Click here to switch to the map view.

The map label for this gene is rbsK [C]

Identifier: 16127963

GI number: 16127963

Start: 3988875

End: 3989972

Strand: Direct

Name: rbsK [C]

Synonym: CC_3733

Alternate gene names: 16127963

Gene position: 3988875-3989972 (Clockwise)

Preceding gene: 16127961

Following gene: 16127964

Centisome position: 99.3

GC content: 67.03

Gene sequence:

>1098_bases
ATGTCGCAGGGCGATGGGCAACCCTCGCGTTGCCATGGCCGGTCACATCCTTTAATCGCAACGCTGCTTGGACCTTCGGT
CCTGTTCTTTCAAAGGTTTTTCCGTCTCATGACCGCGCTCTACGACGTCGCCGCCATCGGCAACGCCATCGTCGACGTCA
TCGCTCAGTGCGACGACGCCTTCCTCGAGCGCGAGGGCCTGGTCAAGGGCTCGATGGCCCTGATCGATCCGGCGCGCGCC
GCCAGCCTGTACGACGTGATGTCTGCCGCGATCGAAGCCTCGGGCGGCAGCGCCGCCAACACGGTGGCGGGCGTGGCCAG
CTTCGGCGGCAAGGCGGCGTTTCTGGGCAAGGTCGCGGACGACCAGCTGGGCCGCGTTTTCCGCCACGACATGAACGCGA
TCGGCTGCGTGTTCACGACCCCGCCGCTCGCCGAAGGCCCGGCGACGGCCCAGAGCCTGATCAACGTCACGCCCGACGCT
CAGCGCACCATGTCGACCTATCTGGGCGCCTGCGTCGAACTGAACCCCGCCGACGTCGACCCGGACATCATCGAGGCCGC
GCAGATCTCGTATCTGGAAGGCTATCTGTTCGATCCGCCCGAAGCGCGCCGCGCCTTCGCCAAGGCCGCCGCCCTCGCAC
ACGGCTCGGACCGCAAGATCGCCCTGACCCTGTCCGACAGCTTCGTCGTCGATCGCCACCGCGGCGCCCTGCTGGGCTTC
GTCGAGACCCAGTGCGACATCGTCTTCGCCAACGCCGCCGAGGTCTGCGCCCTGTTCGAGACCGACGATTTCGACGCGGC
GGTGAAGGCCCTGGCCGAACGCTGCGAGATCGCCGCCGTGACCCGCAGCGAAAAGGGCTCGGTGGTCGCAGCAAACGGGC
AGTTGCACGAAATCTCGGCCTACCCCGTGGAAAAAGTCGTGGACACGACCGGCGCGGGCGACCAATACGCGGCGGGTTTC
CTCTTTGGCCTTTCCCAGGGCCGCCCGCTGCCTATCTGTGGCCAGCTGGGCAGCCTGGCGGCCGCCGAGGTGATCGACCA
CTACGGTCCGCGTCCGCAGGTGTCCCTGCGCGAGCTGGCTGAAAAGAACGGACTTTAG

Upstream 100 bases:

>100_bases
TCAACCAGCTGTCGCCATAGCGATGCTCGTCACGAGCCGGGACCAGGAGCAGAACGTCGACCATCGGTTTACCCATGCTT
GCTAGAACAGCGCAGCTAGG

Downstream 100 bases:

>100_bases
AGCTCAAATGGCCCGCACCGCTGAAGTGGTCCGCGAGACGAAGGAGACCCAGATCCGGGTCTGGATCGATCTCGACGGGA
CCGGCGTCTCGACGATCTCC

Product: carbohydrate kinase

Products: ADP; H+; alpha-D-Ribose 5-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MSQGDGQPSRCHGRSHPLIATLLGPSVLFFQRFFRLMTALYDVAAIGNAIVDVIAQCDDAFLEREGLVKGSMALIDPARA
ASLYDVMSAAIEASGGSAANTVAGVASFGGKAAFLGKVADDQLGRVFRHDMNAIGCVFTTPPLAEGPATAQSLINVTPDA
QRTMSTYLGACVELNPADVDPDIIEAAQISYLEGYLFDPPEARRAFAKAAALAHGSDRKIALTLSDSFVVDRHRGALLGF
VETQCDIVFANAAEVCALFETDDFDAAVKALAERCEIAAVTRSEKGSVVAANGQLHEISAYPVEKVVDTTGAGDQYAAGF
LFGLSQGRPLPICGQLGSLAAAEVIDHYGPRPQVSLRELAEKNGL

Sequences:

