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The map label for this gene is apt [H]

Identifier: 161523711

GI number: 161523711

Start: 579767

End: 580333

Strand: Direct

Name: apt [H]

Synonym: Bmul_0531

Alternate gene names: 161523711

Gene position: 579767-580333 (Clockwise)

Preceding gene: 161523710

Following gene: 161523712

Centisome position: 16.81

GC content: 66.84

Gene sequence:

>567_bases
ATGTCGCATTCGTCGTCGGGCGCACCGCTCGATCCGGTCGCCTTCATTCACAGCCAGATCCGCACCGTGCCCGACTGGCC
GCAGCCGGGCGTGATGTTCCGCGACATCACGACGCTGCTGCAGAGTCCGAAGGCGCTGCGCATCCTCGTCGATCTGTTCG
TCGAGCGCTATGTCGACGCGAAGCTCGACTACGTCGCCGGGCTCGACGCGCGCGGCTTCATCATCGCGCCGATCGTCGCG
TACGAGCTCAGCGTCGGCTTCGTGCCGATCCGCAAGGTCGGCAAGCTGCCGTACAAGACGCGTTCGGAATCGTACGAGCT
CGAGTACGGCAGCGCGACCGTCGAGATCCACGAGGACGCGTGCAAGCCGGGCGACCGCGTGATCATCATGGACGACCTGA
TCGCGACCGGCGGCACGATGATGGCCGGACGCAACCTGCTGGAGCGGCTCGGCGCCGTCGTCGTCGAAGGCGCGGCGATC
ATCGATCTGCCCGATCTCGGCGGCTCGGCGCTGCTGCGCAATGCGGGGCTGCCCGTCTATACCGTCACCGAATTCGCCGG
CCACTGA

Upstream 100 bases:

>100_bases
ATCCGCCGGCCGTGGCCGCGTGAGCCGCGATTCATTACCCGACCCGTATTTTTTCGAAACGGTGCCCGATCTTCGCGCAC
CGTTTTTTTCGGAGAGTTTC

Downstream 100 bases:

>100_bases
GCGCCGGTTCACGCAGCGAGGCCACGATGCCGAACTTCATGCTGTTTCTCGCCACGTCGATCGCGATCACGTTCGCGCCG
GGTCCCGACAACCTGCAGGT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSHSSSGAPLDPVAFIHSQIRTVPDWPQPGVMFRDITTLLQSPKALRILVDLFVERYVDAKLDYVAGLDARGFIIAPIVA
YELSVGFVPIRKVGKLPYKTRSESYELEYGSATVEIHEDACKPGDRVIIMDDLIATGGTMMAGRNLLERLGAVVVEGAAI
IDLPDLGGSALLRNAGLPVYTVTEFAGH

Sequences:

>Translated_188_residues
MSHSSSGAPLDPVAFIHSQIRTVPDWPQPGVMFRDITTLLQSPKALRILVDLFVERYVDAKLDYVAGLDARGFIIAPIVA
YELSVGFVPIRKVGKLPYKTRSESYELEYGSATVEIHEDACKPGDRVIIMDDLIATGGTMMAGRNLLERLGAVVVEGAAI
IDLPDLGGSALLRNAGLPVYTVTEFAGH
>Mature_187_residues
SHSSSGAPLDPVAFIHSQIRTVPDWPQPGVMFRDITTLLQSPKALRILVDLFVERYVDAKLDYVAGLDARGFIIAPIVAY
ELSVGFVPIRKVGKLPYKTRSESYELEYGSATVEIHEDACKPGDRVIIMDDLIATGGTMMAGRNLLERLGAVVVEGAAII
DLPDLGGSALLRNAGLPVYTVTEFAGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=177, Percent_Identity=44.6327683615819, Blast_Score=150, Evalue=8e-37,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=48.062015503876, Blast_Score=125, Evalue=2e-29,
Organism=Escherichia coli, GI1786675, Length=176, Percent_Identity=49.4318181818182, Blast_Score=183, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17509087, Length=164, Percent_Identity=44.5121951219512, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=167, Percent_Identity=40.1197604790419, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=32.1637426900585, Blast_Score=85, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136334, Length=164, Percent_Identity=40.2439024390244, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20339; Mature: 20208

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSSSGAPLDPVAFIHSQIRTVPDWPQPGVMFRDITTLLQSPKALRILVDLFVERYVDA
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
KLDYVAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYKTRSESYELEYGSATVEIHEDA
HHHHHHCCCCCCEEEHHHHHHHHHCCCEEHHHHCCCCCCCCCCCEEEEECCEEEEEECCC
CKPGDRVIIMDDLIATGGTMMAGRNLLERLGAVVVEGAAIIDLPDLGGSALLRNAGLPVY
CCCCCEEEEEECHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEE
TVTEFAGH
EECCCCCC
>Mature Secondary Structure 
SHSSSGAPLDPVAFIHSQIRTVPDWPQPGVMFRDITTLLQSPKALRILVDLFVERYVDA
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
KLDYVAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYKTRSESYELEYGSATVEIHEDA
HHHHHHCCCCCCEEEHHHHHHHHHCCCEEHHHHCCCCCCCCCCCEEEEECCEEEEEECCC
CKPGDRVIIMDDLIATGGTMMAGRNLLERLGAVVVEGAAIIDLPDLGGSALLRNAGLPVY
CCCCCEEEEEECHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEE
TVTEFAGH
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA