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The map label for this gene is rsh [H]

Identifier: 16125800

GI number: 16125800

Start: 1716172

End: 1718400

Strand: Direct

Name: rsh [H]

Synonym: CC_1553

Alternate gene names: 16125800

Gene position: 1716172-1718400 (Clockwise)

Preceding gene: 16125799

Following gene: 16125802

Centisome position: 42.72

GC content: 67.07

Gene sequence:

>2229_bases
TTGTCGTCTGTGGCCCCCGTCGCTGTGACCGAAGCGCCGGCCAAGCCGCGCCCCAAGTTTCTTCGCCAATACGAACTGAT
CGAGCGGGTCCACGCCTATGACCCGACCGCCGACGAGGCGCTGCTGAACCGCGCCTATGTCTATGCGATGCGCATGCACG
GCTCGCAGACGCGGGCCAGCGGCGATCCCTACTATGCTCACCCGATCGAGGTGGCGGGCATCCTCACCGAGTATCGGCTG
GACACCGCGACCATCGTCACCGCGCTCCTGCACGACGTGATCGAGGACACCCCGGTCACTAAGGAAGAGATCGCCAAGCT
GTTCGGCGAGGAGATCGGCGAGCTGGTCGAGGGCGTCACCAAGCTCTCCAAGCTTGAGCTGCAGGCCGAGCATATGCGGC
AGGCCGAGAACCTGCGCAAATTCATCCTGGCCATCTCCAAGGACGTGCGCGTCCTGCTGGTCAAGCTGGCCGACCGTCTG
CACAACATGCGGACGCTGCACTTCATCAAGAACCAGGCCAAGCGCGAGCGCATCGCCCGCGAGACGCGCGACATCTACGC
GCCCCTGGCCCGCAATATCGGCTGTCACCGCATCTGCACCGAGCTGGAGGAGCTCAGCTTCCAGCACACCAACCCGGTGG
CGCGCGACGCCATCATCCGGCGCCTGGACGTCCTGCGCGAGGAGCAGGGCGGGGCGGTGACGCTGGTCAGTCAGGAAATC
GCGGCGCGCCTGGAGTCGGCCAGTTTGCCGGCGCGGGTCTTTGGCCGCGAGAAGTCGCCCTACTCGATCTGGCGCAAGCT
GCAGCGCAAGTCGATCGGCTTCTCGCAGATGTCAGACATCTATGCGTTCCGGGTGATCGTCGACAGTGAGGAAGACTGCT
ATCGGGCGCTTGGCGTGGTCCACCGCGCCTGGTCCAGCGTGCCCGACCGCTTCAAGGACTATATCTCGACGCCTAAGCGG
AACAACTACCGCTCGCTGCACACCACCGTGGTGGGGCCGCGCGGCATGCGCATCGAGATGCAGATCCGCACCGAGAGCAT
GGACCGCGTCAACGAAGAGGGCGTCGCCGCCCACTTCCGCTACAAGGACGCCTCCTACGGGCTCGACCTGGAAGGCATGG
AGGCCGCCGGCGGCCGCGACCCGCTGGCCAACCTGCGCCAGCTGGTCCAGGTGCTGGAGCATGGCGGCGACAGCGAAGAA
CTGGTCGAACACGCCAAGCTCGAGATGTTCCTCGACCAGGTTTTCGTGTTCACGCCCAAGGGCAAGCTGGTCAGCCTGCC
GCGCGGGGCCATGCCACTGGACTTCGCCTATGCGGTTCACACCAGCGTCGGCGATACCTGTATCGGTGTGAAGATCAATG
GCGAGCTCAAGCCGCTGCGCACGCCGCTGGTCAATGGCGATGTGGTTGAGGTGGTCCGGGGCTCCAAGCCCGTGGTCCCG
CCCGACTGGCGCTCGCTGACGGTGACGGGCCGCGCCCGTTCGGCCATCCGCCGCCATATCCGCCAGACCGAGAAGGAAGA
GTTCCTGCGTCTGGGCCGCGCGTCGCTGGAGCAGGTGTTCGAGCGCGCCGGCAAGAAGCTGAAGGACGTGTCGCTGCGGC
CGATCCTGGAGCGCTTCGTGCTGGAGACTGACGAGGCCCTGTTCGACGCTGTCGGGCGCGGTCGGGTGTCGCCCAGCCAG
GTGCTGGAGACCGCCTATCCGGGCATGAAGGACTCCGAGCGCGAGGCCGCTACGGCCCGGCGCAAGATCGAAGGCGGCCA
GGAGGCGGCGCGGCTCTATGTGCGCGGCGGCGGTCTGACGCCCGGCGTCTCACTGCACTTCGCCCACTGCTGCAGCGCCG
TGCCGGGCGACCGCATCGTCGGCATCCTGCGCGAGGATGGTGAGGGCCTGGACGTCCACACCATCGACTGTCCGCGCCTG
GCCGAATACGAGGACCGCGAGGAACTCTGGCGCGACCTGAACTGGACGCCCGAGGCCGAGCGCTCGACGATCTCGCTGAC
CCGCCTGCACGCCACCATCCAGAACGCGCCCGGCGTGCTGGGCCTGGTTTGCACGATCATCGGCGAGGCCGGCGGCAACA
TCGTCAACCTGCGCATGCACCACCGGCAGAGCGACTTCTTCGACACCGACATCGACGTCGAGGTCCGCGACGCCAAGCAC
CTGACCAACATCCAGGCGGCGCTGCGGGCGTGTCCCTCGGTGGAGACGGTGGACCGGACGCGGGGGTAG

Upstream 100 bases:

>100_bases
CCCCGACGGCGCAGACCCTCTGACCCTTGAAGCGGTCGATCAGACCGCTCCATCCGAACGCGCGCCGGATTCGCCCCCCA
CGGGGACCGAATCGGGCGCG

Downstream 100 bases:

>100_bases
GGGGGCGGAACGAGGACCCTCTCCTTCAGGGAGAGGGACTGGGCCATTGCGGAGCGATGGGAGGGAGAGGGGTTACGCAG
TCTGACGGCGTGCCGGCACT

Product: guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MSSVAPVAVTEAPAKPRPKFLRQYELIERVHAYDPTADEALLNRAYVYAMRMHGSQTRASGDPYYAHPIEVAGILTEYRL
DTATIVTALLHDVIEDTPVTKEEIAKLFGEEIGELVEGVTKLSKLELQAEHMRQAENLRKFILAISKDVRVLLVKLADRL
HNMRTLHFIKNQAKRERIARETRDIYAPLARNIGCHRICTELEELSFQHTNPVARDAIIRRLDVLREEQGGAVTLVSQEI
AARLESASLPARVFGREKSPYSIWRKLQRKSIGFSQMSDIYAFRVIVDSEEDCYRALGVVHRAWSSVPDRFKDYISTPKR
NNYRSLHTTVVGPRGMRIEMQIRTESMDRVNEEGVAAHFRYKDASYGLDLEGMEAAGGRDPLANLRQLVQVLEHGGDSEE
LVEHAKLEMFLDQVFVFTPKGKLVSLPRGAMPLDFAYAVHTSVGDTCIGVKINGELKPLRTPLVNGDVVEVVRGSKPVVP
PDWRSLTVTGRARSAIRRHIRQTEKEEFLRLGRASLEQVFERAGKKLKDVSLRPILERFVLETDEALFDAVGRGRVSPSQ
VLETAYPGMKDSEREAATARRKIEGGQEAARLYVRGGGLTPGVSLHFAHCCSAVPGDRIVGILREDGEGLDVHTIDCPRL
AEYEDREELWRDLNWTPEAERSTISLTRLHATIQNAPGVLGLVCTIIGEAGGNIVNLRMHHRQSDFFDTDIDVEVRDAKH
LTNIQAALRACPSVETVDRTRG

Sequences:

