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The map label for this gene is dut

Identifier: 16127943

GI number: 16127943

Start: 3967749

End: 3968216

Strand: Direct

Name: dut

Synonym: CC_3713

Alternate gene names: 16127943

Gene position: 3967749-3968216 (Clockwise)

Preceding gene: 16127942

Following gene: 16127944

Centisome position: 98.78

GC content: 69.23

Gene sequence:

>468_bases
ATGTCCGCCATCCCCGCTGGTCTCGCCATTCGTTTCAAGCGCTGGGAGGGCAACGCCGACCTGCCGGTCCCCGCCTACGC
CACGGTCGGCGCGGCGGGTTTCGACCTGCGGGCCCATGTGCCGGATGACGCGCCGATCGTCCTGAAGCCGGGCGCCCGTT
GCATGGCCCCGACGGGCTTTTCGGTTGCGATCCCCGACGGCTACGAGATGCAGGTGCGTCCGCGCTCGGGACTTGCGCTC
AAGAACGGCGTCACGGTCGTCAACGCGCCGGGCACCGTCGACAGCGACTATCGCGGCCAGGTCTGCGTGCTGCTGATCAA
TCTGGGCGAAGAGGACTTCACGATCCGCCGTGGCGACCGCATCGCCCAGGGCGTCATCGCCGCCGCGCCCCAATGGCCCC
TGGTCGAGGTCGAGGACCTGGACGCGACAGAGCGAGGCGCGGGCGGTTTCGGATCTACCGGAGTCTAG

Upstream 100 bases:

>100_bases
CCGCTCAGATCGCCCAACGGATCGCAGAGGCCTTGGGTTAGCCTTCAGAGCGCCGGGCAAATCAGCTACAGCCGGAGCTA
ACGCGTCCGAGGAGCTCCGC

Downstream 100 bases:

>100_bases
TTGGCCACAGGCTGGATGGCCCGCAGGCCCAGGACCAGGTAGCCGCCAAACCCTGCGGCGAAGGCGGCGGCGGCCATCCA
CAGAACCGGGCGGATCATGT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MSAIPAGLAIRFKRWEGNADLPVPAYATVGAAGFDLRAHVPDDAPIVLKPGARCMAPTGFSVAIPDGYEMQVRPRSGLAL
KNGVTVVNAPGTVDSDYRGQVCVLLINLGEEDFTIRRGDRIAQGVIAAAPQWPLVEVEDLDATERGAGGFGSTGV

Sequences:

>Translated_155_residues
MSAIPAGLAIRFKRWEGNADLPVPAYATVGAAGFDLRAHVPDDAPIVLKPGARCMAPTGFSVAIPDGYEMQVRPRSGLAL
KNGVTVVNAPGTVDSDYRGQVCVLLINLGEEDFTIRRGDRIAQGVIAAAPQWPLVEVEDLDATERGAGGFGSTGV
>Mature_154_residues
SAIPAGLAIRFKRWEGNADLPVPAYATVGAAGFDLRAHVPDDAPIVLKPGARCMAPTGFSVAIPDGYEMQVRPRSGLALK
NGVTVVNAPGTVDSDYRGQVCVLLINLGEEDFTIRRGDRIAQGVIAAAPQWPLVEVEDLDATERGAGGFGSTGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI4503423, Length=148, Percent_Identity=41.2162162162162, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI70906444, Length=147, Percent_Identity=40.8163265306122, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI70906441, Length=148, Percent_Identity=41.2162162162162, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1790071, Length=136, Percent_Identity=44.1176470588235, Blast_Score=112, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71988561, Length=146, Percent_Identity=43.8356164383562, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319729, Length=138, Percent_Identity=39.1304347826087, Blast_Score=91, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24583610, Length=146, Percent_Identity=41.7808219178082, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19921126, Length=146, Percent_Identity=41.7808219178082, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_CAUCN (B8GVZ0)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002519201.1
- ProteinModelPortal:   B8GVZ0
- SMR:   B8GVZ0
- GeneID:   7332676
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_03828
- OMA:   NEAYTIN
- ProtClustDB:   CLSK2461482
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 16216; Mature: 16084

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: BINDING 88-88

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIPAGLAIRFKRWEGNADLPVPAYATVGAAGFDLRAHVPDDAPIVLKPGARCMAPTGF
CCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCCEEECCCCCEECCCCC
SVAIPDGYEMQVRPRSGLALKNGVTVVNAPGTVDSDYRGQVCVLLINLGEEDFTIRRGDR
EEECCCCCEEEEECCCCEEECCCEEEEECCCCCCCCCCCEEEEEEEECCCCCEEEECCCC
IAQGVIAAAPQWPLVEVEDLDATERGAGGFGSTGV
HHCCEEECCCCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAIPAGLAIRFKRWEGNADLPVPAYATVGAAGFDLRAHVPDDAPIVLKPGARCMAPTGF
CCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCCEEECCCCCEECCCCC
SVAIPDGYEMQVRPRSGLALKNGVTVVNAPGTVDSDYRGQVCVLLINLGEEDFTIRRGDR
EEECCCCCEEEEECCCCEEECCCEEEEECCCCCCCCCCCEEEEEEEECCCCCEEEECCCC
IAQGVIAAAPQWPLVEVEDLDATERGAGGFGSTGV
HHCCEEECCCCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA