BacMap

Definition	Caulobacter crescentus CB15 chromosome, complete genome.
Accession	NC_002696
Length	4,016,947

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The map label for this gene is ppi [H]

Identifier: 16125831

GI number: 16125831

Start: 1750533

End: 1751000

Strand: Direct

Name: ppi [H]

Synonym: CC_1584

Alternate gene names: 16125831

Gene position: 1750533-1751000 (Clockwise)

Preceding gene: 16125830

Following gene: 16125834

Centisome position: 43.58

GC content: 66.24

Gene sequence:

>468_bases
ATGTCGGCCGACCTCGAAAACACCCTGATCCTGACGCTCGAGAGCGGTCCGGTCACCATCAAGCTGCGTCCCGACCTGGC
GCCGGGGCACGTGGCCCGCATCAAGGAACTGGTGCGCGAAGGCTTCTACGACGGCGTCGTCTTCCACCGCGTGATCCCGG
GCTTCATGGCCCAGGGCGGCGACCCGAGCGGCACCGGCCGTGGCGGTTCGGACAAGCCGGATCTGAAGGCCGAGTTCAAC
GACGAATCGCACGTGCGCGGCGTCTGCTCGATGGCCCGCACGCCGAACCCGGACTCGGCCAACAGCCAGTTCTTCATCGT
CTTCGACGACGCCACGTTCCTCGACAAGCAATACACTGTCTGGGGCCAGGTGACCGAAGGCATGGAACATGTTGACGCAC
TGCCGAAGGGCGAGCCGCCGCGCGCGCCGGGCAAGATCGTCAGCGCTAAGATCGCCGCTGACGCCTAG

Upstream 100 bases:

>100_bases
GTCCGCTGAGGCTAAACCGATTTCCGGCCGCAACTTGGTTCACAGGCGGGCGTGAACCGCGCTAGAAGCGCGGATAACAC
TCGCCATCCAAGGGAAGACC

Downstream 100 bases:

>100_bases
AGCCCTTTAGCTTTAGATGGAAACATCTAAAGCGTTTGAAAGGGCTCTAAGTGTTTGATTTTAGCGCCTGTTTATCTGGT
TTAGATGGTTCCATCTAAAC

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MSADLENTLILTLESGPVTIKLRPDLAPGHVARIKELVREGFYDGVVFHRVIPGFMAQGGDPSGTGRGGSDKPDLKAEFN
DESHVRGVCSMARTPNPDSANSQFFIVFDDATFLDKQYTVWGQVTEGMEHVDALPKGEPPRAPGKIVSAKIAADA

Sequences:

>Translated_155_residues
MSADLENTLILTLESGPVTIKLRPDLAPGHVARIKELVREGFYDGVVFHRVIPGFMAQGGDPSGTGRGGSDKPDLKAEFN
DESHVRGVCSMARTPNPDSANSQFFIVFDDATFLDKQYTVWGQVTEGMEHVDALPKGEPPRAPGKIVSAKIAADA
>Mature_154_residues
SADLENTLILTLESGPVTIKLRPDLAPGHVARIKELVREGFYDGVVFHRVIPGFMAQGGDPSGTGRGGSDKPDLKAEFND
ESHVRGVCSMARTPNPDSANSQFFIVFDDATFLDKQYTVWGQVTEGMEHVDALPKGEPPRAPGKIVSAKIAADA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=135, Percent_Identity=39.2592592592593, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI7706339, Length=131, Percent_Identity=36.6412213740458, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI64276486, Length=156, Percent_Identity=35.2564102564103, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI24308049, Length=159, Percent_Identity=34.5911949685535, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI22547212, Length=155, Percent_Identity=38.7096774193548, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI7657473, Length=155, Percent_Identity=38.7096774193548, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI22547215, Length=155, Percent_Identity=38.7096774193548, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI256017253, Length=129, Percent_Identity=38.7596899224806, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI221139811, Length=129, Percent_Identity=38.7596899224806, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI256017251, Length=129, Percent_Identity=38.7596899224806, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310129267, Length=127, Percent_Identity=37.7952755905512, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310120620, Length=127, Percent_Identity=37.7952755905512, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI178057341, Length=130, Percent_Identity=37.6923076923077, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=37.6923076923077, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI45439316, Length=133, Percent_Identity=35.3383458646617, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310110104, Length=127, Percent_Identity=37.007874015748, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI303305009, Length=142, Percent_Identity=33.8028169014084, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI209417936, Length=130, Percent_Identity=37.6923076923077, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI30102944, Length=130, Percent_Identity=37.6923076923077, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI219842199, Length=130, Percent_Identity=37.6923076923077, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI5174637, Length=124, Percent_Identity=36.2903225806452, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI310127646, Length=129, Percent_Identity=35.6589147286822, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI310114371, Length=129, Percent_Identity=35.6589147286822, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI310119221, Length=129, Percent_Identity=35.6589147286822, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI5031987, Length=128, Percent_Identity=39.0625, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1789763, Length=166, Percent_Identity=36.7469879518072, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1786736, Length=128, Percent_Identity=39.0625, Blast_Score=82, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=127, Percent_Identity=37.7952755905512, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=137, Percent_Identity=36.4963503649635, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=159, Percent_Identity=35.2201257861635, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=150, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=133, Percent_Identity=35.3383458646617, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17539498, Length=143, Percent_Identity=36.3636363636364, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=159, Percent_Identity=35.2201257861635, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=148, Percent_Identity=34.4594594594595, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=146, Percent_Identity=35.6164383561644, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=128, Percent_Identity=37.5, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=146, Percent_Identity=37.6712328767123, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17986117, Length=155, Percent_Identity=41.2903225806452, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI19922376, Length=129, Percent_Identity=37.2093023255814, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24652460, Length=159, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45549139, Length=145, Percent_Identity=34.4827586206897, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17647301, Length=132, Percent_Identity=34.8484848484849, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664125, Length=128, Percent_Identity=37.5, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357783, Length=128, Percent_Identity=37.5, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357249, Length=123, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16665; Mature: 16534

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADLENTLILTLESGPVTIKLRPDLAPGHVARIKELVREGFYDGVVFHRVIPGFMAQGG
CCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
DPSGTGRGGSDKPDLKAEFNDESHVRGVCSMARTPNPDSANSQFFIVFDDATFLDKQYTV
CCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCEECCCEEEE
WGQVTEGMEHVDALPKGEPPRAPGKIVSAKIAADA
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
SADLENTLILTLESGPVTIKLRPDLAPGHVARIKELVREGFYDGVVFHRVIPGFMAQGG
CCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
DPSGTGRGGSDKPDLKAEFNDESHVRGVCSMARTPNPDSANSQFFIVFDDATFLDKQYTV
CCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCEECCCEEEE
WGQVTEGMEHVDALPKGEPPRAPGKIVSAKIAADA
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA