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The map label for this gene is yngG [H]

Identifier: 161524727

GI number: 161524727

Start: 1705111

End: 1706088

Strand: Reverse

Name: yngG [H]

Synonym: Bmul_1554

Alternate gene names: 161524727

Gene position: 1706088-1705111 (Counterclockwise)

Preceding gene: 161524728

Following gene: 161524726

Centisome position: 49.47

GC content: 69.43

Gene sequence:

>978_bases
ATGAACGCTCGACACCAACGGTACAAACCGCTCCATCTGCACGAAGTCGCGCCGCGCGACGGTTTCCAGAACGAAGCGGC
ATTCGTCGACACCGACGCCAAGATCGCGCTGATCGACGCGCTGAGCGCGTGCGGCTACGCGAAGATCGAAGTCACGTCGT
TCACGTCGCCGAAGGCGATCCCCGCGCTGCGCGACGCGGAGGCCGTGATGCACGGCATCGCGCGCGTGCCGGGCGTCGTC
TACACCGCGCTCGTGCCGAACGTGCGCGGCGCGGAGCGCGCGCTGTCGTGCGGCGTCGACGAGGTGAACCTCGTGATGTC
GGCAAGCGACAGCCACAACCGCGCGAACCTGCGGATGACGCGCGAGCAGTCGTTCGCACAGCTGCGCGAGGTGATCGACG
CGGTGCGCGGCACGGGCATCGCGATCAACGTGTCGCTGTCCACCGCGATGGGATGCCCGATGGAAGGCGACGTGCCTGCC
GAAACGGTGCTCGCATGGATGCAGCGGTTCGCCGATCTCGGCGTGCACGGCTTCACGCTTTGCGACACGACCGGCATGGC
GTTTCCGTCGCAGGTGCGCGACCTCTGCGAACGCGCACGCGCGCGCTTCGGTGCGCTGCCGCTGACGCTGCACTTTCACA
ATACGCGCGGAATGGCGCTCGCGAACACGCTCGCGGCGCTCGACGCCGGCATCGACCGCTTCGACGCGTCGCTCGGCGGC
CTCGGCGGCTGCCCCTACGCACCGGGCGCGACCGGCAACGCGTGCACCGAGGAGCTCGTGCACATGCTCGAGCTCGACGG
CTACGACACCGGCGTCGATCTTGCGGCCGTGCTCGCCGCGGCCGCACGATTGCCCGCGCTGATCGGTCACGACGTGCCGA
GCCAGTTGCTGAAAGCCGGGCGCCGCTCGGACCTGCATCGCCCGCCGGCCGAAGCGAGCGCAGCGCCGCGCGTTGTCGTC
GATGGAGCACGCACATGA

Upstream 100 bases:

>100_bases
ACTCGGCGCGGATACCGACACGGTGCTCGAATCGCTCGGCATCGATGCGGCGACGCGCGACGACTGGCGCGCTCGCGGCG
TGATCTGACGGAGGCTCGAC

Downstream 100 bases:

>100_bases
CACTGATCGATCGCATCGACCATCTCGTGCTGACCTGCGTCGATCCCGAGCGCACGCGGCAGTTCTATGTCGACGTGCTG
CAGATGCGGCTCGAAACGTT

Product: pyruvate carboxyltransferase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MNARHQRYKPLHLHEVAPRDGFQNEAAFVDTDAKIALIDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIARVPGVV
YTALVPNVRGAERALSCGVDEVNLVMSASDSHNRANLRMTREQSFAQLREVIDAVRGTGIAINVSLSTAMGCPMEGDVPA
ETVLAWMQRFADLGVHGFTLCDTTGMAFPSQVRDLCERARARFGALPLTLHFHNTRGMALANTLAALDAGIDRFDASLGG
LGGCPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAAAARLPALIGHDVPSQLLKAGRRSDLHRPPAEASAAPRVVV
DGART

Sequences:

>Translated_325_residues
MNARHQRYKPLHLHEVAPRDGFQNEAAFVDTDAKIALIDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIARVPGVV
YTALVPNVRGAERALSCGVDEVNLVMSASDSHNRANLRMTREQSFAQLREVIDAVRGTGIAINVSLSTAMGCPMEGDVPA
ETVLAWMQRFADLGVHGFTLCDTTGMAFPSQVRDLCERARARFGALPLTLHFHNTRGMALANTLAALDAGIDRFDASLGG
LGGCPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAAAARLPALIGHDVPSQLLKAGRRSDLHRPPAEASAAPRVVV
DGART
>Mature_325_residues
MNARHQRYKPLHLHEVAPRDGFQNEAAFVDTDAKIALIDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIARVPGVV
YTALVPNVRGAERALSCGVDEVNLVMSASDSHNRANLRMTREQSFAQLREVIDAVRGTGIAINVSLSTAMGCPMEGDVPA
ETVLAWMQRFADLGVHGFTLCDTTGMAFPSQVRDLCERARARFGALPLTLHFHNTRGMALANTLAALDAGIDRFDASLGG
LGGCPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAAAARLPALIGHDVPSQLLKAGRRSDLHRPPAEASAAPRVVV
DGART

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=291, Percent_Identity=38.8316151202749, Blast_Score=217, Evalue=9e-57,
Organism=Homo sapiens, GI109150422, Length=285, Percent_Identity=38.2456140350877, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI109150427, Length=285, Percent_Identity=38.2456140350877, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI260654708, Length=116, Percent_Identity=43.9655172413793, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17510563, Length=283, Percent_Identity=38.5159010600707, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320071, Length=234, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320019, Length=224, Percent_Identity=28.125, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582381, Length=291, Percent_Identity=36.7697594501718, Blast_Score=201, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 34429; Mature: 34429

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARHQRYKPLHLHEVAPRDGFQNEAAFVDTDAKIALIDALSACGYAKIEVTSFTSPKAI
CCCCCCCCCCCHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCC
PALRDAEAVMHGIARVPGVVYTALVPNVRGAERALSCGVDEVNLVMSASDSHNRANLRMT
CCHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCEEEH
REQSFAQLREVIDAVRGTGIAINVSLSTAMGCPMEGDVPAETVLAWMQRFADLGVHGFTL
HHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
CDTTGMAFPSQVRDLCERARARFGALPLTLHFHNTRGMALANTLAALDAGIDRFDASLGG
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
LGGCPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAAAARLPALIGHDVPSQLLKAG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RRSDLHRPPAEASAAPRVVVDGART
HHCCCCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure
MNARHQRYKPLHLHEVAPRDGFQNEAAFVDTDAKIALIDALSACGYAKIEVTSFTSPKAI
CCCCCCCCCCCHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCC
PALRDAEAVMHGIARVPGVVYTALVPNVRGAERALSCGVDEVNLVMSASDSHNRANLRMT
CCHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCEEEH
REQSFAQLREVIDAVRGTGIAINVSLSTAMGCPMEGDVPAETVLAWMQRFADLGVHGFTL
HHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
CDTTGMAFPSQVRDLCERARARFGALPLTLHFHNTRGMALANTLAALDAGIDRFDASLGG
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
LGGCPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAAAARLPALIGHDVPSQLLKAG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RRSDLHRPPAEASAAPRVVVDGART
HHCCCCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]