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The map label for this gene is epsC [H]

Identifier: 16127440

GI number: 16127440

Start: 3465102

End: 3466985

Strand: Direct

Name: epsC [H]

Synonym: CC_3210

Alternate gene names: 16127440

Gene position: 3465102-3466985 (Clockwise)

Preceding gene: 16127439

Following gene: 16127444

Centisome position: 86.26

GC content: 69.32

Gene sequence:

>1884_bases
ATGGGGCATGCAGGAAAGATCGCGACCCACGTTCTGCTGGCCTTCGTGGCCCTGCTGGCCGGTCGCTATCTCGTCATCGA
CATGCCGTTCACGCGGGACACGCTGCTTCAGGCGACCCTGTACGGCCTCGCAGCATTCATCGTGGAGTTGGCTTTCCGGG
TGGAGCGGGCCCCGTGGCGCTTCGTCTCGGCCACCGACCACCTGCGACTTCTCCGCTCGGCCGTCCTGACGGCGGCGGCG
TTCCTGGTCATTACCCGCCTGACCCATCCAGGCATCGACGGTGGCCTGCGCACCGTGGCCGGCGCGGCCCTGATCCAGGC
GGCGCTGCTGTCGGCGCTGCGGGTGATCCGGCGGAGCCTGCATGAGCGAATGCTGCTCGATTCGGTGCTGCGCCTTGGCC
CCGCCTCGATGCATCCGGCGCTGCCGCGCCTGCTGATCATCGGCTCGGCCTCCGAGGCCGAAGCCTTCCTGCGCGCGCCG
GCCGGGCTTGGCGAACGTTACGCCCCGATCGGCGTGGTCTCGCCGCTCGACCGCGAGACCGGCGATGAACTGCGCGGCGT
CTGCGTTCTGGGCTCGATCGCCGATTTCGACAGCGTGCTGGCCCGTCTGCGCGACAGCGGCCTGTCGCCGGCCGCGATCC
TGTTCCTCACCGACAGCGCGATGAGCACCTTCGGCGCCGAGCGTCTGGGCCGCTTGAAGACGGAAGGCGTGCGCCTGCTG
CGCCGCCACGGCGTGGTCGAGATGGGCGCGGCGGCCAACACCCCCCAGCTGCGCGAGATCAGCATCGAGGAACTCTTGAG
CCGGCCGCCTGTCCGACTGGATCCAGAGCCGGTTCGCGCGCTGGTGTCCGGTCGACGGGTGCTGGTGACAGGCGCGGGGG
GCAGCATCGGTTCCGAGCTCTGCCGTCAGATCGCCGCCAGCGGCTGCGCCCATCTGACCATGGTCGACGCCTCCGAATAC
AACCTGTTCCACATCGAGCGCGAGATCGCCGAGCGGCACCCGCTCCTCTCGCGTCGTGAGGCGCTCTGCGACGTCCGCGA
CGCCGCCCGCGTCCAGCGTGTCTTCACGGAGATGAAGCCGGACATCATCTTCCACGCTGCGGCGCTGAAGCATGTCACGC
TGGTGGAGAACCACCCCTGCGAGGGCGTCCGCACCAATGTGCTGGGCACCCGCAACGTGGCCGTCGCCGCCAAGGCCTGC
GGCGCGGCGCATCTCGCCTTGATCTCGACGGACAAGGCCGTCGCGCCGACCAGCGTGATGGGCGCGGCCAAGCGTGTCGC
CGAGGCCGTGGCGCGTCAGTACGGCGGCGGCGGCGACATGCGGGTCAGCATCGTGCGCTTTGGCAATGTGCTGGGCTCGG
CCGGATCGGTCGTTCCGATCTTCAAGAGCCAGATCGCCCGGGGCGGGCCGATCACCCTGACCCACGCCGAGGTCGAACGC
TATTTCATGACCATCCCGGAGGCGGTGCAGCTTGTGCTCCGCGCCGTGGCCCTGTCGATGATCGCTTCGGAACCCGAGGC
CGGTGTGCTGACCCTGGAGATGGGCGAGCCGGTGAAGATCATCGACCTGGCCCGGCGGATGATCGAGCTGCAGGGCCTGA
CGCCCGGGCGCGACATCGATATCCAGATCACGGGCCTGCGTCCCGGCGAGAAATTGACGGAGACGCTCGTCGACGTGAAC
GAGGTGGCGCGCCTGAAGGCGCCCGGCATCATGGAAGCGGTTCGTCTGGCGCCCGCTCCCATCATCGCCGACGAGCGCCT
CGCCGAACTGGACGCCCTGGCCGAGGTCGGCGACGAAGCGGGCGTGCGCGCCCGTCTCTTCGCGTTGGTCGAGGACCTCC
GTCAGGTTGGCCCGTCCAAGGTCGTGAAGATCCGGGCGTCCTGA

