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The map label for this gene is ytpA [H]

Identifier: 161525416

GI number: 161525416

Start: 2459585

End: 2460493

Strand: Direct

Name: ytpA [H]

Synonym: Bmul_2246

Alternate gene names: 161525416

Gene position: 2459585-2460493 (Clockwise)

Preceding gene: 161525410

Following gene: 161525418

Centisome position: 71.32

GC content: 74.92

Gene sequence:

>909_bases
ATGACGGTTACGACCACGCAGGCCGAGGCGCCGGCCGGCGCGCGCACGGCGCCCGCGCCGCACATCGGGCGGCTGCGCAC
CGCGGACGGACTCGAGCTCGCGTCGTACCGCTGGCCCGCCGACGCCCGCGCGACGGCGCCGCGCGCGACGGTCGCGCTGC
TGCACGGCCTGGCCGAACACGCGGGCCGTTACGCGCCGCTCGCAGCCCGCCTGAACGCGGCCGGCATCGACCTGCTCGCG
ATCGACCTGCGCGGCCACGGCCGCTCGCCCGGCAAGCGCGCGTGGGTCGCGCGCTTCGACGAATACCTCGACGACGCCGA
CGCGCTCGTGGCCGAAGCCGCGCGCGCGTCGACGCCGCTGTTCCTGATGGGTCACAGCATGGGCGGCGCGATCGCCGCGC
TGTACGCGATCGAGCGCGCGCCGGCGCGCGGGCGCACGCTGGCCGGCCTCGTGCTGTCCAGCCCGGCGCTCGCGCCGGGC
CGCGACGTGCCGCGCTGGATGCTCGCGCTCAGCCGCGTGATCAGCCGGGTCTGGCCGACCTTCCCGGCGATCCGGATCGA
CGCGGCGCTGCTGTCGCGCGACGCGAACGTCGTCGTCGCGAATCGCGCGGACCCGCTCGTGCATCACGGCCCCGTGCCGG
CGCGCACGGGCGCGGAAATCCTCGACGCGATGGCGCGCATCGAGCGCGGCCGCGATACGCTGCGCGTTCCGGTGCTCGTC
TACCACGGCACCGCGGACAAACTGACCGAACCGGACGGCAGCCGCGCGTTCGGCGCACGCGTCGGCTCGGCCGACCGCAC
GCTGACACTGTACGAAGGCGGATTTCACGAAACGATGAACGACATCGAGCGCGAGCGCGTGATCGATGCGCTGATCGGCT
GGATAGATGCGCGCGTGCCGGCGCGCTGA

Upstream 100 bases:

>100_bases
TTTCATAACCGCACGATATTAGAGGAACGCCGCGAGCGCGCCGACGCGGCGGCGCGACTATGATCCCGACACGCCGACGA
ACCAACGGGAGACACGCGAG

Downstream 100 bases:

>100_bases
CTGCGGGCCGGGCGCGGGCCGTCAGATGCCGGCGAGCACGCGCAGATGCGCGACGACGCTGCGCCCGAGCGCGGATAGGT
TGTAGCCGCCCTCGAGACAG

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTVTTTQAEAPAGARTAPAPHIGRLRTADGLELASYRWPADARATAPRATVALLHGLAEHAGRYAPLAARLNAAGIDLLA
IDLRGHGRSPGKRAWVARFDEYLDDADALVAEAARASTPLFLMGHSMGGAIAALYAIERAPARGRTLAGLVLSSPALAPG
RDVPRWMLALSRVISRVWPTFPAIRIDAALLSRDANVVVANRADPLVHHGPVPARTGAEILDAMARIERGRDTLRVPVLV
YHGTADKLTEPDGSRAFGARVGSADRTLTLYEGGFHETMNDIERERVIDALIGWIDARVPAR

Sequences:

>Translated_302_residues
MTVTTTQAEAPAGARTAPAPHIGRLRTADGLELASYRWPADARATAPRATVALLHGLAEHAGRYAPLAARLNAAGIDLLA
IDLRGHGRSPGKRAWVARFDEYLDDADALVAEAARASTPLFLMGHSMGGAIAALYAIERAPARGRTLAGLVLSSPALAPG
RDVPRWMLALSRVISRVWPTFPAIRIDAALLSRDANVVVANRADPLVHHGPVPARTGAEILDAMARIERGRDTLRVPVLV
YHGTADKLTEPDGSRAFGARVGSADRTLTLYEGGFHETMNDIERERVIDALIGWIDARVPAR
>Mature_301_residues
TVTTTQAEAPAGARTAPAPHIGRLRTADGLELASYRWPADARATAPRATVALLHGLAEHAGRYAPLAARLNAAGIDLLAI
DLRGHGRSPGKRAWVARFDEYLDDADALVAEAARASTPLFLMGHSMGGAIAALYAIERAPARGRTLAGLVLSSPALAPGR
DVPRWMLALSRVISRVWPTFPAIRIDAALLSRDANVVVANRADPLVHHGPVPARTGAEILDAMARIERGRDTLRVPVLVY
HGTADKLTEPDGSRAFGARVGSADRTLTLYEGGFHETMNDIERERVIDALIGWIDARVPAR

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=291, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI6005786, Length=291, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1787678, Length=284, Percent_Identity=25, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322756, Length=304, Percent_Identity=27.3026315789474, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 32260; Mature: 32129

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTTTQAEAPAGARTAPAPHIGRLRTADGLELASYRWPADARATAPRATVALLHGLAEH
CCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHH
AGRYAPLAARLNAAGIDLLAIDLRGHGRSPGKRAWVARFDEYLDDADALVAEAARASTPL
CCCCCCHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCE
FLMGHSMGGAIAALYAIERAPARGRTLAGLVLSSPALAPGRDVPRWMLALSRVISRVWPT
EEEECCCCHHHHHHHHHHCCCCCCCEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
FPAIRIDAALLSRDANVVVANRADPLVHHGPVPARTGAEILDAMARIERGRDTLRVPVLV
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEE
YHGTADKLTEPDGSRAFGARVGSADRTLTLYEGGFHETMNDIERERVIDALIGWIDARVP
EECCHHHCCCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AR
CC
>Mature Secondary Structure 
TVTTTQAEAPAGARTAPAPHIGRLRTADGLELASYRWPADARATAPRATVALLHGLAEH
CEECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHH
AGRYAPLAARLNAAGIDLLAIDLRGHGRSPGKRAWVARFDEYLDDADALVAEAARASTPL
CCCCCCHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCE
FLMGHSMGGAIAALYAIERAPARGRTLAGLVLSSPALAPGRDVPRWMLALSRVISRVWPT
EEEECCCCHHHHHHHHHHCCCCCCCEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
FPAIRIDAALLSRDANVVVANRADPLVHHGPVPARTGAEILDAMARIERGRDTLRVPVLV
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEE
YHGTADKLTEPDGSRAFGARVGSADRTLTLYEGGFHETMNDIERERVIDALIGWIDARVP
EECCHHHCCCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]