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The map label for this gene is pyrE

Identifier: 16125802

GI number: 16125802

Start: 1719038

End: 1719622

Strand: Direct

Name: pyrE

Synonym: CC_1555

Alternate gene names: 16125802

Gene position: 1719038-1719622 (Clockwise)

Preceding gene: 16125800

Following gene: 16125804

Centisome position: 42.79

GC content: 69.57

Gene sequence:

>585_bases
ATGACCAACGACGACGTCCTCGACGAATTCCGCGCCGCAGGGGCCCTGCGCGAAGGCCACTTCGTGCTGTCCAGCGGCCT
GCATAGCCCGGTGTTCCTGCAGAAGAACCTGGTGTTCATGCGCCCCGAGCGCTGCGAGCGCCTCTGCAAGGCCTTGGCGC
AGAAGATCATCGCCACGGTGGGCCAGGTCGATGTGGCGGTCTCGCCGGCCGTCGGCGGCATCATTCCGGGCTATGAGACC
GCGCGCCACCTCAACGTGCCGTCGATCTATGTCGAGCGCGAGGGCGGCGGCTTCAAGTTCCGGCGCGGCTTCCACCTGGA
GCCCGGCCAGAAGGTCGTGATGGTCGAGGACATCGTCACCACCGGCCTGTCGTCGCGCGAGTGCATCCAGGCGATCAAGG
ACGCCGGCGGCGACGTCGTGGCGGCTGCGTGCATCGTCGACCGCTCGGGCGGCAAGGCCGATGTCGGCGTGCCGCTGATC
GCCCTGGCCAGCCTGGAAGTCCCGGCCTATCCGGCCGACGCCCTGCCGCCGGAGCTGGCCGCGATCCCGATCGAGGATCC
GGGCAGCCGCCGGCTGAAGGGCTGA

Upstream 100 bases:

>100_bases
CGTTGGGCTTCTTCCGTCATGGTCGCGGTAGAGCCCGAAACGCGATGCCGAGGCAACCGGGATTTGAAGACTCGCCCGCT
TGGGCCTATAGGCAGCGCTC

Downstream 100 bases:

>100_bases
GCGAGCACGTCACACGATAAAGGGTGTCATCCCGGAAGCCTCGCAGAGGCTATCCGGGACCCAGGGGTGACGAAGCGCTG
TGCGCGCCGCCCCTGGGTCC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MTNDDVLDEFRAAGALREGHFVLSSGLHSPVFLQKNLVFMRPERCERLCKALAQKIIATVGQVDVAVSPAVGGIIPGYET
ARHLNVPSIYVEREGGGFKFRRGFHLEPGQKVVMVEDIVTTGLSSRECIQAIKDAGGDVVAAACIVDRSGGKADVGVPLI
ALASLEVPAYPADALPPELAAIPIEDPGSRRLKG

Sequences:

>Translated_194_residues
MTNDDVLDEFRAAGALREGHFVLSSGLHSPVFLQKNLVFMRPERCERLCKALAQKIIATVGQVDVAVSPAVGGIIPGYET
ARHLNVPSIYVEREGGGFKFRRGFHLEPGQKVVMVEDIVTTGLSSRECIQAIKDAGGDVVAAACIVDRSGGKADVGVPLI
ALASLEVPAYPADALPPELAAIPIEDPGSRRLKG
>Mature_193_residues
TNDDVLDEFRAAGALREGHFVLSSGLHSPVFLQKNLVFMRPERCERLCKALAQKIIATVGQVDVAVSPAVGGIIPGYETA
RHLNVPSIYVEREGGGFKFRRGFHLEPGQKVVMVEDIVTTGLSSRECIQAIKDAGGDVVAAACIVDRSGGKADVGVPLIA
LASLEVPAYPADALPPELAAIPIEDPGSRRLKG

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_CAUCN (B8H621)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002516997.1
- ProteinModelPortal:   B8H621
- SMR:   B8H621
- GeneID:   7331602
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_01624
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20583; Mature: 20452

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 120-120 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDDVLDEFRAAGALREGHFVLSSGLHSPVFLQKNLVFMRPERCERLCKALAQKIIATV
CCCHHHHHHHHHHCCCCCCCEEEECCCCCCEEEECCEEEECCHHHHHHHHHHHHHHHHHH
GQVDVAVSPAVGGIIPGYETARHLNVPSIYVEREGGGFKFRRGFHLEPGQKVVMVEDIVT
CCCEEEECCCCCCCCCCCHHHHHCCCCEEEEEECCCCEEEECCCCCCCCCEEEEEHHHHH
TGLSSRECIQAIKDAGGDVVAAACIVDRSGGKADVGVPLIALASLEVPAYPADALPPELA
CCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCE
AIPIEDPGSRRLKG
EEECCCCCCCCCCC
>Mature Secondary Structure 
TNDDVLDEFRAAGALREGHFVLSSGLHSPVFLQKNLVFMRPERCERLCKALAQKIIATV
CCHHHHHHHHHHCCCCCCCEEEECCCCCCEEEECCEEEECCHHHHHHHHHHHHHHHHHH
GQVDVAVSPAVGGIIPGYETARHLNVPSIYVEREGGGFKFRRGFHLEPGQKVVMVEDIVT
CCCEEEECCCCCCCCCCCHHHHHCCCCEEEEEECCCCEEEECCCCCCCCCEEEEEHHHHH
TGLSSRECIQAIKDAGGDVVAAACIVDRSGGKADVGVPLIALASLEVPAYPADALPPELA
CCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCE
AIPIEDPGSRRLKG
EEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA