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The map label for this gene is ntpA [H]

Identifier: 161523755

GI number: 161523755

Start: 626906

End: 627400

Strand: Direct

Name: ntpA [H]

Synonym: Bmul_0575

Alternate gene names: 161523755

Gene position: 626906-627400 (Clockwise)

Preceding gene: 161523754

Following gene: 161523756

Centisome position: 18.18

GC content: 67.07

Gene sequence:

>495_bases
ATGACGAAGCCGCCGAAAATTCCCGAATCCGTTCTCGTCGTGATCTACACGCCCGAACTCGACGTGCTGGTGATCAAACG
TGCCGATCAGCCCGATTTCTGGCAATCGGTGACCGGGTCGAAGGACACGCTCGACGAGCCGCTCGCCGTCACGGCTGCGC
GCGAGGTCGCGGAAGAGACGGGCATCGTGATCGGCACGGCCGACGTGCCGGCCGCCGCGCTCGTCGACTGGCAGCACCGG
ATCGAATACACCATCTATCCGCAATATCTGCACCGCTATGCGCCGGGCGTCACGCGCAACACCGAGCACTGGTTCGGGCT
TTGCGTGCCGCGCCGCGTCGACGTCACGCTCTCGCCGCGCGAGCACGTCGACTATGCGTGGCTGCCGTATCGCGACGCGG
CCGCGCGCTGCTTCTCGCCGTCGAACGCCGACGCGATCCTGCAGCTTCCGGTGCGCGCGTCGCTCGTGCACCTGCCGCAC
GGCTCGTCCGCATGA

Upstream 100 bases:

>100_bases
GCGCCTTTTTCGTTTTTTGCGGTACAGTCGCAGCACCTGCTGCGTGCTCGGCGACGATGCTCGCCCGACGCGCGGCCGCC
TCGCGCCGTATGAAACAAAG

Downstream 100 bases:

>100_bases
ATGCGGAAACCCGCAAGCGCTTCGCGCAGTTGCGGCAGATGTTCCTGCAGGAGCGCGGCTCCGCGTCGCGGCTCGCGTTC
ACGACCGGCAACACGGTGCG

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MTKPPKIPESVLVVIYTPELDVLVIKRADQPDFWQSVTGSKDTLDEPLAVTAAREVAEETGIVIGTADVPAAALVDWQHR
IEYTIYPQYLHRYAPGVTRNTEHWFGLCVPRRVDVTLSPREHVDYAWLPYRDAAARCFSPSNADAILQLPVRASLVHLPH
GSSA

Sequences:

>Translated_164_residues
MTKPPKIPESVLVVIYTPELDVLVIKRADQPDFWQSVTGSKDTLDEPLAVTAAREVAEETGIVIGTADVPAAALVDWQHR
IEYTIYPQYLHRYAPGVTRNTEHWFGLCVPRRVDVTLSPREHVDYAWLPYRDAAARCFSPSNADAILQLPVRASLVHLPH
GSSA
>Mature_163_residues
TKPPKIPESVLVVIYTPELDVLVIKRADQPDFWQSVTGSKDTLDEPLAVTAAREVAEETGIVIGTADVPAAALVDWQHRI
EYTIYPQYLHRYAPGVTRNTEHWFGLCVPRRVDVTLSPREHVDYAWLPYRDAAARCFSPSNADAILQLPVRASLVHLPHG
SSA

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=153, Percent_Identity=43.7908496732026, Blast_Score=106, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18283; Mature: 18152

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPPKIPESVLVVIYTPELDVLVIKRADQPDFWQSVTGSKDTLDEPLAVTAAREVAEET
CCCCCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
GIVIGTADVPAAALVDWQHRIEYTIYPQYLHRYAPGVTRNTEHWFGLCVPRRVDVTLSPR
CEEEECCCCCHHHHCCHHHHEEEEECHHHHHHHCCCCCCCCCCEEEEECCCEEEEEECCH
EHVDYAWLPYRDAAARCFSPSNADAILQLPVRASLVHLPHGSSA
HHCCEEECCCCHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCC
>Mature Secondary Structure 
TKPPKIPESVLVVIYTPELDVLVIKRADQPDFWQSVTGSKDTLDEPLAVTAAREVAEET
CCCCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
GIVIGTADVPAAALVDWQHRIEYTIYPQYLHRYAPGVTRNTEHWFGLCVPRRVDVTLSPR
CEEEECCCCCHHHHCCHHHHEEEEECHHHHHHHCCCCCCCCCCEEEEECCCEEEEEECCH
EHVDYAWLPYRDAAARCFSPSNADAILQLPVRASLVHLPHGSSA
HHCCEEECCCCHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]