Upstream 100 bases:

>100_bases
CGGCGCGGCTGAAACCGCGACGGCATAGAATTGACGTGCTAAGCCCGGATTTGAGTTCGCCGGGCGTGACCCGACCTTCA
CCGCTTCAGAGGTTCGTTTC

Downstream 100 bases:

>100_bases
AACGGCCAGGATCGCGCCCCGCTCAATGGAAATCGCGGCTGCGGAGCAGGCGGCCTGACACCTTCTGGCGTATGCGCGGC
GCGGGCGCGCCCGGCTCGTC

Product: hypothetical protein

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MGHAGKIATHVLLAFVALLAGRYLVIDMPFTRDTLLQATLYGLAAFIVELAFRVERAPWRFVSATDHLRLLRSAVLTAAA
FLVITRLTHPGIDGGLRTVAGAALIQAALLSALRVIRRSLHERMLLDSVLRLGPASMHPALPRLLIIGSASEAEAFLRAP
AGLGERYAPIGVVSPLDRETGDELRGVCVLGSIADFDSVLARLRDSGLSPAAILFLTDSAMSTFGAERLGRLKTEGVRLL
RRHGVVEMGAAANTPQLREISIEELLSRPPVRLDPEPVRALVSGRRVLVTGAGGSIGSELCRQIAASGCAHLTMVDASEY
NLFHIEREIAERHPLLSRREALCDVRDAARVQRVFTEMKPDIIFHAAALKHVTLVENHPCEGVRTNVLGTRNVAVAAKAC
GAAHLALISTDKAVAPTSVMGAAKRVAEAVARQYGGGGDMRVSIVRFGNVLGSAGSVVPIFKSQIARGGPITLTHAEVER
YFMTIPEAVQLVLRAVALSMIASEPEAGVLTLEMGEPVKIIDLARRMIELQGLTPGRDIDIQITGLRPGEKLTETLVDVN
EVARLKAPGIMEAVRLAPAPIIADERLAELDALAEVGDEAGVRARLFALVEDLRQVGPSKVVKIRAS

Sequences:

>Translated_627_residues
MGHAGKIATHVLLAFVALLAGRYLVIDMPFTRDTLLQATLYGLAAFIVELAFRVERAPWRFVSATDHLRLLRSAVLTAAA
FLVITRLTHPGIDGGLRTVAGAALIQAALLSALRVIRRSLHERMLLDSVLRLGPASMHPALPRLLIIGSASEAEAFLRAP
AGLGERYAPIGVVSPLDRETGDELRGVCVLGSIADFDSVLARLRDSGLSPAAILFLTDSAMSTFGAERLGRLKTEGVRLL
RRHGVVEMGAAANTPQLREISIEELLSRPPVRLDPEPVRALVSGRRVLVTGAGGSIGSELCRQIAASGCAHLTMVDASEY
NLFHIEREIAERHPLLSRREALCDVRDAARVQRVFTEMKPDIIFHAAALKHVTLVENHPCEGVRTNVLGTRNVAVAAKAC
GAAHLALISTDKAVAPTSVMGAAKRVAEAVARQYGGGGDMRVSIVRFGNVLGSAGSVVPIFKSQIARGGPITLTHAEVER
YFMTIPEAVQLVLRAVALSMIASEPEAGVLTLEMGEPVKIIDLARRMIELQGLTPGRDIDIQITGLRPGEKLTETLVDVN
EVARLKAPGIMEAVRLAPAPIIADERLAELDALAEVGDEAGVRARLFALVEDLRQVGPSKVVKIRAS
>Mature_626_residues
GHAGKIATHVLLAFVALLAGRYLVIDMPFTRDTLLQATLYGLAAFIVELAFRVERAPWRFVSATDHLRLLRSAVLTAAAF
LVITRLTHPGIDGGLRTVAGAALIQAALLSALRVIRRSLHERMLLDSVLRLGPASMHPALPRLLIIGSASEAEAFLRAPA
GLGERYAPIGVVSPLDRETGDELRGVCVLGSIADFDSVLARLRDSGLSPAAILFLTDSAMSTFGAERLGRLKTEGVRLLR
RHGVVEMGAAANTPQLREISIEELLSRPPVRLDPEPVRALVSGRRVLVTGAGGSIGSELCRQIAASGCAHLTMVDASEYN
LFHIEREIAERHPLLSRREALCDVRDAARVQRVFTEMKPDIIFHAAALKHVTLVENHPCEGVRTNVLGTRNVAVAAKACG
AAHLALISTDKAVAPTSVMGAAKRVAEAVARQYGGGGDMRVSIVRFGNVLGSAGSVVPIFKSQIARGGPITLTHAEVERY
FMTIPEAVQLVLRAVALSMIASEPEAGVLTLEMGEPVKIIDLARRMIELQGLTPGRDIDIQITGLRPGEKLTETLVDVNE
VARLKAPGIMEAVRLAPAPIIADERLAELDALAEVGDEAGVRARLFALVEDLRQVGPSKVVKIRAS

Specific function: Involved in biofilm formation [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 67106; Mature: 66975

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHAGKIATHVLLAFVALLAGRYLVIDMPFTRDTLLQATLYGLAAFIVELAFRVERAPWR
CCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
FVSATDHLRLLRSAVLTAAAFLVITRLTHPGIDGGLRTVAGAALIQAALLSALRVIRRSL
EECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HERMLLDSVLRLGPASMHPALPRLLIIGSASEAEAFLRAPAGLGERYAPIGVVSPLDRET
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GDELRGVCVLGSIADFDSVLARLRDSGLSPAAILFLTDSAMSTFGAERLGRLKTEGVRLL
CHHHCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHH
RRHGVVEMGAAANTPQLREISIEELLSRPPVRLDPEPVRALVSGRRVLVTGAGGSIGSEL
HHCCCEEECCCCCCCCHHHCCHHHHHCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHH
CRQIAASGCAHLTMVDASEYNLFHIEREIAERHPLLSRREALCDVRDAARVQRVFTEMKP
HHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DIIFHAAALKHVTLVENHPCEGVRTNVLGTRNVAVAAKACGAAHLALISTDKAVAPTSVM
HHHHHHHHHHHHHEECCCCCCCCEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHH
GAAKRVAEAVARQYGGGGDMRVSIVRFGNVLGSAGSVVPIFKSQIARGGPITLTHAEVER
HHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHCCCCCCHHHHHHHHCCCCCEEEEHHHHHH
YFMTIPEAVQLVLRAVALSMIASEPEAGVLTLEMGEPVKIIDLARRMIELQGLTPGRDID
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEE
IQITGLRPGEKLTETLVDVNEVARLKAPGIMEAVRLAPAPIIADERLAELDALAEVGDEA
EEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
GVRARLFALVEDLRQVGPSKVVKIRAS
CHHHHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
GHAGKIATHVLLAFVALLAGRYLVIDMPFTRDTLLQATLYGLAAFIVELAFRVERAPWR
CCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
FVSATDHLRLLRSAVLTAAAFLVITRLTHPGIDGGLRTVAGAALIQAALLSALRVIRRSL
EECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HERMLLDSVLRLGPASMHPALPRLLIIGSASEAEAFLRAPAGLGERYAPIGVVSPLDRET
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GDELRGVCVLGSIADFDSVLARLRDSGLSPAAILFLTDSAMSTFGAERLGRLKTEGVRLL
CHHHCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHH
RRHGVVEMGAAANTPQLREISIEELLSRPPVRLDPEPVRALVSGRRVLVTGAGGSIGSEL
HHCCCEEECCCCCCCCHHHCCHHHHHCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHH
CRQIAASGCAHLTMVDASEYNLFHIEREIAERHPLLSRREALCDVRDAARVQRVFTEMKP
HHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DIIFHAAALKHVTLVENHPCEGVRTNVLGTRNVAVAAKACGAAHLALISTDKAVAPTSVM
HHHHHHHHHHHHHEECCCCCCCCEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHH
GAAKRVAEAVARQYGGGGDMRVSIVRFGNVLGSAGSVVPIFKSQIARGGPITLTHAEVER
HHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHCCCCCCHHHHHHHHCCCCCEEEEHHHHHH
YFMTIPEAVQLVLRAVALSMIASEPEAGVLTLEMGEPVKIIDLARRMIELQGLTPGRDID
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEE
IQITGLRPGEKLTETLVDVNEVARLKAPGIMEAVRLAPAPIIADERLAELDALAEVGDEA
EEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
GVRARLFALVEDLRQVGPSKVVKIRAS
CHHHHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969506; 9384377 [H]