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The map label for this gene is moeA [H]

Identifier: 16127439

GI number: 16127439

Start: 3463787

End: 3465013

Strand: Direct

Name: moeA [H]

Synonym: CC_3209

Alternate gene names: 16127439

Gene position: 3463787-3465013 (Clockwise)

Preceding gene: 16127438

Following gene: 16127440

Centisome position: 86.23

GC content: 72.13

Gene sequence:

>1227_bases
ATGGCCGACTCGCCCTCTGCAAACTTGAGAAACCTGACCGTCGAGGAAGCCCGCCGCCGCATGCTCGACGGCGCGTCACG
CCTCGGCGTTGAAACCGCGCCCTTGGCGGAGAGCCTTGGCCGAACGCTCGCCGAGCCCGTGGTGGCTGGCCGCGCGCAAC
CGCCTTTCGCGGCTTCGGCCATGGACGGCTGGGCGATCCGACGTTCTGACTACGCCCCTGGGGCGGCCTTCCGGATCGTC
GGCGAAAGCGCGGCCGGCGCCGCCTACCCACGCCCCGTCGCCTCCGGAGAAGCGGTGCGAATTTTCACCGGCGCGCCCGT
GCCGGCGGAAGCCGATCTCGTCATCATCCAGGAAGAAGCGACCCGCGAGGGCGACCAGGTCCGCTTCGACGCCGGCCCTG
ATCCTCGCGCCAACGTCCGGGCGGCCGGCGGCGATTTCAAGGATGGCGACACGCTTCTCCTGGACGGCGTTGTCATCGAC
CCCTGGCGCCTTTCCCTCATCGCTGCGGCGGGACGCGCCGAGGTGTCGGTCGCGCGACGTCCGCGCGTCGCGATCTTGGC
CACCGGCGACGAACTCGCGCCGCCCGGCGCATCGCCCCGGCCCGACCAGATTTTCGAGAGCGGCTCCTACGGCCTCGCGG
CGCTGATCGAGGCCTGGGGCGGTGAGGCGATCCGACTTTCCCCGCAGGGCGACGACGCCCAGGCGATCGCCAGCGCCGTT
TCGCCCGCGCCCGTCGACGTCATCGTCACGATCGGCGGCGCCTCGGTCGGCGACCATGACCTGGTCAAACCCGCACTCCG
AACGCTGGGCCTTGCGCTTTCGGTCGAGACGGTCGCCGTGCGCCCCGGCAAGCCGACCTGGAGCGGGCGGTTGCCGGACG
GTCGCCGCGTGGTGGGTCTGCCAGGAAACCCGGCCTCGGCGCTGGTGTGCGCGGAACTCTTCCTGCGGCCTCTGCTGGCG
GCTCTCACGGGCGCGGCGCCGGATATCCGCCTCATTCCCGCGGGCTTGGCCGCCCCGCTTCCGGCGGGCGGACCGCGGGA
GCATTGGATGCGCGCCGCGCTGTCGACGGATCCGGACGGGCGAGTCGTCGCGACACCCTTCCCCGATCAGGATTCCTCTC
TGGTCAGCGTGTTCGCGCGCGCCGATGCTCTGCTACGGCGACGGCCTGGCGCGCCCCCTGCGGCGACGGGCGAGGTTGTC
GATGTTCTGCCGCTCCGGCGCGGCTGA

Upstream 100 bases:

>100_bases
CAGGATGGGGCCAAGCGGGTTCGGGCGGATCGAGAGATACTCTCGGTGCTCGCCCGATCTTGGACCTCACCGTTGGAGCG
AGATCGGCTAGGGTCTTTGA

Downstream 100 bases:

>100_bases
AACCGCGACGGCATAGAATTGACGTGCTAAGCCCGGATTTGAGTTCGCCGGGCGTGACCCGACCTTCACCGCTTCAGAGG
TTCGTTTCATGGGGCATGCA

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MADSPSANLRNLTVEEARRRMLDGASRLGVETAPLAESLGRTLAEPVVAGRAQPPFAASAMDGWAIRRSDYAPGAAFRIV
GESAAGAAYPRPVASGEAVRIFTGAPVPAEADLVIIQEEATREGDQVRFDAGPDPRANVRAAGGDFKDGDTLLLDGVVID
PWRLSLIAAAGRAEVSVARRPRVAILATGDELAPPGASPRPDQIFESGSYGLAALIEAWGGEAIRLSPQGDDAQAIASAV
SPAPVDVIVTIGGASVGDHDLVKPALRTLGLALSVETVAVRPGKPTWSGRLPDGRRVVGLPGNPASALVCAELFLRPLLA
ALTGAAPDIRLIPAGLAAPLPAGGPREHWMRAALSTDPDGRVVATPFPDQDSSLVSVFARADALLRRRPGAPPAATGEVV
DVLPLRRG

Sequences:

>Translated_408_residues
MADSPSANLRNLTVEEARRRMLDGASRLGVETAPLAESLGRTLAEPVVAGRAQPPFAASAMDGWAIRRSDYAPGAAFRIV
GESAAGAAYPRPVASGEAVRIFTGAPVPAEADLVIIQEEATREGDQVRFDAGPDPRANVRAAGGDFKDGDTLLLDGVVID
PWRLSLIAAAGRAEVSVARRPRVAILATGDELAPPGASPRPDQIFESGSYGLAALIEAWGGEAIRLSPQGDDAQAIASAV
SPAPVDVIVTIGGASVGDHDLVKPALRTLGLALSVETVAVRPGKPTWSGRLPDGRRVVGLPGNPASALVCAELFLRPLLA
ALTGAAPDIRLIPAGLAAPLPAGGPREHWMRAALSTDPDGRVVATPFPDQDSSLVSVFARADALLRRRPGAPPAATGEVV
DVLPLRRG
>Mature_407_residues
ADSPSANLRNLTVEEARRRMLDGASRLGVETAPLAESLGRTLAEPVVAGRAQPPFAASAMDGWAIRRSDYAPGAAFRIVG
ESAAGAAYPRPVASGEAVRIFTGAPVPAEADLVIIQEEATREGDQVRFDAGPDPRANVRAAGGDFKDGDTLLLDGVVIDP
WRLSLIAAAGRAEVSVARRPRVAILATGDELAPPGASPRPDQIFESGSYGLAALIEAWGGEAIRLSPQGDDAQAIASAVS
PAPVDVIVTIGGASVGDHDLVKPALRTLGLALSVETVAVRPGKPTWSGRLPDGRRVVGLPGNPASALVCAELFLRPLLAA
LTGAAPDIRLIPAGLAAPLPAGGPREHWMRAALSTDPDGRVVATPFPDQDSSLVSVFARADALLRRRPGAPPAATGEVVD
VLPLRRG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=419, Percent_Identity=33.6515513126492, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI10880983, Length=419, Percent_Identity=33.6515513126492, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1787049, Length=385, Percent_Identity=34.025974025974, Blast_Score=181, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=409, Percent_Identity=30.5623471882641, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=373, Percent_Identity=27.0777479892761, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136978, Length=367, Percent_Identity=30.2452316076294, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24638841, Length=367, Percent_Identity=30.2452316076294, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42054; Mature: 41923

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSPSANLRNLTVEEARRRMLDGASRLGVETAPLAESLGRTLAEPVVAGRAQPPFAASA
CCCCCCCCHHCCCHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHC
MDGWAIRRSDYAPGAAFRIVGESAAGAAYPRPVASGEAVRIFTGAPVPAEADLVIIQEEA
CCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCC
TREGDQVRFDAGPDPRANVRAAGGDFKDGDTLLLDGVVIDPWRLSLIAAAGRAEVSVARR
CCCCCEEEECCCCCCCCCEEECCCCCCCCCEEEECCEEECCHHEEEEEECCCCEEEECCC
PRVAILATGDELAPPGASPRPDQIFESGSYGLAALIEAWGGEAIRLSPQGDDAQAIASAV
CCEEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHC
SPAPVDVIVTIGGASVGDHDLVKPALRTLGLALSVETVAVRPGKPTWSGRLPDGRRVVGL
CCCCEEEEEEECCCCCCCHHHHHHHHHHHCEEEEEEEEEECCCCCCCCCCCCCCCEEEEC
PGNPASALVCAELFLRPLLAALTGAAPDIRLIPAGLAAPLPAGGPREHWMRAALSTDPDG
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCC
RVVATPFPDQDSSLVSVFARADALLRRRPGAPPAATGEVVDVLPLRRG
CEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCC
>Mature Secondary Structure 
ADSPSANLRNLTVEEARRRMLDGASRLGVETAPLAESLGRTLAEPVVAGRAQPPFAASA
CCCCCCCHHCCCHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHC
MDGWAIRRSDYAPGAAFRIVGESAAGAAYPRPVASGEAVRIFTGAPVPAEADLVIIQEEA
CCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCC
TREGDQVRFDAGPDPRANVRAAGGDFKDGDTLLLDGVVIDPWRLSLIAAAGRAEVSVARR
CCCCCEEEECCCCCCCCCEEECCCCCCCCCEEEECCEEECCHHEEEEEECCCCEEEECCC
PRVAILATGDELAPPGASPRPDQIFESGSYGLAALIEAWGGEAIRLSPQGDDAQAIASAV
CCEEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHC
SPAPVDVIVTIGGASVGDHDLVKPALRTLGLALSVETVAVRPGKPTWSGRLPDGRRVVGL
CCCCEEEEEEECCCCCCCHHHHHHHHHHHCEEEEEEEEEECCCCCCCCCCCCCCCEEEEC
PGNPASALVCAELFLRPLLAALTGAAPDIRLIPAGLAAPLPAGGPREHWMRAALSTDPDG
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCC
RVVATPFPDQDSSLVSVFARADALLRRRPGAPPAATGEVVDVLPLRRG
CEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]