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The map label for this gene is fadA [H]

Identifier: 161523760

GI number: 161523760

Start: 633944

End: 635143

Strand: Direct

Name: fadA [H]

Synonym: Bmul_0580

Alternate gene names: 161523760

Gene position: 633944-635143 (Clockwise)

Preceding gene: 161523759

Following gene: 161523761

Centisome position: 18.38

GC content: 68.17

Gene sequence:

>1200_bases
ATGAGCAAACAACTGCAAGACGCATACATCGTCGCCGCCAGCCGCACGCCGATCGGCAAGGCCCCGCGCGGCGTCTTCAA
GAACACGCGTCCGGACGAGCTGCTGGTGCACGCGATCAAGTCGACGGTCGCACAGGTGCCGGGCTTCGACACGAAGCTGA
TCGAGGACGCGATCATCGGTTGCGCGATTCCGGAAGCGGAGCAGGGCCTGAACGTCGCGCGCATGGGCGCGCTGCTCGCG
GGCCTGCCGCAAACGGTCGGCGGCGTCACGGTCAACCGCTTCTGCGCATCGGGCATCACCGCACTCGCGATGGCGGCCGA
CCGCATTCGCGTCGGCGAATCGGACGCGCTGCTCGCCGGCGGCTGCGAATCGATGAGCATGGTGCCGATGATGGGCAACA
AGCCGTCGATGTCGCCGCACATCTTCGATCGCAACGAAGACATCGGCATCGCGTACGGGATGGGTCTGACGGCCGAGCGC
GTGGCCGACCAGTGGAAGGTAAGCCGCGAAGACCAGGACGCGTTCTCGGTCGAGTCGCACCGCAAGGCGCTCGCCGCGCA
GCAGGCCGGCGAGTTCGCGGACGAAATCGCGCCGTACACGATCACCGAGCGCTTCCCGAATCTCGCGAGCGGCGAGATCG
ACGTGAAGACGCGCGAGATCAAGCTCGACGAAGGCCCGCGCGCCGATACGTCGCTCGAGGGCCTCGCGAAGCTGCGCGCG
GTGTTCGCGAACAAGGGTTCGGTCACGGCCGGCAACAGCTCGCAGACGTCGGACGGCGCGGGCGCGCTGCTCGTCGTCTC
GGAGAAGGTGCTCAAGCAGTTCAACCTGACGCCGCTCGCGCGCTTCGTGAGCTTCGCGGTGCGCGGCGTGCCGCCGGAAA
TCATGGGCATCGGGCCGAAGGAAGCGATTCCGGCCGCGCTGAAGGCCGCGGGCCTGAAGCAGGACGATCTCGACTGGATC
GAGCTGAACGAGGCATTTGCCGCGCAGTCGCTCGCCGTGATCCGCGATCTCGGCCTCGATCCGTCGAAGGTGAACCCGCT
CGGCGGCGCGATCGCGCTCGGCCACCCGCTCGGCGCGACCGGCGCGATTCGCGCGGCGACCGTCGTGCACGGCCTGCGCC
GCCGCAACCTGAAGTACGGGATGGTCACGATGTGCGTCGGCACCGGCATGGGCGCGGCGGGCATCATCGAACGCCTGTAA

Upstream 100 bases:

>100_bases
AGCTGCTCGGCACGCAGAAGACGCAGGAACGGATCATGGGCATGTTGCAGACCGGCAAGCCGGTGCGTAACTGAGCGAGC
GATAAGGCAAGGAGTTTCAA

Downstream 100 bases:

>100_bases
GCGGGACGCGACGAAACGCGACGACGGTGCGCGGGCGGCGAGCTCGCGCACCGTTTTTCATTCCGGTAGGGGCAAGTCAA
AGGAGACGATGGTGGCCGAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSTVAQVPGFDTKLIEDAIIGCAIPEAEQGLNVARMGALLA
GLPQTVGGVTVNRFCASGITALAMAADRIRVGESDALLAGGCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAER
VADQWKVSREDQDAFSVESHRKALAAQQAGEFADEIAPYTITERFPNLASGEIDVKTREIKLDEGPRADTSLEGLAKLRA
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWI
ELNEAFAAQSLAVIRDLGLDPSKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Sequences:

>Translated_399_residues
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSTVAQVPGFDTKLIEDAIIGCAIPEAEQGLNVARMGALLA
GLPQTVGGVTVNRFCASGITALAMAADRIRVGESDALLAGGCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAER
VADQWKVSREDQDAFSVESHRKALAAQQAGEFADEIAPYTITERFPNLASGEIDVKTREIKLDEGPRADTSLEGLAKLRA
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWI
ELNEAFAAQSLAVIRDLGLDPSKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
>Mature_398_residues
SKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSTVAQVPGFDTKLIEDAIIGCAIPEAEQGLNVARMGALLAG
LPQTVGGVTVNRFCASGITALAMAADRIRVGESDALLAGGCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAERV
ADQWKVSREDQDAFSVESHRKALAAQQAGEFADEIAPYTITERFPNLASGEIDVKTREIKLDEGPRADTSLEGLAKLRAV
FANKGSVTAGNSSQTSDGAGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWIE
LNEAFAAQSLAVIRDLGLDPSKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=43.8775510204082, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI167614485, Length=407, Percent_Identity=39.5577395577396, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI148539872, Length=341, Percent_Identity=40.7624633431085, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=36.0493827160494, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI4504327, Length=440, Percent_Identity=29.5454545454545, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=31.8877551020408, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=44.0389294403893, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=42.5, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=40.3940886699507, Blast_Score=259, Evalue=1e-70,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=39.3564356435644, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1788683, Length=380, Percent_Identity=32.1052631578947, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=42.0398009950249, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=36.8550368550369, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=32.8358208955224, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=445, Percent_Identity=30.3370786516854, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17535917, Length=399, Percent_Identity=29.0726817042606, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=41.7910447761194, Blast_Score=282, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6325229, Length=406, Percent_Identity=38.1773399014778, Blast_Score=230, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=39.9014778325123, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI17648125, Length=410, Percent_Identity=39.5121951219512, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=33.9853300733496, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=31.2217194570136, Blast_Score=158, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41939; Mature: 41808

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSTVAQVPGFDTKLIEDAIIG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPQTVGGVTVNRFCASGITALAMAADRIRVGESDALLAG
CCCCCHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAERVADQWKVSREDQDAFSVESH
CCCCCEECCCCCCCCCCCCCEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKALAAQQAGEFADEIAPYTITERFPNLASGEIDVKTREIKLDEGPRADTSLEGLAKLRA
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDLDWIELNEAFAAQSLAVIRDLGLDPSKVNPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC
>Mature Secondary Structure 
SKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSTVAQVPGFDTKLIEDAIIG
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPQTVGGVTVNRFCASGITALAMAADRIRVGESDALLAG
CCCCCHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAERVADQWKVSREDQDAFSVESH
CCCCCEECCCCCCCCCCCCCEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKALAAQQAGEFADEIAPYTITERFPNLASGEIDVKTREIKLDEGPRADTSLEGLAKLRA
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDLDWIELNEAFAAQSLAVIRDLGLDPSKVNPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]