>Translated_742_residues
MSSVAPVAVTEAPAKPRPKFLRQYELIERVHAYDPTADEALLNRAYVYAMRMHGSQTRASGDPYYAHPIEVAGILTEYRL
DTATIVTALLHDVIEDTPVTKEEIAKLFGEEIGELVEGVTKLSKLELQAEHMRQAENLRKFILAISKDVRVLLVKLADRL
HNMRTLHFIKNQAKRERIARETRDIYAPLARNIGCHRICTELEELSFQHTNPVARDAIIRRLDVLREEQGGAVTLVSQEI
AARLESASLPARVFGREKSPYSIWRKLQRKSIGFSQMSDIYAFRVIVDSEEDCYRALGVVHRAWSSVPDRFKDYISTPKR
NNYRSLHTTVVGPRGMRIEMQIRTESMDRVNEEGVAAHFRYKDASYGLDLEGMEAAGGRDPLANLRQLVQVLEHGGDSEE
LVEHAKLEMFLDQVFVFTPKGKLVSLPRGAMPLDFAYAVHTSVGDTCIGVKINGELKPLRTPLVNGDVVEVVRGSKPVVP
PDWRSLTVTGRARSAIRRHIRQTEKEEFLRLGRASLEQVFERAGKKLKDVSLRPILERFVLETDEALFDAVGRGRVSPSQ
VLETAYPGMKDSEREAATARRKIEGGQEAARLYVRGGGLTPGVSLHFAHCCSAVPGDRIVGILREDGEGLDVHTIDCPRL
AEYEDREELWRDLNWTPEAERSTISLTRLHATIQNAPGVLGLVCTIIGEAGGNIVNLRMHHRQSDFFDTDIDVEVRDAKH
LTNIQAALRACPSVETVDRTRG
>Mature_741_residues
SSVAPVAVTEAPAKPRPKFLRQYELIERVHAYDPTADEALLNRAYVYAMRMHGSQTRASGDPYYAHPIEVAGILTEYRLD
TATIVTALLHDVIEDTPVTKEEIAKLFGEEIGELVEGVTKLSKLELQAEHMRQAENLRKFILAISKDVRVLLVKLADRLH
NMRTLHFIKNQAKRERIARETRDIYAPLARNIGCHRICTELEELSFQHTNPVARDAIIRRLDVLREEQGGAVTLVSQEIA
ARLESASLPARVFGREKSPYSIWRKLQRKSIGFSQMSDIYAFRVIVDSEEDCYRALGVVHRAWSSVPDRFKDYISTPKRN
NYRSLHTTVVGPRGMRIEMQIRTESMDRVNEEGVAAHFRYKDASYGLDLEGMEAAGGRDPLANLRQLVQVLEHGGDSEEL
VEHAKLEMFLDQVFVFTPKGKLVSLPRGAMPLDFAYAVHTSVGDTCIGVKINGELKPLRTPLVNGDVVEVVRGSKPVVPP
DWRSLTVTGRARSAIRRHIRQTEKEEFLRLGRASLEQVFERAGKKLKDVSLRPILERFVLETDEALFDAVGRGRVSPSQV
LETAYPGMKDSEREAATARRKIEGGQEAARLYVRGGGLTPGVSLHFAHCCSAVPGDRIVGILREDGEGLDVHTIDCPRLA
EYEDREELWRDLNWTPEAERSTISLTRLHATIQNAPGVLGLVCTIIGEAGGNIVNLRMHHRQSDFFDTDIDVEVRDAKHL
TNIQAALRACPSVETVDRTRG

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=722, Percent_Identity=38.2271468144044, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1789147, Length=723, Percent_Identity=30.7053941908714, Blast_Score=343, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI25143118, Length=155, Percent_Identity=36.7741935483871, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24650996, Length=124, Percent_Identity=38.7096774193548, Blast_Score=70, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83315; Mature: 83184

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVAPVAVTEAPAKPRPKFLRQYELIERVHAYDPTADEALLNRAYVYAMRMHGSQTRAS
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
GDPYYAHPIEVAGILTEYRLDTATIVTALLHDVIEDTPVTKEEIAKLFGEEIGELVEGVT
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
KLSKLELQAEHMRQAENLRKFILAISKDVRVLLVKLADRLHNMRTLHFIKNQAKRERIAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETRDIYAPLARNIGCHRICTELEELSFQHTNPVARDAIIRRLDVLREEQGGAVTLVSQEI
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
AARLESASLPARVFGREKSPYSIWRKLQRKSIGFSQMSDIYAFRVIVDSEEDCYRALGVV
HHHHHHCCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHEEEEEEECCCHHHHHHHHHH
HRAWSSVPDRFKDYISTPKRNNYRSLHTTVVGPRGMRIEMQIRTESMDRVNEEGVAAHFR
HHHHHHCHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHHHHCCCCCCEEEEE
YKDASYGLDLEGMEAAGGRDPLANLRQLVQVLEHGGDSEELVEHAKLEMFLDQVFVFTPK
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCC
GKLVSLPRGAMPLDFAYAVHTSVGDTCIGVKINGELKPLRTPLVNGDVVEVVRGSKPVVP
CCEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCC
PDWRSLTVTGRARSAIRRHIRQTEKEEFLRLGRASLEQVFERAGKKLKDVSLRPILERFV
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHH
LETDEALFDAVGRGRVSPSQVLETAYPGMKDSEREAATARRKIEGGQEAARLYVRGGGLT
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHEEEEEECCCCC
PGVSLHFAHCCSAVPGDRIVGILREDGEGLDVHTIDCPRLAEYEDREELWRDLNWTPEAE
CCHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCCCCC
RSTISLTRLHATIQNAPGVLGLVCTIIGEAGGNIVNLRMHHRQSDFFDTDIDVEVRDAKH
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEECCHHH
LTNIQAALRACPSVETVDRTRG
HHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
SSVAPVAVTEAPAKPRPKFLRQYELIERVHAYDPTADEALLNRAYVYAMRMHGSQTRAS
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
GDPYYAHPIEVAGILTEYRLDTATIVTALLHDVIEDTPVTKEEIAKLFGEEIGELVEGVT
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
KLSKLELQAEHMRQAENLRKFILAISKDVRVLLVKLADRLHNMRTLHFIKNQAKRERIAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETRDIYAPLARNIGCHRICTELEELSFQHTNPVARDAIIRRLDVLREEQGGAVTLVSQEI
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
AARLESASLPARVFGREKSPYSIWRKLQRKSIGFSQMSDIYAFRVIVDSEEDCYRALGVV
HHHHHHCCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHEEEEEEECCCHHHHHHHHHH
HRAWSSVPDRFKDYISTPKRNNYRSLHTTVVGPRGMRIEMQIRTESMDRVNEEGVAAHFR
HHHHHHCHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHHHHCCCCCCEEEEE
YKDASYGLDLEGMEAAGGRDPLANLRQLVQVLEHGGDSEELVEHAKLEMFLDQVFVFTPK
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCC
GKLVSLPRGAMPLDFAYAVHTSVGDTCIGVKINGELKPLRTPLVNGDVVEVVRGSKPVVP
CCEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCC
PDWRSLTVTGRARSAIRRHIRQTEKEEFLRLGRASLEQVFERAGKKLKDVSLRPILERFV
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHH
LETDEALFDAVGRGRVSPSQVLETAYPGMKDSEREAATARRKIEGGQEAARLYVRGGGLT
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHEEEEEECCCCC
PGVSLHFAHCCSAVPGDRIVGILREDGEGLDVHTIDCPRLAEYEDREELWRDLNWTPEAE
CCHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCCCCC
RSTISLTRLHATIQNAPGVLGLVCTIIGEAGGNIVNLRMHHRQSDFFDTDIDVEVRDAKH
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEECCHHH
LTNIQAALRACPSVETVDRTRG
HHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA