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The map label for this gene is hutH [H]

Identifier: 161524273

GI number: 161524273

Start: 1201019

End: 1202539

Strand: Direct

Name: hutH [H]

Synonym: Bmul_1098

Alternate gene names: 161524273

Gene position: 1201019-1202539 (Clockwise)

Preceding gene: 161524272

Following gene: 161524274

Centisome position: 34.83

GC content: 67.92

Gene sequence:

>1521_bases
ATGATCACGCTTACCCCCGGCCACCTGACCCTCCCGCAACTGCGCCAGATCGCGCGCGAGCCCGTGCAGCTGACGCTGGA
TCCGGCCAGCTTCGCGAAGATCGACGCGGGCGCGAAGGCCGTGTCCGACATCGCCGCGAAGGGCGAGCCGGCGTACGGCA
TCAACACGGGCTTCGGTCGTCTGGCCAGCACGCATATCCCGCACGATCAGCTCGAATTGCTGCAGAAGAACCTCGTGCTG
TCGCATGCAGTCGGTGTCGGCGAGCCGATGGCGCGTTCGTCGGTGCGTCTGCTGATCGCGCTGAAGCTGTCGAGCCTCGG
CCGCGGCCATTCGGGCATTCGCCGCGAAGTGATGGACGCGCTGATCAAGCTGTTCAACGCCGACGTGCTGCCGCTGATTC
CGGTGAAGGGCTCGGTCGGCGCATCGGGCGACCTCGCGCCGCTCGCGCACATGTCGGCCGTGCTGCTCGGCGTCGGCGAA
GTGTTCATTCGCGGCGAGCGCGCGAGCGCGGTGGACGGGTTGCGCGTCGCGGGCCTCGCGCCGCTGACGCTGCAGGCGAA
GGAAGGCCTCGCGCTGCTGAACGGTACGCAGGCGTCGACGGCGCTCGCGCTCGACAACCTGTTCGCGATCGAAGACCTGT
ACCGCACGGCGCTCGTCGCCGGCGCGCTGTCGGTCGATGCGGCGGCCGGCTCGGTGAAGCCGTTCGACGCGCGCATCCAC
GAACTGCGCGGCCATCGCGGCCAGATCGATGCGGCGGCCGCGTATCGCGAGCTGCTCGAAGGCTCGGCGATCAACCTCTC
GCATCGCGACTGCGGCAAGGTGCAGGATCCGTACAGCCTGCGCTGCCAGCCGCAGGTGATGGGCGCGTGCCTGGACCAGA
TGCGTCATGCGGCCGACGTGCTGCTCGTCGAGGCGAACGCGGTATCGGACAACCCGCTGATCTTCCCGGATACCGGCGAA
GTGCTGTCGGGCGGCAATTTCCATGCGGAGCCCGTCGCGTTCGCGGCCGACAACCTCGCGCTCGCGGCTGCGGAAATCGG
CGCGCTGGCCGAGCGCCGCATCGCGCTGCTGATCGACGCGACGCTGTCGGGCCTGCCGCCGTTCCTCGTGAAGGATGGCG
GCGTGAACTCGGGCTTCATGATTGCGCACGTGACGGCAGCTGCGCTCGCATCGGAGAACAAGACGCTCGCGCATCCGGCG
TCGGTCGATTCGCTGCCGACCTCGGCGAACCAGGAAGACCACGTGTCGATGGCGACGTTCGCGGCACGCAAGCTGGCCGA
CATCGCCGACAACACGAAGCACATCCTCGCGATCGAACTGCTCGCGGCCGCGCAGGGCGTCGATCTGCGCGAGAACGAGA
CGAGCCCGAAGCTCGCGGAAGTGATGAAGACGATTCGCAGCAAGGTCGCGCATTACGAGCTCGACCACTACTTTGCGCCG
GACATCGCCGTGATCGCGAAGCTCGTCGTCGAGCGCGCGTTCGCGAAGCACTGCCCGTTCGCCTTCGCATCGGAGCAGTA
A

