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The map label for this gene is gmk

Identifier: 16125927

GI number: 16125927

Start: 1854711

End: 1855352

Strand: Direct

Name: gmk

Synonym: CC_1681

Alternate gene names: 16125927

Gene position: 1854711-1855352 (Clockwise)

Preceding gene: 16125926

Following gene: 16125937

Centisome position: 46.17

GC content: 62.93

Gene sequence:

>642_bases
TTGAATAAGTCCCATCATCCCCATCGTGGTCTGCTGCTGATGGTCGTCGCGCCTTCGGGCGTCGGCAAGACGTCGCTGAC
CCGCCGCCTCGTCTCTGACCATGGCGATCTGCACCTGTCGATCAGCGCCACCACGCGCGATCCGCGTCCTGGCGAGCATG
ACGGCCGCGACTATCACTTCGTCTCGCGCGACAAGTTCCAGGGCATGCTGGCCGAGGATGCGTTCCTGGAATGGGCCGAG
GTCTACGGAAACTTCTATGGCAGCCCCAAGGCGCCGATCATGGATGCGCTGAGCCGCGGCGAAAGCGTGCTGTTCGACAT
CGACTTTCAAGGCGCGATGAAGGTGCACAAGCAGGCCGGCGCTGACAGCGTGCTGGTCTATATCCTGCCGCCGTCGCTGG
CCGAGATGAGCCGTCGCCTGCACACGCGCAGCCAGGACAGCGAAGAGGTCATCCACCGCCGTCTGTCGCGGGCCAAGGAC
GAGGTCGCGGCCTGGGAGCAGTTTGACTACGTCATCCTCAATGACGATTTCGACCGGGCCTATGCTGATCTGGCCCACAT
CTACCACGCCGAACGGCTGAAGCGGGCGCGCAACCCGTGGATCGGCGATCTGGTCAGCGATCTTCTGAAGGAAGAGATCT
AG

Upstream 100 bases:

>100_bases
TCCAACACCCTCTGCTCGAAATCGGCCCTGACCAGCCTGACCGCGATCGGTCTGGAGCTGAAGGCCGTCATCGAGCAGTT
CCGCGAGCAGGTTCAGAACG

Downstream 100 bases:

>100_bases
GGCGGGCGACGAGCCACCGCCCGCCGCCGCGACCTTGCCTAAAGCGCGCGTCGGCCGAAGACCAGATGATACAGCGCCAG
GATCACCACGGCGCCGATCG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MNKSHHPHRGLLLMVVAPSGVGKTSLTRRLVSDHGDLHLSISATTRDPRPGEHDGRDYHFVSRDKFQGMLAEDAFLEWAE
VYGNFYGSPKAPIMDALSRGESVLFDIDFQGAMKVHKQAGADSVLVYILPPSLAEMSRRLHTRSQDSEEVIHRRLSRAKD
EVAAWEQFDYVILNDDFDRAYADLAHIYHAERLKRARNPWIGDLVSDLLKEEI

Sequences:

>Translated_213_residues
MNKSHHPHRGLLLMVVAPSGVGKTSLTRRLVSDHGDLHLSISATTRDPRPGEHDGRDYHFVSRDKFQGMLAEDAFLEWAE
VYGNFYGSPKAPIMDALSRGESVLFDIDFQGAMKVHKQAGADSVLVYILPPSLAEMSRRLHTRSQDSEEVIHRRLSRAKD
EVAAWEQFDYVILNDDFDRAYADLAHIYHAERLKRARNPWIGDLVSDLLKEEI
>Mature_213_residues
MNKSHHPHRGLLLMVVAPSGVGKTSLTRRLVSDHGDLHLSISATTRDPRPGEHDGRDYHFVSRDKFQGMLAEDAFLEWAE
VYGNFYGSPKAPIMDALSRGESVLFDIDFQGAMKVHKQAGADSVLVYILPPSLAEMSRRLHTRSQDSEEVIHRRLSRAKD
EVAAWEQFDYVILNDDFDRAYADLAHIYHAERLKRARNPWIGDLVSDLLKEEI

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=189, Percent_Identity=35.978835978836, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI4504221, Length=189, Percent_Identity=35.978835978836, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI226874831, Length=189, Percent_Identity=35.978835978836, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=28.2828282828283, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI38570142, Length=188, Percent_Identity=28.1914893617021, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI262118259, Length=177, Percent_Identity=24.2937853107345, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI4505237, Length=177, Percent_Identity=24.2937853107345, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI262118255, Length=177, Percent_Identity=24.2937853107345, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI262118263, Length=177, Percent_Identity=24.2937853107345, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI52630447, Length=187, Percent_Identity=26.2032085561497, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI14780902, Length=190, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1790080, Length=204, Percent_Identity=46.5686274509804, Blast_Score=177, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI193203132, Length=186, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17508835, Length=186, Percent_Identity=33.3333333333333, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=26.5193370165746, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988041, Length=182, Percent_Identity=26.3736263736264, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=179, Percent_Identity=26.8156424581006, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=39.344262295082, Blast_Score=152, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21356141, Length=183, Percent_Identity=34.9726775956284, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI116007136, Length=183, Percent_Identity=28.4153005464481, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI85724806, Length=183, Percent_Identity=28.4153005464481, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45554481, Length=183, Percent_Identity=28.4153005464481, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24640542, Length=183, Percent_Identity=28.4153005464481, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45554489, Length=183, Percent_Identity=28.4153005464481, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI161077626, Length=183, Percent_Identity=28.4153005464481, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI85816281, Length=208, Percent_Identity=25.9615384615385, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85816106, Length=208, Percent_Identity=25.9615384615385, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45551002, Length=208, Percent_Identity=25.9615384615385, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CAUCR (Q9A7N9)

Other databases:

- EMBL:   AE005673
- PIR:   G87457
- RefSeq:   NP_420491.1
- ProteinModelPortal:   Q9A7N9
- SMR:   Q9A7N9
- GeneID:   942041
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_1681
- NMPDR:   fig|190650.1.peg.1671
- TIGR:   CC_1681
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24220; Mature: 24220

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSHHPHRGLLLMVVAPSGVGKTSLTRRLVSDHGDLHLSISATTRDPRPGEHDGRDYHF
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEE
VSRDKFQGMLAEDAFLEWAEVYGNFYGSPKAPIMDALSRGESVLFDIDFQGAMKVHKQAG
ECHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHCC
ADSVLVYILPPSLAEMSRRLHTRSQDSEEVIHRRLSRAKDEVAAWEQFDYVILNDDFDRA
CCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHH
YADLAHIYHAERLKRARNPWIGDLVSDLLKEEI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNKSHHPHRGLLLMVVAPSGVGKTSLTRRLVSDHGDLHLSISATTRDPRPGEHDGRDYHF
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEE
VSRDKFQGMLAEDAFLEWAEVYGNFYGSPKAPIMDALSRGESVLFDIDFQGAMKVHKQAG
ECHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHCC
ADSVLVYILPPSLAEMSRRLHTRSQDSEEVIHRRLSRAKDEVAAWEQFDYVILNDDFDRA
CCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHH
YADLAHIYHAERLKRARNPWIGDLVSDLLKEEI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647