRYYEVSSVSNCTDYQ
HHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEEEEEEEECCCCCEEEECCCCCCHHHH
SRRSNTRFRREDGKLDFVHTLNGSGLATSRLMVALLENNQREDGSVCIPNVLQRYLNGQS
HHHCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCC
TLNPTI
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]