Upstream 100 bases:

>100_bases
GGAAACTCCTGAGTCGAAATCGGCGAAAACGGGTTGTCTAGACAAGTCGCGGTCGCTACACTGCAATCCATCCCGAACTT
GTCTAGACAGGATTGCACAC

Downstream 100 bases:

>100_bases
GCCGATGAGCGCGCCGGTCTACCAGGAGATCAAGGATTTCATCCTGGCCCGCATCCACGCCGGCGAATGGGCGGAGGGCG
ATCAGGTGCCGTCCGAGAAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MITLTPGHLTLPQLRQIAREPVQLTLDPASFAKIDAGAKAVSDIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARSSVRLLIALKLSSLGRGHSGIRREVMDALIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGE
VFIRGERASAVDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNLFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
ELRGHRGQIDAAAAYRELLEGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRHAADVLLVEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIADNTKHILAIELLAAAQGVDLRENETSPKLAEVMKTIRSKVAHYELDHYFAP
DIAVIAKLVVERAFAKHCPFAFASEQ

Sequences:

>Translated_506_residues
MITLTPGHLTLPQLRQIAREPVQLTLDPASFAKIDAGAKAVSDIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARSSVRLLIALKLSSLGRGHSGIRREVMDALIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGE
VFIRGERASAVDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNLFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
ELRGHRGQIDAAAAYRELLEGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRHAADVLLVEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIADNTKHILAIELLAAAQGVDLRENETSPKLAEVMKTIRSKVAHYELDHYFAP
DIAVIAKLVVERAFAKHCPFAFASEQ
>Mature_506_residues
MITLTPGHLTLPQLRQIAREPVQLTLDPASFAKIDAGAKAVSDIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARSSVRLLIALKLSSLGRGHSGIRREVMDALIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGE
VFIRGERASAVDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNLFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
ELRGHRGQIDAAAAYRELLEGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRHAADVLLVEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIADNTKHILAIELLAAAQGVDLRENETSPKLAEVMKTIRSKVAHYELDHYFAP
DIAVIAKLVVERAFAKHCPFAFASEQ

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=497, Percent_Identity=44.466800804829, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567831, Length=476, Percent_Identity=43.6974789915966, Blast_Score=363, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53208; Mature: 53208

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLTPGHLTLPQLRQIAREPVQLTLDPASFAKIDAGAKAVSDIAAKGEPAYGINTGFGR
CEEECCCCCCHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
LASTHIPHDQLELLQKNLVLSHAVGVGEPMARSSVRLLIALKLSSLGRGHSGIRREVMDA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEEEEHHHCCCCCHHHHHHHHHH
LIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGEVFIRGERASAVDGLRVAGLA
HHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEECCCC
PLTLQAKEGLALLNGTQASTALALDNLFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ELRGHRGQIDAAAAYRELLEGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRHAADV
HHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCE
LLVEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDA
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEEC
TLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATF
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
AARKLADIADNTKHILAIELLAAAQGVDLRENETSPKLAEVMKTIRSKVAHYELDHYFAP
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCC
DIAVIAKLVVERAFAKHCPFAFASEQ
CHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MITLTPGHLTLPQLRQIAREPVQLTLDPASFAKIDAGAKAVSDIAAKGEPAYGINTGFGR
CEEECCCCCCHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
LASTHIPHDQLELLQKNLVLSHAVGVGEPMARSSVRLLIALKLSSLGRGHSGIRREVMDA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEEEEHHHCCCCCHHHHHHHHHH
LIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGEVFIRGERASAVDGLRVAGLA
HHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEECCCC
PLTLQAKEGLALLNGTQASTALALDNLFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ELRGHRGQIDAAAAYRELLEGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRHAADV
HHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCE
LLVEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDA
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEEC
TLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATF
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
AARKLADIADNTKHILAIELLAAAQGVDLRENETSPKLAEVMKTIRSKVAHYELDHYFAP
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCC
DIAVIAKLVVERAFAKHCPFAFASEQ
CHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA