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The map label for this gene is murC [H]

Identifier: 161485639

GI number: 161485639

Start: 2854253

End: 2855653

Strand: Direct

Name: murC [H]

Synonym: CPE2493

Alternate gene names: 161485639

Gene position: 2854253-2855653 (Clockwise)

Preceding gene: 18311442

Following gene: 18311476

Centisome position: 94.16

GC content: 30.76

Gene sequence:

>1401_bases
GTGTATATAAGTAAAGGAGTTGATATCTTGTCTTTCGATTTATTAAAAGATATTAATAAAAAAGTTCATTTCATAGGAAT
TGGTGGAGTTAGTATGAGTGGCTTAGCTGCTGTATTACTTAACGCTGGTTACAAAGTTTCAGGATCTGATTCAAAAGAAT
CAGAAATTACTAATAGATTAAAAGAAGAAGGTGCAAAAATATACATAGGTCACAGTAAAGATAATTTACAAGATGTTGAT
GTAGTTGTATATACTGCAGCAATACCTAGCGATAACCCTGAAATAATTAAGGCTAAAGAGGATAATCTTATTTTAATGGA
CAGGGCTGAATTTTTAGGACAAATTATGAAAGGTCATAAATTCAATGTTGCTGTCGCTGGAACTCACGGAAAAACTACTA
CTACTTCAATGATTTCTCATGTTGCCCTTAGTGCAGATTTAGACCCTACAATATTAGTTGGTGGAGATTTAGACATTATT
CATGGAAACTTTAGAGTTGGAAACAGTGAATACTTTATAACAGAAGCTTGTGAATATAAACAAAGTTTCTTAAGATTCTT
CCCTTATGTTGGAATAATATTAAACATAGATGCAGACCATCTAGATTTCTATAAGGACATAAACCACATAAAAGATACAT
TTAAACAATTCGTTAGACTTATACCTAATGATGGATATATCATAGGAAATGCTGATGATGAAAAAGTTATGGAAGTTCTT
GAAGTAGCTAAATGCAATGTATTAACTTATGGAATTAATAATGGGGATATACAAGCTAGAAATATAGAGTTTAATGAAAA
AGGTTGTGCTACTTTTGATGTATTTAGAAATGAAGAAAAACTTCTTTCTCTTTCTTTAAATGTACCTGGTATGCATAATG
TATCAAACTCATTATCAGCTGTATGTTTAGCAGAAATATTCAATATAAACGCTGATTCAATAGTATCAGGTCTTTCATCC
TTTGGAGGAGCTCATAAAAGATTCGAATACAAGGGTACTAAAAATGATATAACTGTTATTGATGATTACGCTCACCACCC
TGTTGAAATAAAAGCTACTCTAAGCACAGCTAAAAAAATGAATCACAATAGAATAGTTTGTGTATTCCAACCACATACTT
ACACAAGAACAAAAACTCTATTTAATGATTTTGTTAAATGTTTTGATGATTGTGATGAGCTTGTTTTAATGGATATATAC
GCAGCTAGAGAAAAAGATTTAGGTGAAATAAATTCAGATCAATTAGGAGATGCTATAAGAGCTCATGGAGTTAAATGTAC
AAATGTACACTCTCATGAAGAAGCATTAGAATATGTAAATGCTAACTTATCAAAAGGTGACTTACTTTTAACAGTTGGAG
CTGGTGATGTAGTTAAAGTTGGTGAACTTTTTTTAAAGTAA

Upstream 100 bases:

>100_bases
TTGTCAGTTATTTTTAGCACTAAACTAAATAAATTTTCATAAAATGATTTTAAAAAGAATTTTTTTGTGTGCTTTTCCAA
AAAAGTGTATATAATTATTA

Downstream 100 bases:

>100_bases
ATTAATTTAAAGACTATTTTATTAAAAAATAGTCTTTTTTTTATTTGCATTCTTATAAAAATAATGTTATCATTTACATG
TAGTGATTCTCTCTTTGTAC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MYISKGVDILSFDLLKDINKKVHFIGIGGVSMSGLAAVLLNAGYKVSGSDSKESEITNRLKEEGAKIYIGHSKDNLQDVD
VVVYTAAIPSDNPEIIKAKEDNLILMDRAEFLGQIMKGHKFNVAVAGTHGKTTTTSMISHVALSADLDPTILVGGDLDII
HGNFRVGNSEYFITEACEYKQSFLRFFPYVGIILNIDADHLDFYKDINHIKDTFKQFVRLIPNDGYIIGNADDEKVMEVL
EVAKCNVLTYGINNGDIQARNIEFNEKGCATFDVFRNEEKLLSLSLNVPGMHNVSNSLSAVCLAEIFNINADSIVSGLSS
FGGAHKRFEYKGTKNDITVIDDYAHHPVEIKATLSTAKKMNHNRIVCVFQPHTYTRTKTLFNDFVKCFDDCDELVLMDIY
AAREKDLGEINSDQLGDAIRAHGVKCTNVHSHEEALEYVNANLSKGDLLLTVGAGDVVKVGELFLK

Sequences:

