| Definition | Caulobacter crescentus CB15 chromosome, complete genome. |
|---|---|
| Accession | NC_002696 |
| Length | 4,016,947 |
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The map label for this gene is coaBC [H]
Identifier: 16127942
GI number: 16127942
Start: 3966451
End: 3967689
Strand: Direct
Name: coaBC [H]
Synonym: CC_3712
Alternate gene names: 16127942
Gene position: 3966451-3967689 (Clockwise)
Preceding gene: 16127939
Following gene: 16127943
Centisome position: 98.74
GC content: 68.44
Gene sequence:
>1239_bases ATGGGCATGTGCTGGGGGAACGACCGGAGCGTGGAGCGGGACGTGGGCGAGAAGCGGGTTCTTCTGATCGTCGGCGGCGG TGTGGCGGCCTACAAGGCGCTGCTGCTGACGCGCCTTCTAAGAAAGGCCGGCGTGGCCGTGCGACCGATCCTGACCAAGG CCGGCGCCGCGTTCGTCACGCCTTTGTCTCTGGCCGCGCTGGCCGAGGACAAGGTCTACGAGGATCTCTTCTCGCTGACC GACGAGCATGAGATGGGCCATATCGAGCTGTCGCGCTCGGCTGATCTCGTGGTGGTGGCGCCGGCGACCGCTGACCTGAT CGCCAAGGCGGCCCAGGGTCTGGCCGGAGACCTGGCCTCCACTACGCTGCTGGCCACCGACAAGCCTGTCCTGATGGCCC CAGCCATGAACGTGCGCATGTGGCTGCATCCAGCAACCCAACGCAACATCGCGACTCTCGAGGCCGACGGCGTGCGCTTC GTCGGCCCTGAGGAGGGCGCCATGGCATGCGGTGAATTCGGCCCCGGTCGTCTGGCCGAACCCGAGGCGATCTTCGCCGC GATCATGGCGGCGCTGGAAGGTCCCGCCGCCCGACCGCTGGAGGGCAAGCGGGCGCTGGTCACCGCTGGACCCACGTTCG AACCCATCGATCCCGTGCGCGGCATTACAAACCGGTCCAGCGGCAAACAGGGCTTCGCTATCGCTGAGGCCCTGGCCAAG CTCGGCGCAGAGGTGACCTTGATCGCTGGCCCCGTCGCGCTTCCGACCCCACCCGGCGTCCGCCGGATCGATGTCGAGAC CGCCCGACAGATGCTGGCGGCCAGCCAGGCCGCTCTGCCCGCCGACGTCGGCGTCTTTGTCGCGGCTGTGGCCGACTGGC GGGTCGACGAGGCGTTTGGCAGCAAGCTGAAGAAGGAGAAGGGCGGACCGCCGGCCCTGACCTTCGTCGAGAATCCCGAC ATCCTGGCGACCTTGTCGGCCAGCGGACCCCATCGCCCGCGCCTTGTCGTCGGTTTCGCGGCGGAGACCGACCATGTCGA GGAGCACGCCCGCGCCAAGCTGGCGCGCAAGGGTTGCGACTGGATCATCGCCAACGATGTCACCGAGCCCGGCGTCATGG GCGGCGGCGAGAACGCCGTGCTGCTGGTGACCAAAACCGGAACCGAGCGCTGGGACCGCGCCGCCAAGGATCGGGTCGCC GCTCAGATCGCCCAACGGATCGCAGAGGCCTTGGGTTAG
Upstream 100 bases:
>100_bases ATAACCCAATTGCTCTACCTAGACGATTGATGAACGAAAGCGGAACGCGAGTCGAGTCCCTTTTTCGCCCTCCGATTGGC TCTGGCGCTTTGGCGCGCGG
Downstream 100 bases:
>100_bases CCTTCAGAGCGCCGGGCAAATCAGCTACAGCCGGAGCTAACGCGTCCGAGGAGCTCCGCATGTCCGCCATCCCCGCTGGT CTCGCCATTCGTTTCAAGCG
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 412; Mature: 411
Protein sequence:
>412_residues MGMCWGNDRSVERDVGEKRVLLIVGGGVAAYKALLLTRLLRKAGVAVRPILTKAGAAFVTPLSLAALAEDKVYEDLFSLT DEHEMGHIELSRSADLVVVAPATADLIAKAAQGLAGDLASTTLLATDKPVLMAPAMNVRMWLHPATQRNIATLEADGVRF VGPEEGAMACGEFGPGRLAEPEAIFAAIMAALEGPAARPLEGKRALVTAGPTFEPIDPVRGITNRSSGKQGFAIAEALAK LGAEVTLIAGPVALPTPPGVRRIDVETARQMLAASQAALPADVGVFVAAVADWRVDEAFGSKLKKEKGGPPALTFVENPD ILATLSASGPHRPRLVVGFAAETDHVEEHARAKLARKGCDWIIANDVTEPGVMGGGENAVLLVTKTGTERWDRAAKDRVA AQIAQRIAEALG
Sequences:
>Translated_412_residues MGMCWGNDRSVERDVGEKRVLLIVGGGVAAYKALLLTRLLRKAGVAVRPILTKAGAAFVTPLSLAALAEDKVYEDLFSLT DEHEMGHIELSRSADLVVVAPATADLIAKAAQGLAGDLASTTLLATDKPVLMAPAMNVRMWLHPATQRNIATLEADGVRF VGPEEGAMACGEFGPGRLAEPEAIFAAIMAALEGPAARPLEGKRALVTAGPTFEPIDPVRGITNRSSGKQGFAIAEALAK LGAEVTLIAGPVALPTPPGVRRIDVETARQMLAASQAALPADVGVFVAAVADWRVDEAFGSKLKKEKGGPPALTFVENPD ILATLSASGPHRPRLVVGFAAETDHVEEHARAKLARKGCDWIIANDVTEPGVMGGGENAVLLVTKTGTERWDRAAKDRVA AQIAQRIAEALG >Mature_411_residues GMCWGNDRSVERDVGEKRVLLIVGGGVAAYKALLLTRLLRKAGVAVRPILTKAGAAFVTPLSLAALAEDKVYEDLFSLTD EHEMGHIELSRSADLVVVAPATADLIAKAAQGLAGDLASTTLLATDKPVLMAPAMNVRMWLHPATQRNIATLEADGVRFV GPEEGAMACGEFGPGRLAEPEAIFAAIMAALEGPAARPLEGKRALVTAGPTFEPIDPVRGITNRSSGKQGFAIAEALAKL GAEVTLIAGPVALPTPPGVRRIDVETARQMLAASQAALPADVGVFVAAVADWRVDEAFGSKLKKEKGGPPALTFVENPDI LATLSASGPHRPRLVVGFAAETDHVEEHARAKLARKGCDWIIANDVTEPGVMGGGENAVLLVTKTGTERWDRAAKDRVAA QIAQRIAEALG
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=173, Percent_Identity=34.6820809248555, Blast_Score=85, Evalue=1e-16, Organism=Escherichia coli, GI87082301, Length=367, Percent_Identity=48.5013623978202, Blast_Score=296, Evalue=2e-81, Organism=Caenorhabditis elegans, GI17560194, Length=198, Percent_Identity=29.7979797979798, Blast_Score=80, Evalue=3e-15, Organism=Saccharomyces cerevisiae, GI6322762, Length=183, Percent_Identity=27.3224043715847, Blast_Score=76, Evalue=1e-14, Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=29.7872340425532, Blast_Score=80, Evalue=2e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 43106; Mature: 42975
Theoretical pI: Translated: 6.02; Mature: 6.02
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGMCWGNDRSVERDVGEKRVLLIVGGGVAAYKALLLTRLLRKAGVAVRPILTKAGAAFVT CCCCCCCCCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHCCCHHHH PLSLAALAEDKVYEDLFSLTDEHEMGHIELSRSADLVVVAPATADLIAKAAQGLAGDLAS HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHH TTLLATDKPVLMAPAMNVRMWLHPATQRNIATLEADGVRFVGPEEGAMACGEFGPGRLAE EEEEECCCCEEEECCCCEEEEEECCCCCCEEEEECCCEEEECCCCCCEECCCCCCCCCCC PEAIFAAIMAALEGPAARPLEGKRALVTAGPTFEPIDPVRGITNRSSGKQGFAIAEALAK HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHH LGAEVTLIAGPVALPTPPGVRRIDVETARQMLAASQAALPADVGVFVAAVADWRVDEAFG CCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHH SKLKKEKGGPPALTFVENPDILATLSASGPHRPRLVVGFAAETDHVEEHARAKLARKGCD HHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCC WIIANDVTEPGVMGGGENAVLLVTKTGTERWDRAAKDRVAAQIAQRIAEALG EEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC >Mature Secondary Structure GMCWGNDRSVERDVGEKRVLLIVGGGVAAYKALLLTRLLRKAGVAVRPILTKAGAAFVT CCCCCCCCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHCCCHHHH PLSLAALAEDKVYEDLFSLTDEHEMGHIELSRSADLVVVAPATADLIAKAAQGLAGDLAS HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHH TTLLATDKPVLMAPAMNVRMWLHPATQRNIATLEADGVRFVGPEEGAMACGEFGPGRLAE EEEEECCCCEEEECCCCEEEEEECCCCCCEEEEECCCEEEECCCCCCEECCCCCCCCCCC PEAIFAAIMAALEGPAARPLEGKRALVTAGPTFEPIDPVRGITNRSSGKQGFAIAEALAK HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHH LGAEVTLIAGPVALPTPPGVRRIDVETARQMLAASQAALPADVGVFVAAVADWRVDEAFG CCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHH SKLKKEKGGPPALTFVENPDILATLSASGPHRPRLVVGFAAETDHVEEHARAKLARKGCD HHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCC WIIANDVTEPGVMGGGENAVLLVTKTGTERWDRAAKDRVAAQIAQRIAEALG EEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7542800 [H]