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The map label for this gene is pepA

Identifier: 16125937

GI number: 16125937

Start: 1866023

End: 1867504

Strand: Direct

Name: pepA

Synonym: CC_1692

Alternate gene names: 16125937

Gene position: 1866023-1867504 (Clockwise)

Preceding gene: 16125927

Following gene: 16125938

Centisome position: 46.45

GC content: 68.42

Gene sequence:

>1482_bases
ATGCGTATCGAGTTCGTTCCCGTCGACACCCAGGCCGGCGCCACCGCCGCGCTCGCGGTCCTGGCTCACGAAGGCGCCGC
CTTGTCGCCCGAAGCCCGCGCGGCCAACGAGGCCACCGGCGGCGCCCTGGCGCGCGCCATCGCCGGCGGACGCTTCACGG
GCGCCAAGGGTCAGACGCTCGACATCGTCGCCCCGAACGGACTGGAAGCCGCACGTGTGGTTCTGGTCGGGGTGGATGGC
TCCGGCGCCGTCGAGCCCGAGGCGGTCGAACTGGCCGCCGCTTCGGCCTTCCAGGCCGTGAAGACCTCGGGCGTGGTCGA
GCTGGTGCTCAAGCTGGGCGCCGACGCCGAGACCGCCGCCCGCGCCGCCTTCGGCGCGCGCCTGGCCGCTTACCGCTTCG
ACAAGTACCGCACCACCGAAAAGGCCGAAAAGAAGCCCTCGGTCCAGGTGGTCAAGATCGCCGCCGCCGATCCGGTCAAG
GCGCAGAAGGCCTATGAGCCGCTGGCGGCCCTGGCCGACGCGATCGTGTTCAGCCGTAACCTCGTCTCCGAGCCGGCCAA
CATCCTGCATCCGGAGGAATTCGCCGCCCGCGCCAAGGGCCTGGAAAGCCTGGGCCTGGAGGTCGAGATCCTGGGCGAGG
CCGAGATGGCCAAGCTGGGCATGGGCAGCCTTCTGGGCGTCGGGCAGGGCAGCGTCCGCGAAAGCCAGCTCGTCATCATG
AAGTGGATGGGCGCGGCTGATAAGTCGGCCCAGCCGATCGCCTTCGTCGGCAAGGGCGTGTGCTTCGACACTGGCGGCAT
CTCGATCAAGCCGGCCGACGGCATGGAAGACATGAAGTGGGACATGGGCGGGGCGGCCGCCGTGGCCGGCGTCATGCACG
CCCTGGCCGGCCGCAAGGCCAAGGTCAACGCCATCGGCGTGCTGGGCCTCGTCGAGAACATGCCCGACGGCAACGCCCAG
CGTCCGGGCGATGTGGTCACCTCGATGTCGGGCCAGACCATCGAGGTTATCAACACCGACGCCGAAGGCCGCCTCGTTCT
GGCCGACGCGCTTTGGTACACGCAGGAGCGTTTCAAGCCCCAGTTCATGATCGACCTGGCCACCCTGACCGGCGCGATCA
TCATCTCGCTGGGTCATGACTACGCCGGTTTGTTCAGCAATAACGATGGCTTGTCGGAAAAACTTCTCGCGGCCGGCAAG
GCCGAGCGTGAGAGCCTGTGGCGCCTGCCGCTGCCGGCCGCCTATGAGAAGCAGATCGAAAGCCCGATCGCCGACATGAA
GAACATCGGCGGGCGTCCGGCCGGTTCGATCACGGCGGGCCTGTTCCTGCAGAAGTTCGTCAACGGCGTGCCGTGGGCCC
ACCTCGACATCGCCTCGGTCGCCTGGAAGAAGCCCTCGGCCGATCCGACCGTGCCCGATGGCGCGGTGGGCTATGGCGTG
CGTCTGCTCAACCGCCTCGTCGCCGACGCCTACGAAGGCTGA

Upstream 100 bases:

>100_bases
CTTTTCTAAGGCGCGGCATTGGACTATGCCGCCTTGATGAGGTGAGCCGGCGCGCGGTTTGATGCGCCGCTTACGGTCGC
CCAAATTGCAGGAGCGCGGC

Downstream 100 bases:

>100_bases
TCCGAAGAGGCTGTCATCCCGGCCCAGCGCAAAGCGCGCCGAGCCGGGACCGCCCCAAGCGCCGCGTTTGTCGCGGTCCC
GGGTCTTCGCTACGCTCGCC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MRIEFVPVDTQAGATAALAVLAHEGAALSPEARAANEATGGALARAIAGGRFTGAKGQTLDIVAPNGLEAARVVLVGVDG
SGAVEPEAVELAAASAFQAVKTSGVVELVLKLGADAETAARAAFGARLAAYRFDKYRTTEKAEKKPSVQVVKIAAADPVK
AQKAYEPLAALADAIVFSRNLVSEPANILHPEEFAARAKGLESLGLEVEILGEAEMAKLGMGSLLGVGQGSVRESQLVIM
KWMGAADKSAQPIAFVGKGVCFDTGGISIKPADGMEDMKWDMGGAAAVAGVMHALAGRKAKVNAIGVLGLVENMPDGNAQ
RPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQERFKPQFMIDLATLTGAIIISLGHDYAGLFSNNDGLSEKLLAAGK
AERESLWRLPLPAAYEKQIESPIADMKNIGGRPAGSITAGLFLQKFVNGVPWAHLDIASVAWKKPSADPTVPDGAVGYGV
RLLNRLVADAYEG

Sequences:

>Translated_493_residues
MRIEFVPVDTQAGATAALAVLAHEGAALSPEARAANEATGGALARAIAGGRFTGAKGQTLDIVAPNGLEAARVVLVGVDG
SGAVEPEAVELAAASAFQAVKTSGVVELVLKLGADAETAARAAFGARLAAYRFDKYRTTEKAEKKPSVQVVKIAAADPVK
AQKAYEPLAALADAIVFSRNLVSEPANILHPEEFAARAKGLESLGLEVEILGEAEMAKLGMGSLLGVGQGSVRESQLVIM
KWMGAADKSAQPIAFVGKGVCFDTGGISIKPADGMEDMKWDMGGAAAVAGVMHALAGRKAKVNAIGVLGLVENMPDGNAQ
RPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQERFKPQFMIDLATLTGAIIISLGHDYAGLFSNNDGLSEKLLAAGK
AERESLWRLPLPAAYEKQIESPIADMKNIGGRPAGSITAGLFLQKFVNGVPWAHLDIASVAWKKPSADPTVPDGAVGYGV
RLLNRLVADAYEG
>Mature_493_residues
MRIEFVPVDTQAGATAALAVLAHEGAALSPEARAANEATGGALARAIAGGRFTGAKGQTLDIVAPNGLEAARVVLVGVDG
SGAVEPEAVELAAASAFQAVKTSGVVELVLKLGADAETAARAAFGARLAAYRFDKYRTTEKAEKKPSVQVVKIAAADPVK
AQKAYEPLAALADAIVFSRNLVSEPANILHPEEFAARAKGLESLGLEVEILGEAEMAKLGMGSLLGVGQGSVRESQLVIM
KWMGAADKSAQPIAFVGKGVCFDTGGISIKPADGMEDMKWDMGGAAAVAGVMHALAGRKAKVNAIGVLGLVENMPDGNAQ
RPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQERFKPQFMIDLATLTGAIIISLGHDYAGLFSNNDGLSEKLLAAGK
AERESLWRLPLPAAYEKQIESPIADMKNIGGRPAGSITAGLFLQKFVNGVPWAHLDIASVAWKKPSADPTVPDGAVGYGV
RLLNRLVADAYEG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=402, Percent_Identity=37.0646766169154, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI47155554, Length=335, Percent_Identity=34.9253731343284, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1790710, Length=487, Percent_Identity=39.6303901437372, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI87082123, Length=323, Percent_Identity=39.0092879256966, Blast_Score=188, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=330, Percent_Identity=34.5454545454545, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=163, Percent_Identity=35.5828220858896, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24662227, Length=440, Percent_Identity=30.6818181818182, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI20129969, Length=440, Percent_Identity=29.0909090909091, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24661038, Length=409, Percent_Identity=30.5623471882641, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21355725, Length=379, Percent_Identity=31.6622691292876, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20129963, Length=403, Percent_Identity=30.5210918114144, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI161077148, Length=433, Percent_Identity=28.8683602771363, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI20130057, Length=433, Percent_Identity=28.8683602771363, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI21355645, Length=450, Percent_Identity=27.7777777777778, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24662223, Length=450, Percent_Identity=27.7777777777778, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI21357381, Length=319, Percent_Identity=35.423197492163, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI221379063, Length=319, Percent_Identity=35.423197492163, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI221379062, Length=319, Percent_Identity=35.423197492163, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI19922386, Length=448, Percent_Identity=28.3482142857143, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24646701, Length=159, Percent_Identity=35.2201257861635, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646703, Length=159, Percent_Identity=35.2201257861635, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358201, Length=159, Percent_Identity=35.2201257861635, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_CAUCR (Q9A7M9)

Other databases:

- EMBL:   AE005673
- PIR:   A87459
- RefSeq:   NP_420501.1
- ProteinModelPortal:   Q9A7M9
- SMR:   Q9A7M9
- MEROPS:   M17.003
- GeneID:   942053
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_1692
- NMPDR:   fig|190650.1.peg.1681
- TIGR:   CC_1692
- HOGENOM:   HBG742580
- OMA:   CKPTRII
- ProtClustDB:   PRK00913
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51175; Mature: 51175

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 270-270 ACT_SITE 344-344

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEFVPVDTQAGATAALAVLAHEGAALSPEARAANEATGGALARAIAGGRFTGAKGQTL
CEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHCCCCEECCCCCEE
DIVAPNGLEAARVVLVGVDGSGAVEPEAVELAAASAFQAVKTSGVVELVLKLGADAETAA
EEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RAAFGARLAAYRFDKYRTTEKAEKKPSVQVVKIAAADPVKAQKAYEPLAALADAIVFSRN
HHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LVSEPANILHPEEFAARAKGLESLGLEVEILGEAEMAKLGMGSLLGVGQGSVRESQLVIM
HHHCCHHHCCHHHHHHHHCCHHHHCCEEEEECCHHHHHCCCCHHCCCCCCCCCCCCEEEE
KWMGAADKSAQPIAFVGKGVCFDTGGISIKPADGMEDMKWDMGGAAAVAGVMHALAGRKA
EECCCCCCCCCCEEEECCCEEEECCCEEECCCCCCHHHHCCCCHHHHHHHHHHHHCCCCC
KVNAIGVLGLVENMPDGNAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQERFKP
EEEEEEEEHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCC
QFMIDLATLTGAIIISLGHDYAGLFSNNDGLSEKLLAAGKAERESLWRLPLPAAYEKQIE
CCEEEHHHHHCEEEEEECCCCCCCCCCCCCHHHHHHHCCCHHHHHHCCCCCCHHHHHHHH
SPIADMKNIGGRPAGSITAGLFLQKFVNGVPWAHLDIASVAWKKPSADPTVPDGAVGYGV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCCHHHHHH
RLLNRLVADAYEG
HHHHHHHHHHCCC
>Mature Secondary Structure
MRIEFVPVDTQAGATAALAVLAHEGAALSPEARAANEATGGALARAIAGGRFTGAKGQTL
CEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHCCCCEECCCCCEE
DIVAPNGLEAARVVLVGVDGSGAVEPEAVELAAASAFQAVKTSGVVELVLKLGADAETAA
EEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RAAFGARLAAYRFDKYRTTEKAEKKPSVQVVKIAAADPVKAQKAYEPLAALADAIVFSRN
HHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LVSEPANILHPEEFAARAKGLESLGLEVEILGEAEMAKLGMGSLLGVGQGSVRESQLVIM
HHHCCHHHCCHHHHHHHHCCHHHHCCEEEEECCHHHHHCCCCHHCCCCCCCCCCCCEEEE
KWMGAADKSAQPIAFVGKGVCFDTGGISIKPADGMEDMKWDMGGAAAVAGVMHALAGRKA
EECCCCCCCCCCEEEECCCEEEECCCEEECCCCCCHHHHCCCCHHHHHHHHHHHHCCCCC
KVNAIGVLGLVENMPDGNAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQERFKP
EEEEEEEEHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCC
QFMIDLATLTGAIIISLGHDYAGLFSNNDGLSEKLLAAGKAERESLWRLPLPAAYEKQIE
CCEEEHHHHHCEEEEEECCCCCCCCCCCCCHHHHHHHCCCHHHHHHCCCCCCHHHHHHHH
SPIADMKNIGGRPAGSITAGLFLQKFVNGVPWAHLDIASVAWKKPSADPTVPDGAVGYGV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCCHHHHHH
RLLNRLVADAYEG
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647