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The map label for this gene is hisB

Identifier: 16127964

GI number: 16127964

Start: 3989980

End: 3990570

Strand: Direct

Name: hisB

Synonym: CC_3734

Alternate gene names: 16127964

Gene position: 3989980-3990570 (Clockwise)

Preceding gene: 16127963

Following gene: 16127965

Centisome position: 99.33

GC content: 63.96

Gene sequence:

>591_bases
ATGGCCCGCACCGCTGAAGTGGTCCGCGAGACGAAGGAGACCCAGATCCGGGTCTGGATCGATCTCGACGGGACCGGCGT
CTCGACGATCTCCACCGGCATTGGTTTCTACGACCATATGCTGGAGAGCTTCGCGCGCCATGGCGGCTTCGACCTGAAGG
TCGAGACCAAGGGCGATCTGCACATCGACATGCACCATACGGTCGAGGACACCGGCATCGTGCTGGGCCAGGCGATCCAC
AAAGCGCTGGACGGCTTCAAGGGCATCCGACGCTTCGGCTCGGCCTATATCCCGATGGACGAGACCCTGACGCGCTGCGC
CATCGACCTGTCGAACCGGCCGTATCTGATCTGGAAGGTCGAGTTCAAGCGGCCCAAGGTCGGCGAGATGGACACCGAGC
TCTTCAAGGAGTTCCACCACGCGTTCGCGATGAACAGCGGGGCGTGCATCCATCTGGAAACGCTCTACGGCGACAACACC
CACCACGTCGCCGAAAGCGGCTTCAAGGCCCTGGCCCGGGCGCTGCGTCAGGCGGTCGAGATCGACCCCAAGACCGGCGG
CCAGGCTCCGTCCACCAAGGGCGTGCTGTAG

Upstream 100 bases:

>100_bases
CTGGGCAGCCTGGCGGCCGCCGAGGTGATCGACCACTACGGTCCGCGTCCGCAGGTGTCCCTGCGCGAGCTGGCTGAAAA
GAACGGACTTTAGAGCTCAA

Downstream 100 bases:

>100_bases
GAACCTGATTTCATGCAGACCGTCGCCCTGATCGATTACGGGTCGGGCAACCTGCGTTCGGCCGAGAAGGCCCTGCGTGA
GGCGGCCCGACGCCGCGCGC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MARTAEVVRETKETQIRVWIDLDGTGVSTISTGIGFYDHMLESFARHGGFDLKVETKGDLHIDMHHTVEDTGIVLGQAIH
KALDGFKGIRRFGSAYIPMDETLTRCAIDLSNRPYLIWKVEFKRPKVGEMDTELFKEFHHAFAMNSGACIHLETLYGDNT
HHVAESGFKALARALRQAVEIDPKTGGQAPSTKGVL

Sequences:

>Translated_196_residues
MARTAEVVRETKETQIRVWIDLDGTGVSTISTGIGFYDHMLESFARHGGFDLKVETKGDLHIDMHHTVEDTGIVLGQAIH
KALDGFKGIRRFGSAYIPMDETLTRCAIDLSNRPYLIWKVEFKRPKVGEMDTELFKEFHHAFAMNSGACIHLETLYGDNT
HHVAESGFKALARALRQAVEIDPKTGGQAPSTKGVL
>Mature_195_residues
ARTAEVVRETKETQIRVWIDLDGTGVSTISTGIGFYDHMLESFARHGGFDLKVETKGDLHIDMHHTVEDTGIVLGQAIHK
ALDGFKGIRRFGSAYIPMDETLTRCAIDLSNRPYLIWKVEFKRPKVGEMDTELFKEFHHAFAMNSGACIHLETLYGDNTH
HVAESGFKALARALRQAVEIDPKTGGQAPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=51.5463917525773, Blast_Score=192, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=43.1192660550459, Blast_Score=177, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_CAUCN (B8GW12)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002519223.1
- ProteinModelPortal:   B8GW12
- SMR:   B8GW12
- GeneID:   7332698
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_03850
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21811; Mature: 21680

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTAEVVRETKETQIRVWIDLDGTGVSTISTGIGFYDHMLESFARHGGFDLKVETKGDL
CCCHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCE
HIDMHHTVEDTGIVLGQAIHKALDGFKGIRRFGSAYIPMDETLTRCAIDLSNRPYLIWKV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEE
EFKRPKVGEMDTELFKEFHHAFAMNSGACIHLETLYGDNTHHVAESGFKALARALRQAVE
EECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
IDPKTGGQAPSTKGVL
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARTAEVVRETKETQIRVWIDLDGTGVSTISTGIGFYDHMLESFARHGGFDLKVETKGDL
CCHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCE
HIDMHHTVEDTGIVLGQAIHKALDGFKGIRRFGSAYIPMDETLTRCAIDLSNRPYLIWKV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEE
EFKRPKVGEMDTELFKEFHHAFAMNSGACIHLETLYGDNTHHVAESGFKALARALRQAVE
EECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
IDPKTGGQAPSTKGVL
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA