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The map label for this gene is fabG [C]

Identifier: 16126332

GI number: 16126332

Start: 2303025

End: 2303930

Strand: Direct

Name: fabG [C]

Synonym: CC_2093

Alternate gene names: 16126332

Gene position: 2303025-2303930 (Clockwise)

Preceding gene: 16126331

Following gene: 16126333

Centisome position: 57.33

GC content: 66.0

Gene sequence:

>906_bases
ATGGCGGACATCCGCTTCGACGGCAAGGTGGCGATCGTGACGGGCGCCGGCGGCGGGCTTGGCCGACAGCACGCCCTGGA
ACTGGCGCGTCGCGGCGCCAAGGTCGTGGTCAACGACCTGGGCGGCTCGATGGACGGCTCGGGCGGTTCGTCCGAAGCGG
CCCAGAAGGTGGTCGACGAGATCAAGGCCTTAGGCGGCGAAGCCATCGCCAACGGCTCTTCGGTCACCGACGACGCGGGC
GTCGCCCTGATGATCAAGCAGGCCATGGACACCTGGGGCCGCATCGACATCCTGATCGCCAACGCCGGCATCCTGCGCGA
CAAGACCCTGACCAAGATGGAGCTGGCCGACTTCGAGCTGGTCATGCAGGTCCACGTCTTCGGCACCTTCAAGCCGATCA
AGGCCGTCTGGGACATCATGAAGGCCCAGAACTATGGCCGCATCGTCGTGACGACCTCGTCGTCGGGCATGTACGGCAAC
TTCGGCCAGAGCAACTACGGCGCGGCCAAGATGGCGGTGCTGGGCCTGATGAACACCCTCAAGCTCGAGGGCGCCAAGAA
CGACGTCAAGATCAACGCCATCAGCCCGGTCGCGGCCACCCGCATGACCGAGGGCCTGATGCCGCCCGAAGTGCTGGCCA
AGCTGGCGCCGGAATATGTGACGCCGGGCGTCGTCTATCTCTGCTCGGACGAAGCGCCTACCGGCGCGATCCTGACCGCC
GGCGCCGGCGCCTTCGCCCTGTCGCGGATCTATGAGACCGAGGGTGTCTATCTGGGCGAAGGCGGCCTGTCGGCCGAGGA
AGTCCGTGACAGCTGGGGTCAGATCACCGCCGAGGATGGCCAGAAGGCCTATTTCAACGGCGGCGAACAAGGCCAGAAGT
TCTTCCGCAAGATGGCCGGCGGCTGA

Upstream 100 bases:

>100_bases
GGGCGCTCATCAAATCCAGACAGGAGCCTCCCCTTGACCTCCCCTCTCCCGCGCCGCACAAACGCGCCAAACCAAACACA
CGTTTGAGGGAGACTTCGGC

Downstream 100 bases:

>100_bases
CGCGCCAGAAATAAAACAAGGATCGAAAAGCAACGTTCGATCAATATTCGACAGAACAGTGATTAATGCGGGGGCTTTCA
GCCCCCGTTTCTTTTACATG

Product: 3-oxoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSMDGSGGSSEAAQKVVDEIKALGGEAIANGSSVTDDAG
VALMIKQAMDTWGRIDILIANAGILRDKTLTKMELADFELVMQVHVFGTFKPIKAVWDIMKAQNYGRIVVTTSSSGMYGN
FGQSNYGAAKMAVLGLMNTLKLEGAKNDVKINAISPVAATRMTEGLMPPEVLAKLAPEYVTPGVVYLCSDEAPTGAILTA
GAGAFALSRIYETEGVYLGEGGLSAEEVRDSWGQITAEDGQKAYFNGGEQGQKFFRKMAGG

Sequences:

>Translated_301_residues
MADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSMDGSGGSSEAAQKVVDEIKALGGEAIANGSSVTDDAG
VALMIKQAMDTWGRIDILIANAGILRDKTLTKMELADFELVMQVHVFGTFKPIKAVWDIMKAQNYGRIVVTTSSSGMYGN
FGQSNYGAAKMAVLGLMNTLKLEGAKNDVKINAISPVAATRMTEGLMPPEVLAKLAPEYVTPGVVYLCSDEAPTGAILTA
GAGAFALSRIYETEGVYLGEGGLSAEEVRDSWGQITAEDGQKAYFNGGEQGQKFFRKMAGG
>Mature_300_residues
ADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSMDGSGGSSEAAQKVVDEIKALGGEAIANGSSVTDDAGV
ALMIKQAMDTWGRIDILIANAGILRDKTLTKMELADFELVMQVHVFGTFKPIKAVWDIMKAQNYGRIVVTTSSSGMYGNF
GQSNYGAAKMAVLGLMNTLKLEGAKNDVKINAISPVAATRMTEGLMPPEVLAKLAPEYVTPGVVYLCSDEAPTGAILTAG
AGAFALSRIYETEGVYLGEGGLSAEEVRDSWGQITAEDGQKAYFNGGEQGQKFFRKMAGG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=278, Percent_Identity=45.3237410071942, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=29.0836653386454, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4503817, Length=194, Percent_Identity=28.8659793814433, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=28.9795918367347, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI25282469, Length=242, Percent_Identity=28.099173553719, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI40807363, Length=228, Percent_Identity=28.5087719298246, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI157739938, Length=189, Percent_Identity=28.042328042328, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4758504, Length=202, Percent_Identity=30.1980198019802, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI31542939, Length=258, Percent_Identity=25.968992248062, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=33.0708661417323, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=30.7086614173228, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=31.9838056680162, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789057, Length=216, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789208, Length=207, Percent_Identity=28.9855072463768, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790717, Length=215, Percent_Identity=26.9767441860465, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787526, Length=247, Percent_Identity=27.9352226720648, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786812, Length=191, Percent_Identity=30.3664921465969, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI87082160, Length=189, Percent_Identity=25.9259259259259, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788459, Length=239, Percent_Identity=27.1966527196653, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=278, Percent_Identity=49.2805755395683, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=32.520325203252, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=31.404958677686, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=180, Percent_Identity=33.8888888888889, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=294, Percent_Identity=25.8503401360544, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI193203115, Length=295, Percent_Identity=26.4406779661017, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=204, Percent_Identity=30.3921568627451, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=230, Percent_Identity=26.9565217391304, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=240, Percent_Identity=32.0833333333333, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=248, Percent_Identity=27.8225806451613, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=180, Percent_Identity=32.7777777777778, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=209, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=212, Percent_Identity=31.1320754716981, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=234, Percent_Identity=26.9230769230769, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=291, Percent_Identity=43.298969072165, Blast_Score=238, Evalue=6e-64,
Organism=Drosophila melanogaster, GI18859837, Length=277, Percent_Identity=48.7364620938628, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24640492, Length=238, Percent_Identity=26.890756302521, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24639444, Length=193, Percent_Identity=34.7150259067358, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24649181, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737361, Length=223, Percent_Identity=30.4932735426009, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571526, Length=193, Percent_Identity=30.5699481865285, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581726, Length=219, Percent_Identity=29.6803652968037, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281364892, Length=177, Percent_Identity=28.8135593220339, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=192, Percent_Identity=30.7291666666667, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355631, Length=182, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357041, Length=193, Percent_Identity=28.4974093264249, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24644339, Length=266, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356301, Length=226, Percent_Identity=27.4336283185841, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357673, Length=209, Percent_Identity=25.8373205741627, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31509; Mature: 31378

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSMDGSGGSSEAAQKVVDE
CCCEEECCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
IKALGGEAIANGSSVTDDAGVALMIKQAMDTWGRIDILIANAGILRDKTLTKMELADFEL
HHHCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEECCCCHHHHHHHHHHH
VMQVHVFGTFKPIKAVWDIMKAQNYGRIVVTTSSSGMYGNFGQSNYGAAKMAVLGLMNTL
EEEEHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KLEGAKNDVKINAISPVAATRMTEGLMPPEVLAKLAPEYVTPGVVYLCSDEAPTGAILTA
EECCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHCHHHCCCCEEEEECCCCCCCEEEEC
GAGAFALSRIYETEGVYLGEGGLSAEEVRDSWGQITAEDGQKAYFNGGEQGQKFFRKMAG
CCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCEECCCCCEEECCCCHHHHHHHHHHCC
G
C
>Mature Secondary Structure 
ADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSMDGSGGSSEAAQKVVDE
CCEEECCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
IKALGGEAIANGSSVTDDAGVALMIKQAMDTWGRIDILIANAGILRDKTLTKMELADFEL
HHHCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEECCCCHHHHHHHHHHH
VMQVHVFGTFKPIKAVWDIMKAQNYGRIVVTTSSSGMYGNFGQSNYGAAKMAVLGLMNTL
EEEEHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KLEGAKNDVKINAISPVAATRMTEGLMPPEVLAKLAPEYVTPGVVYLCSDEAPTGAILTA
EECCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHCHHHCCCCEEEEECCCCCCCEEEEC
GAGAFALSRIYETEGVYLGEGGLSAEEVRDSWGQITAEDGQKAYFNGGEQGQKFFRKMAG
CCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCEECCCCCEEECCCCHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]