>Translated_365_residues
MSQGDGQPSRCHGRSHPLIATLLGPSVLFFQRFFRLMTALYDVAAIGNAIVDVIAQCDDAFLEREGLVKGSMALIDPARA
ASLYDVMSAAIEASGGSAANTVAGVASFGGKAAFLGKVADDQLGRVFRHDMNAIGCVFTTPPLAEGPATAQSLINVTPDA
QRTMSTYLGACVELNPADVDPDIIEAAQISYLEGYLFDPPEARRAFAKAAALAHGSDRKIALTLSDSFVVDRHRGALLGF
VETQCDIVFANAAEVCALFETDDFDAAVKALAERCEIAAVTRSEKGSVVAANGQLHEISAYPVEKVVDTTGAGDQYAAGF
LFGLSQGRPLPICGQLGSLAAAEVIDHYGPRPQVSLRELAEKNGL
>Mature_364_residues
SQGDGQPSRCHGRSHPLIATLLGPSVLFFQRFFRLMTALYDVAAIGNAIVDVIAQCDDAFLEREGLVKGSMALIDPARAA
SLYDVMSAAIEASGGSAANTVAGVASFGGKAAFLGKVADDQLGRVFRHDMNAIGCVFTTPPLAEGPATAQSLINVTPDAQ
RTMSTYLGACVELNPADVDPDIIEAAQISYLEGYLFDPPEARRAFAKAAALAHGSDRKIALTLSDSFVVDRHRGALLGFV
ETQCDIVFANAAEVCALFETDDFDAAVKALAERCEIAAVTRSEKGSVVAANGQLHEISAYPVEKVVDTTGAGDQYAAGFL
FGLSQGRPLPICGQLGSLAAAEVIDHYGPRPQVSLRELAEKNGL

Specific function: Ribose metabolism; first step. [C]

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family [H]

Homologues:

Organism=Homo sapiens, GI32484975, Length=334, Percent_Identity=23.9520958083832, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI32484973, Length=334, Percent_Identity=23.9520958083832, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790193, Length=272, Percent_Identity=27.2058823529412, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17541820, Length=340, Percent_Identity=23.8235294117647, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322565, Length=335, Percent_Identity=26.2686567164179, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355521, Length=341, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356339, Length=331, Percent_Identity=24.4712990936556, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24663633, Length=331, Percent_Identity=24.4712990936556, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: 2.7.1.15 [C]

Molecular weight: Translated: 38353; Mature: 38222

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQGDGQPSRCHGRSHPLIATLLGPSVLFFQRFFRLMTALYDVAAIGNAIVDVIAQCDDA
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLEREGLVKGSMALIDPARAASLYDVMSAAIEASGGSAANTVAGVASFGGKAAFLGKVAD
HHHHCCCCCCCHHEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEECCCHHH
DQLGRVFRHDMNAIGCVFTTPPLAEGPATAQSLINVTPDAQRTMSTYLGACVELNPADVD
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCC
PDIIEAAQISYLEGYLFDPPEARRAFAKAAALAHGSDRKIALTLSDSFVVDRHRGALLGF
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEE
VETQCDIVFANAAEVCALFETDDFDAAVKALAERCEIAAVTRSEKGSVVAANGQLHEISA
EECCCCEEEECHHHEEEEECCCCHHHHHHHHHHHHHEEEEECCCCCCEEEECCCEEEECC
YPVEKVVDTTGAGDQYAAGFLFGLSQGRPLPICGQLGSLAAAEVIDHYGPRPQVSLRELA
CCHHHHHHCCCCCCHHHHHHHEECCCCCCCCHHCCHHHHHHHHHHHHCCCCCCHHHHHHH
EKNGL
HHCCC
>Mature Secondary Structure 
SQGDGQPSRCHGRSHPLIATLLGPSVLFFQRFFRLMTALYDVAAIGNAIVDVIAQCDDA
CCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLEREGLVKGSMALIDPARAASLYDVMSAAIEASGGSAANTVAGVASFGGKAAFLGKVAD
HHHHCCCCCCCHHEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEECCCHHH
DQLGRVFRHDMNAIGCVFTTPPLAEGPATAQSLINVTPDAQRTMSTYLGACVELNPADVD
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCC
PDIIEAAQISYLEGYLFDPPEARRAFAKAAALAHGSDRKIALTLSDSFVVDRHRGALLGF
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEE
VETQCDIVFANAAEVCALFETDDFDAAVKALAERCEIAAVTRSEKGSVVAANGQLHEISA
EECCCCEEEECHHHEEEEECCCCHHHHHHHHHHHHHEEEEECCCCCCEEEECCCEEEECC
YPVEKVVDTTGAGDQYAAGFLFGLSQGRPLPICGQLGSLAAAEVIDHYGPRPQVSLRELA
CCHHHHHHCCCCCCHHHHHHHEECCCCCCCCHHCCHHHHHHHHHHHHCCCCCCHHHHHHH
EKNGL
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; D-Ribose [C]

Specific reaction: ATP + D-Ribose --> ADP + H+ + alpha-D-Ribose 5-phosphate [C]

General reaction: Phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]