>Translated_466_residues
MYISKGVDILSFDLLKDINKKVHFIGIGGVSMSGLAAVLLNAGYKVSGSDSKESEITNRLKEEGAKIYIGHSKDNLQDVD
VVVYTAAIPSDNPEIIKAKEDNLILMDRAEFLGQIMKGHKFNVAVAGTHGKTTTTSMISHVALSADLDPTILVGGDLDII
HGNFRVGNSEYFITEACEYKQSFLRFFPYVGIILNIDADHLDFYKDINHIKDTFKQFVRLIPNDGYIIGNADDEKVMEVL
EVAKCNVLTYGINNGDIQARNIEFNEKGCATFDVFRNEEKLLSLSLNVPGMHNVSNSLSAVCLAEIFNINADSIVSGLSS
FGGAHKRFEYKGTKNDITVIDDYAHHPVEIKATLSTAKKMNHNRIVCVFQPHTYTRTKTLFNDFVKCFDDCDELVLMDIY
AAREKDLGEINSDQLGDAIRAHGVKCTNVHSHEEALEYVNANLSKGDLLLTVGAGDVVKVGELFLK
>Mature_466_residues
MYISKGVDILSFDLLKDINKKVHFIGIGGVSMSGLAAVLLNAGYKVSGSDSKESEITNRLKEEGAKIYIGHSKDNLQDVD
VVVYTAAIPSDNPEIIKAKEDNLILMDRAEFLGQIMKGHKFNVAVAGTHGKTTTTSMISHVALSADLDPTILVGGDLDII
HGNFRVGNSEYFITEACEYKQSFLRFFPYVGIILNIDADHLDFYKDINHIKDTFKQFVRLIPNDGYIIGNADDEKVMEVL
EVAKCNVLTYGINNGDIQARNIEFNEKGCATFDVFRNEEKLLSLSLNVPGMHNVSNSLSAVCLAEIFNINADSIVSGLSS
FGGAHKRFEYKGTKNDITVIDDYAHHPVEIKATLSTAKKMNHNRIVCVFQPHTYTRTKTLFNDFVKCFDDCDELVLMDIY
AAREKDLGEINSDQLGDAIRAHGVKCTNVHSHEEALEYVNANLSKGDLLLTVGAGDVVKVGELFLK

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=456, Percent_Identity=35.7456140350877, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1790680, Length=394, Percent_Identity=28.4263959390863, Blast_Score=175, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51487; Mature: 51487

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYISKGVDILSFDLLKDINKKVHFIGIGGVSMSGLAAVLLNAGYKVSGSDSKESEITNRL
CCCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHH
KEEGAKIYIGHSKDNLQDVDVVVYTAAIPSDNPEIIKAKEDNLILMDRAEFLGQIMKGHK
HHCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCEEEECCCCEEEEEHHHHHHHHHCCCE
FNVAVAGTHGKTTTTSMISHVALSADLDPTILVGGDLDIIHGNFRVGNSEYFITEACEYK
EEEEEECCCCCCHHHHHHHHHHEECCCCCEEEECCCEEEEECCEEECCCCEEEEHHHHHH
QSFLRFFPYVGIILNIDADHLDFYKDINHIKDTFKQFVRLIPNDGYIIGNADDEKVMEVL
HHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
EVAKCNVLTYGINNGDIQARNIEFNEKGCATFDVFRNEEKLLSLSLNVPGMHNVSNSLSA
HHHHCEEEEEECCCCCEEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHH
VCLAEIFNINADSIVSGLSSFGGAHKRFEYKGTKNDITVIDDYAHHPVEIKATLSTAKKM
HHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCEEEEEEHHHHHHC
NHNRIVCVFQPHTYTRTKTLFNDFVKCFDDCDELVLMDIYAAREKDLGEINSDQLGDAIR
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
AHGVKCTNVHSHEEALEYVNANLSKGDLLLTVGAGDVVKVGELFLK
HCCCEEECCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MYISKGVDILSFDLLKDINKKVHFIGIGGVSMSGLAAVLLNAGYKVSGSDSKESEITNRL
CCCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHH
KEEGAKIYIGHSKDNLQDVDVVVYTAAIPSDNPEIIKAKEDNLILMDRAEFLGQIMKGHK
HHCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCEEEECCCCEEEEEHHHHHHHHHCCCE
FNVAVAGTHGKTTTTSMISHVALSADLDPTILVGGDLDIIHGNFRVGNSEYFITEACEYK
EEEEEECCCCCCHHHHHHHHHHEECCCCCEEEECCCEEEEECCEEECCCCEEEEHHHHHH
QSFLRFFPYVGIILNIDADHLDFYKDINHIKDTFKQFVRLIPNDGYIIGNADDEKVMEVL
HHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
EVAKCNVLTYGINNGDIQARNIEFNEKGCATFDVFRNEEKLLSLSLNVPGMHNVSNSLSA
HHHHCEEEEEECCCCCEEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHH
VCLAEIFNINADSIVSGLSSFGGAHKRFEYKGTKNDITVIDDYAHHPVEIKATLSTAKKM
HHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCEEEEEEHHHHHHC
NHNRIVCVFQPHTYTRTKTLFNDFVKCFDDCDELVLMDIYAAREKDLGEINSDQLGDAIR
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
AHGVKCTNVHSHEEALEYVNANLSKGDLLLTVGAGDVVKVGELFLK
HCCCEEECCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA